Motif ID: NR5A1,2.p2

Z-value: 1.776


Transcription factors associated with NR5A1,2.p2:

Gene SymbolEntrez IDGene Name
NR5A1 2516 nuclear receptor subfamily 5, group A, member 1
NR5A2 2494 nuclear receptor subfamily 5, group A, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR5A2chr1_+_1999967290.313.3e-06Click!
NR5A1chr9_-_1272696890.188.8e-03Click!


Activity profile for motif NR5A1,2.p2.

activity profile for motif NR5A1,2.p2


Sorted Z-values histogram for motif NR5A1,2.p2

Sorted Z-values for motif NR5A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR5A1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_55464605 32.193 NM_057176
 BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr11_-_5275904 27.279 NM_000184
 HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr11_-_5271035 27.168 NM_000559
 HBG1
hemoglobin, gamma A
chr10_-_101190201 26.008 NM_002079
 GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
chr22_+_41865112 23.866 NM_001098
 ACO2
aconitase 2, mitochondrial
chrX_+_103031433 23.819 NM_001128834
 PLP1
proteolipid protein 1
chrX_+_103031797 23.555 PLP1
proteolipid protein 1
chrX_+_103031753 21.437 NM_000533
NM_199478
 PLP1

proteolipid protein 1

chr12_-_120554558 20.871 RAB35
RAB35, member RAS oncogene family
chr12_-_9268440 19.637 A2M
alpha-2-macroglobulin
chr12_-_9268522 19.417 NM_000014
 A2M
alpha-2-macroglobulin
chr6_-_108145507 18.706 NM_198081
 SCML4
sex comb on midleg-like 4 (Drosophila)
chr12_-_9268513 18.669 A2M
alpha-2-macroglobulin
chr2_-_218843541 18.363 TNS1
tensin 1
chr14_+_93389491 17.745 CHGA
chromogranin A (parathyroid secretory protein 1)
chr5_-_42811959 17.507 NM_001085486
NM_001093726
NM_005410
 SEPP1


selenoprotein P, plasma, 1


chr17_-_48271968 16.967


chr5_-_11904127 16.271 CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr2_+_98262497 15.395 NM_001862
 COX5B
cytochrome c oxidase subunit Vb
chr3_+_133464883 14.635 NM_001063
 TF
transferrin

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 90 entries
enrichment   p-value GO term description
4.41 1.02e-02 GO:0046470 phosphatidylcholine metabolic process
3.25 1.45e-03 GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
3.20 4.15e-02 GO:0006096 glycolysis
3.06 7.92e-06 GO:0022904 respiratory electron transport chain
2.94 1.12e-03 GO:0034754 cellular hormone metabolic process
2.89 2.20e-02 GO:0072376 protein activation cascade
2.67 3.42e-05 GO:0045333 cellular respiration
2.51 8.42e-06 GO:0006936 muscle contraction
2.48 4.58e-04 GO:0022900 electron transport chain
2.41 1.64e-05 GO:0003012 muscle system process
2.33 2.33e-03 GO:0006006 glucose metabolic process
2.25 1.51e-02 GO:0060537 muscle tissue development
2.22 8.46e-03 GO:0042445 hormone metabolic process
2.17 4.56e-06 GO:0015980 energy derivation by oxidation of organic compounds
2.17 7.52e-04 GO:0010817 regulation of hormone levels
2.17 1.94e-02 GO:0045165 cell fate commitment
2.11 1.84e-08 GO:0006091 generation of precursor metabolites and energy
2.11 3.16e-03 GO:0007517 muscle organ development
2.01 2.63e-03 GO:0008202 steroid metabolic process
1.84 1.85e-02 GO:0061061 muscle structure development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 43 entries
enrichment   p-value GO term description
5.87 3.97e-03 GO:0005833 hemoglobin complex
3.67 8.32e-07 GO:0000786 nucleosome
3.00 1.50e-02 GO:0031093 platelet alpha granule lumen
2.94 2.01e-02 GO:0034774 secretory granule lumen
2.88 1.55e-02 GO:0031983 vesicle lumen
2.82 3.53e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.67 1.14e-02 GO:0070469 respiratory chain
2.65 6.06e-06 GO:0043292 contractile fiber
2.65 2.31e-05 GO:0044449 contractile fiber part
2.60 5.46e-04 GO:0032993 protein-DNA complex
2.60 4.24e-02 GO:0005746 mitochondrial respiratory chain
2.58 4.71e-05 GO:0030016 myofibril
2.52 1.08e-03 GO:0030017 sarcomere
2.42 3.66e-04 GO:0044455 mitochondrial membrane part
2.05 2.06e-03 GO:0030424 axon
2.02 1.77e-02 GO:0045211 postsynaptic membrane
1.89 1.20e-04 GO:0005743 mitochondrial inner membrane
1.81 1.74e-03 GO:0044456 synapse part
1.81 4.92e-02 GO:0030141 stored secretory granule
1.77 3.24e-02 GO:0016323 basolateral plasma membrane

Gene overrepresentation in function category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
5.42 1.69e-02 GO:0005344 oxygen transporter activity
3.88 3.09e-02 GO:0050840 extracellular matrix binding
3.80 6.53e-06 GO:0003707 steroid hormone receptor activity
3.75 4.03e-06 GO:0004879 ligand-dependent nuclear receptor activity
2.22 1.01e-02 GO:0020037 heme binding
2.19 1.43e-02 GO:0015276 ligand-gated ion channel activity
2.19 1.43e-02 GO:0022834 ligand-gated channel activity
2.15 1.47e-02 GO:0046906 tetrapyrrole binding
1.87 1.81e-03 GO:0005261 cation channel activity
1.86 4.37e-02 GO:0010843 promoter binding
1.79 3.13e-03 GO:0022836 gated channel activity
1.76 2.58e-02 GO:0032403 protein complex binding
1.69 3.17e-03 GO:0005216 ion channel activity
1.68 2.53e-03 GO:0015267 channel activity
1.68 2.94e-03 GO:0022838 substrate-specific channel activity
1.67 2.78e-03 GO:0022803 passive transmembrane transporter activity
1.66 4.70e-02 GO:0003779 actin binding
1.61 6.91e-04 GO:0008324 cation transmembrane transporter activity
1.58 1.17e-04 GO:0016491 oxidoreductase activity
1.56 4.47e-04 GO:0043565 sequence-specific DNA binding