Motif ID: PRRX1,2.p2

Z-value: 1.461


Transcription factors associated with PRRX1,2.p2:

Gene SymbolEntrez IDGene Name
PRRX1 5396 paired related homeobox 1
PRRX2 51450 paired related homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PRRX1chr1_+_1706333120.221.2e-03Click!
PRRX2chr9_+_132428016-0.072.8e-01Click!


Activity profile for motif PRRX1,2.p2.

activity profile for motif PRRX1,2.p2


Sorted Z-values histogram for motif PRRX1,2.p2

Sorted Z-values for motif PRRX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PRRX1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_94297448 44.215 PEG10
paternally expressed 10
chr5_+_71502700 38.959 MAP1B
microtubule-associated protein 1B
chr1_+_151032683 37.103 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_151032866 36.400 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_151032880 36.304 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr4_-_176733413 26.168 GPM6A
glycoprotein M6A
chr2_-_55199894 26.006


chr1_+_84630575 22.553 NM_001242860
NM_001242861
 PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chrX_-_13835012 21.858 GPM6B
glycoprotein M6B
chr3_+_158787040 21.134 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
 IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr2_-_44586854 20.599 NM_001042385
NM_001042386
 PREPL

prolyl endopeptidase-like

chr4_-_176733901 19.092 GPM6A
glycoprotein M6A
chr3_-_25683825 18.512 TOP2B
topoisomerase (DNA) II beta 180kDa
chr2_-_55237255 18.380 NM_007008
 RTN4
reticulon 4
chrX_+_114827818 17.269 NM_001136025
NM_001172335
 PLS3

plastin 3

chr1_+_84630374 17.049 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr3_+_159557745 16.989 SCHIP1
schwannomin interacting protein 1
chr17_-_1248346 16.812 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr4_+_158141735 16.503 NM_000826
NM_001083619
NM_001083620
 GRIA2


glutamate receptor, ionotropic, AMPA 2


chr12_-_46633551 15.996 SLC38A1
solute carrier family 38, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 52 entries
enrichment   p-value GO term description
4.88 1.55e-02 GO:0007026 negative regulation of microtubule depolymerization
4.60 3.32e-02 GO:0031114 regulation of microtubule depolymerization
3.21 3.56e-02 GO:0030521 androgen receptor signaling pathway
2.73 2.00e-02 GO:0030518 steroid hormone receptor signaling pathway
2.21 6.86e-03 GO:0007156 homophilic cell adhesion
1.74 2.97e-02 GO:0016337 cell-cell adhesion
1.72 3.39e-02 GO:0051325 interphase
1.72 3.77e-02 GO:0051329 interphase of mitotic cell cycle
1.70 4.83e-02 GO:0006511 ubiquitin-dependent protein catabolic process
1.69 4.86e-02 GO:0019941 modification-dependent protein catabolic process
1.66 3.92e-02 GO:0044419 interspecies interaction between organisms
1.58 3.90e-03 GO:0000278 mitotic cell cycle
1.55 2.27e-02 GO:0044265 cellular macromolecule catabolic process
1.54 3.84e-03 GO:0006396 RNA processing
1.47 3.35e-02 GO:0022403 cell cycle phase
1.45 2.25e-06 GO:0007399 nervous system development
1.45 1.28e-02 GO:0022402 cell cycle process
1.45 3.07e-02 GO:2000026 regulation of multicellular organismal development
1.39 1.92e-02 GO:0007049 cell cycle
1.35 7.12e-04 GO:0006996 organelle organization

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
1.57 2.30e-03 GO:0005730 nucleolus
1.43 7.00e-06 GO:0005654 nucleoplasm
1.38 5.17e-07 GO:0031981 nuclear lumen
1.36 2.07e-07 GO:0044428 nuclear part
1.33 6.13e-07 GO:0043233 organelle lumen
1.33 8.74e-07 GO:0070013 intracellular organelle lumen
1.33 5.67e-06 GO:0005829 cytosol
1.32 1.39e-06 GO:0031974 membrane-enclosed lumen
1.28 8.32e-06 GO:0043228 non-membrane-bounded organelle
1.28 8.32e-06 GO:0043232 intracellular non-membrane-bounded organelle
1.22 7.88e-05 GO:0032991 macromolecular complex
1.21 4.16e-09 GO:0044422 organelle part
1.21 2.07e-08 GO:0044446 intracellular organelle part
1.21 2.43e-03 GO:0043234 protein complex
1.20 8.37e-09 GO:0044444 cytoplasmic part
1.19 9.28e-15 GO:0005737 cytoplasm
1.16 6.98e-05 GO:0005634 nucleus
1.14 1.70e-08 GO:0043231 intracellular membrane-bounded organelle
1.14 2.43e-08 GO:0043227 membrane-bounded organelle
1.13 2.79e-10 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
2.21 2.82e-02 GO:0051427 hormone receptor binding
1.53 6.60e-04 GO:0005509 calcium ion binding
1.50 6.32e-06 GO:0005102 receptor binding
1.27 2.52e-24 GO:0005515 protein binding
1.12 7.81e-14 GO:0005488 binding