Motif ID: PRDM1.p3

Z-value: 1.332


Transcription factors associated with PRDM1.p3:

Gene SymbolEntrez IDGene Name
PRDM1 639 PR domain containing 1, with ZNF domain

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PRDM1chr6_+_106534188-0.009.6e-01Click!


Activity profile for motif PRDM1.p3.

activity profile for motif PRDM1.p3


Sorted Z-values histogram for motif PRDM1.p3

Sorted Z-values for motif PRDM1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM1.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_32821924 33.126 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr14_+_24605366 28.001 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr14_+_24605393 25.340 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr16_-_67970734 24.079 NM_002801
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr1_-_111746917 23.945 DENND2D
DENN/MADD domain containing 2D
chr16_-_67970651 19.706 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr11_+_63304272 18.779 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr12_+_25205180 16.582 NM_001204126
NM_001204127
NM_006152
LRMP


lymphoid-restricted membrane protein


chrX_-_118827060 16.235 SEPT6
septin 6
chr6_-_32811773 16.184 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chrX_-_118827322 15.257 NM_015129
NM_145799
NM_145800
NM_145802
SEPT6



septin 6



chr2_-_231084600 14.627 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr1_+_212781969 14.605 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr3_-_49851217 14.138 UBA7
ubiquitin-like modifier activating enzyme 7
chr6_-_33282006 13.843 NM_003190
NM_172208
NM_172209
TAPBP


TAP binding protein (tapasin)


chr5_+_96212167 13.379 ERAP2
endoplasmic reticulum aminopeptidase 2
chr5_-_142815076 13.357 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr3_-_49851356 13.287 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr14_-_69262959 12.836 NM_001244701
ZFP36L1
zinc finger protein 36, C3H type-like 1
chr2_+_231280906 12.365 SP100
SP100 nuclear antigen
chr12_-_57505176 11.970 NM_001178078
NM_001178080
NM_001178081
NM_003153
STAT6



signal transducer and activator of transcription 6, interleukin-4 induced



chr20_+_388941 11.575 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr12_+_25205488 10.961 LRMP
lymphoid-restricted membrane protein
chr6_-_33281847 10.742 TAPBP
TAP binding protein (tapasin)
chr1_+_212782103 10.043 ATF3
activating transcription factor 3
chr17_-_48271365 9.955


chr20_+_388717 9.944 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr22_-_36556781 9.667 NM_145640
APOL3
apolipoprotein L, 3
chr2_-_152146373 8.622 NM_004688
NMI
N-myc (and STAT) interactor
chr6_-_31704272 8.617 CLIC1
chloride intracellular channel 1
chr12_+_6561176 8.536 NM_018009
TAPBPL
TAP binding protein-like
chr2_+_231191877 8.390 NM_138402
SP140L
SP140 nuclear body protein-like
chrX_-_118827155 8.332 SEPT6
septin 6
chr14_+_58711457 8.144 NM_002788
NM_152132
PSMA3

proteasome (prosome, macropain) subunit, alpha type, 3

chr8_+_144640476 8.078 NM_024736
GSDMD
gasdermin D
chr14_+_58711555 7.977 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr14_-_69259654 7.632 ZFP36L1
zinc finger protein 36, C3H type-like 1
chr19_+_49838700 7.409 CD37
CD37 molecule
chr12_-_57505121 6.947 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr13_-_110802708 6.931 COL4A1
collagen, type IV, alpha 1
chr4_-_186578122 6.705 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr6_-_32812189 6.680 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr5_+_139889635 6.583


chr1_-_154580677 6.483 NM_001111
NM_015840
NM_015841
ADAR


adenosine deaminase, RNA-specific


chr17_+_6659155 6.148 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr10_-_44880452 6.120 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr14_-_24615794 5.981 NM_002818
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr13_+_53216564 5.891 HNRNPA1L2
heterogeneous nuclear ribonucleoprotein A1-like 2
chr19_+_49977817 5.783 NM_001204503
FLT3LG
fms-related tyrosine kinase 3 ligand
chr9_-_16727887 5.748 BNC2
basonuclin 2
chr2_+_3627725 5.684 RPS7
ribosomal protein S7
chr1_-_148176392 5.678


chr1_-_144520918 5.624 LOC728855
uncharacterized LOC728855
chr9_+_137533643 5.607 NM_000093
COL5A1
collagen, type V, alpha 1
chr22_+_39473009 5.583 NM_021822
APOBEC3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr13_+_31309690 5.519 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr7_-_86848818 5.513 NM_024315
C7orf23
chromosome 7 open reading frame 23
chr14_+_58711599 5.468 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr8_+_97506020 5.397 SDC2
syndecan 2
chr3_-_101405400 5.388 NM_000986
RPL24
ribosomal protein L24
chr19_+_49838734 5.332 CD37
CD37 molecule
chrX_-_118827116 5.241 SEPT6
septin 6
chr4_-_185395616 5.193 NM_002199
IRF2
interferon regulatory factor 2
chr19_+_49977465 5.011 NM_001204502
NM_001459
FLT3LG

fms-related tyrosine kinase 3 ligand

chr13_+_31309644 4.917 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr4_+_37892698 4.903 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr3_+_8543508 4.815 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr17_+_41158741 4.752 NM_005533
IFI35
interferon-induced protein 35
chr11_+_64008412 4.732 NM_004470
FKBP2
FK506 binding protein 2, 13kDa
chr11_+_65190272 4.726


chr10_+_63808968 4.595 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr6_-_29527701 4.523 NM_006398
UBD
ubiquitin D
chr1_-_154580632 4.405 ADAR
adenosine deaminase, RNA-specific
chr9_+_112542496 4.335 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr18_+_48405426 4.302 NM_001168335
NM_002396
ME2

malic enzyme 2, NAD(+)-dependent, mitochondrial

chr6_+_26440699 4.290 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr6_-_29527477 4.274 UBD
ubiquitin D
chr8_+_97506071 4.211 SDC2
syndecan 2
chr4_-_186577858 3.876 SORBS2
sorbin and SH3 domain containing 2
chr12_-_57504935 3.824 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr2_-_190044330 3.820 NM_000393
COL5A2
collagen, type V, alpha 2
chr17_+_6659356 3.792 XAF1
XIAP associated factor 1
chr11_-_104839263 3.777 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr1_-_144521169 3.770 FAM91A2
family with sequence similarity 91, member A2
chr11_-_58343308 3.766 NM_004811
LPXN
leupaxin
chr8_+_96145942 3.754 NM_024613
PLEKHF2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr18_-_53071225 3.721 NM_001243232
TCF4
transcription factor 4
chr4_+_152020732 3.695 NM_001006
RPS3A
ribosomal protein S3A
chr17_-_80407601 3.693 NM_001193655
C17orf62
chromosome 17 open reading frame 62
chr1_-_147931877 3.637 FLJ39739
uncharacterized FLJ39739
chr22_+_22550112 3.538


chr13_-_41635072 3.530 ELF1
E74-like factor 1 (ets domain transcription factor)
chr12_-_56709831 3.524 NM_001190991
NM_014255
CNPY2

canopy 2 homolog (zebrafish)

chr14_-_69260630 3.522 NM_001244698
NM_004926
ZFP36L1

zinc finger protein 36, C3H type-like 1

chr1_+_162602308 3.515 DDR2
discoidin domain receptor tyrosine kinase 2
chr1_+_19972259 3.447 NM_001204086
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr5_+_49962920 3.412 PARP8
poly (ADP-ribose) polymerase family, member 8
chr2_+_202122753 3.409 NM_001080125
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr14_-_24615772 3.341 PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr11_-_5706186 3.316 NM_033034
NM_033092
NM_033093
TRIM5


tripartite motif containing 5


chr8_+_97657581 3.313 PGCP
plasma glutamate carboxypeptidase
chrX_-_101112548 3.277 NM_032946
NXF5
nuclear RNA export factor 5
chr12_-_56709656 3.237 CNPY2
canopy 2 homolog (zebrafish)
chr8_+_96145968 3.191 PLEKHF2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr3_-_11623829 3.147 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr8_-_79717540 3.120 NM_000880
NM_001199886
NM_001199887
NM_001199888
IL7



interleukin 7



chr1_+_19971865 3.098 NM_001204085
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr4_-_100242487 3.078 NM_000668
ADH1A
ADH1B
alcohol dehydrogenase 1A (class I), alpha polypeptide
alcohol dehydrogenase 1B (class I), beta polypeptide
chr5_-_96143573 3.077 ERAP1
endoplasmic reticulum aminopeptidase 1
chr6_-_31704281 2.992 CLIC1
chloride intracellular channel 1
chr1_+_151372009 2.948 NM_002796
PSMB4
proteasome (prosome, macropain) subunit, beta type, 4
chr4_+_87856152 2.940 NM_001166693
AFF1
AF4/FMR2 family, member 1
chr2_-_231090443 2.938 NM_001185015
SP110
SP110 nuclear body protein
chr3_-_114343052 2.928 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr2_-_191878883 2.927 STAT1
signal transducer and activator of transcription 1, 91kDa
chr5_+_6746100 2.915 NM_001171806
PAPD7
PAP associated domain containing 7
chr11_+_65190267 2.904 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr21_+_43933983 2.895 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr1_-_144520987 2.877 LOC728855
uncharacterized LOC728855
chr8_+_97505876 2.849 NM_002998
SDC2
syndecan 2
chr12_+_70636773 2.803 NM_014515
NM_001199302
CNOT2

CCR4-NOT transcription complex, subunit 2

chr19_+_13105970 2.802 NM_002501
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr3_+_8543539 2.792 LMCD1
LIM and cysteine-rich domains 1
chr12_-_56709777 2.782 CNPY2
canopy 2 homolog (zebrafish)
chr4_+_76649826 2.768 NM_003715
USO1
USO1 vesicle docking protein homolog (yeast)
chr12_-_49319211 2.751 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chr12_-_31479084 2.708 FAM60A
family with sequence similarity 60, member A
chr5_-_96143689 2.693 NM_001040458
NM_016442
ERAP1

endoplasmic reticulum aminopeptidase 1

chr6_-_112575766 2.690 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr4_+_76649739 2.641 USO1
USO1 vesicle docking protein homolog (yeast)
chr16_+_50776012 2.615 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr8_+_134203281 2.520 NM_001204869
NM_001204870
NM_003882
NM_080838
WISP1



WNT1 inducible signaling pathway protein 1



chr6_+_167525294 2.497 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr3_+_51977286 2.443 PARP3
poly (ADP-ribose) polymerase family, member 3
chr15_-_80263460 2.389 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr7_-_42971730 2.347 PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2
chr12_-_9913415 2.345 NM_001781
CD69
CD69 molecule
chr3_+_69915374 2.345 NM_198177
MITF
microphthalmia-associated transcription factor
chr6_-_112575880 2.314 LAMA4
laminin, alpha 4
chr16_+_50775960 2.295 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr22_+_39417117 2.292 NM_152426
APOBEC3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr5_+_96211643 2.236 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr1_+_162602198 2.170 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr7_-_92463211 2.169 NM_001259
CDK6
cyclin-dependent kinase 6
chr1_+_104159953 2.150 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr8_+_97505895 2.105 SDC2
syndecan 2
chr8_+_97657592 2.090 PGCP
plasma glutamate carboxypeptidase
chr12_-_31479120 2.020 NM_001135811
NM_021238
NM_001135812
FAM60A


family with sequence similarity 60, member A


chr10_+_122610853 1.969 WDR11
WD repeat domain 11
chr6_+_25962978 1.956 NM_006355
TRIM38
tripartite motif containing 38
chr7_+_134464161 1.942 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr19_-_11639929 1.898 NM_001142464
NM_001142465
NM_016581
ECSIT


ECSIT homolog (Drosophila)


chr12_-_31479038 1.883 FAM60A
family with sequence similarity 60, member A
chr1_+_2985730 1.875 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr3_+_187871473 1.848 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr14_+_73525232 1.831 RBM25
RNA binding motif protein 25
chr9_-_34710062 1.756 NM_002989
CCL21
chemokine (C-C motif) ligand 21
chr2_+_231090443 1.729 NM_001005176
NM_007237
SP140

SP140 nuclear body protein

chr3_+_107241782 1.714 NM_001142568
NM_020235
BBX

bobby sox homolog (Drosophila)

chr21_-_43346780 1.645 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr1_-_226070032 1.610 TMEM63A
transmembrane protein 63A
chr9_-_123676849 1.572 NM_001190947
TRAF1
TNF receptor-associated factor 1
chr11_-_104905849 1.550 CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr18_+_48405486 1.520 ME2
malic enzyme 2, NAD(+)-dependent, mitochondrial
chr10_+_114135937 1.518 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_-_150738255 1.517 CTSS
cathepsin S
chr16_-_73092533 1.513 NM_001164766
ZFHX3
zinc finger homeobox 3
chr2_-_152146133 1.508 NMI
N-myc (and STAT) interactor
chr9_+_110045551 1.431 RAD23B
RAD23 homolog B (S. cerevisiae)
chr1_-_143744355 1.426 LOC100286793
FLJ39739
uncharacterized LOC100286793
uncharacterized FLJ39739
chr3_-_69129502 1.409 NM_003968
NM_198195
UBA3

ubiquitin-like modifier activating enzyme 3

chr17_+_30677187 1.409 ZNF207
zinc finger protein 207
chr19_+_34710327 1.402 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr9_+_110045516 1.347 NM_002874
RAD23B
RAD23 homolog B (S. cerevisiae)
chr14_+_73525267 1.314 RBM25
RNA binding motif protein 25
chr19_+_20188800 1.286 NM_007138
ZNF90
zinc finger protein 90
chr9_+_123850573 1.284 NM_007018
CNTRL
centriolin
chr20_+_56964162 1.248 NM_001195677
NM_004738
VAPB

VAMP (vesicle-associated membrane protein)-associated protein B and C

chr22_-_31688329 1.241 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr20_+_389346 1.230 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr4_+_76649806 1.228 USO1
USO1 vesicle docking protein homolog (yeast)
chr6_-_24936177 1.226 FAM65B
family with sequence similarity 65, member B
chr22_-_36562224 1.217 NM_145641
NM_145642
APOL3

apolipoprotein L, 3

chr1_-_150780705 1.155 NM_000396
CTSK
cathepsin K
chr20_+_57470200 1.153 GNAS
GNAS complex locus
chr14_+_73525187 1.091 NM_021239
RBM25
RNA binding motif protein 25
chr12_+_102271349 1.081 DRAM1
DNA-damage regulated autophagy modulator 1
chr19_+_39109831 1.050 EIF3K
eukaryotic translation initiation factor 3, subunit K
chr19_-_23578226 1.037 NM_003430
ZNF91
zinc finger protein 91
chr14_-_24701472 1.031 NEDD8
neural precursor cell expressed, developmentally down-regulated 8
chr2_-_127864505 1.008 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chrY_+_7142007 1.003 PRKY
protein kinase, Y-linked, pseudogene
chr2_+_231280870 0.996 NM_001080391
NM_001206701
NM_001206702
NM_001206703
NM_003113
SP100




SP100 nuclear antigen




chr11_-_4414887 0.987 NM_003141
TRIM21
tripartite motif containing 21
chr19_+_39109684 0.969 NM_013234
EIF3K
eukaryotic translation initiation factor 3, subunit K
chr1_-_150738232 0.967 CTSS
cathepsin S
chr10_+_114136014 0.951 ACSL5
acyl-CoA synthetase long-chain family member 5
chr11_+_5646206 0.898 NM_021616
TRIM34
tripartite motif containing 34
chr8_-_42065037 0.869 PLAT
plasminogen activator, tissue
chr22_-_30642683 0.852 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.95 1.39e-05 GO:0002376 immune system process
79.47 3.86e-05 GO:0002483 antigen processing and presentation of endogenous peptide antigen
79.47 3.86e-05 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
15.00 4.25e-05 GO:0006521 regulation of cellular amino acid metabolic process
11.47 6.81e-05 GO:0031575 mitotic cell cycle G1/S transition checkpoint
11.47 6.81e-05 GO:0071779 G1/S transition checkpoint
3.34 9.40e-05 GO:0006508 proteolysis
10.91 1.06e-04 GO:2000045 regulation of G1/S transition of mitotic cell cycle
13.03 1.32e-04 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
13.03 1.32e-04 GO:0072395 signal transduction involved in cell cycle checkpoint
13.03 1.32e-04 GO:0072401 signal transduction involved in DNA integrity checkpoint
13.03 1.32e-04 GO:0072404 signal transduction involved in G1/S transition checkpoint
13.03 1.32e-04 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
13.03 1.32e-04 GO:0072422 signal transduction involved in DNA damage checkpoint
13.03 1.32e-04 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
13.03 1.32e-04 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
12.82 1.50e-04 GO:0060337 type I interferon-mediated signaling pathway
12.82 1.50e-04 GO:0071357 cellular response to type I interferon
10.40 1.60e-04 GO:0030330 DNA damage response, signal transduction by p53 class mediator
12.62 1.70e-04 GO:0034340 response to type I interferon
2.14 1.87e-04 GO:0048522 positive regulation of cellular process
12.42 1.93e-04 GO:0033238 regulation of cellular amine metabolic process
12.42 1.93e-04 GO:0071158 positive regulation of cell cycle arrest
2.22 1.95e-04 GO:0090304 nucleic acid metabolic process
56.77 2.66e-04 GO:0019883 antigen processing and presentation of endogenous antigen
11.87 2.77e-04 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
11.69 3.11e-04 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
11.36 3.91e-04 GO:0051352 negative regulation of ligase activity
11.36 3.91e-04 GO:0051444 negative regulation of ubiquitin-protein ligase activity
1.67 4.30e-04 GO:0043170 macromolecule metabolic process
11.20 4.37e-04 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.01 6.18e-04 GO:0048518 positive regulation of biological process
7.47 7.52e-04 GO:0010565 regulation of cellular ketone metabolic process
10.33 8.21e-04 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
10.19 9.07e-04 GO:0000216 M/G1 transition of mitotic cell cycle
10.19 9.07e-04 GO:0051443 positive regulation of ubiquitin-protein ligase activity
1.98 1.03e-03 GO:0051171 regulation of nitrogen compound metabolic process
8.36 1.04e-03 GO:0042770 signal transduction in response to DNA damage
3.21 1.09e-03 GO:0006955 immune response
9.94 1.10e-03 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
8.28 1.13e-03 GO:0000084 S phase of mitotic cell cycle
2.31 1.21e-03 GO:0016070 RNA metabolic process
8.13 1.32e-03 GO:0051320 S phase
9.70 1.33e-03 GO:0051351 positive regulation of ligase activity
3.71 1.49e-03 GO:0044265 cellular macromolecule catabolic process
2.95 1.56e-03 GO:0051704 multi-organism process
9.14 2.09e-03 GO:0031397 negative regulation of protein ubiquitination
1.44 2.38e-03 GO:0050789 regulation of biological process
4.51 2.39e-03 GO:0051603 proteolysis involved in cellular protein catabolic process
8.84 2.71e-03 GO:0051438 regulation of ubiquitin-protein ligase activity
4.42 2.99e-03 GO:0044257 cellular protein catabolic process
6.41 3.02e-03 GO:0031400 negative regulation of protein modification process
7.22 3.57e-03 GO:0007093 mitotic cell cycle checkpoint
8.46 3.76e-03 GO:0051340 regulation of ligase activity
30.57 5.18e-03 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
1.79 5.55e-03 GO:0060255 regulation of macromolecule metabolic process
4.16 6.05e-03 GO:0044419 interspecies interaction between organisms
4.13 6.47e-03 GO:0030163 protein catabolic process
1.40 7.76e-03 GO:0065007 biological regulation
7.57 8.57e-03 GO:0090068 positive regulation of cell cycle process
6.44 9.05e-03 GO:0000082 G1/S transition of mitotic cell cycle
4.30 9.11e-03 GO:0019941 modification-dependent protein catabolic process
1.63 9.13e-03 GO:0044260 cellular macromolecule metabolic process
7.50 9.19e-03 GO:0000077 DNA damage checkpoint
4.27 9.77e-03 GO:0043632 modification-dependent macromolecule catabolic process
7.36 1.05e-02 GO:0031398 positive regulation of protein ubiquitination
3.20 1.14e-02 GO:0009057 macromolecule catabolic process
1.73 1.22e-02 GO:0080090 regulation of primary metabolic process
1.86 1.32e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.16 1.35e-02 GO:0051726 regulation of cell cycle
5.40 1.37e-02 GO:0019221 cytokine-mediated signaling pathway
7.04 1.47e-02 GO:0031570 DNA integrity checkpoint
49.67 1.54e-02 GO:0016553 base conversion or substitution editing
4.80 1.58e-02 GO:0032269 negative regulation of cellular protein metabolic process
3.00 1.62e-02 GO:0002682 regulation of immune system process
2.56 1.71e-02 GO:0042981 regulation of apoptosis
1.66 1.81e-02 GO:0019222 regulation of metabolic process
1.70 1.84e-02 GO:0031323 regulation of cellular metabolic process
1.42 1.96e-02 GO:0050794 regulation of cellular process
2.54 1.97e-02 GO:0043067 regulation of programmed cell death
1.41 2.03e-02 GO:0008152 metabolic process
5.81 2.06e-02 GO:0010498 proteasomal protein catabolic process
5.81 2.06e-02 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
2.67 2.11e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.46 2.31e-02 GO:0050896 response to stimulus
4.60 2.36e-02 GO:0051248 negative regulation of protein metabolic process
4.22 2.39e-02 GO:0034097 response to cytokine stimulus
2.50 2.54e-02 GO:0010941 regulation of cell death
6.31 3.23e-02 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
4.88 3.32e-02 GO:0071345 cellular response to cytokine stimulus
19.87 3.32e-02 GO:0048002 antigen processing and presentation of peptide antigen
19.87 3.32e-02 GO:0070206 protein trimerization
1.88 3.45e-02 GO:0006950 response to stress
3.77 3.57e-02 GO:0045087 innate immune response
4.05 3.58e-02 GO:0006511 ubiquitin-dependent protein catabolic process
4.32 4.11e-02 GO:0007346 regulation of mitotic cell cycle
2.69 4.39e-02 GO:0006952 defense response
2.69 4.48e-02 GO:0044093 positive regulation of molecular function

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
14.20 1.85e-06 GO:0000502 proteasome complex
29.81 4.76e-06 GO:0005839 proteasome core complex
1.48 5.44e-03 GO:0005634 nucleus
99.34 1.45e-02 GO:0071797 LUBAC complex
66.23 4.33e-02 GO:0005588 collagen type V
66.23 4.33e-02 GO:0008537 proteasome activator complex
66.23 4.33e-02 GO:0030895 apolipoprotein B mRNA editing enzyme complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
28.39 7.66e-06 GO:0004298 threonine-type endopeptidase activity
28.39 7.66e-06 GO:0070003 threonine-type peptidase activity
1.23 7.57e-04 GO:0005488 binding
2.08 8.69e-04 GO:0008270 zinc ion binding
3.42 9.62e-04 GO:0070011 peptidase activity, acting on L-amino acid peptides
3.30 1.57e-03 GO:0008233 peptidase activity
1.39 4.96e-03 GO:0005515 protein binding
1.87 7.86e-03 GO:0046914 transition metal ion binding
3.64 1.08e-02 GO:0004175 endopeptidase activity
12.82 4.23e-02 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines