Motif ID: NFATC1..3.p2

Z-value: 1.426


Transcription factors associated with NFATC1..3.p2:

Gene SymbolEntrez IDGene Name
NFATC1 4772 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 4773 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 4775 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFATC3chr16_+_68119350-0.282.0e-05Click!
NFATC1chr18_+_771559270.144.4e-02Click!


Activity profile for motif NFATC1..3.p2.

activity profile for motif NFATC1..3.p2


Sorted Z-values histogram for motif NFATC1..3.p2

Sorted Z-values for motif NFATC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_238322840 46.223 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
 COL6A3




collagen, type VI, alpha 3




chr2_-_238322770 44.200 COL6A3
collagen, type VI, alpha 3
chr2_+_189839132 43.950 COL3A1
collagen, type III, alpha 1
chr2_-_238322815 36.100 COL6A3
collagen, type VI, alpha 3
chr2_+_189839078 34.846 NM_000090
 COL3A1
collagen, type III, alpha 1
chr2_+_189839113 33.063 COL3A1
collagen, type III, alpha 1
chr12_-_91573264 27.767 NM_133503
 DCN
decorin
chr12_+_13349720 21.734 EMP1
epithelial membrane protein 1
chr12_+_13349601 21.414 NM_001423
 EMP1
epithelial membrane protein 1
chr2_-_216259197 19.664 FN1
fibronectin 1
chr7_+_23286384 17.397 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_23286386 17.255 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_23286390 17.240 GPNMB
glycoprotein (transmembrane) nmb
chr12_-_15038724 15.951 NM_000900
NM_001190839
 MGP

matrix Gla protein

chr17_-_15164043 15.921 NM_153322
 PMP22
peripheral myelin protein 22
chr1_-_150780705 14.013 NM_000396
 CTSK
cathepsin K
chr3_-_195310985 13.867 NM_001647
 APOD
apolipoprotein D
chr6_-_169653922 13.595 THBS2
thrombospondin 2
chr12_-_9268513 13.379 A2M
alpha-2-macroglobulin
chr7_+_116164838 13.341 NM_001753
 CAV1
caveolin 1, caveolae protein, 22kDa

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 71 entries
enrichment   p-value GO term description
2.95 6.95e-03 GO:0002576 platelet degranulation
2.75 3.67e-06 GO:0040017 positive regulation of locomotion
2.71 1.53e-05 GO:0030335 positive regulation of cell migration
2.71 1.53e-05 GO:2000147 positive regulation of cell motility
2.68 1.06e-02 GO:0030198 extracellular matrix organization
2.67 4.26e-02 GO:0051271 negative regulation of cellular component movement
2.53 1.14e-04 GO:0051272 positive regulation of cellular component movement
2.50 5.01e-08 GO:0030334 regulation of cell migration
2.49 1.89e-02 GO:0007565 female pregnancy
2.47 8.66e-08 GO:2000145 regulation of cell motility
2.45 9.30e-04 GO:0050900 leukocyte migration
2.40 7.28e-08 GO:0051270 regulation of cellular component movement
2.37 1.79e-07 GO:0040012 regulation of locomotion
2.31 3.23e-02 GO:0007156 homophilic cell adhesion
2.24 1.52e-04 GO:0030168 platelet activation
2.23 7.91e-06 GO:0006954 inflammatory response
2.15 3.28e-02 GO:0051251 positive regulation of lymphocyte activation
2.13 2.03e-03 GO:0032101 regulation of response to external stimulus
2.05 1.20e-03 GO:0048545 response to steroid hormone stimulus
2.04 1.75e-02 GO:0051249 regulation of lymphocyte activation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
6.41 9.14e-03 GO:0005583 fibrillar collagen
5.75 6.82e-03 GO:0042613 MHC class II protein complex
4.20 2.67e-04 GO:0005581 collagen
3.71 2.08e-05 GO:0031091 platelet alpha granule
3.64 5.27e-04 GO:0031093 platelet alpha granule lumen
3.57 7.41e-04 GO:0034774 secretory granule lumen
3.49 5.43e-04 GO:0031983 vesicle lumen
3.42 1.42e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.27 1.27e-22 GO:0005615 extracellular space
2.07 7.39e-22 GO:0044421 extracellular region part
2.04 1.61e-05 GO:0005578 proteinaceous extracellular matrix
2.01 5.54e-03 GO:0030141 stored secretory granule
1.98 6.11e-06 GO:0031012 extracellular matrix
1.89 1.35e-02 GO:0016323 basolateral plasma membrane
1.69 9.65e-21 GO:0005576 extracellular region
1.48 2.90e-05 GO:0031226 intrinsic to plasma membrane
1.48 3.47e-05 GO:0005887 integral to plasma membrane
1.38 2.11e-06 GO:0044459 plasma membrane part
1.21 4.99e-04 GO:0005886 plasma membrane
1.20 8.70e-04 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
6.04 2.02e-03 GO:0008329 pattern recognition receptor activity
3.53 1.28e-02 GO:0003823 antigen binding
3.36 3.49e-03 GO:0003707 steroid hormone receptor activity
3.28 1.70e-02 GO:0008009 chemokine activity
3.17 8.34e-03 GO:0004879 ligand-dependent nuclear receptor activity
2.82 7.87e-05 GO:0019838 growth factor binding
2.44 4.23e-06 GO:0005125 cytokine activity
2.29 2.38e-04 GO:0005126 cytokine receptor binding
2.26 4.56e-03 GO:0005539 glycosaminoglycan binding
2.22 3.85e-03 GO:0001871 pattern binding
2.22 3.85e-03 GO:0030247 polysaccharide binding
1.82 8.71e-04 GO:0030246 carbohydrate binding
1.71 2.56e-09 GO:0005102 receptor binding
1.26 4.01e-02 GO:0004871 signal transducer activity
1.26 4.01e-02 GO:0060089 molecular transducer activity
1.12 1.12e-02 GO:0005515 protein binding