Motif ID: NKX2-1,4.p2

Z-value: 1.160


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-1chr14_-_369893330.229.4e-04Click!
NKX2-4chr20_-_213780460.055.1e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_101846668 19.181 GRIK2
glutamate receptor, ionotropic, kainate 2
chr4_-_102268483 16.977 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr17_-_29641087 15.551 EVI2B
ecotropic viral integration site 2B
chr17_-_29641094 13.080 NM_006495
 EVI2B
ecotropic viral integration site 2B
chr19_-_40440532 12.589 NM_003890
 FCGBP
Fc fragment of IgG binding protein
chrX_+_48542159 11.594 NM_000377
 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr2_-_217724781 11.366 NM_003284
 TNP1
transition protein 1 (during histone to protamine replacement)
chr20_+_4702499 10.398 NM_012409
 PRND
prion protein 2 (dublet)
chr4_+_102734982 10.059 NM_001083907
 BANK1
B-cell scaffold protein with ankyrin repeats 1
chr22_-_36019363 10.053 NM_203377
 MB
myoglobin
chr2_-_89165652 9.783


chr17_-_10452939 9.586 NM_001100112
NM_017534
 MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr4_-_174320616 9.353 NM_007281
 SCRG1
stimulator of chondrogenesis 1
chr5_+_156820161 9.003 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr14_+_39703119 8.976 NM_054024
 MIA2
melanoma inhibitory activity 2
chr2_+_28615668 8.586 FOSL2
FOS-like antigen 2
chr17_-_29641068 8.447 EVI2B
ecotropic viral integration site 2B
chr1_+_152850797 8.418 NM_030663
 SMCP
sperm mitochondria-associated cysteine-rich protein
chr15_-_83474805 8.306 NM_001007122
 FSD2
fibronectin type III and SPRY domain containing 2
chrX_-_72434656 7.725 NAP1L2
nucleosome assembly protein 1-like 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
5.56 4.36e-02 GO:0042113 B cell activation
5.07 2.24e-03 GO:0042110 T cell activation
4.09 1.28e-03 GO:0046649 lymphocyte activation
3.67 1.50e-03 GO:0045321 leukocyte activation
3.55 8.81e-03 GO:0002253 activation of immune response
3.24 2.06e-05 GO:0050776 regulation of immune response
3.12 1.66e-02 GO:0050778 positive regulation of immune response
3.00 2.91e-08 GO:0006955 immune response
2.83 2.49e-03 GO:0002684 positive regulation of immune system process
2.74 1.97e-03 GO:0001775 cell activation
2.68 1.02e-10 GO:0002376 immune system process
2.68 4.19e-05 GO:0002682 regulation of immune system process
2.35 8.49e-04 GO:0006952 defense response
1.79 1.68e-03 GO:0048513 organ development
1.75 8.00e-04 GO:0065008 regulation of biological quality
1.61 1.63e-03 GO:0048731 system development
1.56 2.60e-03 GO:0048856 anatomical structure development
1.52 6.93e-04 GO:0023052 signaling
1.47 2.40e-02 GO:0007275 multicellular organismal development
1.46 3.31e-02 GO:0007165 signal transduction

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
3.23 4.21e-03 GO:0005792 microsome
3.12 6.47e-03 GO:0042598 vesicular fraction
2.87 7.43e-09 GO:0005615 extracellular space
2.57 9.93e-09 GO:0044421 extracellular region part
2.17 3.06e-11 GO:0005576 extracellular region
1.92 1.08e-03 GO:0005887 integral to plasma membrane
1.89 1.81e-03 GO:0031226 intrinsic to plasma membrane
1.70 2.21e-04 GO:0044459 plasma membrane part
1.41 1.64e-03 GO:0071944 cell periphery
1.40 3.69e-03 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
29.63 1.06e-03 GO:0030492 hemoglobin binding
22.22 4.78e-03 GO:0019864 IgG binding
4.04 2.83e-03 GO:0030414 peptidase inhibitor activity
3.96 7.35e-03 GO:0004866 endopeptidase inhibitor activity
3.92 4.09e-03 GO:0008083 growth factor activity
3.80 1.12e-02 GO:0061135 endopeptidase regulator activity
3.38 2.07e-02 GO:0061134 peptidase regulator activity
3.21 3.65e-02 GO:0005125 cytokine activity
2.78 4.19e-02 GO:0004857 enzyme inhibitor activity
1.90 3.18e-02 GO:0030234 enzyme regulator activity
1.87 2.92e-02 GO:0005102 receptor binding