Motif ID: NHLH1,2.p2

Z-value: 2.103


Transcription factors associated with NHLH1,2.p2:

Gene SymbolEntrez IDGene Name
NHLH1 4807 nescient helix loop helix 1
NHLH2 4808 nescient helix loop helix 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NHLH2chr1_-_1163836920.518.8e-16Click!
NHLH1chr1_+_1603368560.473.9e-13Click!


Activity profile for motif NHLH1,2.p2.

activity profile for motif NHLH1,2.p2


Sorted Z-values histogram for motif NHLH1,2.p2

Sorted Z-values for motif NHLH1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_35521591 41.904 NM_001037
NM_199037
 SCN1B

sodium channel, voltage-gated, type I, beta

chr8_+_24771276 39.890 NEFM
neurofilament, medium polypeptide
chr8_+_24771268 34.605 NM_005382
 NEFM
neurofilament, medium polypeptide
chr18_-_74691951 32.843 MBP
myelin basic protein
chr3_-_195306274 32.155 APOD
apolipoprotein D
chrX_-_13956530 27.148 GPM6B
glycoprotein M6B
chr14_+_100150596 26.922 NM_006668
 CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr11_-_125366048 26.908 NM_005103
NM_022549
 FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr1_+_233749749 26.867 NM_002245
 KCNK1
potassium channel, subfamily K, member 1
chr20_-_23618382 26.616 NM_000099
 CST3
cystatin C
chr2_+_233498206 25.247 NM_025202
 EFHD1
EF-hand domain family, member D1
chr6_-_159420796 25.087 RSPH3
radial spoke 3 homolog (Chlamydomonas)
chr14_-_103988829 24.141 CKB
creatine kinase, brain
chrX_-_13956644 24.096 NM_001001994
 GPM6B
glycoprotein M6B
chr3_-_149688886 24.059 PFN2
profilin 2
chr16_-_57318574 23.868 NM_015993
 PLLP
plasmolipin
chr1_+_77747727 23.352 AK5
adenylate kinase 5
chrX_-_13956445 23.210


chr20_+_10199455 22.741 NM_003081
NM_130811
 SNAP25

synaptosomal-associated protein, 25kDa

chr16_+_58497628 22.700 NDRG4
NDRG family member 4

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 174 entries
enrichment   p-value GO term description
4.00 9.96e-04 GO:0042551 neuron maturation
3.98 2.29e-02 GO:0043401 steroid hormone mediated signaling pathway
3.13 3.92e-02 GO:0007632 visual behavior
2.71 1.79e-03 GO:0007200 activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
2.66 2.61e-08 GO:0007202 activation of phospholipase C activity
2.63 4.16e-08 GO:0010863 positive regulation of phospholipase C activity
2.58 6.11e-08 GO:0010518 positive regulation of phospholipase activity
2.56 7.18e-03 GO:0048016 inositol phosphate-mediated signaling
2.51 1.33e-07 GO:0010517 regulation of phospholipase activity
2.51 1.10e-02 GO:0031281 positive regulation of cyclase activity
2.51 1.10e-02 GO:0045762 positive regulation of adenylate cyclase activity
2.49 2.98e-06 GO:0045761 regulation of adenylate cyclase activity
2.46 5.10e-07 GO:0019933 cAMP-mediated signaling
2.46 2.81e-02 GO:0007190 activation of adenylate cyclase activity
2.44 6.70e-06 GO:0031279 regulation of cyclase activity
2.44 1.65e-03 GO:0050770 regulation of axonogenesis
2.42 1.13e-06 GO:0060193 positive regulation of lipase activity
2.42 2.49e-02 GO:0007194 negative regulation of adenylate cyclase activity
2.42 2.49e-02 GO:0031280 negative regulation of cyclase activity
2.42 2.49e-02 GO:0051349 positive regulation of lyase activity

Gene overrepresentation in compartment category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
3.26 2.54e-02 GO:0044304 main axon
2.14 8.66e-03 GO:0033267 axon part
2.01 3.08e-06 GO:0030424 axon
1.92 7.75e-05 GO:0043025 neuronal cell body
1.89 1.01e-04 GO:0044297 cell body
1.79 7.23e-04 GO:0030425 dendrite
1.77 7.90e-09 GO:0043005 neuron projection
1.64 6.95e-06 GO:0045202 synapse
1.58 4.90e-17 GO:0005887 integral to plasma membrane
1.57 5.09e-17 GO:0031226 intrinsic to plasma membrane
1.55 4.28e-04 GO:0044463 cell projection part
1.53 1.70e-03 GO:0031012 extracellular matrix
1.53 2.03e-02 GO:0044456 synapse part
1.43 3.58e-06 GO:0042995 cell projection
1.42 3.58e-17 GO:0044459 plasma membrane part
1.42 4.73e-05 GO:0031982 vesicle
1.39 5.44e-04 GO:0031988 membrane-bounded vesicle
1.39 7.38e-03 GO:0030054 cell junction
1.37 1.06e-03 GO:0031410 cytoplasmic vesicle
1.37 3.48e-03 GO:0016023 cytoplasmic membrane-bounded vesicle

Gene overrepresentation in function category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
2.91 3.46e-02 GO:0017046 peptide hormone binding
2.64 3.17e-02 GO:0008227 G-protein coupled amine receptor activity
2.34 4.54e-02 GO:0003707 steroid hormone receptor activity
1.91 4.18e-04 GO:0005085 guanyl-nucleotide exchange factor activity
1.80 2.82e-02 GO:0005516 calmodulin binding
1.60 9.76e-03 GO:0032403 protein complex binding
1.56 2.85e-02 GO:0005261 cation channel activity
1.52 5.73e-04 GO:0030695 GTPase regulator activity
1.52 3.86e-02 GO:0022836 gated channel activity
1.51 4.92e-04 GO:0060589 nucleoside-triphosphatase regulator activity
1.50 2.01e-03 GO:0019904 protein domain specific binding
1.48 1.37e-02 GO:0005216 ion channel activity
1.47 1.40e-02 GO:0015267 channel activity
1.47 1.58e-02 GO:0022803 passive transmembrane transporter activity
1.47 1.65e-02 GO:0022838 substrate-specific channel activity
1.43 3.86e-03 GO:0008324 cation transmembrane transporter activity
1.38 2.52e-03 GO:0015075 ion transmembrane transporter activity
1.38 7.20e-03 GO:0043565 sequence-specific DNA binding
1.38 4.80e-02 GO:0008092 cytoskeletal protein binding
1.37 3.15e-03 GO:0042802 identical protein binding