Motif ID: NR4A2.p2

Z-value: 1.486


Transcription factors associated with NR4A2.p2:

monomer

Gene SymbolEntrez IDGene Name
NR4A2 4929 nuclear receptor subfamily 4, group A, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR4A2chr2_-_157189040-0.101.4e-01Click!


Activity profile for motif NR4A2.p2.

activity profile for motif NR4A2.p2


Sorted Z-values histogram for motif NR4A2.p2

Sorted Z-values for motif NR4A2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR4A2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_-_62130390 24.008 NM_001958
 EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr12_-_16759531 22.737 NM_018640
 LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_16759430 20.469 LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_16759939 19.086 NM_001243613
 LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_+_236849753 18.130 NM_001103
 ACTN2
actinin, alpha 2
chr12_-_16759733 14.696 NM_001243610
 LMO3
LIM domain only 3 (rhombotin-like 2)
chr5_+_80529138 14.666 NM_001099735
NM_001099736
NM_001825
 CKMT2


creatine kinase, mitochondrial 2 (sarcomeric)


chr12_-_16760935 13.682 NM_001001395
NM_001243609
 LMO3

LIM domain only 3 (rhombotin-like 2)

chr12_-_16758839 13.641 NM_001243612
 LMO3
LIM domain only 3 (rhombotin-like 2)
chr8_+_145149985 13.211 CYC1
cytochrome c-1
chr1_-_229569839 13.125 NM_001100
 ACTA1
actin, alpha 1, skeletal muscle
chr11_-_64528186 12.903 NM_001164716
NM_005609
 PYGM

phosphorylase, glycogen, muscle

chr22_-_36019363 12.569 NM_203377
 MB
myoglobin
chr1_-_154164551 12.391 NM_152263
 TPM3
tropomyosin 3
chr17_+_4854383 12.274 NM_001193503
NM_001976
NM_053013
 ENO3


enolase 3 (beta, muscle)


chr3_-_47957475 11.905


chr15_+_43885251 10.971 NM_020990
 CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr1_+_55464605 9.970 NM_057176
 BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr19_+_35629727 9.412 NM_021902
 FXYD1
FXYD domain containing ion transport regulator 1
chrX_+_38420690 8.712 NM_004615
 TSPAN7
tetraspanin 7

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 101 entries
enrichment   p-value GO term description
4.52 4.74e-02 GO:0015985 energy coupled proton transport, down electrochemical gradient
4.52 4.74e-02 GO:0015986 ATP synthesis coupled proton transport
4.26 5.51e-07 GO:0042773 ATP synthesis coupled electron transport
4.26 5.51e-07 GO:0042775 mitochondrial ATP synthesis coupled electron transport
4.16 5.11e-16 GO:0022904 respiratory electron transport chain
4.07 1.38e-04 GO:0006120 mitochondrial electron transport, NADH to ubiquinone
3.94 4.31e-19 GO:0045333 cellular respiration
3.91 4.59e-02 GO:0008207 C21-steroid hormone metabolic process
3.82 8.63e-06 GO:0006119 oxidative phosphorylation
3.22 5.54e-03 GO:0061041 regulation of wound healing
3.18 3.96e-11 GO:0022900 electron transport chain
2.93 2.75e-19 GO:0015980 energy derivation by oxidation of organic compounds
2.91 1.94e-02 GO:0007194 negative regulation of adenylate cyclase activity
2.91 1.94e-02 GO:0031280 negative regulation of cyclase activity
2.91 1.94e-02 GO:0051350 negative regulation of lyase activity
2.86 2.64e-02 GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
2.80 8.58e-03 GO:0015711 organic anion transport
2.66 1.83e-21 GO:0006091 generation of precursor metabolites and energy
2.49 8.60e-04 GO:0030817 regulation of cAMP biosynthetic process
2.47 1.09e-03 GO:0030814 regulation of cAMP metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 51 entries
enrichment   p-value GO term description
6.11 3.90e-02 GO:0034366 spherical high-density lipoprotein particle
5.18 4.47e-02 GO:0001917 photoreceptor inner segment
4.31 3.06e-02 GO:0005753 mitochondrial proton-transporting ATP synthase complex
3.97 1.40e-05 GO:0005747 mitochondrial respiratory chain complex I
3.97 1.40e-05 GO:0030964 NADH dehydrogenase complex
3.97 1.40e-05 GO:0045271 respiratory chain complex I
3.70 1.26e-08 GO:0070469 respiratory chain
3.47 1.47e-06 GO:0005746 mitochondrial respiratory chain
3.12 1.44e-10 GO:0044455 mitochondrial membrane part
2.82 1.31e-02 GO:0031983 vesicle lumen
2.65 9.56e-18 GO:0005743 mitochondrial inner membrane
2.46 2.40e-15 GO:0019866 organelle inner membrane
2.25 1.66e-03 GO:0043292 contractile fiber
2.18 9.26e-03 GO:0030016 myofibril
2.16 1.44e-02 GO:0044449 contractile fiber part
2.11 5.14e-12 GO:0031966 mitochondrial membrane
2.05 1.97e-11 GO:0005740 mitochondrial envelope
1.95 1.60e-03 GO:0030141 stored secretory granule
1.87 8.52e-12 GO:0044429 mitochondrial part
1.85 3.82e-02 GO:0030424 axon

Gene overrepresentation in function category:

Showing 1 to 20 of 30 entries
enrichment   p-value GO term description
4.18 8.57e-06 GO:0003954 NADH dehydrogenase activity
4.18 8.57e-06 GO:0008137 NADH dehydrogenase (ubiquinone) activity
4.18 8.57e-06 GO:0050136 NADH dehydrogenase (quinone) activity
3.62 3.19e-02 GO:0051539 4 iron, 4 sulfur cluster binding
3.60 1.86e-04 GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
3.35 1.87e-04 GO:0003707 steroid hormone receptor activity
3.17 5.88e-04 GO:0004879 ligand-dependent nuclear receptor activity
2.98 1.16e-04 GO:0005200 structural constituent of cytoskeleton
2.91 5.11e-03 GO:0033293 monocarboxylic acid binding
2.63 1.79e-02 GO:0005496 steroid binding
2.61 2.17e-03 GO:0016651 oxidoreductase activity, acting on NADH or NADPH
2.60 2.67e-04 GO:0015078 hydrogen ion transmembrane transporter activity
2.24 2.10e-05 GO:0015077 monovalent inorganic cation transmembrane transporter activity
2.22 6.83e-04 GO:0008509 anion transmembrane transporter activity
1.99 1.87e-04 GO:0022890 inorganic cation transmembrane transporter activity
1.98 4.66e-02 GO:0004252 serine-type endopeptidase activity
1.97 4.19e-02 GO:0031406 carboxylic acid binding
1.67 5.81e-07 GO:0016491 oxidoreductase activity
1.64 1.00e-06 GO:0015075 ion transmembrane transporter activity
1.64 2.53e-03 GO:0008289 lipid binding