Motif ID: REST.p3

Z-value: 3.279


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RESTchr4_+_57775064,
chr4_+_57774035		-0.671.2e-29Click!


Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 110 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_44657812 160.702 NM_020708
 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr4_+_158141735 154.459 NM_000826
NM_001083619
NM_001083620
 GRIA2


glutamate receptor, ionotropic, AMPA 2


chr20_+_44657858 151.763 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr20_+_5891973 140.293 NM_001819
 CHGB
chromogranin B (secretogranin 1)
chr12_+_175872 135.359 NM_001170738
 IQSEC3
IQ motif and Sec7 domain 3
chrX_-_47479229 134.497 NM_006950
NM_133499
 SYN1

synapsin I

chr14_+_93389444 127.147 NM_001275
 CHGA
chromogranin A (parathyroid secretory protein 1)
chr3_-_187388105 125.702 NM_001048
 SST
somatostatin
chr1_+_33352071 121.804 NM_002143
 HPCA
hippocalcin
chr14_+_93389491 118.937 CHGA
chromogranin A (parathyroid secretory protein 1)
chr17_+_42385780 110.196 NM_001144825
NM_001144826
NM_006695
 RUNDC3A


RUN domain containing 3A


chr12_+_113229548 105.900 NM_001143854
NM_014954
 RPH3A

rabphilin 3A homolog (mouse)

chr11_-_123524881 100.407 SCN3B
sodium channel, voltage-gated, type III, beta
chr1_-_241520467 96.953 NM_002924
 RGS7
regulator of G-protein signaling 7
chr16_+_24267474 90.552 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr8_-_57358511 88.354 NM_006211
 PENK
proenkephalin
chr17_+_30813928 86.272 NM_003885
 CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chrX_-_49056638 84.939 NM_003179
 SYP
synaptophysin
chr11_-_66115016 83.534 NM_006876
 B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr14_-_51561657 80.899 TRIM9
tripartite motif containing 9

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 41 entries
enrichment   p-value GO term description
46.40 1.63e-02 GO:0051954 positive regulation of amine transport
33.52 2.77e-03 GO:0060078 regulation of postsynaptic membrane potential
21.75 1.64e-02 GO:0051952 regulation of amine transport
20.12 2.24e-02 GO:0051899 membrane depolarization
13.22 1.24e-05 GO:0031644 regulation of neurological system process
12.98 8.90e-05 GO:0051969 regulation of transmission of nerve impulse
11.84 3.19e-02 GO:0007218 neuropeptide signaling pathway
11.43 3.76e-02 GO:0001505 regulation of neurotransmitter levels
11.39 7.09e-03 GO:0003001 generation of a signal involved in cell-cell signaling
11.39 7.09e-03 GO:0023061 signal release
10.82 4.90e-02 GO:0007626 locomotory behavior
10.78 9.71e-03 GO:0050804 regulation of synaptic transmission
9.59 2.97e-11 GO:0007268 synaptic transmission
9.51 1.98e-02 GO:0042391 regulation of membrane potential
8.99 1.97e-11 GO:0019226 transmission of nerve impulse
8.99 1.97e-11 GO:0035637 multicellular organismal signaling
7.69 8.61e-05 GO:0007610 behavior
6.86 1.44e-07 GO:0007186 G-protein coupled receptor protein signaling pathway
6.52 1.46e-03 GO:0044057 regulation of system process
6.50 4.27e-05 GO:0046903 secretion

Gene overrepresentation in compartment category:

Showing 1 to 20 of 36 entries
enrichment   p-value GO term description
100.53 1.73e-02 GO:0032590 dendrite membrane
35.49 9.07e-03 GO:0032589 neuron projection membrane
31.28 2.63e-07 GO:0030672 synaptic vesicle membrane
20.81 5.14e-08 GO:0008021 synaptic vesicle
18.93 1.08e-06 GO:0030665 clathrin coated vesicle membrane
14.90 1.75e-02 GO:0034707 chloride channel complex
14.00 1.18e-05 GO:0030662 coated vesicle membrane
12.50 8.03e-07 GO:0030136 clathrin-coated vesicle
10.22 5.52e-06 GO:0030135 coated vesicle
10.17 1.57e-02 GO:0019717 synaptosome
10.14 4.88e-08 GO:0030659 cytoplasmic vesicle membrane
9.80 7.43e-08 GO:0012506 vesicle membrane
9.78 1.56e-08 GO:0044456 synapse part
9.47 2.35e-04 GO:0043025 neuronal cell body
9.20 2.91e-04 GO:0044297 cell body
8.42 4.74e-07 GO:0044433 cytoplasmic vesicle part
8.30 7.49e-09 GO:0045202 synapse
8.16 1.11e-02 GO:0045211 postsynaptic membrane
7.74 1.04e-03 GO:0034702 ion channel complex
7.50 4.83e-03 GO:0030425 dendrite

Gene overrepresentation in function category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
100.53 1.96e-02 GO:0016933 extracellular-glycine-gated ion channel activity
100.53 1.96e-02 GO:0016934 extracellular-glycine-gated chloride channel activity
80.43 3.26e-02 GO:0022824 transmitter-gated ion channel activity
80.43 3.26e-02 GO:0022835 transmitter-gated channel activity
67.02 4.87e-02 GO:0005237 inhibitory extracellular ligand-gated ion channel activity
46.40 4.39e-03 GO:0016594 glycine binding
38.30 4.26e-04 GO:0005184 neuropeptide hormone activity
21.40 4.66e-04 GO:0005231 excitatory extracellular ligand-gated ion channel activity
16.76 2.00e-04 GO:0005230 extracellular ligand-gated ion channel activity
12.20 1.29e-03 GO:0005179 hormone activity
9.66 4.88e-03 GO:0015276 ligand-gated ion channel activity
9.66 4.88e-03 GO:0022834 ligand-gated channel activity
8.18 4.89e-02 GO:0043176 amine binding
6.69 3.11e-04 GO:0022836 gated channel activity
6.34 4.90e-05 GO:0005216 ion channel activity
6.25 5.79e-05 GO:0022838 substrate-specific channel activity
6.06 8.01e-05 GO:0015267 channel activity
6.04 8.23e-05 GO:0022803 passive transmembrane transporter activity
5.34 4.51e-02 GO:0005261 cation channel activity
4.28 2.29e-04 GO:0015075 ion transmembrane transporter activity