Motif ID: PBX1.p2

Z-value: 1.380


Transcription factors associated with PBX1.p2:

Gene SymbolEntrez IDGene Name
PBX1 5087 pre-B-cell leukemia homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PBX1chr1_+_164528914-0.468.5e-13Click!


Activity profile for motif PBX1.p2.

activity profile for motif PBX1.p2


Sorted Z-values histogram for motif PBX1.p2

Sorted Z-values for motif PBX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_28241233 39.561 NM_002946
 RPA2
replication protein A2, 32kDa
chr5_+_162864571 39.419 NM_004060
NM_199246
 CCNG1

cyclin G1

chr9_+_140135698 34.638 NM_006088
 TUBB4B
tubulin, beta 4B class IVb
chrX_+_119737743 34.563 NM_014060
 MCTS1
malignant T cell amplified sequence 1
chr9_+_140135738 32.071 TUBB4B
tubulin, beta 4B class IVb
chr17_+_8191814 32.011 NM_001177801
NM_001177802
NM_016492
 RANGRF


RAN guanine nucleotide release factor


chr7_-_7680048 28.893 RPA3
replication protein A3, 14kDa
chr4_-_174255454 27.727 NM_001130688
NM_002129
 HMGB2

high mobility group box 2

chrX_+_119737905 27.551 MCTS1
malignant T cell amplified sequence 1
chr9_+_140135742 26.285 TUBB4B
tubulin, beta 4B class IVb
chrX_+_119737984 25.573 MCTS1
malignant T cell amplified sequence 1
chr12_+_64803741 25.371 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr3_-_32544358 24.483 NM_017801
 CMTM6
CKLF-like MARVEL transmembrane domain containing 6
chr12_+_49658862 23.896 NM_032704
 TUBA1C
tubulin, alpha 1c
chr3_+_172468469 23.418 ECT2
epithelial cell transforming sequence 2 oncogene
chr6_+_111195986 23.367 NM_001634
NM_001033059
 AMD1

adenosylmethionine decarboxylase 1

chr6_-_75965845 22.639 TMEM30A
transmembrane protein 30A
chr1_-_28240953 22.607 RPA2
replication protein A2, 32kDa
chr12_+_49658865 22.297 TUBA1C
tubulin, alpha 1c
chr2_+_216986817 21.728 XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 64 entries
enrichment   p-value GO term description
9.19 1.13e-02 GO:0034976 response to endoplasmic reticulum stress
8.17 4.51e-10 GO:0065004 protein-DNA complex assembly
7.73 1.33e-09 GO:0071824 protein-DNA complex subunit organization
7.58 4.29e-02 GO:0030071 regulation of mitotic metaphase/anaphase transition
7.53 3.91e-07 GO:0006334 nucleosome assembly
7.22 3.90e-04 GO:0010948 negative regulation of cell cycle process
7.14 8.85e-07 GO:0031497 chromatin assembly
6.79 1.91e-06 GO:0034728 nucleosome organization
6.42 4.77e-08 GO:0006333 chromatin assembly or disassembly
6.42 4.13e-02 GO:0045732 positive regulation of protein catabolic process
5.80 7.13e-06 GO:0006323 DNA packaging
5.27 1.19e-05 GO:0071103 DNA conformation change
4.76 3.54e-12 GO:0034622 cellular macromolecular complex assembly
4.75 1.45e-04 GO:0043623 cellular protein complex assembly
4.33 2.85e-02 GO:0010639 negative regulation of organelle organization
4.29 2.80e-05 GO:0071156 regulation of cell cycle arrest
4.25 7.26e-05 GO:0000075 cell cycle checkpoint
4.19 3.96e-02 GO:0007093 mitotic cell cycle checkpoint
4.17 1.95e-02 GO:0006310 DNA recombination
4.15 2.50e-12 GO:0034621 cellular macromolecular complex subunit organization

Gene overrepresentation in compartment category:

Showing 1 to 20 of 38 entries
enrichment   p-value GO term description
12.03 1.10e-02 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
8.66 2.48e-06 GO:0000786 nucleosome
7.77 6.88e-03 GO:0005876 spindle microtubule
6.84 1.09e-06 GO:0032993 protein-DNA complex
5.91 4.98e-03 GO:0000922 spindle pole
4.33 9.30e-07 GO:0000785 chromatin
3.63 4.46e-03 GO:0005819 spindle
3.55 9.98e-09 GO:0044427 chromosomal part
3.31 7.07e-09 GO:0005694 chromosome
3.10 2.82e-02 GO:0000228 nuclear chromosome
2.95 6.80e-03 GO:0005874 microtubule
2.30 1.78e-02 GO:0030529 ribonucleoprotein complex
2.05 4.30e-02 GO:0015630 microtubule cytoskeleton
1.98 1.56e-04 GO:0005654 nucleoplasm
1.96 1.15e-08 GO:0070013 intracellular organelle lumen
1.92 3.44e-08 GO:0043233 organelle lumen
1.89 8.34e-08 GO:0031974 membrane-enclosed lumen
1.89 5.32e-07 GO:0044428 nuclear part
1.89 1.04e-05 GO:0031981 nuclear lumen
1.86 4.50e-09 GO:0043228 non-membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
8.36 1.65e-05 GO:0003697 single-stranded DNA binding
3.51 7.06e-03 GO:0043566 structure-specific DNA binding
2.06 6.78e-03 GO:0003723 RNA binding
1.44 9.33e-03 GO:0003676 nucleic acid binding
1.34 2.97e-06 GO:0005515 protein binding
1.15 1.08e-03 GO:0005488 binding