Motif ID: POU6F1.p2

Z-value: 1.140


Transcription factors associated with POU6F1.p2:

Gene SymbolEntrez IDGene Name
POU6F1 5463 POU class 6 homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU6F1chr12_-_516114760.371.2e-08Click!


Activity profile for motif POU6F1.p2.

activity profile for motif POU6F1.p2


Sorted Z-values histogram for motif POU6F1.p2

Sorted Z-values for motif POU6F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU6F1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_74422920 26.742 ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr13_-_45010974 25.609 TSC22D1
TSC22 domain family, member 1
chr15_+_74422742 24.837 NM_020851
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr10_+_5005685 24.518 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr13_-_45010994 23.675 TSC22D1
TSC22 domain family, member 1
chr13_-_45010937 23.424 TSC22D1
TSC22 domain family, member 1
chr22_+_22735134 19.958 CYAT1
immunoglobulin lambda light chain-like
chr10_+_5005601 15.902 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr10_+_5005453 15.600 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr22_+_22786283 15.530


chrX_+_135278912 15.232 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr12_-_51611476 13.727 POU6F1
POU class 6 homeobox 1
chr13_-_45011389 13.561 NM_001243797
TSC22D1
TSC22 domain family, member 1
chr12_-_91572328 11.820 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chr9_-_95166827 11.589 NM_014057
NM_033014
OGN

osteoglycin

chr2_+_113816214 10.796 NM_173170
IL36RN
interleukin 36 receptor antagonist
chr13_-_45011059 10.486 NM_006022
TSC22D1
TSC22 domain family, member 1
chr4_+_70861647 10.476 NM_001009181
NM_003154
STATH

statherin

chrX_+_67913479 10.441 NM_001142504
STARD8
StAR-related lipid transfer (START) domain containing 8
chr22_+_39101954 10.186 GTPBP1
GTP binding protein 1
chr3_-_13057130 9.934


chr22_+_22735202 9.852


chr7_-_100026284 9.632 NM_017984
ZCWPW1
zinc finger, CW type with PWWP domain 1
chr1_-_116311161 9.587 CASQ2
calsequestrin 2 (cardiac muscle)
chr7_-_64023444 9.583


chr1_-_116311330 9.541 CASQ2
calsequestrin 2 (cardiac muscle)
chr19_+_39899749 9.507


chrX_+_65382432 9.451 NM_138737
HEPH
hephaestin
chr9_+_34458810 9.147 NM_012144
DNAI1
dynein, axonemal, intermediate chain 1
chr1_-_116311398 8.991 NM_001232
CASQ2
calsequestrin 2 (cardiac muscle)
chr7_+_39017608 8.844 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr22_+_22735207 8.775 IGLJ3
immunoglobulin lambda joining 3
chr10_-_5045967 8.374 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr7_-_27183225 8.057 NM_019102
HOXA5
homeobox A5
chr5_-_137475076 8.048 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr3_-_57678594 7.580 NM_152678
FAM116A
family with sequence similarity 116, member A
chr18_+_47088400 6.725 NM_006033
LIPG
lipase, endothelial
chrX_+_91090459 6.304 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr17_-_2996289 5.966 NM_002548
OR1D2
olfactory receptor, family 1, subfamily D, member 2
chr3_+_46919235 5.846 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr17_-_48945338 5.661 NM_001243877
TOB1
transducer of ERBB2, 1
chr19_-_49658645 5.588 NM_002152
HRC
histidine rich calcium binding protein
chr16_-_31439650 5.523 NM_005205
COX6A2
cytochrome c oxidase subunit VIa polypeptide 2
chr3_-_123339178 5.510 MYLK
myosin light chain kinase
chr1_+_104159953 5.496 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr17_+_17608163 5.482


chr6_+_27925018 5.459 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr6_+_72926144 5.351 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr11_-_83393436 5.317 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr1_-_89664510 5.311 NM_052941
GBP4
guanylate binding protein 4
chr13_-_45048436 5.245 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr16_-_70834884 5.152 VAC14
Vac14 homolog (S. cerevisiae)
chr14_+_39703119 5.123 NM_054024
MIA2
melanoma inhibitory activity 2
chr16_-_70835044 5.057 VAC14
Vac14 homolog (S. cerevisiae)
chr17_-_67240955 5.048 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr4_-_87028805 4.986 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr22_+_40322609 4.939 GRAP2
GRB2-related adaptor protein 2
chr16_-_70835061 4.854 VAC14
Vac14 homolog (S. cerevisiae)
chr11_-_59633942 4.825 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr5_+_125759076 4.818 GRAMD3
GRAM domain containing 3
chr22_-_22863504 4.736 NM_080764
ZNF280B
zinc finger protein 280B
chr1_+_196621007 4.707 NM_000186
NM_001014975
CFH

complement factor H

chr17_-_66951381 4.700 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr19_-_33360641 4.679 NM_001126335
NM_001243036
NM_014270
SLC7A9


solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9


chr2_-_216241321 4.652 FN1
fibronectin 1
chr12_+_21284127 4.638 NM_006446
SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr12_-_16760935 4.533 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr22_+_22758538 4.478


chr6_+_54173202 4.405 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr17_+_41857802 4.363 NM_001136483
C17orf105
chromosome 17 open reading frame 105
chr4_+_175839508 4.303 NM_001130703
NM_001130704
NM_001130705
NM_014269
ADAM29



ADAM metallopeptidase domain 29



chr16_+_2653350 4.286 LOC652276
potassium channel tetramerisation domain containing 5 pseudogene
chr6_+_72926462 4.267 NM_001168410
RIMS1
regulating synaptic membrane exocytosis 1
chr7_+_142829169 4.264 NM_002652
PIP
prolactin-induced protein
chr16_-_32688052 4.207 NM_016212
TP53TG3
TP53 target 3
chr10_+_96443250 4.157 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr6_-_136847078 4.144 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr19_-_21950322 4.095 NM_173531
ZNF100
zinc finger protein 100
chr6_+_144612872 4.069 NM_007124
UTRN
utrophin
chr5_+_125758818 4.067 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr16_+_33261514 4.059 NM_016212
TP53TG3
TP53 target 3
chr19_-_18632857 4.026 ELL
elongation factor RNA polymerase II
chr1_-_104239071 4.015 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr4_+_78432905 3.887 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr2_-_1926501 3.874 MYT1L
myelin transcription factor 1-like
chr16_-_70835067 3.843 VAC14
Vac14 homolog (S. cerevisiae)
chr4_+_71587674 3.785 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr21_+_19289656 3.771 NM_001204175
NM_001204176
NM_001204177
NM_001204178
CHODL



chondrolectin



chr5_+_92918924 3.747 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr9_-_215892 3.730 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr2_-_169887832 3.717 NM_003742
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr4_-_122085475 3.668 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr16_+_33204979 3.631 NM_016212
TP53TG3
TP53 target 3
chr16_+_81272293 3.614 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr1_+_153003677 3.583 NM_003125
SPRR1B
small proline-rich protein 1B
chr8_+_19796581 3.465 NM_000237
LPL
lipoprotein lipase
chr5_-_160279045 3.459 NM_025153
ATP10B
ATPase, class V, type 10B
chr10_+_97889467 3.393 NM_014803
ZNF518A
zinc finger protein 518A
chr12_-_28124915 3.377 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr2_+_233390869 3.352 NM_000751
CHRND
cholinergic receptor, nicotinic, delta
chr2_+_89185055 3.316


chr19_+_24269877 3.307 NM_203282
ZNF254
zinc finger protein 254
chr6_-_49834188 3.296 NM_001131
NM_170609
CRISP1

cysteine-rich secretory protein 1

chr16_-_70835060 3.270 NM_018052
VAC14
Vac14 homolog (S. cerevisiae)
chr19_-_18632886 3.266 NM_006532
ELL
elongation factor RNA polymerase II
chr7_+_100027253 3.260 NM_019606
MEPCE
methylphosphate capping enzyme
chr14_+_70918873 3.241 NM_003813
ADAM21
ADAM metallopeptidase domain 21
chr7_-_27159213 3.240 NM_030661
HOXA3
homeobox A3
chr5_-_75919051 3.168 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr14_-_107013474 3.106 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr18_+_61144143 3.086 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr11_+_71927818 3.080 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr11_+_5009420 3.023 NM_021801
MMP26
matrix metallopeptidase 26
chr9_-_95298251 3.016 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr1_-_104238785 2.972 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr13_-_46679143 2.940 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr3_+_186330859 2.888 AHSG
alpha-2-HS-glycoprotein
chr9_+_19290748 2.865 NM_017925
DENND4C
DENN/MADD domain containing 4C
chr10_+_104503724 2.861 NM_001083913
C10orf26
chromosome 10 open reading frame 26
chr17_-_10421858 2.845 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr17_-_39041436 2.811 NM_019010
KRT20
keratin 20
chr1_+_46379258 2.801 MAST2
microtubule associated serine/threonine kinase 2
chr11_+_74699939 2.752 NM_006656
NEU3
sialidase 3 (membrane sialidase)
chr2_-_89619820 2.688 IGKC
immunoglobulin kappa constant
chr2_+_176969233 2.659


chr22_+_23040394 2.655 IGL@
immunoglobulin lambda locus
chr12_-_7848324 2.637 NM_020634
GDF3
growth differentiation factor 3
chrX_+_65382627 2.636 HEPH
hephaestin
chr4_+_88720701 2.632 NM_004967
IBSP
integrin-binding sialoprotein
chr6_+_100054649 2.626 NM_021620
PRDM13
PR domain containing 13
chr8_+_17396285 2.570 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr6_+_154407641 2.561 NM_001145287
OPRM1
opioid receptor, mu 1
chr12_-_4488707 2.538 NM_020638
FGF23
fibroblast growth factor 23
chr7_-_99766191 2.483 GAL3ST4
galactose-3-O-sulfotransferase 4
chr6_+_30130982 2.467 NM_033229
TRIM15
tripartite motif containing 15
chr1_-_163113938 2.432 RGS5
regulator of G-protein signaling 5
chr1_+_26503973 2.408 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr2_+_210444154 2.396 MAP2
microtubule-associated protein 2
chr1_+_104198140 2.341 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr8_-_67090690 2.334 NM_000756
CRH
corticotropin releasing hormone
chr1_-_193155723 2.332 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr7_-_83278478 2.323 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr1_+_15272414 2.286 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr3_-_18480203 2.281 NM_001131010
SATB1
SATB homeobox 1
chr6_+_134758840 2.270 LOC154092
uncharacterized LOC154092
chr7_-_50628744 2.244 NM_000790
NM_001242886
NM_001242887
NM_001242888
NM_001242889
NM_001242890
DDC





dopa decarboxylase (aromatic L-amino acid decarboxylase)





chr4_+_62362838 2.232 NM_015236
LPHN3
latrophilin 3
chr4_+_41614911 2.229 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chrX_+_41583407 2.219 NM_080817
GPR82
G protein-coupled receptor 82
chr12_+_51985016 2.216 NM_014191
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr5_-_138211054 2.203 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chrX_-_32173585 2.162 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr14_-_101036130 2.135 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr1_+_162332772 2.134 NM_001126060
NOS1AP
nitric oxide synthase 1 (neuronal) adaptor protein
chr17_-_56492938 2.115 RNF43
ring finger protein 43
chr10_-_15902455 2.098 NM_024948
FAM188A
family with sequence similarity 188, member A
chr6_-_49754899 2.096 NM_138733
PGK2
phosphoglycerate kinase 2
chr5_-_147162251 2.015 NM_014790
JAKMIP2
janus kinase and microtubule interacting protein 2
chr22_+_22712091 1.982 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr17_+_20771745 1.956


chr5_+_147443534 1.944 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr1_+_226012974 1.914 NM_000120
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr1_+_13521962 1.908 NM_001100114
PRAMEF21
PRAME family member 21
chr5_+_140220811 1.898 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr7_-_99766238 1.880 NM_024637
GAL3ST4
galactose-3-O-sulfotransferase 4
chr19_-_22379752 1.819 NM_001001411
ZNF676
zinc finger protein 676
chr7_+_48211054 1.817 NM_152701
ABCA13
ATP-binding cassette, sub-family A (ABC1), member 13
chr15_+_52121855 1.795 TMOD3
tropomodulin 3 (ubiquitous)
chr15_+_93443418 1.788 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr19_+_15852200 1.769 NM_013938
OR10H3
olfactory receptor, family 10, subfamily H, member 3
chr1_+_18081807 1.760 NM_030812
ACTL8
actin-like 8
chr3_+_186330711 1.758 AHSG
alpha-2-HS-glycoprotein
chr7_+_138818489 1.758 NM_001144920
NM_001144923
NM_024926
TTC26


tetratricopeptide repeat domain 26


chr1_-_117746457 1.718 NM_001253849
VTCN1
V-set domain containing T cell activation inhibitor 1
chr1_+_104292439 1.710 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr1_-_13673510 1.688 NM_001099854
PRAMEF14
PRAME family member 14
chr14_-_107013122 1.665 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr7_+_93535819 1.660 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr2_-_183387063 1.643 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr7_-_100425035 1.639 NM_004444
EPHB4
EPH receptor B4
chr1_+_160336856 1.635 NM_005598
NHLH1
nescient helix loop helix 1
chr11_+_124824012 1.630 NM_025004
CCDC15
coiled-coil domain containing 15
chr11_-_8190535 1.607 NM_001135109
NM_001206671
NM_001206672
NM_024557
RIC3



resistance to inhibitors of cholinesterase 3 homolog (C. elegans)



chr3_+_142442855 1.597


chr14_-_106926393 1.595 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr13_-_52980628 1.553 NM_018676
NM_199263
THSD1

thrombospondin, type I, domain containing 1

chr13_+_52586516 1.534 NM_001004127
ALG11
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
chr6_-_112575708 1.526 LAMA4
laminin, alpha 4
chr4_+_95376396 1.525 PDLIM5
PDZ and LIM domain 5
chr5_-_134871638 1.495 NM_006161
NEUROG1
neurogenin 1
chr1_+_196743929 1.482 NM_001166624
NM_021023
CFHR3

complement factor H-related 3

chr12_-_11062160 1.467 NM_023920
TAS2R13
taste receptor, type 2, member 13
chr5_-_24645084 1.437 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chrX_-_139866582 1.436 NM_004065
CDR1
cerebellar degeneration-related protein 1, 34kDa
chr11_-_36619776 1.436 NM_000536
NM_001243785
NM_001243786
RAG2


recombination activating gene 2


chr7_+_107110501 1.389 NM_005295
GPR22
G protein-coupled receptor 22
chr1_-_160549226 1.375 CD84
CD84 molecule
chr3_-_150920946 1.364 NM_013308
GPR171
G protein-coupled receptor 171
chr14_-_106691698 1.360


chr4_-_25032306 1.358 NM_018176
LGI2
leucine-rich repeat LGI family, member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.44 1.23e-03 GO:0032501 multicellular organismal process
1.84 2.58e-03 GO:0048513 organ development
29.60 5.16e-03 GO:0030502 negative regulation of bone mineralization
25.90 1.02e-02 GO:0070168 negative regulation of biomineral tissue development
4.27 1.36e-02 GO:0006936 muscle contraction
3.55 2.68e-02 GO:0008202 steroid metabolic process
1.57 2.86e-02 GO:0048731 system development
3.92 3.37e-02 GO:0003012 muscle system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.88 2.85e-05 GO:0005576 extracellular region
1.81 7.72e-05 GO:0044459 plasma membrane part
2.37 5.58e-04 GO:0005615 extracellular space
2.14 8.22e-04 GO:0044421 extracellular region part
2.02 9.85e-04 GO:0005887 integral to plasma membrane
1.98 1.60e-03 GO:0031226 intrinsic to plasma membrane
14.39 3.44e-03 GO:0032982 myosin filament
2.17 4.87e-03 GO:0005626 insoluble fraction
2.17 6.32e-03 GO:0005624 membrane fraction
1.40 1.49e-02 GO:0005886 plasma membrane
1.40 1.65e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
9.07 2.87e-03 GO:0003823 antigen binding
38.85 8.04e-03 GO:0047023 androsterone dehydrogenase activity
38.85 8.04e-03 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
2.97 1.16e-02 GO:0003779 actin binding
10.79 2.33e-02 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
7.23 4.69e-02 GO:0008307 structural constituent of muscle