Motif ID: NRF1.p2

Z-value: 6.613


Transcription factors associated with NRF1.p2:

Gene SymbolEntrez IDGene Name
NRF1 4899 nuclear respiratory factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NRF1chr7_+_129269916-0.491.0e-14Click!


Activity profile for motif NRF1.p2.

activity profile for motif NRF1.p2


Sorted Z-values histogram for motif NRF1.p2

Sorted Z-values for motif NRF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NRF1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_110045516 148.800 NM_002874
 RAD23B
RAD23 homolog B (S. cerevisiae)
chr9_+_110045551 141.032 RAD23B
RAD23 homolog B (S. cerevisiae)
chr12_+_131356557 131.599 NM_006325
 RAN
RAN, member RAS oncogene family
chr2_+_264843 122.474 NM_001040649
NM_004300
NM_007099
 ACP1


acid phosphatase 1, soluble


chr5_+_170814707 122.259 NM_001037738
NM_002520
NM_199185
 NPM1


nucleophosmin (nucleolar phosphoprotein B23, numatrin)


chr12_+_131356617 118.029 RAN
RAN, member RAS oncogene family
chr9_+_110045565 116.429 RAD23B
RAD23 homolog B (S. cerevisiae)
chr19_-_50432952 112.614 NM_016553
 NUP62
nucleoporin 62kDa
chr5_+_170814952 111.630 NPM1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
chr2_-_33824294 111.598 NM_015475
 FAM98A
family with sequence similarity 98, member A
chr11_-_64545231 102.151 NM_001178031
 SF1
splicing factor 1
chr8_-_117887045 101.282 NM_006265
 RAD21
RAD21 homolog (S. pombe)
chr8_-_117886881 100.019 RAD21
RAD21 homolog (S. pombe)
chr19_-_50432734 96.429 NM_012346
NM_153718
NM_153719
NM_001193357
NM_172374
 NUP62



IL4I1
nucleoporin 62kDa



interleukin 4 induced 1
chr17_+_49337909 94.581 UTP18
UTP18 small subunit (SSU) processome component homolog (yeast)
chr12_-_54070108 92.998 NM_005176
 ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr17_+_49337892 92.058 NM_016001
 UTP18
UTP18 small subunit (SSU) processome component homolog (yeast)
chr8_+_42249383 91.510 VDAC3
voltage-dependent anion channel 3
chr16_-_66864864 89.963 NM_001018159
NM_001018160
NM_003905
 NAE1


NEDD8 activating enzyme E1 subunit 1


chr16_-_66864803 89.413 NAE1
NEDD8 activating enzyme E1 subunit 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 176 entries
enrichment   p-value GO term description
4.85 3.28e-05 GO:0006413 translational initiation
4.84 6.84e-10 GO:0006405 RNA export from nucleus
4.64 1.02e-07 GO:0006406 mRNA export from nucleus
4.50 4.91e-03 GO:0000245 spliceosome assembly
4.18 9.77e-09 GO:0051168 nuclear export
4.15 3.24e-02 GO:0009060 aerobic respiration
4.08 3.49e-03 GO:0006369 termination of RNA polymerase II transcription
4.02 5.72e-11 GO:0051028 mRNA transport
3.97 8.90e-12 GO:0050657 nucleic acid transport
3.97 8.90e-12 GO:0050658 RNA transport
3.97 8.90e-12 GO:0051236 establishment of RNA localization
3.96 1.12e-03 GO:0007051 spindle organization
3.93 5.97e-12 GO:0006403 RNA localization
3.90 8.78e-20 GO:0000375 RNA splicing, via transesterification reactions
3.90 1.45e-02 GO:0000070 mitotic sister chromatid segregation
3.88 5.37e-19 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
3.88 5.37e-19 GO:0000398 nuclear mRNA splicing, via spliceosome
3.73 6.15e-03 GO:0006119 oxidative phosphorylation
3.69 9.87e-05 GO:0006200 ATP catabolic process
3.63 3.67e-02 GO:0000819 sister chromatid segregation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 72 entries
enrichment   p-value GO term description
6.85 3.59e-02 GO:0005868 cytoplasmic dynein complex
6.14 2.18e-02 GO:0005665 DNA-directed RNA polymerase II, core complex
4.56 1.30e-02 GO:0044452 nucleolar part
3.80 1.87e-11 GO:0044455 mitochondrial membrane part
3.80 1.05e-05 GO:0000922 spindle pole
3.80 1.05e-05 GO:0070469 respiratory chain
3.74 6.27e-05 GO:0005746 mitochondrial respiratory chain
3.47 1.28e-04 GO:0005643 nuclear pore
3.45 2.68e-02 GO:0016469 proton-transporting two-sector ATPase complex
3.30 5.37e-05 GO:0046930 pore complex
3.23 1.73e-02 GO:0034708 methyltransferase complex
3.23 1.73e-02 GO:0035097 histone methyltransferase complex
3.18 3.71e-04 GO:0071013 catalytic step 2 spliceosome
3.17 1.23e-03 GO:0000777 condensed chromosome kinetochore
3.11 1.80e-04 GO:0000776 kinetochore
3.07 3.60e-07 GO:0005681 spliceosomal complex
2.96 3.78e-03 GO:0000779 condensed chromosome, centromeric region
2.87 3.15e-08 GO:0005819 spindle
2.73 9.55e-22 GO:0030529 ribonucleoprotein complex
2.73 2.50e-05 GO:0000775 chromosome, centromeric region

Gene overrepresentation in function category:

Showing 1 to 20 of 35 entries
enrichment   p-value GO term description
11.41 3.50e-03 GO:0017070 U6 snRNA binding
4.04 2.06e-04 GO:0003743 translation initiation factor activity
3.99 2.68e-03 GO:0003899 DNA-directed RNA polymerase activity
3.99 2.68e-03 GO:0034062 RNA polymerase activity
3.24 1.86e-04 GO:0008135 translation factor activity, nucleic acid binding
3.20 1.40e-02 GO:0003697 single-stranded DNA binding
3.03 1.65e-05 GO:0051082 unfolded protein binding
2.83 3.73e-04 GO:0016779 nucleotidyltransferase activity
2.48 7.50e-27 GO:0003723 RNA binding
2.25 3.49e-02 GO:0004386 helicase activity
2.21 2.71e-02 GO:0004518 nuclease activity
2.15 8.42e-03 GO:0003682 chromatin binding
2.10 1.86e-02 GO:0043566 structure-specific DNA binding
2.00 2.00e-02 GO:0004842 ubiquitin-protein ligase activity
1.94 6.64e-04 GO:0016887 ATPase activity
1.94 3.32e-02 GO:0019787 small conjugating protein ligase activity
1.92 1.30e-02 GO:0016881 acid-amino acid ligase activity
1.85 1.96e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.76 1.99e-03 GO:0016874 ligase activity
1.71 9.82e-06 GO:0016462 pyrophosphatase activity