Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.464


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-5chr5_-_1726620850.221.2e-03Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_71502700 67.496 MAP1B
microtubule-associated protein 1B
chr12_-_16760935 61.131 NM_001001395
NM_001243609
 LMO3

LIM domain only 3 (rhombotin-like 2)

chr6_-_46293404 45.382 RCAN2
regulator of calcineurin 2
chr12_-_16759430 44.599 LMO3
LIM domain only 3 (rhombotin-like 2)
chr14_+_92788924 43.840 NM_153648
 SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr4_-_176734181 37.170 NM_201591
 GPM6A
glycoprotein M6A
chr4_-_176733901 33.836 GPM6A
glycoprotein M6A
chr19_+_45409003 32.141 NM_000041
 APOE
apolipoprotein E
chr18_+_21572736 30.453 NM_153211
 TTC39C
tetratricopeptide repeat domain 39C
chr18_-_74728963 28.182 MBP
myelin basic protein
chr7_-_27205148 27.390 NM_152739
 HOXA9
homeobox A9
chr18_-_74729049 26.996 NM_001025081
NM_001025090
NM_001025092
NM_002385
 MBP



myelin basic protein



chr6_-_46293628 26.791 NM_005822
 RCAN2
regulator of calcineurin 2
chr12_-_16759733 26.519 NM_001243610
 LMO3
LIM domain only 3 (rhombotin-like 2)
chr13_-_36429798 24.500 NM_001195415
NM_001195416
NM_001195430
 DCLK1


doublecortin-like kinase 1


chr17_+_74553845 24.218 LOC100507246
uncharacterized LOC100507246
chr12_-_16759939 24.105 NM_001243613
 LMO3
LIM domain only 3 (rhombotin-like 2)
chr7_-_27205123 24.036 HOXA9
homeobox A9
chr4_-_39033981 23.780 NM_024943
 TMEM156
transmembrane protein 156
chr12_-_16757944 23.350 LMO3
LIM domain only 3 (rhombotin-like 2)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 44 entries
enrichment   p-value GO term description
13.57 1.96e-02 GO:0007603 phototransduction, visible light
7.24 9.97e-04 GO:0007602 phototransduction
5.87 8.63e-03 GO:0009583 detection of light stimulus
4.49 2.00e-02 GO:0009582 detection of abiotic stimulus
3.98 1.11e-05 GO:0007156 homophilic cell adhesion
3.30 2.62e-02 GO:0051606 detection of stimulus
3.00 2.06e-02 GO:0019935 cyclic-nucleotide-mediated signaling
2.85 1.03e-03 GO:0007601 visual perception
2.85 1.03e-03 GO:0050953 sensory perception of light stimulus
2.80 4.07e-05 GO:0016337 cell-cell adhesion
2.34 1.07e-08 GO:0007267 cell-cell signaling
2.28 2.16e-04 GO:0019226 transmission of nerve impulse
2.28 2.16e-04 GO:0035637 multicellular organismal signaling
2.25 1.73e-07 GO:0007155 cell adhesion
2.25 1.73e-07 GO:0022610 biological adhesion
2.23 2.42e-03 GO:0007268 synaptic transmission
2.07 2.59e-02 GO:0051094 positive regulation of developmental process
2.03 4.99e-07 GO:0007154 cell communication
2.02 2.03e-03 GO:0048878 chemical homeostasis
1.96 2.41e-02 GO:0007186 G-protein coupled receptor protein signaling pathway

Gene overrepresentation in compartment category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
9.05 3.57e-02 GO:0001518 voltage-gated sodium channel complex
8.68 9.43e-03 GO:0034706 sodium channel complex
7.24 3.11e-02 GO:0032982 myosin filament
6.33 2.14e-02 GO:0034364 high-density lipoprotein particle
2.79 1.42e-02 GO:0045211 postsynaptic membrane
2.24 4.51e-04 GO:0045202 synapse
2.19 1.87e-02 GO:0044456 synapse part
2.08 1.59e-11 GO:0005887 integral to plasma membrane
2.07 1.09e-06 GO:0005615 extracellular space
2.04 5.61e-11 GO:0031226 intrinsic to plasma membrane
1.95 3.12e-07 GO:0044421 extracellular region part
1.95 1.03e-03 GO:0030054 cell junction
1.81 5.29e-13 GO:0044459 plasma membrane part
1.79 1.40e-03 GO:0005624 membrane fraction
1.76 2.01e-03 GO:0005626 insoluble fraction
1.72 2.01e-09 GO:0005576 extracellular region
1.65 1.67e-03 GO:0000267 cell fraction
1.46 8.96e-10 GO:0005886 plasma membrane
1.45 1.51e-09 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
2.73 1.96e-02 GO:0008083 growth factor activity
1.79 1.27e-02 GO:0043565 sequence-specific DNA binding
1.43 4.43e-02 GO:0004872 receptor activity
1.41 1.79e-02 GO:0004871 signal transducer activity
1.41 1.79e-02 GO:0060089 molecular transducer activity