Motif ID: NKX2-2,8.p2

Z-value: 1.776


Transcription factors associated with NKX2-2,8.p2:

Gene SymbolEntrez IDGene Name
NKX2-2 4821 NK2 homeobox 2
NKX2-8 26257 NK2 homeobox 8

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-8chr14_-_37051785-0.502.4e-15Click!
NKX2-2chr20_-_21494663-0.274.6e-05Click!


Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_225370687 86.564 CUL3
cullin 3
chr15_+_80390757 65.073 NM_001242919
 ZFAND6
zinc finger, AN1-type domain 6
chr2_-_225378320 58.261 CUL3
cullin 3
chr3_-_121379757 52.551 NM_005335
 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_-_121379701 50.642 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr10_-_98336445 47.849 TM9SF3
transmembrane 9 superfamily member 3
chr5_+_115898218 39.851


chr3_+_152017193 38.387 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
 MBNL1




muscleblind-like (Drosophila)




chr2_+_228356287 37.197 AGFG1
ArfGAP with FG repeats 1
chr11_-_47510518 35.583 NM_001025596
NM_001172640
 CELF1

CUGBP, Elav-like family member 1

chr19_+_49838673 33.266 NM_001040031
NM_001774
 CD37

CD37 molecule

chr12_+_69004614 32.603 NM_001010942
NM_001251917
NM_001251918
NM_001251921
NM_001251922
NM_015646
 RAP1B





RAP1B, member of RAS oncogene family





chr19_+_49838700 31.885 CD37
CD37 molecule
chr5_-_137848517 31.456 ETF1
eukaryotic translation termination factor 1
chr12_+_64803741 31.451 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr17_+_26794838 30.306


chr18_+_29671817 29.903 NM_016271
 RNF138
ring finger protein 138
chr9_+_131447364 29.799 NM_001248000
 SET
SET nuclear oncogene
chr5_+_162930230 28.506 NM_182796
 MAT2B
methionine adenosyltransferase II, beta
chr5_-_98262217 28.257 NM_001270
 CHD1
chromodomain helicase DNA binding protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
2.49 2.31e-02 GO:0044419 interspecies interaction between organisms
1.77 3.61e-04 GO:0006996 organelle organization
1.60 1.32e-04 GO:0071842 cellular component organization at cellular level
1.56 2.97e-04 GO:0071841 cellular component organization or biogenesis at cellular level
1.52 2.85e-02 GO:0090304 nucleic acid metabolic process
1.51 3.23e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.46 3.92e-03 GO:0034641 cellular nitrogen compound metabolic process
1.44 4.85e-03 GO:0016043 cellular component organization
1.44 5.37e-03 GO:0006807 nitrogen compound metabolic process
1.43 4.13e-03 GO:0071840 cellular component organization or biogenesis
1.40 6.44e-04 GO:0044260 cellular macromolecule metabolic process
1.40 1.72e-03 GO:0051716 cellular response to stimulus
1.39 3.07e-02 GO:0007165 signal transduction
1.33 5.06e-03 GO:0043170 macromolecule metabolic process
1.31 5.75e-04 GO:0044237 cellular metabolic process
1.30 2.07e-06 GO:0065007 biological regulation
1.30 1.02e-05 GO:0050789 regulation of biological process
1.30 5.27e-05 GO:0050794 regulation of cellular process
1.28 2.93e-03 GO:0044238 primary metabolic process
1.26 2.07e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
5.83 7.58e-05 GO:0005643 nuclear pore
4.85 6.85e-04 GO:0046930 pore complex
2.63 2.31e-02 GO:0005635 nuclear envelope
1.53 2.52e-03 GO:0044428 nuclear part
1.39 3.55e-02 GO:0043228 non-membrane-bounded organelle
1.39 3.55e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.37 6.92e-03 GO:0032991 macromolecular complex
1.31 3.32e-04 GO:0005634 nucleus
1.27 3.58e-07 GO:0005737 cytoplasm
1.26 7.87e-03 GO:0044422 organelle part
1.24 4.05e-02 GO:0044446 intracellular organelle part
1.21 1.07e-05 GO:0043226 organelle
1.21 1.38e-05 GO:0043229 intracellular organelle
1.21 1.35e-04 GO:0043227 membrane-bounded organelle
1.21 1.85e-04 GO:0043231 intracellular membrane-bounded organelle
1.19 6.10e-08 GO:0044424 intracellular part
1.17 2.34e-06 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.95 2.93e-03 GO:0003723 RNA binding
1.34 1.10e-08 GO:0005515 protein binding
1.15 2.94e-05 GO:0005488 binding