Motif ID: MYFfamily.p2

Z-value: 2.733


Transcription factors associated with MYFfamily.p2:

Gene SymbolEntrez IDGene Name
MYF5 4617 myogenic factor 5
MYF6 4618 myogenic factor 6 (herculin)
MYOD1 4654 myogenic differentiation 1
MYOG 4656 myogenin (myogenic factor 4)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MYF5chr12_+_811106890.665.3e-29Click!
MYOD1chr11_+_177411090.622.9e-24Click!
MYF6chr12_+_811014070.586.4e-21Click!
MYOGchr1_-_2030553760.472.0e-13Click!


Activity profile for motif MYFfamily.p2.

activity profile for motif MYFfamily.p2


Sorted Z-values histogram for motif MYFfamily.p2

Sorted Z-values for motif MYFfamily.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MYFfamily.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_137801178 63.601 NM_001964
 EGR1
early growth response 1
chr1_-_57045214 50.183 PPAP2B
phosphatidic acid phosphatase type 2B
chr4_-_57976516 49.111 IGFBP7
insulin-like growth factor binding protein 7
chr4_-_57976550 49.068 NM_001253835
NM_001553
 IGFBP7

insulin-like growth factor binding protein 7

chr6_+_99282597 47.833 POU3F2
POU class 3 homeobox 2
chr19_+_33182689 45.349 NM_001105570
 NUDT19
nudix (nucleoside diphosphate linked moiety X)-type motif 19
chr18_+_21594349 44.292 NM_001135993
NM_001243425
 TTC39C

tetratricopeptide repeat domain 39C

chr4_-_57976355 42.453 IGFBP7
insulin-like growth factor binding protein 7
chr6_+_45390284 40.162 RUNX2
runt-related transcription factor 2
chr1_-_57045129 39.031 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_57044980 38.705 PPAP2B
phosphatidic acid phosphatase type 2B
chr6_+_45390376 38.476 RUNX2
runt-related transcription factor 2
chr6_-_91006460 37.314 NM_021813
 BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr1_-_57045235 37.299 NM_003713
 PPAP2B
phosphatidic acid phosphatase type 2B
chr12_+_66218879 35.956 HMGA2
high mobility group AT-hook 2
chr3_-_195306274 34.921 APOD
apolipoprotein D
chr5_+_137801166 34.102 EGR1
early growth response 1
chr5_-_139422725 33.356 NRG2
neuregulin 2
chr2_+_203499819 32.973 NM_173511
 FAM117B
family with sequence similarity 117, member B
chr5_-_178772328 30.762 ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif, 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 235 entries
enrichment   p-value GO term description
3.29 1.23e-02 GO:0061035 regulation of cartilage development
3.25 3.68e-03 GO:0042733 embryonic digit morphogenesis
3.18 2.22e-02 GO:0045778 positive regulation of ossification
3.13 1.07e-03 GO:0009187 cyclic nucleotide metabolic process
2.76 4.38e-05 GO:0050770 regulation of axonogenesis
2.71 3.67e-02 GO:0048663 neuron fate commitment
2.65 1.56e-04 GO:0022612 gland morphogenesis
2.43 1.20e-03 GO:0007160 cell-matrix adhesion
2.38 3.20e-02 GO:0042472 inner ear morphogenesis
2.37 2.53e-02 GO:0006937 regulation of muscle contraction
2.32 3.32e-04 GO:0061138 morphogenesis of a branching epithelium
2.31 2.17e-02 GO:0002576 platelet degranulation
2.29 2.77e-03 GO:0048839 inner ear development
2.26 3.68e-06 GO:0019935 cyclic-nucleotide-mediated signaling
2.26 4.82e-04 GO:0019933 cAMP-mediated signaling
2.25 3.97e-02 GO:0042471 ear morphogenesis
2.24 3.95e-03 GO:0031589 cell-substrate adhesion
2.22 8.86e-10 GO:0030168 platelet activation
2.19 1.95e-03 GO:0043583 ear development
2.19 7.00e-03 GO:0031279 regulation of cyclase activity

Gene overrepresentation in compartment category:

Showing 1 to 20 of 40 entries
enrichment   p-value GO term description
2.98 2.51e-03 GO:0005581 collagen
2.79 9.26e-04 GO:0031093 platelet alpha granule lumen
2.79 4.09e-02 GO:0042611 MHC protein complex
2.75 4.35e-04 GO:0031983 vesicle lumen
2.73 1.44e-03 GO:0034774 secretory granule lumen
2.62 3.30e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.41 1.16e-02 GO:0031091 platelet alpha granule
2.38 1.88e-03 GO:0005604 basement membrane
2.32 8.98e-06 GO:0044420 extracellular matrix part
2.08 1.88e-14 GO:0031012 extracellular matrix
2.00 9.01e-04 GO:0043235 receptor complex
1.97 1.35e-09 GO:0005578 proteinaceous extracellular matrix
1.86 1.07e-04 GO:0034702 ion channel complex
1.81 3.74e-02 GO:0034703 cation channel complex
1.77 1.08e-27 GO:0031226 intrinsic to plasma membrane
1.77 5.94e-27 GO:0005887 integral to plasma membrane
1.77 3.64e-02 GO:0045211 postsynaptic membrane
1.76 3.02e-03 GO:0030141 stored secretory granule
1.73 8.01e-20 GO:0044421 extracellular region part
1.70 2.11e-13 GO:0005615 extracellular space

Gene overrepresentation in function category:

Showing 1 to 20 of 54 entries
enrichment   p-value GO term description
5.22 2.82e-02 GO:0043121 neurotrophin binding
4.47 5.13e-04 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
3.48 5.59e-03 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
3.41 1.70e-03 GO:0005158 insulin receptor binding
3.34 1.07e-02 GO:0004112 cyclic-nucleotide phosphodiesterase activity
2.84 1.53e-05 GO:0004714 transmembrane receptor protein tyrosine kinase activity
2.80 3.21e-07 GO:0019199 transmembrane receptor protein kinase activity
2.67 1.15e-08 GO:0019838 growth factor binding
2.33 2.02e-02 GO:0005178 integrin binding
2.31 2.57e-03 GO:0005201 extracellular matrix structural constituent
2.03 2.41e-02 GO:0005057 receptor signaling protein activity
1.97 2.85e-03 GO:0004713 protein tyrosine kinase activity
1.93 4.47e-02 GO:0008201 heparin binding
1.90 1.84e-06 GO:0032403 protein complex binding
1.90 4.08e-02 GO:0030674 protein binding, bridging
1.87 1.19e-02 GO:0005539 glycosaminoglycan binding
1.82 2.39e-06 GO:0022836 gated channel activity
1.80 2.25e-02 GO:0001871 pattern binding
1.80 2.25e-02 GO:0030247 polysaccharide binding
1.78 8.78e-05 GO:0005261 cation channel activity