Motif ID: NR6A1.p2

Z-value: 1.023


Transcription factors associated with NR6A1.p2:

Gene SymbolEntrez IDGene Name
NR6A1 2649 nuclear receptor subfamily 6, group A, member 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR6A1chr9_-_1275333970.421.0e-10Click!


Activity profile for motif NR6A1.p2.

activity profile for motif NR6A1.p2


Sorted Z-values histogram for motif NR6A1.p2

Sorted Z-values for motif NR6A1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR6A1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_6720585 47.207 NM_000064
C3
complement component 3
chr17_-_48264039 44.376 COL1A1
collagen, type I, alpha 1
chr22_+_23229959 27.017 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr1_+_19923457 20.471 NM_001204088
NM_001204089
NM_001032363
NM_001204082
NM_001204083
C1orf151-NBL1

MINOS1


C1orf151-NBL1 readthrough

mitochondrial inner membrane organizing system 1


chr2_-_224903324 19.651 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr9_-_14313899 18.506 NFIB
nuclear factor I/B
chr7_-_150038689 17.666 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr15_+_101420004 16.815 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr3_-_52312257 15.613 WDR82
WD repeat domain 82
chr9_-_14313509 15.420 NFIB
nuclear factor I/B
chr14_-_106967528 14.842 IGHA1
IGHA2
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr7_+_100199881 13.468 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr16_+_56642477 12.911 NM_005953
MT2A
metallothionein 2A
chr9_-_14314036 12.037 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr9_+_124043719 11.477 GSN
gelsolin
chr15_+_101420032 11.201 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr6_+_129204285 9.691 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr17_-_29624249 8.772 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr14_-_106111114 7.502 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr6_+_31973358 7.464 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr14_-_106539099 7.154 IGHA1
IGHG1
IGHG3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr3_+_133464883 6.988 NM_001063
TF
transferrin
chr10_-_126107493 6.832 NM_000274
NM_001171814
OAT

ornithine aminotransferase

chr1_+_225997742 6.784 NM_001136018
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr10_+_89419352 6.713 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr9_-_38069082 6.103 SHB
Src homology 2 domain containing adaptor protein B
chr12_+_109273856 5.999 NM_001917
DAO
D-amino-acid oxidase
chr1_+_225997804 5.924 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr14_-_106453162 5.869 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr10_+_123754141 5.277 TACC2
transforming, acidic coiled-coil containing protein 2
chr3_+_133465204 5.025 TF
transferrin
chr2_+_18059923 4.408 NM_002252
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr14_-_106471439 4.018 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr2_-_162930629 3.926 DPP4
dipeptidyl-peptidase 4
chr9_-_38069207 3.879 NM_003028
SHB
Src homology 2 domain containing adaptor protein B
chr3_+_46619075 3.808 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr12_-_16760935 3.776 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr13_+_23755059 3.725 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr3_+_133465098 3.704 TF
transferrin
chr9_+_35792405 3.697 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr13_-_42535066 3.469 KIAA0564
KIAA0564
chr22_-_24059436 3.400


chr14_-_106733392 3.365 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr9_-_21228132 3.359 NM_021268
IFNA17
interferon, alpha 17
chr9_-_21217303 3.315 NM_002173
IFNA16
interferon, alpha 16
chr10_-_126107454 3.306 OAT
ornithine aminotransferase
chr2_+_33701678 3.297 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chrX_-_138724851 3.281 NM_001171877
NM_001171878
NM_001171879
NM_005369
MCF2



MCF.2 cell line derived transforming sequence



chrX_+_48620153 3.240 NM_001080489
GLOD5
glyoxalase domain containing 5
chr7_+_28530747 2.777 CREB5
cAMP responsive element binding protein 5
chr1_+_78511588 2.751 NM_017655
GIPC2
GIPC PDZ domain containing family, member 2
chr2_-_162930500 2.677 DPP4
dipeptidyl-peptidase 4
chr2_-_162930544 2.624 DPP4
dipeptidyl-peptidase 4
chr16_+_1386197 2.539 NM_001199096
BAIAP3
BAI1-associated protein 3
chr9_-_21166609 2.526 NM_002175
IFNA21
interferon, alpha 21
chr4_-_48014960 2.516 NM_000087
CNGA1
cyclic nucleotide gated channel alpha 1
chr8_+_142432006 2.499 NM_007079
NM_032611
PTP4A3

protein tyrosine phosphatase type IVA, member 3

chr2_+_33172368 2.492 NM_206943
LTBP1
latent transforming growth factor beta binding protein 1
chr22_-_24059502 2.348 GUSBP11
glucuronidase, beta pseudogene 11
chr9_-_14313943 2.329 NFIB
nuclear factor I/B
chr5_+_140749830 2.281 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr7_-_137531585 2.150 NM_004717
DGKI
diacylglycerol kinase, iota
chr1_-_20834609 2.130 NM_024544
MUL1
mitochondrial E3 ubiquitin protein ligase 1
chr12_+_7169192 2.082


chr6_-_132910824 2.065 NM_003967
TAAR5
trace amine associated receptor 5
chr12_-_58135853 2.002 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr6_-_43484503 1.902 YIPF3
Yip1 domain family, member 3
chr1_-_20834516 1.886 MUL1
mitochondrial E3 ubiquitin protein ligase 1
chr11_+_35684418 1.800 TRIM44
tripartite motif containing 44
chr12_+_2921786 1.749 NM_018463
ITFG2
integrin alpha FG-GAP repeat containing 2
chr22_-_24059524 1.735 GUSBP11
glucuronidase, beta pseudogene 11
chr20_-_3149070 1.711 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr2_-_162929928 1.693 DPP4
dipeptidyl-peptidase 4
chr5_-_41213513 1.690 NM_000065
C6
complement component 6
chr16_-_3306586 1.663 NM_000243
NM_001198536
MEFV

Mediterranean fever

chr1_-_161102457 1.633 NM_001039711
NM_032998
DEDD

death effector domain containing

chr5_-_65017874 1.606 NM_019072
SGTB
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr19_-_43709692 1.502 NM_002780
NM_213633
PSG4

pregnancy specific beta-1-glycoprotein 4

chr9_-_21207141 1.467 NM_002171
IFNA10
interferon, alpha 10
chr19_+_496453 1.435 NM_130760
NM_130762
MADCAM1

mucosal vascular addressin cell adhesion molecule 1

chr8_-_145701139 1.283 FOXH1
forkhead box H1
chr8_-_93115453 1.233 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr12_+_100897137 1.217 NM_001206992
NM_001206993
NR1H4

nuclear receptor subfamily 1, group H, member 4

chr2_-_241759627 1.142 NM_001244008
NM_004321
KIF1A

kinesin family member 1A

chr1_+_212738675 1.137 NM_001030287
ATF3
activating transcription factor 3
chr12_+_108956293 1.135 NM_014301
NM_213595
ISCU

iron-sulfur cluster scaffold homolog (E. coli)

chr14_-_106641585 1.126 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr11_+_71709951 1.091 NM_001039659
NM_001039660
NM_173044
NM_005699
NM_173042
IL18BP




interleukin 18 binding protein




chr1_+_9299902 1.075 H6PD
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr19_-_5846465 1.075 FUT3
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
chr7_-_2883649 1.064 NM_007353
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr6_-_43484701 1.055 NM_015388
YIPF3
Yip1 domain family, member 3
chr2_-_211090146 0.997 NM_001608
ACADL
acyl-CoA dehydrogenase, long chain
chr1_+_176432306 0.987 NM_020318
NM_021936
PAPPA2

pappalysin 2

chr2_-_31361591 0.977 NM_001253826
NM_024572
GALNT14

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)

chr4_-_89205667 0.974 PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr19_-_15083729 0.970 NM_005071
SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr16_+_3451154 0.868 NM_001032292
NM_003450
ZNF174

zinc finger protein 174

chr3_+_186383770 0.791 NM_000412
HRG
histidine-rich glycoprotein
chr8_-_145701717 0.780 NM_003923
FOXH1
forkhead box H1
chr12_-_110252600 0.764 NM_001177431
NM_001177428
NM_001177433
NM_147204
TRPV4



transient receptor potential cation channel, subfamily V, member 4



chr12_-_7261788 0.763 NM_016546
C1RL
complement component 1, r subcomponent-like
chr6_-_32339648 0.754 NM_006781
C6orf10
chromosome 6 open reading frame 10
chr17_+_12692779 0.735 NM_014859
ARHGAP44
Rho GTPase activating protein 44
chr7_-_126883568 0.713 NM_000845
GRM8
glutamate receptor, metabotropic 8
chr4_+_41614725 0.686 LIMCH1
LIM and calponin homology domains 1
chr7_+_73868236 0.683 GTF2IRD1
GTF2I repeat domain containing 1
chr1_+_26503973 0.653 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr16_+_56995761 0.632 NM_000078
CETP
cholesteryl ester transfer protein, plasma
chr1_+_63063186 0.621 NM_014495
ANGPTL3
angiopoietin-like 3
chr14_-_106967080 0.597 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_+_185046682 0.590 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr1_-_40236926 0.589 NM_022120
OXCT2
3-oxoacid CoA transferase 2
chr19_+_41620336 0.557 NM_000774
CYP2F1
cytochrome P450, family 2, subfamily F, polypeptide 1
chr14_-_106452693 0.503 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr22_+_51041561 0.480 NM_016431
MAPK8IP2
mitogen-activated protein kinase 8 interacting protein 2
chrX_+_47229981 0.469 NM_003446
ZNF157
zinc finger protein 157
chr4_-_90758126 0.457 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr2_+_24150144 0.445 UBXN2A
UBX domain protein 2A
chr7_-_87936202 0.417 NM_001205315
NM_001205316
NM_024636
STEAP4


STEAP family member 4


chr12_-_10562142 0.416 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 readthrough
killer cell lectin-like receptor subfamily C, member 4
chrX_+_8432870 0.364 NM_001001888
VCX3B
VCX3A
variable charge, X-linked 3B
variable charge, X-linked 3A
chr11_+_66314373 0.360 NM_001104
ACTN3
actinin, alpha 3
chr11_+_111957611 0.325 SDHD
succinate dehydrogenase complex, subunit D, integral membrane protein
chr14_-_47120940 0.299 NM_080746
RPL10L
ribosomal protein L10-like
chr1_+_6684924 0.280 NM_001195753
THAP3
THAP domain containing, apoptosis associated protein 3
chrX_-_104465349 0.249 NM_031274
TEX13A
testis expressed 13A
chr9_+_37485911 0.237 NM_022490
POLR1E
polymerase (RNA) I polypeptide E, 53kDa
chr18_+_33767420 0.214 NM_017947
MOCOS
molybdenum cofactor sulfurase
chr3_-_128294928 0.206 NM_007354
C3orf27
chromosome 3 open reading frame 27
chr9_-_130679210 0.202 NM_175039
NM_175040
ST6GALNAC4

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

chr12_-_6484389 0.176 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr21_-_37914897 0.165 NM_001146078
CLDN14
claudin 14
chr16_+_31494438 0.160 NM_003041
SLC5A2
solute carrier family 5 (sodium/glucose cotransporter), member 2
chr11_+_66624501 0.133 LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr11_+_118754474 0.130 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr3_+_46411632 0.108 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr11_-_111957417 0.106 NM_012459
TIMM8B
translocase of inner mitochondrial membrane 8 homolog B (yeast)
chrX_-_8139307 0.070 NM_016378
VCX2
variable charge, X-linked 2
chr9_-_134955056 0.044 MED27
mediator complex subunit 27
chr7_-_100240334 0.016 TFR2
transferrin receptor 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.07 1.11e-04 GO:0006955 immune response
3.01 1.02e-03 GO:0002376 immune system process
20.81 2.38e-03 GO:0002455 humoral immune response mediated by circulating immunoglobulin
2.43 4.31e-03 GO:0048583 regulation of response to stimulus
11.81 7.20e-03 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
11.50 8.40e-03 GO:0002250 adaptive immune response
13.24 2.29e-02 GO:0016064 immunoglobulin mediated immune response
13.01 2.50e-02 GO:0019724 B cell mediated immunity
145.59 2.90e-02 GO:0001969 regulation of activation of membrane attack complex
145.59 2.90e-02 GO:0001970 positive regulation of activation of membrane attack complex
145.59 2.90e-02 GO:0045917 positive regulation of complement activation
145.59 2.90e-02 GO:2000259 positive regulation of protein activation cascade
19.42 3.12e-02 GO:0060338 regulation of type I interferon-mediated signaling pathway
18.79 3.57e-02 GO:0006958 complement activation, classical pathway
36.40 4.12e-02 GO:0010953 regulation of protein maturation by peptide bond cleavage
36.40 4.12e-02 GO:0070613 regulation of protein processing

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.37 4.01e-04 GO:0005576 extracellular region
3.43 5.67e-04 GO:0005624 membrane fraction
3.33 8.84e-04 GO:0005626 insoluble fraction
2.68 9.87e-03 GO:0000267 cell fraction
2.72 1.29e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
25.48 1.52e-06 GO:0003823 antigen binding