Motif ID: PAX2.p2

Z-value: 1.811


Transcription factors associated with PAX2.p2:

Gene SymbolEntrez IDGene Name
PAX2 5076 paired box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX2chr10_+_1025053370.111.2e-01Click!


Activity profile for motif PAX2.p2.

activity profile for motif PAX2.p2


Sorted Z-values histogram for motif PAX2.p2

Sorted Z-values for motif PAX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_-_44258210 42.803 NM_014351
 SULT4A1
sulfotransferase family 4A, member 1
chr1_-_154193044 29.169 C1orf43
chromosome 1 open reading frame 43
chr1_+_11866240 25.930 CLCN6
chloride channel 6
chrX_-_102319080 22.337 BEX1
brain expressed, X-linked 1
chrX_-_102319096 21.964 NM_018476
 BEX1
brain expressed, X-linked 1
chr16_+_23847359 21.415 PRKCB
protein kinase C, beta
chr1_+_11866206 19.893 NM_001286
NM_021735
NM_021736
NM_021737
 CLCN6



chloride channel 6



chr14_-_93651242 19.890 NM_022151
 MOAP1
modulator of apoptosis 1
chr3_-_98241357 19.330 CLDND1
claudin domain containing 1
chr14_+_24584009 19.235 DCAF11
DDB1 and CUL4 associated factor 11
chr17_+_6915952 18.081 RNASEK
ribonuclease, RNase K
chr14_-_93651182 17.717 MOAP1
modulator of apoptosis 1
chrX_-_47479229 17.657 NM_006950
NM_133499
 SYN1

synapsin I

chr2_-_136875629 17.499 NM_003467
 CXCR4
chemokine (C-X-C motif) receptor 4
chr11_-_116968986 17.426 NM_025164
 SIK3
SIK family kinase 3
chr7_+_149571029 16.888 ATP6V0E2
ATPase, H+ transporting V0 subunit e2
chrX_-_106960028 16.465 TSC22D3
TSC22 domain family, member 3
chr19_-_10764449 16.259 LOC147727
uncharacterized LOC147727
chr6_+_139456240 15.719 NM_016217
 HECA
headcase homolog (Drosophila)
chr14_+_24584321 15.617 DCAF11
DDB1 and CUL4 associated factor 11

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
2.98 6.32e-03 GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
2.70 3.92e-02 GO:0007269 neurotransmitter secretion
2.58 4.23e-03 GO:0001505 regulation of neurotransmitter levels
1.92 1.12e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.89 4.79e-04 GO:0032870 cellular response to hormone stimulus
1.84 7.63e-04 GO:0071495 cellular response to endogenous stimulus
1.83 2.19e-05 GO:0007268 synaptic transmission
1.79 1.21e-05 GO:0019226 transmission of nerve impulse
1.79 1.21e-05 GO:0035637 multicellular organismal signaling
1.60 9.99e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.57 1.78e-03 GO:0071310 cellular response to organic substance
1.54 9.57e-05 GO:0006351 transcription, DNA-dependent
1.51 3.48e-02 GO:0009725 response to hormone stimulus
1.50 4.59e-03 GO:0007267 cell-cell signaling
1.49 2.26e-02 GO:0009719 response to endogenous stimulus
1.46 2.54e-02 GO:0016192 vesicle-mediated transport
1.45 2.05e-03 GO:0032774 RNA biosynthetic process
1.41 2.12e-04 GO:0035556 intracellular signal transduction
1.41 8.29e-03 GO:0007154 cell communication
1.40 1.10e-03 GO:0010033 response to organic substance

Gene overrepresentation in compartment category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
2.19 2.87e-02 GO:0030133 transport vesicle
2.04 9.85e-03 GO:0005769 early endosome
1.69 4.58e-02 GO:0044440 endosomal part
1.64 9.38e-04 GO:0005768 endosome
1.43 4.39e-03 GO:0031982 vesicle
1.43 8.64e-03 GO:0031410 cytoplasmic vesicle
1.42 1.79e-02 GO:0031988 membrane-bounded vesicle
1.41 2.92e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.37 1.19e-02 GO:0005794 Golgi apparatus
1.14 2.98e-08 GO:0005737 cytoplasm
1.14 4.44e-04 GO:0044444 cytoplasmic part
1.14 1.60e-03 GO:0005634 nucleus
1.12 1.00e-06 GO:0043227 membrane-bounded organelle
1.12 1.71e-06 GO:0043231 intracellular membrane-bounded organelle
1.11 1.51e-11 GO:0044424 intracellular part
1.11 3.64e-11 GO:0005622 intracellular
1.11 7.17e-07 GO:0043226 organelle
1.11 9.74e-07 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
3.02 4.01e-03 GO:0003707 steroid hormone receptor activity
3.00 2.52e-03 GO:0004879 ligand-dependent nuclear receptor activity
1.69 2.22e-03 GO:0000988 protein binding transcription factor activity
1.69 2.22e-03 GO:0000989 transcription factor binding transcription factor activity
1.67 3.85e-03 GO:0003712 transcription cofactor activity
1.49 1.69e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.43 9.65e-03 GO:0016301 kinase activity
1.42 2.41e-02 GO:0019899 enzyme binding
1.40 2.93e-03 GO:0001071 nucleic acid binding transcription factor activity
1.40 2.93e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.29 1.31e-02 GO:0032559 adenyl ribonucleotide binding
1.29 1.36e-02 GO:0030554 adenyl nucleotide binding
1.28 2.53e-02 GO:0005524 ATP binding
1.27 5.54e-03 GO:0032553 ribonucleotide binding
1.27 5.54e-03 GO:0032555 purine ribonucleotide binding
1.27 6.26e-03 GO:0017076 purine nucleotide binding
1.27 7.72e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.24 7.43e-03 GO:0000166 nucleotide binding
1.21 7.13e-15 GO:0005515 protein binding
1.11 2.40e-13 GO:0005488 binding