Motif ID: NR3C1.p2

Z-value: 1.310


Transcription factors associated with NR3C1.p2:

Gene SymbolEntrez IDGene Name
NR3C1 2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR3C1chr5_-_142783059-0.291.4e-05Click!


Activity profile for motif NR3C1.p2.

activity profile for motif NR3C1.p2


Sorted Z-values histogram for motif NR3C1.p2

Sorted Z-values for motif NR3C1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR3C1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_91572328 24.933 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chr21_-_46340776 22.777 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr11_+_73358593 22.081 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr21_-_46340821 22.046 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr7_+_23286390 21.590 GPNMB
glycoprotein (transmembrane) nmb
chr22_+_22712091 20.863 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr7_+_23286386 20.799 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_23286384 20.616 GPNMB
glycoprotein (transmembrane) nmb
chr3_-_187463227 20.574 BCL6
B-cell CLL/lymphoma 6
chr2_-_237172987 19.131 NM_212556
ASB18
ankyrin repeat and SOCS box containing 18
chr7_+_20655244 18.844 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr19_-_36643770 18.811 NM_001864
COX7A1
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
chr10_+_70847817 17.450 NM_002727
SRGN
serglycin
chr7_-_124405029 15.140 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr8_-_110655418 14.435 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr17_-_8055684 13.099 NM_002616
PER1
period homolog 1 (Drosophila)
chr6_-_6320875 12.916 F13A1
coagulation factor XIII, A1 polypeptide
chr1_+_44115804 12.884 KDM4A
lysine (K)-specific demethylase 4A
chrY_+_16168097 12.744 NM_181880
NM_004679
VCY1B
VCX3A
VCY
variable charge, Y-linked 1B
variable charge, X-linked 3A
variable charge, Y-linked
chr19_+_15783827 12.527 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr1_-_153085963 12.189 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr6_-_6320897 12.130 NM_000129
F13A1
coagulation factor XIII, A1 polypeptide
chr18_-_53068755 11.781 TCF4
transcription factor 4
chr16_-_68482373 11.739 NM_018667
SMPD3
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
chr6_-_32191779 11.550 NM_004557
NOTCH4
notch 4
chr1_-_204459445 11.450 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr7_-_37393271 11.333 NM_001206482
ELMO1
engulfment and cell motility 1
chr1_+_20964414 11.281


chr12_-_123466195 11.256 ABCB9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr1_+_44115828 11.103 KDM4A
lysine (K)-specific demethylase 4A
chr5_+_180467224 10.978 NM_152547
BTNL9
butyrophilin-like 9
chr5_-_42811959 10.809 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr19_+_39899749 10.650


chr10_+_121578768 10.368 NM_001243194
INPP5F
inositol polyphosphate-5-phosphatase F
chr1_-_160492982 10.272 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chrX_+_128913897 10.125 SASH3
SAM and SH3 domain containing 3
chr15_-_45670955 10.009 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chrX_+_128913881 9.996 NM_018990
SASH3
SAM and SH3 domain containing 3
chr2_+_113816214 9.908 NM_173170
IL36RN
interleukin 36 receptor antagonist
chr7_+_23286277 9.861 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr2_-_89292396 9.808 IGKC
immunoglobulin kappa constant
chr7_+_105603656 9.731 NM_152750
CDHR3
cadherin-related family member 3
chr7_+_87563432 9.678 NM_004194
NM_016351
NM_021721
NM_021722
NM_021723
ADAM22




ADAM metallopeptidase domain 22




chr7_+_23286401 9.432 GPNMB
glycoprotein (transmembrane) nmb
chr17_-_26903854 9.228 ALDOC
aldolase C, fructose-bisphosphate
chr16_+_30386097 9.219 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr1_+_22979681 9.177 NM_000491
C1QB
complement component 1, q subcomponent, B chain
chr1_+_158223926 9.161 NM_001763
CD1A
CD1a molecule
chr16_+_8814567 8.877 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr15_-_34212523 8.827


chr11_+_60048013 8.666 NM_001243266
NM_024021
NM_148975
MS4A4A


membrane-spanning 4-domains, subfamily A, member 4


chr2_-_85895863 8.533 NM_000542
NM_198843
SFTPB

surfactant protein B

chr17_+_37824506 8.501 NM_002686
PNMT
phenylethanolamine N-methyltransferase
chr6_-_108145507 8.150 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr2_+_31456879 7.987 NM_014600
EHD3
EH-domain containing 3
chr14_+_24616707 7.962 RNF31
ring finger protein 31
chr6_+_134210247 7.871 NM_198392
NM_003206
TCF21

transcription factor 21

chr17_-_70588942 7.779 LOC100499467
uncharacterized LOC100499467
chr1_-_161279724 7.669 NM_000530
MPZ
myelin protein zero
chr10_-_5541401 7.624 NM_017422
CALML5
calmodulin-like 5
chr14_+_24616658 7.581 NM_017999
RNF31
ring finger protein 31
chr3_+_133495925 7.580 TF
transferrin
chr12_+_7055736 7.578 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr6_-_52628272 7.490 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr16_-_4852571 7.485 NM_024589
ROGDI
rogdi homolog (Drosophila)
chr17_-_46115135 7.347 NM_016429
COPZ2
coatomer protein complex, subunit zeta 2
chr18_-_24442534 7.287 NM_004028
AQP4
aquaporin 4
chr11_-_36619776 7.279 NM_000536
NM_001243785
NM_001243786
RAG2


recombination activating gene 2


chr6_+_134210264 7.246 TCF21
transcription factor 21
chr3_+_45067750 7.190 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr12_+_51318515 7.148 NM_014033
METTL7A
methyltransferase like 7A
chr4_+_72204769 7.117 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr3_-_49314281 7.032 NM_198562
C3orf62
chromosome 3 open reading frame 62
chr8_+_103563847 6.999 NM_024410
ODF1
outer dense fiber of sperm tails 1
chr16_-_21314371 6.851 NM_001014444
NM_001888
CRYM

crystallin, mu

chr12_+_51318743 6.849 METTL7A
methyltransferase like 7A
chr16_-_20702577 6.808 NM_052956
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr5_-_149669187 6.790 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr1_-_147232684 6.780 NM_181703
GJA5
gap junction protein, alpha 5, 40kDa
chr1_+_209859524 6.691 NM_001206741
NM_181755
HSD11B1

hydroxysteroid (11-beta) dehydrogenase 1

chr9_-_90749899 6.643 NM_001166137
FAM75C2
family with sequence similarity 75, member C2
chr8_-_30891230 6.605 NM_001015508
PURG
purine-rich element binding protein G
chr1_+_162602308 6.586 DDR2
discoidin domain receptor tyrosine kinase 2
chr1_-_153363544 6.509 NM_002964
S100A8
S100 calcium binding protein A8
chr8_-_120651019 6.269 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr8_-_110657745 6.143 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr1_+_33004771 6.132 NM_001040441
ZBTB8A
zinc finger and BTB domain containing 8A
chr14_+_70918873 6.080 NM_003813
ADAM21
ADAM metallopeptidase domain 21
chrX_+_46940235 6.066 RGN
regucalcin (senescence marker protein-30)
chr14_-_107131217 5.987 IGHA1
immunoglobulin heavy constant alpha 1
chr7_+_94539209 5.952 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr17_-_26903926 5.936 NM_005165
ALDOC
aldolase C, fructose-bisphosphate
chr16_-_5115939 5.913 C16orf89
chromosome 16 open reading frame 89
chr3_-_187452669 5.861 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr12_+_7055753 5.763 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr7_+_123565908 5.752 NM_001174045
NM_001174046
SPAM1

sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)

chr6_+_150690027 5.716 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chr1_+_13495253 5.639 NM_001045480
PRAMEF17
PRAMEF16
PRAME family member 17
PRAME family member 16
chr15_+_75105152 5.635 NM_021819
LMAN1L
lectin, mannose-binding, 1 like
chr1_-_182922504 5.618 NM_030933
SHCBP1L
SHC SH2-domain binding protein 1-like
chr8_+_1952875 5.541 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr14_-_106774311 5.540 IGHA1
immunoglobulin heavy constant alpha 1
chr21_+_41239346 5.469 NM_006198
PCP4
Purkinje cell protein 4
chr6_-_52668599 5.445 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr7_+_123565285 5.412 NM_001174044
NM_003117
NM_153189
SPAM1


sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)


chr6_+_26156552 5.355 HIST1H1E
histone cluster 1, H1e
chr1_+_35225341 5.177 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr1_-_59147727 5.135


chrX_+_18709044 5.078 NM_006240
NM_152224
NM_152226
PPEF1


protein phosphatase, EF-hand calcium binding domain 1


chr6_-_99873129 5.062 NM_015491
NM_032870
PNISR

PNN-interacting serine/arginine-rich protein

chr9_-_77503009 5.060 NM_017662
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr10_-_123353330 4.945 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr22_+_45704821 4.893 NM_001104595
FAM118A
family with sequence similarity 118, member A
chr9_+_102677457 4.876 STX17
syntaxin 17
chr15_+_42694587 4.870 NM_173088
CAPN3
calpain 3, (p94)
chr4_+_86699846 4.792 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr8_-_146202727 4.755 ZNF252
zinc finger protein 252
chr8_-_53322200 4.623 NM_014682
ST18
suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)
chr1_+_173793817 4.597 DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr14_-_106746056 4.566


chr2_+_113342171 4.530 CHCHD5
coiled-coil-helix-coiled-coil-helix domain containing 5
chr11_+_118175294 4.511 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr22_+_22676814 4.472


chr2_-_43453724 4.462 ZFP36L2
zinc finger protein 36, C3H type-like 2
chr15_-_43029318 4.431 NM_138477
CDAN1
congenital dyserythropoietic anemia, type I
chr10_-_47173917 4.374 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr22_+_23040394 4.332 IGL@
immunoglobulin lambda locus
chr4_+_113970784 4.302 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr1_+_43766565 4.288 NM_001253357
NM_005424
TIE1

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

chr8_-_127570465 4.281 FAM84B
family with sequence similarity 84, member B
chr9_+_90532876 4.279 NM_001145124
FAM75C1
family with sequence similarity 75, member C1
chr9_-_73029539 4.267 NM_001206
KLF9
Kruppel-like factor 9
chr2_-_202563353 4.266 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr17_-_43487747 4.235 ARHGAP27
Rho GTPase activating protein 27
chr5_+_35856990 4.186 NM_002185
IL7R
interleukin 7 receptor
chr17_+_7387773 4.124 POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr16_-_31100129 4.123 NM_001039503
PRSS53
protease, serine, 53
chr16_+_3451154 4.119 NM_001032292
NM_003450
ZNF174

zinc finger protein 174

chr1_-_11188800 4.118


chr16_+_90089007 4.116 NM_001481
GAS8
growth arrest-specific 8
chr11_-_118123001 4.105 NM_198275
MPZL3
myelin protein zero-like 3
chr13_+_96204941 4.094 NM_006984
CLDN10
claudin 10
chr12_-_54121203 4.052 NM_001143682
NM_020898
CALCOCO1

calcium binding and coiled-coil domain 1

chr6_-_49844808 4.039 NM_001205220
CRISP1
cysteine-rich secretory protein 1
chr22_+_37678565 4.026 CYTH4
cytohesin 4
chr1_-_151319674 4.000 RFX5
regulatory factor X, 5 (influences HLA class II expression)
chr22_+_37678519 3.986 CYTH4
cytohesin 4
chr6_-_32908583 3.977 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr16_+_31366519 3.959 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr1_+_111770280 3.905 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr2_-_68384575 3.895 NM_138458
WDR92
WD repeat domain 92
chr10_-_123353771 3.852 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr5_-_147162251 3.847 NM_014790
JAKMIP2
janus kinase and microtubule interacting protein 2
chrX_-_135749436 3.809 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr12_-_16758312 3.796 NM_001243611
LMO3
LIM domain only 3 (rhombotin-like 2)
chr5_-_139943829 3.782 APBB3
amyloid beta (A4) precursor protein-binding, family B, member 3
chr6_+_26156558 3.745 NM_005321
HIST1H1E
histone cluster 1, H1e
chr7_+_99621083 3.744 ZKSCAN1
zinc finger with KRAB and SCAN domains 1
chr2_-_214016332 3.691 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr19_+_55014012 3.685 NM_002288
NM_021270
LAIR2

leukocyte-associated immunoglobulin-like receptor 2

chr12_+_69742130 3.673 NM_000239
LYZ
lysozyme
chr1_-_111743261 3.652 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr14_+_23067128 3.593 NM_022060
ABHD4
abhydrolase domain containing 4
chr5_-_149324282 3.564 NM_000440
PDE6A
phosphodiesterase 6A, cGMP-specific, rod, alpha
chr9_-_21202201 3.535 NM_021057
IFNA7
interferon, alpha 7
chr3_-_146213721 3.531 NM_001199979
PLSCR2
phospholipid scramblase 2
chrX_+_65382627 3.511 HEPH
hephaestin
chr5_+_137203559 3.496 MYOT
myotilin
chr19_+_58570606 3.452 NM_001164527
NM_001164529
NM_001164530
NM_003436
NM_007134
ZNF135




zinc finger protein 135




chr19_+_54926721 3.412 TTYH1
tweety homolog 1 (Drosophila)
chr6_-_134496833 3.371 SGK1
serum/glucocorticoid regulated kinase 1
chr17_-_62009620 3.356 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr1_+_159173802 3.349 NM_002036
DARC
Duffy blood group, chemokine receptor
chr17_-_29641094 3.317 NM_006495
EVI2B
ecotropic viral integration site 2B
chr1_+_89829435 3.276 NM_198460
GBP6
guanylate binding protein family, member 6
chr7_-_124405680 3.244 NM_005302
GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr10_+_102672685 3.233 FAM178A
family with sequence similarity 178, member A
chr17_+_77751929 3.218 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr16_-_20338808 3.195 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr4_-_76823575 3.193 NM_006239
PPEF2
protein phosphatase, EF-hand calcium binding domain 2
chr9_+_131388167 3.179 SPTAN1
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
chr3_-_194090459 3.174 NM_001135057
NM_130830
LRRC15

leucine rich repeat containing 15

chr11_-_59633942 3.169 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr1_-_111743297 3.169 DENND2D
DENN/MADD domain containing 2D
chr17_+_11786218 3.123 NM_004662
DNAH9
dynein, axonemal, heavy chain 9
chr12_+_50898744 3.086 NM_173602
DIP2B
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr4_-_95263986 3.078 NM_014485
HPGDS
hematopoietic prostaglandin D synthase
chr11_-_118047145 3.062 SCN2B
sodium channel, voltage-gated, type II, beta
chrX_+_48114796 3.049 NM_005635
SSX1
synovial sarcoma, X breakpoint 1
chr3_+_155838336 3.030 NM_172160
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr17_+_21308447 2.961 NM_001194958
KCNJ18
potassium inwardly-rectifying channel, subfamily J, member 18
chrX_-_100548044 2.960 NM_024885
TAF7L
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
chr14_-_45722604 2.943 NM_018353
MIS18BP1
MIS18 binding protein 1
chr12_-_16757944 2.922 LMO3
LIM domain only 3 (rhombotin-like 2)
chr19_+_50472856 2.907 SIGLEC16
sialic acid binding Ig-like lectin 16 (gene/pseudogene)
chr6_-_89927495 2.906 NM_002042
GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chr1_+_162602198 2.865 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr17_+_7960201 2.840


chr3_+_35722428 2.822 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr17_-_8815799 2.815 NM_014308
PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.27 5.70e-08 GO:0002376 immune system process
2.52 3.32e-06 GO:0006955 immune response
2.07 2.02e-03 GO:0009611 response to wounding
2.47 3.66e-03 GO:0001775 cell activation
2.09 4.44e-03 GO:0006952 defense response
2.47 1.07e-02 GO:0050776 regulation of immune response
1.28 1.25e-02 GO:0050896 response to stimulus
2.77 3.70e-02 GO:0006954 inflammatory response
2.16 3.94e-02 GO:0042060 wound healing

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.46 6.94e-06 GO:0071944 cell periphery
1.47 7.72e-06 GO:0005886 plasma membrane
2.02 2.01e-03 GO:0005615 extracellular space
1.75 3.63e-03 GO:0031226 intrinsic to plasma membrane
1.76 4.11e-03 GO:0005887 integral to plasma membrane
1.53 4.97e-03 GO:0044459 plasma membrane part
1.81 7.43e-03 GO:0044421 extracellular region part
1.49 3.20e-02 GO:0005576 extracellular region
3.30 3.64e-02 GO:0009897 external side of plasma membrane
1.19 3.73e-02 GO:0016020 membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
7.89 4.86e-04 GO:0003823 antigen binding