Motif ID: NFKB1_REL_RELA.p2

Z-value: 2.687


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFKB1chr4_+_1034224790.597.4e-22Click!
RELchr2_+_611087750.571.8e-20Click!
RELAchr11_-_654304270.335.8e-07Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_35873823 65.610 NM_020529
 NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr19_-_41859332 55.388 TGFB1
transforming growth factor, beta 1
chr19_-_41859830 53.119 NM_000660
 TGFB1
transforming growth factor, beta 1
chr19_-_41859519 52.961 TGFB1
transforming growth factor, beta 1
chr5_-_149792276 48.621 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_-_31324975 43.030 NM_005514
 HLA-B
major histocompatibility complex, class I, B
chr6_-_32551993 41.126 HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr6_-_31324955 39.796 HLA-B
major histocompatibility complex, class I, B
chr5_-_149792370 39.795 NM_001025158
NM_001025159
NM_004355
 CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr22_-_37640287 39.677 NM_002872
 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr6_+_29974352 39.197 HLA-J
major histocompatibility complex, class I, J (pseudogene)
chr19_-_41859253 37.478 TGFB1
transforming growth factor, beta 1
chr22_+_22758538 37.303


chr6_+_29910246 32.299 NM_001242758
NM_002116
 HLA-A

major histocompatibility complex, class I, A

chr6_-_31324898 32.233 HLA-B
major histocompatibility complex, class I, B
chr12_+_7055736 31.431 NM_080548
 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr17_+_40440481 31.308 STAT5A
signal transducer and activator of transcription 5A
chr6_+_32605182 29.970 NM_002122
 HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr19_+_1067536 29.034 HMHA1
histocompatibility (minor) HA-1
chr16_+_85932766 28.957 NM_002163
 IRF8
interferon regulatory factor 8

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 234 entries
enrichment   p-value GO term description
8.64 6.75e-03 GO:0002828 regulation of type 2 immune response
5.11 3.35e-03 GO:0042345 regulation of NF-kappaB import into nucleus
4.51 8.21e-07 GO:0034138 toll-like receptor 3 signaling pathway
4.37 1.69e-06 GO:0002756 MyD88-independent toll-like receptor signaling pathway
3.94 3.72e-05 GO:0034130 toll-like receptor 1 signaling pathway
3.94 3.72e-05 GO:0034134 toll-like receptor 2 signaling pathway
3.90 1.01e-05 GO:0008063 Toll signaling pathway
3.90 1.01e-05 GO:0034142 toll-like receptor 4 signaling pathway
3.78 1.38e-02 GO:0051403 stress-activated MAPK cascade
3.72 1.18e-04 GO:0002755 MyD88-dependent toll-like receptor signaling pathway
3.63 2.46e-05 GO:0002224 toll-like receptor signaling pathway
3.50 7.51e-04 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
3.49 3.15e-05 GO:0002758 innate immune response-activating signal transduction
3.47 6.89e-05 GO:0002221 pattern recognition receptor signaling pathway
3.47 2.34e-02 GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
3.42 5.15e-05 GO:0002218 activation of innate immune response
3.41 1.92e-04 GO:0002443 leukocyte mediated immunity
3.41 1.23e-03 GO:0002250 adaptive immune response
3.40 4.62e-03 GO:0002449 lymphocyte mediated immunity
3.39 1.74e-02 GO:0060333 interferon-gamma-mediated signaling pathway

Gene overrepresentation in compartment category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
3.77 3.53e-02 GO:0005581 collagen
2.24 4.56e-02 GO:0009897 external side of plasma membrane
1.73 3.72e-02 GO:0009986 cell surface
1.57 2.38e-03 GO:0005615 extracellular space
1.52 3.79e-05 GO:0005654 nucleoplasm
1.45 1.14e-02 GO:0044421 extracellular region part
1.40 1.95e-02 GO:0005887 integral to plasma membrane
1.39 9.37e-05 GO:0005829 cytosol
1.39 2.02e-02 GO:0031226 intrinsic to plasma membrane
1.36 2.10e-03 GO:0031981 nuclear lumen
1.32 4.54e-03 GO:0044428 nuclear part
1.30 8.12e-12 GO:0005634 nucleus
1.30 9.85e-03 GO:0070013 intracellular organelle lumen
1.30 1.12e-02 GO:0044459 plasma membrane part
1.29 1.29e-02 GO:0043233 organelle lumen
1.28 1.37e-02 GO:0031974 membrane-enclosed lumen
1.14 7.79e-05 GO:0043231 intracellular membrane-bounded organelle
1.13 9.67e-05 GO:0043227 membrane-bounded organelle
1.11 3.81e-06 GO:0044424 intracellular part
1.11 1.68e-03 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
4.32 1.08e-03 GO:0003823 antigen binding
3.66 2.45e-03 GO:0004879 ligand-dependent nuclear receptor activity
3.39 2.58e-02 GO:0003707 steroid hormone receptor activity
2.40 6.79e-04 GO:0005126 cytokine receptor binding
2.10 2.57e-02 GO:0010843 promoter binding
2.04 6.70e-10 GO:0043565 sequence-specific DNA binding
2.00 1.19e-03 GO:0016563 transcription activator activity
1.94 8.86e-03 GO:0008134 transcription factor binding
1.93 3.35e-12 GO:0001071 nucleic acid binding transcription factor activity
1.93 3.35e-12 GO:0003700 sequence-specific DNA binding transcription factor activity
1.79 4.85e-09 GO:0030528 transcription regulator activity
1.77 7.44e-03 GO:0004674 protein serine/threonine kinase activity
1.68 2.39e-03 GO:0004672 protein kinase activity
1.63 1.71e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.57 8.13e-03 GO:0019899 enzyme binding
1.56 5.97e-03 GO:0016301 kinase activity
1.36 1.27e-04 GO:0003677 DNA binding
1.30 3.75e-18 GO:0005515 protein binding
1.25 4.50e-03 GO:0003676 nucleic acid binding
1.15 3.42e-14 GO:0005488 binding