Motif ID: NFE2L2.p2

Z-value: 1.958


Transcription factors associated with NFE2L2.p2:

Gene SymbolEntrez IDGene Name
NFE2L2 4780 nuclear factor (erythroid-derived 2)-like 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2L2chr2_-_1781285270.243.8e-04Click!


Activity profile for motif NFE2L2.p2.

activity profile for motif NFE2L2.p2


Sorted Z-values histogram for motif NFE2L2.p2

Sorted Z-values for motif NFE2L2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_30771520 86.684 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771494 61.924 NM_002815
 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771522 61.634 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771485 61.267 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr14_+_58711555 55.692 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr17_+_30771532 55.319 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_-_73150769 54.957 NM_001002032
NM_001002033
NM_016185
 HN1


hematological and neurological expressed 1


chr14_+_58711457 52.658 NM_002788
NM_152132
 PSMA3

proteasome (prosome, macropain) subunit, alpha type, 3

chr14_+_58711599 52.609 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr2_+_162164785 52.428 NM_005805
 PSMD14
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
chr1_-_225616556 51.543 NM_194442
 LBR
lamin B receptor
chr18_+_158586 47.360 USP14
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr18_+_158480 46.167 NM_001037334
NM_005151
 USP14

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

chr16_+_30077120 44.925 ALDOA
aldolase A, fructose-bisphosphate
chr16_+_30076993 44.558 NM_001243177
NM_184041
 ALDOA

aldolase A, fructose-bisphosphate

chr16_+_30077146 44.096 ALDOA
aldolase A, fructose-bisphosphate
chr6_-_31704304 43.495 CLIC1
chloride intracellular channel 1
chr2_+_231921625 43.218 PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr6_-_31704281 42.592 CLIC1
chloride intracellular channel 1
chr6_-_31704272 42.391 CLIC1
chloride intracellular channel 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 118 entries
enrichment   p-value GO term description
15.35 6.78e-17 GO:0006521 regulation of cellular amino acid metabolic process
13.34 2.15e-15 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
13.34 2.15e-15 GO:0072395 signal transduction involved in cell cycle checkpoint
13.34 2.15e-15 GO:0072401 signal transduction involved in DNA integrity checkpoint
13.34 2.15e-15 GO:0072404 signal transduction involved in G1/S transition checkpoint
13.34 2.15e-15 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
13.34 2.15e-15 GO:0072422 signal transduction involved in DNA damage checkpoint
13.34 2.15e-15 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
13.34 2.15e-15 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
12.71 6.74e-15 GO:0033238 regulation of cellular amine metabolic process
12.71 6.74e-15 GO:0071158 positive regulation of cell cycle arrest
12.53 1.51e-15 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
12.00 4.37e-15 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
11.56 3.49e-13 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
11.42 2.59e-15 GO:0051443 positive regulation of ubiquitin-protein ligase activity
11.34 5.61e-16 GO:0051351 positive regulation of ligase activity
11.07 3.10e-14 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
11.07 9.07e-13 GO:0051352 negative regulation of ligase activity
11.07 9.07e-13 GO:0051444 negative regulation of ubiquitin-protein ligase activity
10.93 4.21e-14 GO:0031575 mitotic cell cycle G1/S transition checkpoint

Gene overrepresentation in compartment category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
24.21 1.54e-04 GO:0019773 proteasome core complex, alpha-subunit complex
21.52 3.38e-04 GO:0005838 proteasome regulatory particle
16.14 1.99e-03 GO:0022624 proteasome accessory complex
15.49 4.70e-06 GO:0005839 proteasome core complex
15.37 2.84e-21 GO:0000502 proteasome complex
1.77 1.71e-05 GO:0005829 cytosol
1.57 1.45e-04 GO:0043234 protein complex
1.44 2.50e-03 GO:0032991 macromolecular complex
1.38 4.48e-11 GO:0005737 cytoplasm
1.27 1.87e-02 GO:0044444 cytoplasmic part
1.20 2.97e-07 GO:0005622 intracellular
1.20 3.25e-06 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
29.05 2.43e-02 GO:0015037 peptide disulfide oxidoreductase activity
14.76 1.04e-05 GO:0004298 threonine-type endopeptidase activity
14.76 1.04e-05 GO:0070003 threonine-type peptidase activity
9.69 1.88e-05 GO:0003823 antigen binding
8.75 4.12e-03 GO:0015036 disulfide oxidoreductase activity
8.30 2.44e-02 GO:0015035 protein disulfide oxidoreductase activity
6.08 1.64e-02 GO:0005097 Rab GTPase activator activity
2.82 1.93e-02 GO:0032403 protein complex binding
2.51 2.03e-02 GO:0004175 endopeptidase activity
2.15 3.01e-02 GO:0008233 peptidase activity
1.46 2.66e-12 GO:0005515 protein binding
1.18 5.38e-06 GO:0005488 binding