Motif ID: NR6A1.p2

Z-value: 1.023


Transcription factors associated with NR6A1.p2:

Gene SymbolEntrez IDGene Name
NR6A1 2649 nuclear receptor subfamily 6, group A, member 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR6A1chr9_-_1275333970.421.0e-10Click!


Activity profile for motif NR6A1.p2.

activity profile for motif NR6A1.p2


Sorted Z-values histogram for motif NR6A1.p2

Sorted Z-values for motif NR6A1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR6A1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 141 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_6720585 47.207 NM_000064
 C3
complement component 3
chr17_-_48264039 44.376 COL1A1
collagen, type I, alpha 1
chr22_+_23229959 27.017 NM_001178126
 IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr1_+_19923457 20.471 NM_001204088
NM_001204089
NM_001032363
NM_001204082
NM_001204083
 C1orf151-NBL1

MINOS1


C1orf151-NBL1 readthrough

mitochondrial inner membrane organizing system 1


chr2_-_224903324 19.651 NM_001136530
 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr9_-_14313899 18.506 NFIB
nuclear factor I/B
chr7_-_150038689 17.666 NM_002889
 RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr15_+_101420004 16.815 NM_000693
 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr3_-_52312257 15.613 WDR82
WD repeat domain 82
chr9_-_14313509 15.420 NFIB
nuclear factor I/B
chr14_-_106967528 14.842 IGHA1
IGHA2
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr7_+_100199881 13.468 NM_002593
 PCOLCE
procollagen C-endopeptidase enhancer
chr16_+_56642477 12.911 NM_005953
 MT2A
metallothionein 2A
chr9_-_14314036 12.037 NM_001190737
NM_005596
 NFIB

nuclear factor I/B

chr9_+_124043719 11.477 GSN
gelsolin
chr15_+_101420032 11.201 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr6_+_129204285 9.691 NM_000426
NM_001079823
 LAMA2

laminin, alpha 2

chr17_-_29624249 8.772 NM_002544
 OMG
oligodendrocyte myelin glycoprotein
chr14_-_106111114 7.502 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr6_+_31973358 7.464 NM_000500
NM_001128590
 CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
145.59 2.90e-02 GO:0001969 regulation of activation of membrane attack complex
145.59 2.90e-02 GO:0001970 positive regulation of activation of membrane attack complex
145.59 2.90e-02 GO:0045917 positive regulation of complement activation
145.59 2.90e-02 GO:2000259 positive regulation of protein activation cascade
36.40 4.12e-02 GO:0010953 regulation of protein maturation by peptide bond cleavage
36.40 4.12e-02 GO:0070613 regulation of protein processing
20.81 2.38e-03 GO:0002455 humoral immune response mediated by circulating immunoglobulin
19.42 3.12e-02 GO:0060338 regulation of type I interferon-mediated signaling pathway
18.79 3.57e-02 GO:0006958 complement activation, classical pathway
13.24 2.29e-02 GO:0016064 immunoglobulin mediated immune response
13.01 2.50e-02 GO:0019724 B cell mediated immunity
11.81 7.20e-03 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
11.50 8.40e-03 GO:0002250 adaptive immune response
4.07 1.11e-04 GO:0006955 immune response
3.01 1.02e-03 GO:0002376 immune system process
2.43 4.31e-03 GO:0048583 regulation of response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
3.43 5.67e-04 GO:0005624 membrane fraction
3.33 8.84e-04 GO:0005626 insoluble fraction
2.72 1.29e-02 GO:0044421 extracellular region part
2.68 9.87e-03 GO:0000267 cell fraction
2.37 4.01e-04 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
25.48 1.52e-06 GO:0003823 antigen binding