Motif ID: NKX6-1,2.p2

Z-value: 0.875


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX6-1chr4_-_85419386-0.128.1e-02Click!


Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_169418167 15.770 NM_001166108
NM_016081
 PALLD

palladin, cytoskeletal associated protein

chr3_-_79817058 12.583 NM_002941
 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr8_+_132991171 12.167 EFR3A
EFR3 homolog A (S. cerevisiae)
chr7_+_94297448 8.988 PEG10
paternally expressed 10
chr7_+_23286420 8.578 GPNMB
glycoprotein (transmembrane) nmb
chr2_-_238322840 8.458 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
 COL6A3




collagen, type VI, alpha 3




chr7_+_23286384 8.440 GPNMB
glycoprotein (transmembrane) nmb
chr1_+_84647342 7.991 NM_001242862
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr6_+_87969619 7.716 ZNF292
zinc finger protein 292
chr7_-_137686814 7.434 NM_001253775
NM_194071
 CREB3L2

cAMP responsive element binding protein 3-like 2

chr7_+_23286386 7.388 GPNMB
glycoprotein (transmembrane) nmb
chr2_-_238322815 7.316 COL6A3
collagen, type VI, alpha 3
chr5_+_140729723 6.915 NM_018922
NM_032095
 PCDHGB1

protocadherin gamma subfamily B, 1

chr7_+_23286390 6.705 GPNMB
glycoprotein (transmembrane) nmb
chrX_+_80457302 6.285 NM_003022
 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr12_-_91505541 6.133 NM_002345
 LUM
lumican
chr20_+_11898536 6.084 NM_014962
 BTBD3
BTB (POZ) domain containing 3
chrX_+_102840412 5.848 NM_001006935
NM_001006937
NM_024863
 TCEAL4


transcription elongation factor A (SII)-like 4


chr1_-_226926875 5.838 NM_002221
 ITPKB
inositol-trisphosphate 3-kinase B
chr12_-_91505215 5.766 LUM
lumican

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
1.59 1.13e-02 GO:0048513 organ development
1.49 1.54e-02 GO:0044267 cellular protein metabolic process
1.43 1.93e-02 GO:0019538 protein metabolic process
1.42 7.33e-03 GO:0007165 signal transduction
1.40 4.84e-03 GO:0023052 signaling
1.33 4.19e-02 GO:0051716 cellular response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
4.31 2.56e-03 GO:0042470 melanosome
4.31 2.56e-03 GO:0048770 pigment granule
1.24 8.08e-06 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
29.47 1.58e-02 GO:0004556 alpha-amylase activity
29.47 1.58e-02 GO:0016160 amylase activity
9.83 4.08e-02 GO:0005161 platelet-derived growth factor receptor binding
1.30 1.19e-06 GO:0005515 protein binding