Motif ID: PITX1..3.p2

Z-value: 2.316


Transcription factors associated with PITX1..3.p2:

Gene SymbolEntrez IDGene Name
PITX1 5307 paired-like homeodomain 1
PITX2 5308 paired-like homeodomain 2
PITX3 5309 paired-like homeodomain 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PITX2chr4_-_1115442060.235.5e-04Click!
PITX3chr10_-_104001229-0.082.2e-01Click!
PITX1chr5_-_1343695710.027.4e-01Click!


Activity profile for motif PITX1..3.p2.

activity profile for motif PITX1..3.p2


Sorted Z-values histogram for motif PITX1..3.p2

Sorted Z-values for motif PITX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_18798077 24.610


chr22_-_17680485 23.483 NM_177405
 CECR1
cat eye syndrome chromosome region, candidate 1
chr19_-_39826625 23.244 GMFG
glia maturation factor, gamma
chr22_-_17690778 22.095 NM_017424
 CECR1
cat eye syndrome chromosome region, candidate 1
chr19_-_39826676 22.033 NM_004877
 GMFG
glia maturation factor, gamma
chr17_-_38821286 21.477 NM_152349
 KRT222
keratin 222
chr3_+_127317271 17.961 MCM2
minichromosome maintenance complex component 2
chr1_-_150738292 17.908 NM_001199739
NM_004079
 CTSS

cathepsin S

chr3_+_127317274 17.802 MCM2
minichromosome maintenance complex component 2
chr9_+_131217433 16.884 NM_153436
 ODF2
outer dense fiber of sperm tails 2
chr3_-_141719188 16.801 NM_001178140
 TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr3_+_127317212 16.294 NM_004526
 MCM2
minichromosome maintenance complex component 2
chr1_-_150738255 16.143 CTSS
cathepsin S
chr16_+_29471206 16.040 NM_001017390
NM_177552
 SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr7_+_73624328 15.768 LAT2
linker for activation of T cells family, member 2
chr20_+_55926144 15.722 NM_003610
 RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr7_+_73624347 15.603 LAT2
linker for activation of T cells family, member 2
chr22_-_42336222 14.995 NM_001110215
 CENPM
centromere protein M
chr12_-_117537090 14.832 NM_001168325
NM_017899
 TESC

tescalcin

chr16_+_30210548 14.711 NM_001017390
NM_177552
 SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 54 entries
enrichment   p-value GO term description
4.18 3.69e-02 GO:0006283 transcription-coupled nucleotide-excision repair
3.79 4.89e-06 GO:0006414 translational elongation
3.79 8.59e-05 GO:0019080 viral genome expression
3.79 8.59e-05 GO:0019083 viral transcription
3.66 1.72e-04 GO:0006415 translational termination
3.36 3.28e-02 GO:0006289 nucleotide-excision repair
3.31 1.13e-03 GO:0043241 protein complex disassembly
3.31 1.13e-03 GO:0043624 cellular protein complex disassembly
3.21 6.54e-04 GO:0032984 macromolecular complex disassembly
3.21 6.54e-04 GO:0034623 cellular macromolecular complex disassembly
3.20 2.14e-04 GO:0031018 endocrine pancreas development
2.89 3.46e-06 GO:0000375 RNA splicing, via transesterification reactions
2.89 5.56e-06 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.89 5.56e-06 GO:0000398 nuclear mRNA splicing, via spliceosome
2.80 2.23e-03 GO:0031016 pancreas development
2.71 1.03e-02 GO:0019058 viral infectious cycle
2.59 4.49e-07 GO:0006412 translation
2.54 2.16e-03 GO:0022411 cellular component disassembly
2.54 2.16e-03 GO:0071845 cellular component disassembly at cellular level
2.52 2.81e-06 GO:0008380 RNA splicing

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
7.69 3.85e-03 GO:0005665 DNA-directed RNA polymerase II, core complex
6.21 5.40e-04 GO:0005689 U12-type spliceosomal complex
4.63 1.89e-03 GO:0022625 cytosolic large ribosomal subunit
4.06 7.96e-06 GO:0022626 cytosolic ribosome
3.09 1.70e-02 GO:0016591 DNA-directed RNA polymerase II, holoenzyme
2.99 5.67e-05 GO:0005681 spliceosomal complex
2.93 2.06e-02 GO:0046930 pore complex
2.36 3.84e-03 GO:0005840 ribosome
2.25 5.07e-09 GO:0030529 ribonucleoprotein complex
1.63 1.39e-06 GO:0005654 nucleoplasm
1.60 5.34e-11 GO:0044428 nuclear part
1.58 3.47e-08 GO:0031981 nuclear lumen
1.50 5.94e-08 GO:0043233 organelle lumen
1.49 9.59e-08 GO:0031974 membrane-enclosed lumen
1.49 1.31e-07 GO:0070013 intracellular organelle lumen
1.45 1.41e-05 GO:0005829 cytosol
1.37 1.44e-07 GO:0032991 macromolecular complex
1.30 1.69e-09 GO:0005634 nucleus
1.23 1.80e-05 GO:0044422 organelle part
1.23 2.11e-05 GO:0044446 intracellular organelle part

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
5.14 1.72e-02 GO:0019843 rRNA binding
2.92 5.31e-05 GO:0003735 structural constituent of ribosome
2.89 5.28e-03 GO:0008026 ATP-dependent helicase activity
2.89 5.28e-03 GO:0070035 purine NTP-dependent helicase activity
2.71 1.60e-03 GO:0004386 helicase activity
2.15 8.46e-13 GO:0003723 RNA binding
1.35 3.62e-06 GO:0003676 nucleic acid binding
1.22 2.61e-08 GO:0005515 protein binding
1.11 1.24e-06 GO:0005488 binding