Motif ID: PAX6.p2

Z-value: 0.616


Transcription factors associated with PAX6.p2:

Gene SymbolEntrez IDGene Name
PAX6 5080 paired box 6

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX6chr11_-_318394470.171.2e-02Click!


Activity profile for motif PAX6.p2.

activity profile for motif PAX6.p2


Sorted Z-values histogram for motif PAX6.p2

Sorted Z-values for motif PAX6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_174320616 24.726 NM_007281
SCRG1
stimulator of chondrogenesis 1
chrX_-_13835213 17.146 GPM6B
glycoprotein M6B
chr16_+_72097124 10.666 NM_020995
HPR
haptoglobin-related protein
chr5_-_141338626 10.327 NM_016580
PCDH12
protocadherin 12
chr3_-_195310770 10.313 APOD
apolipoprotein D
chrX_-_13835187 10.245 GPM6B
glycoprotein M6B
chr3_+_111717585 9.417 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr22_+_39745757 9.031 NM_004711
NM_145731
SYNGR1

synaptogyrin 1

chrX_-_13835012 8.676 GPM6B
glycoprotein M6B
chr5_-_142077508 8.456 NM_001144934
NM_001144935
FGF1

fibroblast growth factor 1 (acidic)

chr4_+_113970784 7.717 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr16_+_72088507 7.454 NM_001126102
NM_005143
HP

haptoglobin

chr6_+_101846668 6.503 GRIK2
glutamate receptor, ionotropic, kainate 2
chr11_-_117747331 5.752 FXYD6
FXYD domain containing ion transport regulator 6
chrX_-_13835313 5.238 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr7_+_155250705 5.034 NM_001427
EN2
engrailed homeobox 2
chr19_-_52133589 5.015 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr4_-_10686314 4.823 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chrX_-_130423387 4.670 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr19_+_7968820 4.648 MAP2K7
mitogen-activated protein kinase kinase 7
chr3_+_133495925 4.515 TF
transferrin
chr19_+_16059817 4.396 NM_001004465
OR10H4
olfactory receptor, family 10, subfamily H, member 4
chr8_+_39792473 4.329 NM_194294
IDO2
indoleamine 2,3-dioxygenase 2
chr1_+_150480584 4.249 ECM1
extracellular matrix protein 1
chrX_-_130423199 4.104 IGSF1
immunoglobulin superfamily, member 1
chr9_-_16870664 3.714 BNC2
basonuclin 2
chr11_+_117947726 3.688 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chrX_-_65259839 3.502 NM_001100431
NM_001184830
NM_001184831
NM_007268
VSIG4



V-set and immunoglobulin domain containing 4



chr5_-_58334936 3.147 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr12_-_71031174 3.010 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr11_+_14926542 3.002 CALCB
calcitonin-related polypeptide beta
chr8_-_87755880 2.961 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr5_+_40909558 2.956 NM_000587
C7
complement component 7
chr18_+_18822168 2.904 NM_001142966
GREB1L
growth regulation by estrogen in breast cancer-like
chr11_+_117947785 2.864 TMPRSS4
transmembrane protease, serine 4
chr12_-_45269340 2.798 NM_001145109
NELL2
NEL-like 2 (chicken)
chr19_+_15852200 2.751 NM_013938
OR10H3
olfactory receptor, family 10, subfamily H, member 3
chr4_+_187148624 2.665 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr9_+_124048396 2.469 GSN
gelsolin
chrX_+_148769902 2.432 NM_001011544
MAGEA11
melanoma antigen family A, 11
chr1_+_147374945 2.329 NM_005267
GJA8
gap junction protein, alpha 8, 50kDa
chr5_+_140254930 2.326 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr17_-_39041436 2.264 NM_019010
KRT20
keratin 20
chr1_-_182922504 2.179 NM_030933
SHCBP1L
SHC SH2-domain binding protein 1-like
chr3_+_108015392 2.115 HHLA2
HERV-H LTR-associating 2
chr1_+_209878135 2.105 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr21_+_39644428 2.058 NM_170737
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_-_12908141 2.024 NM_001146181
HNRNPCL1
LOC649330
heterogeneous nuclear ribonucleoprotein C-like 1
heterogeneous nuclear ribonucleoprotein C-like
chr15_+_29213839 2.004 NM_001130414
NM_005503
APBA2

amyloid beta (A4) precursor protein-binding, family A, member 2

chr5_-_94224601 1.974 MCTP1
multiple C2 domains, transmembrane 1
chr6_-_46703429 1.971 NM_001168357
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr12_+_18414473 1.942 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chr4_-_68749698 1.907 NM_004262
TMPRSS11D
transmembrane protease, serine 11D
chr4_+_88896801 1.753 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chrY_-_27198250 1.746 NM_001002760
NM_001002761
NM_004678
BPY2B
BPY2C
BPY2
basic charge, Y-linked, 2B
basic charge, Y-linked, 2C
basic charge, Y-linked, 2
chr13_+_53602829 1.728 NM_006418
OLFM4
olfactomedin 4
chr15_-_50405512 1.695 ATP8B4
ATPase, class I, type 8B, member 4
chr10_-_82049178 1.643 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr8_-_21771111 1.634 NM_003974
DOK2
docking protein 2, 56kDa
chrX_-_15332680 1.583 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr1_-_31345361 1.575 SDC3
syndecan 3
chr1_+_150480486 1.560 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr3_+_119500930 1.492 NR1I2
nuclear receptor subfamily 1, group I, member 2
chr5_+_55147206 1.452 NM_001242637
NM_001242638
NM_139017
IL31RA


interleukin 31 receptor A


chr19_-_14910947 1.422 NM_198944
OR7C1
olfactory receptor, family 7, subfamily C, member 1
chrY_+_25130409 1.411 NM_001002760
NM_001002761
NM_004678
BPY2B
BPY2C
BPY2
basic charge, Y-linked, 2B
basic charge, Y-linked, 2C
basic charge, Y-linked, 2
chrY_+_26764150 1.411 NM_001002760
NM_001002761
NM_004678
BPY2B
BPY2C
BPY2
basic charge, Y-linked, 2B
basic charge, Y-linked, 2C
basic charge, Y-linked, 2
chr9_-_95166827 1.388 NM_014057
NM_033014
OGN

osteoglycin

chr4_+_71263598 1.384 NM_021225
PROL1
proline rich, lacrimal 1
chr19_+_55249973 1.375 NM_015868
KIR2DL3
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
chr4_+_100495972 1.274 MTTP
microsomal triglyceride transfer protein
chr4_+_70861647 1.249 NM_001009181
NM_003154
STATH

statherin

chr6_+_14117486 1.223 NM_001251901
CD83
CD83 molecule
chr17_+_8213555 1.171 NM_173728
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr11_+_76883823 1.116 MYO7A
myosin VIIA
chr1_+_158901336 1.115 NM_152501
NM_198928
NM_198929
NM_198930
PYHIN1



pyrin and HIN domain family, member 1



chr19_-_54327428 1.096 NM_144687
NLRP12
NLR family, pyrin domain containing 12
chr14_+_29241989 1.081 C14orf23
chromosome 14 open reading frame 23
chr17_+_8214139 1.070 NM_025014
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr1_-_13611532 1.047 NM_001012276
PRAMEF8
PRAMEF7
PRAME family member 8
PRAME family member 7
chr7_+_45067232 0.958 NM_001029835
CCM2
cerebral cavernous malformation 2
chr10_+_102222797 0.951 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chrX_+_144908927 0.914 NM_004709
CXorf1
chromosome X open reading frame 1
chr5_-_58882274 0.892 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_+_140734767 0.891 NM_018917
NM_032053
PCDHGA4

protocadherin gamma subfamily A, 4

chr19_-_14992166 0.883 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr17_-_36956145 0.882 NM_003559
PIP4K2B
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr4_-_26491888 0.865 NM_000730
CCKAR
cholecystokinin A receptor
chr16_-_18937722 0.861 NM_015092
SMG1
smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chr1_+_114522029 0.822 NM_020190
OLFML3
olfactomedin-like 3
chrX_-_15333726 0.801 NM_001201583
NM_080873
ASB11

ankyrin repeat and SOCS box containing 11

chr5_-_135231504 0.788 NM_000590
IL9
interleukin 9
chr20_-_44144263 0.745 NM_006652
SPINT3
serine peptidase inhibitor, Kunitz type, 3
chr3_-_14583587 0.745 NM_001080423
GRIP2
glutamate receptor interacting protein 2
chr20_+_4702499 0.719 NM_012409
PRND
prion protein 2 (dublet)
chr1_-_226926875 0.702 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr2_+_170366211 0.701 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chrX_+_50653734 0.694 NM_005448
BMP15
bone morphogenetic protein 15
chr6_-_136788012 0.678 NM_001198615
MAP7
microtubule-associated protein 7
chr1_-_153044083 0.674 NM_001017418
SPRR2B
small proline-rich protein 2B
chr5_+_175223519 0.642 NM_006650
CPLX2
complexin 2
chr15_+_45544427 0.600 NM_004212
SLC28A2
solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
chr19_-_51961648 0.599 NM_014442
SIGLEC8
sialic acid binding Ig-like lectin 8
chr9_-_95244750 0.574 NM_001193335
NM_017680
ASPN

asporin

chr4_+_71226477 0.545 NM_012390
SMR3B
SMR3A
submaxillary gland androgen regulated protein 3B
submaxillary gland androgen regulated protein 3A
chr8_+_7705401 0.517 NM_058203
NM_001081552
SPAG11B
SPAG11A
sperm associated antigen 11B
sperm associated antigen 11A
chr11_+_71903172 0.492 NM_016729
FOLR1
folate receptor 1 (adult)
chr3_-_108248168 0.476 NM_014981
MYH15
myosin, heavy chain 15
chr3_+_49506079 0.442 NM_001177643
DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr5_+_143191725 0.420 NM_021182
HMHB1
histocompatibility (minor) HB-1
chr21_-_31588242 0.406 NM_199328
CLDN8
claudin 8
chr16_-_51184507 0.399 NM_001127892
SALL1
sal-like 1 (Drosophila)
chr3_+_25470067 0.369 RARB
retinoic acid receptor, beta
chr3_+_119501556 0.368 NM_022002
NR1I2
nuclear receptor subfamily 1, group I, member 2
chr6_-_131291480 0.350 NM_001199389
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr5_+_152870083 0.333 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr18_-_47806361 0.330 NM_001204151
MBD1
methyl-CpG binding domain protein 1
chr8_+_18079176 0.313 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr11_+_118175294 0.307 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr17_+_25958245 0.281 LGALS9
lectin, galactoside-binding, soluble, 9
chr7_+_110731061 0.259 NM_001099658
NM_001099660
NM_018334
LRRN3


leucine rich repeat neuronal 3


chr12_-_133215775 0.246 POLE
polymerase (DNA directed), epsilon
chr12_-_7848324 0.245 NM_020634
GDF3
growth differentiation factor 3
chr8_-_59412695 0.220 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr13_+_24844846 0.216 SPATA13
spermatogenesis associated 13
chr17_+_25958257 0.216 LGALS9
lectin, galactoside-binding, soluble, 9
chr3_+_133118789 0.214 NM_003571
BFSP2
beaded filament structural protein 2, phakinin
chr6_-_35480635 0.209 NM_003322
TULP1
tubby like protein 1
chr7_+_80267782 0.194 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr18_+_32073343 0.193 DTNA
dystrobrevin, alpha
chr16_+_28943259 0.182 NM_001178098
NM_001770
CD19

CD19 molecule

chr22_+_40322609 0.179 GRAP2
GRB2-related adaptor protein 2
chr8_-_95487284 0.178 NM_001205262
NM_012415
RAD54B

RAD54 homolog B (S. cerevisiae)

chr2_+_88047603 0.174 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr15_-_85197502 0.174 WDR73
WD repeat domain 73
chr12_+_21168629 0.164 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr21_-_39870303 0.163 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr7_-_73123431 0.146 STX1A
syntaxin 1A (brain)
chr16_+_82068958 0.134 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr6_-_76203256 0.083 NM_015687
FILIP1
filamin A interacting protein 1
chr15_-_85197512 0.083 NM_032856
WDR73
WD repeat domain 73
chr2_-_163008913 0.076 NM_002054
GCG
glucagon
chr6_+_167704802 0.072 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr5_+_140174443 0.054 NM_018905
NM_031495
PCDHA2

protocadherin alpha 2

chr17_+_9745847 0.046 GLP2R
glucagon-like peptide 2 receptor
chr3_-_15563160 0.008 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
49.48 1.28e-02 GO:0070168 negative regulation of biomineral tissue development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.70 2.01e-07 GO:0005576 extracellular region
3.02 4.31e-03 GO:0005615 extracellular space
1.65 7.19e-03 GO:0005886 plasma membrane
1.63 1.05e-02 GO:0071944 cell periphery
2.60 1.11e-02 GO:0044421 extracellular region part

Nothing significant found in function category.