Motif ID: NKX3-2.p2

Z-value: 1.637


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-2chr4_-_13546037-0.304.8e-06Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_118604417 28.923 NM_001077654
 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr5_+_118604504 27.750 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr16_-_88717395 22.537 NM_000101
 CYBA
cytochrome b-245, alpha polypeptide
chr14_-_107179043 21.679 IGHA1
immunoglobulin heavy constant alpha 1
chr6_-_32497925 20.051 NM_002125
 HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr13_+_31287614 16.859 NM_001204406
 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr5_-_149792370 16.442 NM_001025158
NM_001025159
NM_004355
 CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chrX_-_47518539 15.608 NM_004182
NM_153477
 UXT

ubiquitously-expressed, prefoldin-like chaperone

chr3_+_69134057 14.757 NM_006407
 ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr7_-_26232148 14.448 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr16_-_28222700 13.727 XPO6
exportin 6
chr6_+_32407618 13.457 NM_019111
 HLA-DRA
major histocompatibility complex, class II, DR alpha
chr20_-_34330093 13.183 RBM39
RNA binding motif protein 39
chr16_-_4896197 13.049 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr13_+_31309644 13.018 NM_001629
 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr1_-_31230594 12.997 LAPTM5
lysosomal protein transmembrane 5
chr6_+_29974352 12.922 HLA-J
major histocompatibility complex, class I, J (pseudogene)
chr10_-_75193297 12.686 NM_001024593
 ZMYND17
zinc finger, MYND-type containing 17
chr10_+_11047253 12.484 NM_001025077
 CELF2
CUGBP, Elav-like family member 2
chr6_-_31550065 12.154 NM_002341
NM_009588
 LTB

lymphotoxin beta (TNF superfamily, member 3)


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 178 entries
enrichment   p-value GO term description
3.82 3.35e-03 GO:0006413 translational initiation
3.13 6.52e-03 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
3.13 6.52e-03 GO:0072395 signal transduction involved in cell cycle checkpoint
3.13 6.52e-03 GO:0072401 signal transduction involved in DNA integrity checkpoint
3.13 6.52e-03 GO:0072404 signal transduction involved in G1/S transition checkpoint
3.13 6.52e-03 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
3.13 6.52e-03 GO:0072422 signal transduction involved in DNA damage checkpoint
3.13 6.52e-03 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
3.13 6.52e-03 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
3.12 3.95e-06 GO:0002429 immune response-activating cell surface receptor signaling pathway
3.08 8.69e-03 GO:0031294 lymphocyte costimulation
3.08 8.69e-03 GO:0031295 T cell costimulation
3.04 6.34e-03 GO:0071214 cellular response to abiotic stimulus
3.00 1.20e-05 GO:0002768 immune response-regulating cell surface receptor signaling pathway
2.98 1.27e-04 GO:0050851 antigen receptor-mediated signaling pathway
2.98 1.51e-02 GO:0071158 positive regulation of cell cycle arrest
2.95 1.33e-03 GO:0022618 ribonucleoprotein complex assembly
2.95 1.09e-02 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
2.93 4.33e-03 GO:0050852 T cell receptor signaling pathway
2.88 4.58e-02 GO:0031124 mRNA 3'-end processing

Gene overrepresentation in compartment category:

Showing 1 to 20 of 42 entries
enrichment   p-value GO term description
8.18 4.36e-03 GO:0005885 Arp2/3 protein complex
5.30 1.62e-03 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
4.52 2.71e-02 GO:0031201 SNARE complex
3.60 8.15e-05 GO:0034708 methyltransferase complex
3.60 8.15e-05 GO:0035097 histone methyltransferase complex
2.88 7.73e-03 GO:0000502 proteasome complex
2.07 3.43e-02 GO:0005769 early endosome
2.01 1.68e-03 GO:0016604 nuclear body
1.99 3.24e-09 GO:0030529 ribonucleoprotein complex
1.90 2.06e-03 GO:0000323 lytic vacuole
1.90 2.06e-03 GO:0005764 lysosome
1.76 8.69e-08 GO:0044451 nucleoplasm part
1.75 2.47e-04 GO:0005768 endosome
1.74 2.86e-02 GO:0015629 actin cytoskeleton
1.71 6.42e-23 GO:0005829 cytosol
1.71 2.95e-02 GO:0005773 vacuole
1.70 4.69e-13 GO:0005654 nucleoplasm
1.58 2.16e-13 GO:0031981 nuclear lumen
1.57 8.72e-03 GO:0005694 chromosome
1.55 1.97e-14 GO:0044428 nuclear part

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
3.49 6.73e-03 GO:0043021 ribonucleoprotein binding
3.34 2.39e-02 GO:0003823 antigen binding
1.83 1.01e-10 GO:0003723 RNA binding
1.42 1.35e-49 GO:0005515 protein binding
1.32 1.06e-04 GO:0000166 nucleotide binding
1.22 5.42e-03 GO:0003676 nucleic acid binding
1.17 7.38e-28 GO:0005488 binding