Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.464


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-5chr5_-_1726620850.221.2e-03Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_71502700 67.496 MAP1B
microtubule-associated protein 1B
chr12_-_16760935 61.131 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr6_-_46293404 45.382 RCAN2
regulator of calcineurin 2
chr12_-_16759430 44.599 LMO3
LIM domain only 3 (rhombotin-like 2)
chr14_+_92788924 43.840 NM_153648
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr4_-_176734181 37.170 NM_201591
GPM6A
glycoprotein M6A
chr4_-_176733901 33.836 GPM6A
glycoprotein M6A
chr19_+_45409003 32.141 NM_000041
APOE
apolipoprotein E
chr18_+_21572736 30.453 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr18_-_74728963 28.182 MBP
myelin basic protein
chr7_-_27205148 27.390 NM_152739
HOXA9
homeobox A9
chr18_-_74729049 26.996 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chr6_-_46293628 26.791 NM_005822
RCAN2
regulator of calcineurin 2
chr12_-_16759733 26.519 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chr13_-_36429798 24.500 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr17_+_74553845 24.218 LOC100507246
uncharacterized LOC100507246
chr12_-_16759939 24.105 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr7_-_27205123 24.036 HOXA9
homeobox A9
chr4_-_39033981 23.780 NM_024943
TMEM156
transmembrane protein 156
chr12_-_16757944 23.350 LMO3
LIM domain only 3 (rhombotin-like 2)
chr16_+_7382750 22.815 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr3_-_195310985 22.361 NM_001647
APOD
apolipoprotein D
chr1_+_151032866 22.120 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr14_+_92789536 21.984 NM_153647
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr1_+_50574601 21.380 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr12_-_16759531 20.597 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_-_182357757 20.018 GLUL
glutamate-ammonia ligase
chr7_-_137028533 19.838 NM_002825
PTN
pleiotrophin
chr8_-_110620220 19.565 SYBU
syntabulin (syntaxin-interacting)
chr17_-_29624249 19.385 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr1_+_50574589 18.542 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr6_-_52774460 18.473 NM_000847
GSTA3
glutathione S-transferase alpha 3
chr1_+_151032880 18.362 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr8_-_110655418 17.858 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr1_+_50575465 17.672 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr8_-_82359620 17.175 NM_002677
PMP2
peripheral myelin protein 2
chr1_-_156399183 16.781 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr17_-_78450247 16.768 NM_002522
NPTX1
neuronal pentraxin I
chr3_-_195310770 16.429 APOD
apolipoprotein D
chr1_-_182357871 16.311 GLUL
glutamate-ammonia ligase
chr11_+_92085261 16.006 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr1_+_151032683 15.977 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr8_-_102803438 15.794 NM_032041
NCALD
neurocalcin delta
chrX_-_15333726 15.639 NM_001201583
NM_080873
ASB11

ankyrin repeat and SOCS box containing 11

chr10_+_7745341 14.957 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr4_-_57547845 14.888 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr17_-_42992852 14.840 NM_001131019
NM_001242376
NM_002055
GFAP


glial fibrillary acidic protein


chr3_+_35722428 14.720 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr10_+_7745284 14.699 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr2_+_162272892 14.643 TBR1
T-box, brain, 1
chr15_+_93443418 14.601 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr12_-_4488707 14.510 NM_020638
FGF23
fibroblast growth factor 23
chrX_-_13835313 14.492 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr14_-_60097314 14.472 RTN1
reticulon 1
chr2_+_226265601 13.996 NM_020864
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr10_+_7745354 13.925 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr4_+_88720701 13.533 NM_004967
IBSP
integrin-binding sialoprotein
chr1_+_50569581 13.497 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr11_-_129062092 13.468 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr6_+_134758840 13.189 LOC154092
uncharacterized LOC154092
chr10_+_7745325 12.832 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr12_+_51318743 12.591 METTL7A
methyltransferase like 7A
chr1_+_209878135 12.559 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr2_-_224467095 12.263 SCG2
secretogranin II
chr6_-_136847078 12.104 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr3_+_159557745 12.074 SCHIP1
schwannomin interacting protein 1
chr2_-_31352489 12.068 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr14_-_101036130 12.045 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr2_-_175712276 12.041 NM_001206602
CHN1
chimerin (chimaerin) 1
chr12_+_51318515 11.743 NM_014033
METTL7A
methyltransferase like 7A
chrX_+_144908927 11.601 NM_004709
CXorf1
chromosome X open reading frame 1
chr1_+_33004771 11.313 NM_001040441
ZBTB8A
zinc finger and BTB domain containing 8A
chr3_-_170303774 11.281 NM_020949
SLC7A14
solute carrier family 7 (orphan transporter), member 14
chr1_-_57045214 11.272 PPAP2B
phosphatidic acid phosphatase type 2B
chr14_-_60097531 11.234 NM_206852
RTN1
reticulon 1
chr14_+_21756135 11.227 NM_020366
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr7_-_37024664 10.896 NM_001039459
ELMO1
engulfment and cell motility 1
chr4_-_68749698 10.854 NM_004262
TMPRSS11D
transmembrane protease, serine 11D
chr17_+_42385780 10.815 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chr4_-_87281374 10.649 NM_138980
NM_138982
MAPK10

mitogen-activated protein kinase 10

chr18_-_52988916 10.644 NM_001243234
NM_001243235
TCF4

transcription factor 4

chr19_+_7968701 10.517 MAP2K7
mitogen-activated protein kinase kinase 7
chr1_+_183774214 10.508 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr2_-_224467142 10.446 NM_003469
SCG2
secretogranin II
chr2_-_211018294 10.242 C2orf67
chromosome 2 open reading frame 67
chr3_+_361365 10.207 NM_001253388
CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1)
chr4_+_69313166 10.110 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr10_+_102222797 10.108 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chr12_+_32654976 10.049 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr4_+_94750041 9.957 NM_005172
ATOH1
atonal homolog 1 (Drosophila)
chr4_+_106631966 9.952 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chrX_+_66788682 9.908 NM_001011645
AR
androgen receptor
chr12_-_16758312 9.831 NM_001243611
LMO3
LIM domain only 3 (rhombotin-like 2)
chr14_+_35514112 9.769 NM_001079519
FAM177A1
family with sequence similarity 177, member A1
chr6_+_72926144 9.744 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr8_-_102803196 9.739 NCALD
neurocalcin delta
chr2_+_173686314 9.734 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr10_+_7745229 9.608 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr3_+_39509069 9.573 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr15_+_74422920 9.556 ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr1_+_157963062 9.527 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr2_+_162272800 9.515 TBR1
T-box, brain, 1
chr3_-_52294427 9.514 WDR82
WD repeat domain 82
chr5_-_149669400 9.473 NM_015981
NM_171825
CAMK2A

calcium/calmodulin-dependent protein kinase II alpha

chr4_-_153273683 9.466 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr13_+_96085852 9.456 NM_001160100
NM_182848
CLDN10

claudin 10

chr1_-_57045129 9.378 PPAP2B
phosphatidic acid phosphatase type 2B
chr16_+_86612114 9.348 NM_005250
FOXL1
forkhead box L1
chr1_-_57045235 9.336 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr8_-_102803178 9.324 NCALD
neurocalcin delta
chr5_+_156696351 9.123 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chrM_+_12283 9.025


chr12_+_41086189 9.000 NM_001843
NM_175038
CNTN1

contactin 1

chr2_-_224467049 8.942 SCG2
secretogranin II
chr4_+_62362838 8.877 NM_015236
LPHN3
latrophilin 3
chr12_-_16758839 8.775 NM_001243612
LMO3
LIM domain only 3 (rhombotin-like 2)
chr7_+_129847699 8.703 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr12_+_101988746 8.682 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr10_-_52645384 8.626 A1CF
APOBEC1 complementation factor
chrX_+_68835910 8.593 NM_001005609
NM_001005610
NM_001005612
NM_001005613
NM_001399
EDA




ectodysplasin A




chr7_-_14025826 8.587 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr3_+_159557649 8.582 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr5_+_140771482 8.562 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr9_-_23826062 8.497 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr6_-_6007097 8.496 NRN1
neuritin 1
chr17_+_28268622 8.460 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr5_-_160279045 8.402 NM_025153
ATP10B
ATPase, class V, type 10B
chr17_-_29641068 8.352 EVI2B
ecotropic viral integration site 2B
chr7_+_37723378 8.245


chr5_-_41261539 8.243 NM_001115131
C6
complement component 6
chr12_-_91573264 8.216 NM_133503
DCN
decorin
chr12_-_52886971 8.112 NM_005554
KRT6A
keratin 6A
chr14_+_39703119 8.102 NM_054024
MIA2
melanoma inhibitory activity 2
chr1_-_203055088 8.086 MYOG
myogenin (myogenic factor 4)
chr5_-_141993691 7.974 NM_033137
FGF1
fibroblast growth factor 1 (acidic)
chr2_+_48796158 7.938 NM_172311
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr9_-_215892 7.892 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr7_-_27166638 7.890 NM_153631
HOXA3
homeobox A3
chr4_+_88754120 7.863 NM_001184695
NM_001184696
NM_001184697
NM_020203
MEPE



matrix extracellular phosphoglycoprotein



chr3_-_114478117 7.773 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr4_-_87374282 7.760 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr8_+_24298442 7.757 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr22_-_37215516 7.713 NM_002854
PVALB
parvalbumin
chr5_-_58295758 7.710 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr9_+_82187599 7.699 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr17_-_39093671 7.698 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr5_+_31193852 7.691 CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr8_-_40755328 7.651 NM_001135731
NM_024645
ZMAT4

zinc finger, matrin-type 4

chr10_-_123356158 7.626 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr1_+_205236591 7.621 TMCC2
transmembrane and coiled-coil domain family 2
chr2_+_183943286 7.504 NM_001142314
NM_080876
DUSP19

dual specificity phosphatase 19

chr19_-_36304200 7.502 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr6_-_53013581 7.445 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chr1_+_15990300 7.443


chr11_+_43665772 7.360


chr4_-_16900348 7.355 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr17_+_56315786 7.337 NM_001160102
NM_006151
LPO

lactoperoxidase

chr12_-_10282680 7.335 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr1_+_209757044 7.306 NM_020439
CAMK1G
calcium/calmodulin-dependent protein kinase IG
chr5_+_140186658 7.279 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr5_+_140762401 7.263 NM_018920
NM_032087
PCDHGA7

protocadherin gamma subfamily A, 7

chr4_-_87028805 7.228 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr2_-_65593763 7.183 SPRED2
sprouty-related, EVH1 domain containing 2
chr3_-_8543327 7.154 LOC100288428
uncharacterized LOC100288428
chr10_+_95517565 7.143 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chr6_-_33285493 7.078 NM_005453
ZBTB22
zinc finger and BTB domain containing 22
chr4_-_16900256 7.072 LDB2
LIM domain binding 2
chr2_+_102953716 7.056 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr18_+_72922725 6.988 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chrX_-_13835012 6.981 GPM6B
glycoprotein M6B
chr2_+_210444154 6.956 MAP2
microtubule-associated protein 2
chr5_+_40909617 6.931 C7
complement component 7
chr7_-_97619350 6.931 NM_006188
OCM2
oncomodulin 2
chr12_+_41831484 6.928 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr6_+_121756744 6.881 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr15_+_74422742 6.876 NM_020851
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr10_-_28571014 6.853 NM_173496
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr5_+_140810181 6.829 PCDHGA12
protocadherin gamma subfamily A, 12
chr12_+_21679190 6.825 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr5_+_140868721 6.787 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr4_+_113970784 6.760 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chrX_+_103031797 6.745 PLP1
proteolipid protein 1
chr11_-_102576444 6.742 NM_022122
MMP27
matrix metallopeptidase 27
chrX_+_22050920 6.731 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr8_-_110693233 6.698 NM_001099745
NM_001099746
SYBU

syntabulin (syntaxin-interacting)

chr2_+_103089761 6.665 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr16_+_6823809 6.657 NM_001142334
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr9_-_13250313 6.654 NM_003829
MPDZ
multiple PDZ domain protein
chr11_+_71927818 6.628 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr6_+_72922513 6.577 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr5_-_88179278 6.517 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr10_+_26505235 6.502 NM_000818
NM_001134366
GAD2

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

chr1_-_153044083 6.418 NM_001017418
SPRR2B
small proline-rich protein 2B
chr9_+_82187469 6.383 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr1_+_147374945 6.356 NM_005267
GJA8
gap junction protein, alpha 8, 50kDa
chr5_-_149669187 6.337 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr3_+_35721115 6.332 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr3_-_114343052 6.303 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr4_-_16900028 6.303 LDB2
LIM domain binding 2
chr19_-_3772208 6.257 NM_032753
RAX2
retina and anterior neural fold homeobox 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.50 7.49e-15 GO:0032501 multicellular organismal process
1.51 3.21e-09 GO:0023052 signaling
2.34 1.07e-08 GO:0007267 cell-cell signaling
2.25 1.73e-07 GO:0007155 cell adhesion
2.25 1.73e-07 GO:0022610 biological adhesion
2.03 4.99e-07 GO:0007154 cell communication
1.49 2.90e-06 GO:0048856 anatomical structure development
1.52 3.60e-06 GO:0048731 system development
1.42 5.21e-06 GO:0032502 developmental process
1.68 5.62e-06 GO:0007166 cell surface receptor linked signaling pathway
1.68 1.06e-05 GO:0003008 system process
3.98 1.11e-05 GO:0007156 homophilic cell adhesion
1.44 1.42e-05 GO:0007275 multicellular organismal development
1.44 2.54e-05 GO:0007165 signal transduction
2.80 4.07e-05 GO:0016337 cell-cell adhesion
1.27 5.42e-05 GO:0050896 response to stimulus
2.28 2.16e-04 GO:0019226 transmission of nerve impulse
2.28 2.16e-04 GO:0035637 multicellular organismal signaling
7.24 9.97e-04 GO:0007602 phototransduction
2.85 1.03e-03 GO:0007601 visual perception
2.85 1.03e-03 GO:0050953 sensory perception of light stimulus
1.33 1.11e-03 GO:0051716 cellular response to stimulus
2.02 2.03e-03 GO:0048878 chemical homeostasis
1.51 2.07e-03 GO:0030154 cell differentiation
2.23 2.42e-03 GO:0007268 synaptic transmission
1.89 3.40e-03 GO:2000026 regulation of multicellular organismal development
1.51 4.24e-03 GO:0048513 organ development
1.59 5.02e-03 GO:0007399 nervous system development
1.48 5.19e-03 GO:0048869 cellular developmental process
5.87 8.63e-03 GO:0009583 detection of light stimulus
1.62 1.06e-02 GO:0051239 regulation of multicellular organismal process
13.57 1.96e-02 GO:0007603 phototransduction, visible light
4.49 2.00e-02 GO:0009582 detection of abiotic stimulus
1.17 2.02e-02 GO:0065007 biological regulation
3.00 2.06e-02 GO:0019935 cyclic-nucleotide-mediated signaling
1.72 2.37e-02 GO:0022008 neurogenesis
1.72 2.37e-02 GO:0050793 regulation of developmental process
1.96 2.41e-02 GO:0007186 G-protein coupled receptor protein signaling pathway
2.07 2.59e-02 GO:0051094 positive regulation of developmental process
3.30 2.62e-02 GO:0051606 detection of stimulus
1.74 2.65e-02 GO:0048699 generation of neurons
1.84 2.88e-02 GO:0045595 regulation of cell differentiation
1.11 4.43e-02 GO:0009987 cellular process
1.54 4.87e-02 GO:0050877 neurological system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.81 5.29e-13 GO:0044459 plasma membrane part
2.08 1.59e-11 GO:0005887 integral to plasma membrane
2.04 5.61e-11 GO:0031226 intrinsic to plasma membrane
1.46 8.96e-10 GO:0005886 plasma membrane
1.45 1.51e-09 GO:0071944 cell periphery
1.72 2.01e-09 GO:0005576 extracellular region
1.95 3.12e-07 GO:0044421 extracellular region part
2.07 1.09e-06 GO:0005615 extracellular space
2.24 4.51e-04 GO:0045202 synapse
1.95 1.03e-03 GO:0030054 cell junction
1.79 1.40e-03 GO:0005624 membrane fraction
1.65 1.67e-03 GO:0000267 cell fraction
1.76 2.01e-03 GO:0005626 insoluble fraction
8.68 9.43e-03 GO:0034706 sodium channel complex
2.79 1.42e-02 GO:0045211 postsynaptic membrane
2.19 1.87e-02 GO:0044456 synapse part
6.33 2.14e-02 GO:0034364 high-density lipoprotein particle
7.24 3.11e-02 GO:0032982 myosin filament
9.05 3.57e-02 GO:0001518 voltage-gated sodium channel complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.79 1.27e-02 GO:0043565 sequence-specific DNA binding
1.41 1.79e-02 GO:0004871 signal transducer activity
1.41 1.79e-02 GO:0060089 molecular transducer activity
2.73 1.96e-02 GO:0008083 growth factor activity
1.43 4.43e-02 GO:0004872 receptor activity