Motif ID: NFE2.p2

Z-value: 1.069


Transcription factors associated with NFE2.p2:

Gene SymbolEntrez IDGene Name
NFE2 4778 nuclear factor (erythroid-derived 2), 45kDa

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2chr12_-_54694717,
chr12_-_54689536,
chr12_-_54694647		-0.045.7e-01Click!


Activity profile for motif NFE2.p2.

activity profile for motif NFE2.p2


Sorted Z-values histogram for motif NFE2.p2

Sorted Z-values for motif NFE2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_223889253 58.343 NM_001146068
 CAPN2
calpain 2, (m/II) large subunit
chr14_+_58711599 34.969 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr17_+_30771520 33.274 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr6_-_31704070 19.958 CLIC1
chloride intracellular channel 1
chr3_+_183894736 19.601 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr6_-_31704318 17.903 NM_001288
 CLIC1
chloride intracellular channel 1
chr6_-_31704304 17.433 CLIC1
chloride intracellular channel 1
chr11_-_65667858 17.413 FOSL1
FOS-like antigen 1
chr6_-_31704093 17.275 CLIC1
chloride intracellular channel 1
chr14_+_58711555 17.235 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr6_-_31704281 17.134 CLIC1
chloride intracellular channel 1
chr6_-_31704272 17.042 CLIC1
chloride intracellular channel 1
chr14_+_58711457 17.026 NM_002788
NM_152132
 PSMA3

proteasome (prosome, macropain) subunit, alpha type, 3

chr6_-_31704287 16.977 CLIC1
chloride intracellular channel 1
chr17_+_30771494 16.694 NM_002815
 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr11_-_65667809 16.689 FOSL1
FOS-like antigen 1
chr17_+_30771522 16.580 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771485 16.476 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr1_+_40735749 16.173 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr11_-_16996559 15.917 RPL36A
ribosomal protein L36a

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 201 entries
enrichment   p-value GO term description
10.06 2.03e-11 GO:0006521 regulation of cellular amino acid metabolic process
8.77 8.29e-11 GO:0071158 positive regulation of cell cycle arrest
8.74 3.88e-10 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
8.74 3.88e-10 GO:0072395 signal transduction involved in cell cycle checkpoint
8.74 3.88e-10 GO:0072401 signal transduction involved in DNA integrity checkpoint
8.74 3.88e-10 GO:0072404 signal transduction involved in G1/S transition checkpoint
8.74 3.88e-10 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
8.74 3.88e-10 GO:0072422 signal transduction involved in DNA damage checkpoint
8.74 3.88e-10 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
8.74 3.88e-10 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
8.33 1.03e-09 GO:0033238 regulation of cellular amine metabolic process
7.84 3.46e-09 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
7.54 2.79e-08 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
7.51 8.09e-09 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
7.21 6.25e-08 GO:0051352 negative regulation of ligase activity
7.21 6.25e-08 GO:0051444 negative regulation of ubiquitin-protein ligase activity
7.19 1.52e-09 GO:2000045 regulation of G1/S transition of mitotic cell cycle
7.19 5.24e-09 GO:0031575 mitotic cell cycle G1/S transition checkpoint
7.19 5.24e-09 GO:0071779 G1/S transition checkpoint
6.92 3.88e-08 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

Gene overrepresentation in compartment category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
15.59 1.98e-03 GO:0005838 proteasome regulatory particle
14.03 4.83e-04 GO:0022624 proteasome accessory complex
9.82 1.15e-03 GO:0005839 proteasome core complex
9.80 4.25e-14 GO:0000502 proteasome complex
5.37 1.12e-02 GO:0031093 platelet alpha granule lumen
5.26 1.34e-02 GO:0034774 secretory granule lumen
5.05 1.87e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
4.86 2.58e-02 GO:0031983 vesicle lumen
1.85 5.07e-03 GO:0005626 insoluble fraction
1.80 1.78e-02 GO:0005624 membrane fraction
1.79 1.09e-03 GO:0000267 cell fraction
1.79 2.24e-02 GO:0031982 vesicle
1.78 4.00e-02 GO:0031410 cytoplasmic vesicle
1.75 1.72e-07 GO:0005829 cytosol
1.57 7.40e-07 GO:0043234 protein complex
1.45 4.53e-05 GO:0032991 macromolecular complex
1.33 6.60e-12 GO:0005737 cytoplasm
1.33 6.40e-06 GO:0044444 cytoplasmic part
1.17 2.38e-06 GO:0044424 intracellular part
1.16 1.19e-05 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
9.35 2.46e-03 GO:0004298 threonine-type endopeptidase activity
9.35 2.46e-03 GO:0070003 threonine-type peptidase activity
7.24 4.42e-03 GO:0015036 disulfide oxidoreductase activity
4.95 3.25e-02 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors
3.43 2.27e-04 GO:0005126 cytokine receptor binding
2.58 1.07e-02 GO:0032403 protein complex binding
2.06 3.21e-04 GO:0019899 enzyme binding
1.68 4.47e-02 GO:0005102 receptor binding
1.48 2.09e-19 GO:0005515 protein binding
1.25 2.23e-02 GO:0003824 catalytic activity
1.17 1.55e-07 GO:0005488 binding