Motif ID: MTF1.p2

Z-value: 2.864


Transcription factors associated with MTF1.p2:

Gene SymbolEntrez IDGene Name
MTF1 4520 metal-regulatory transcription factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MTF1chr1_-_38325224-0.252.4e-04Click!


Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_101459410 72.523


chr5_-_11904127 68.544 CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr16_+_58497548 63.712 NM_020465
 NDRG4
NDRG family member 4
chr7_+_64498643 63.413 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr16_+_56659679 57.084 MT1E
metallothionein 1E
chr1_+_104068312 54.397 RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr16_+_56659584 54.147 NM_175617
 MT1E
metallothionein 1E
chr5_-_11903964 53.820 NM_001332
 CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr16_+_58497628 44.828 NDRG4
NDRG family member 4
chr16_+_56703725 44.306 NM_005951
 MT1H
metallothionein 1H
chr1_-_32229635 41.177 NM_001703
 BAI2
brain-specific angiogenesis inhibitor 2
chr10_+_124220990 38.777 NM_002775
 HTRA1
HtrA serine peptidase 1
chr16_+_58497993 38.529 NM_001130487
 NDRG4
NDRG family member 4
chr16_+_56623266 37.837 NM_005954
 MT3
metallothionein 3
chr20_-_3154169 37.260 ProSAPiP1
ProSAPiP1 protein
chr19_+_33685489 36.157 NM_002333
 LRP3
low density lipoprotein receptor-related protein 3
chr9_-_139922705 35.089 NM_001606
 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr15_-_29862926 34.857 NM_015307
 FAM189A1
family with sequence similarity 189, member A1
chr7_-_994008 34.560 ADAP1
ArfGAP with dual PH domains 1
chr16_+_56666533 33.748 NM_176870
 MT1M
metallothionein 1M

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 297 entries
enrichment   p-value GO term description
5.14 4.74e-02 GO:0060687 regulation of branching involved in prostate gland morphogenesis
3.77 4.25e-02 GO:0048048 embryonic eye morphogenesis
3.63 3.06e-02 GO:0007398 ectoderm development
3.52 2.13e-02 GO:0046928 regulation of neurotransmitter secretion
3.43 1.45e-02 GO:0002027 regulation of heart rate
3.09 4.31e-02 GO:0051588 regulation of neurotransmitter transport
2.81 1.24e-09 GO:0001505 regulation of neurotransmitter levels
2.81 3.58e-02 GO:0042733 embryonic digit morphogenesis
2.79 2.20e-02 GO:0001952 regulation of cell-matrix adhesion
2.78 5.29e-06 GO:0007269 neurotransmitter secretion
2.76 5.14e-03 GO:0007613 memory
2.62 2.09e-03 GO:0090090 negative regulation of canonical Wnt receptor signaling pathway
2.61 1.65e-05 GO:0010721 negative regulation of cell development
2.57 3.88e-06 GO:0008016 regulation of heart contraction
2.57 7.93e-04 GO:0050768 negative regulation of neurogenesis
2.52 8.01e-08 GO:0006836 neurotransmitter transport
2.52 5.45e-03 GO:0048593 camera-type eye morphogenesis
2.43 1.32e-02 GO:0007612 learning
2.42 3.49e-02 GO:0032412 regulation of ion transmembrane transporter activity
2.39 2.02e-02 GO:0034765 regulation of ion transmembrane transport

Gene overrepresentation in compartment category:

Showing 1 to 20 of 42 entries
enrichment   p-value GO term description
2.84 1.24e-02 GO:0034704 calcium channel complex
2.70 1.88e-03 GO:0043679 axon terminus
2.57 5.13e-03 GO:0044306 neuron projection terminus
2.18 6.69e-04 GO:0030665 clathrin coated vesicle membrane
2.13 1.30e-03 GO:0008021 synaptic vesicle
2.09 4.84e-04 GO:0019898 extrinsic to membrane
2.03 2.61e-02 GO:0033267 axon part
2.02 4.80e-05 GO:0034703 cation channel complex
1.95 2.88e-02 GO:0008076 voltage-gated potassium channel complex
1.95 2.88e-02 GO:0034705 potassium channel complex
1.87 3.80e-02 GO:0019717 synaptosome
1.82 9.05e-04 GO:0030136 clathrin-coated vesicle
1.81 3.92e-04 GO:0030424 axon
1.79 4.87e-02 GO:0030662 coated vesicle membrane
1.73 5.50e-04 GO:0034702 ion channel complex
1.71 4.31e-08 GO:0045202 synapse
1.69 1.55e-07 GO:0043005 neuron projection
1.66 8.85e-05 GO:0044456 synapse part
1.62 2.36e-02 GO:0030135 coated vesicle
1.55 3.63e-04 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

Showing 1 to 20 of 66 entries
enrichment   p-value GO term description
3.16 3.43e-03 GO:0005245 voltage-gated calcium channel activity
2.63 2.29e-03 GO:0046332 SMAD binding
2.54 1.58e-06 GO:0019199 transmembrane receptor protein kinase activity
2.53 1.22e-04 GO:0004714 transmembrane receptor protein tyrosine kinase activity
2.31 6.53e-06 GO:0005057 receptor signaling protein activity
2.20 2.61e-03 GO:0005262 calcium channel activity
2.03 3.36e-05 GO:0022843 voltage-gated cation channel activity
1.93 8.60e-04 GO:0004713 protein tyrosine kinase activity
1.90 2.24e-05 GO:0005244 voltage-gated ion channel activity
1.90 2.24e-05 GO:0022832 voltage-gated channel activity
1.88 6.81e-03 GO:0005267 potassium channel activity
1.83 5.94e-07 GO:0005261 cation channel activity
1.81 1.06e-02 GO:0005516 calmodulin binding
1.73 5.51e-06 GO:0022836 gated channel activity
1.71 2.87e-02 GO:0005085 guanyl-nucleotide exchange factor activity
1.69 1.86e-04 GO:0032403 protein complex binding
1.65 1.38e-02 GO:0000975 regulatory region DNA binding
1.65 1.38e-02 GO:0001067 regulatory region nucleic acid binding
1.65 1.38e-02 GO:0044212 transcription regulatory region DNA binding
1.64 5.09e-03 GO:0019900 kinase binding