Motif ID: RORA.p2

Z-value: 0.966


Transcription factors associated with RORA.p2:

Gene SymbolEntrez IDGene Name
RORA 6095 RAR-related orphan receptor A

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RORAchr15_-_615214780.432.0e-11Click!


Activity profile for motif RORA.p2.

activity profile for motif RORA.p2


Sorted Z-values histogram for motif RORA.p2

Sorted Z-values for motif RORA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RORA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_49140569 22.558 NM_001352
DBP
D site of albumin promoter (albumin D-box) binding protein
chr10_-_52645384 17.731 A1CF
APOBEC1 complementation factor
chr12_-_42538432 16.620 NM_001099650
NM_173601
GXYLT1

glucoside xylosyltransferase 1

chr11_+_107461955 15.833 ELMOD1
ELMO/CED-12 domain containing 1
chr1_+_104198140 15.076 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr1_-_235812994 14.679 NM_001098722
GNG4
guanine nucleotide binding protein (G protein), gamma 4
chr11_+_13299260 13.936 NM_001030272
NM_001030273
NM_001178
ARNTL


aryl hydrocarbon receptor nuclear translocator-like


chr4_-_186732208 13.464 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr6_-_152623213 13.382 SYNE1
spectrin repeat containing, nuclear envelope 1
chr11_+_13299372 13.059 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr11_+_13299376 12.766 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr11_+_13299349 12.543 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr11_+_107462073 12.252 ELMOD1
ELMO/CED-12 domain containing 1
chr16_-_1832571 12.110 SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chr16_-_1832576 11.735 NM_080861
SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chr5_-_134914968 11.733 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr16_-_1832304 11.592 SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chr19_+_1269244 11.208 NM_001280
CIRBP
cold inducible RNA binding protein
chr11_+_13299391 10.904 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr11_-_120008801 10.799 TRIM29
tripartite motif containing 29
chr8_-_134072404 9.970 NM_006748
SLA
Src-like-adaptor
chr11_+_13299329 9.819 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr6_-_136847743 9.176 NM_001198614
NM_001198618
NM_001198619
MAP7


microtubule-associated protein 7


chr12_-_56211503 8.861 SARNP
SAP domain containing ribonucleoprotein
chr7_+_101928417 7.758 SH2B2
SH2B adaptor protein 2
chr11_-_64527369 7.739 PYGM
phosphorylase, glycogen, muscle
chr1_+_17846818 7.436 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr6_+_43738757 7.251 VEGFA
vascular endothelial growth factor A
chr2_-_16081703 6.812 MYCNOS
MYCN opposite strand/antisense RNA (non-protein coding)
chr7_+_101928390 6.801 NM_020979
SH2B2
SH2B adaptor protein 2
chr2_+_121554866 6.528 NM_005270
GLI2
GLI family zinc finger 2
chr17_-_34308455 6.370 NM_004590
CCL16
chemokine (C-C motif) ligand 16
chr3_+_44596596 6.200 NM_018651
NM_025169
ZNF167

zinc finger protein 167

chr16_-_21831730 6.095 RRN3P1
RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
chr16_+_58534045 5.977 NM_001242833
NM_001242834
NM_001242835
NM_001242836
NDRG4



NDRG family member 4



chr11_-_2160199 5.962 NM_000612
IGF2
insulin-like growth factor 2 (somatomedin A)
chr1_-_203155867 5.921 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chrX_-_71527000 5.884 NM_001144886
CITED1
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
chr1_-_203155910 5.835 NM_001276
CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr11_+_107461807 5.766 NM_001130037
NM_018712
ELMOD1

ELMO/CED-12 domain containing 1

chr1_+_104198301 5.670 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr1_-_104239071 5.651 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr10_-_52645430 5.650 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr2_-_154335181 5.505 NM_019845
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr3_+_1134619 5.201 NM_014461
CNTN6
contactin 6
chr13_-_27334777 5.167 NM_005288
GPR12
G protein-coupled receptor 12
chr11_-_67271839 4.894 PITPNM1
phosphatidylinositol transfer protein, membrane-associated 1
chr4_-_120243257 4.578 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr12_+_93963597 4.571 NM_003877
SOCS2
suppressor of cytokine signaling 2
chr11_-_2159784 4.549 IGF2
insulin-like growth factor 2 (somatomedin A)
chr16_+_27325269 4.539 IL4R
interleukin 4 receptor
chr5_-_154230157 4.467 C5orf4
chromosome 5 open reading frame 4
chr17_-_38859976 4.441 NM_019016
KRT24
keratin 24
chr5_+_66124603 4.284 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr8_-_120651019 4.048 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr10_-_72141347 3.773 NM_207119
LRRC20
leucine rich repeat containing 20
chr19_+_50321503 3.736 NM_030973
MED25
mediator complex subunit 25
chr1_-_85155885 3.731 NM_001166295
NM_001166417
NM_001166293
NM_001166294
NM_014021
SSX2IP




synovial sarcoma, X breakpoint 2 interacting protein




chr2_+_27301434 3.701 NM_007046
EMILIN1
elastin microfibril interfacer 1
chr7_+_120969089 3.595 NM_057168
WNT16
wingless-type MMTV integration site family, member 16
chr22_+_41957011 3.568 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr11_-_6462129 3.458 NM_000613
HPX
hemopexin
chr16_+_1832928 3.343 NM_012225
NUBP2
nucleotide binding protein 2
chr16_+_24266873 3.222 NM_006539
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr13_-_52733995 3.212 NM_001146099
NM_002498
NEK3

NIMA (never in mitosis gene a)-related kinase 3

chr7_+_20655244 3.181 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr6_-_155635562 3.067 TFB1M
transcription factor B1, mitochondrial
chr1_+_20396652 3.030 NM_000929
PLA2G5
phospholipase A2, group V
chr18_+_32073245 2.996 NM_001198945
NM_001392
NM_032975
NM_032979
DTNA



dystrobrevin, alpha



chr16_-_15188089 2.992 NM_018427
RRN3
RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
chr11_-_120008738 2.968 TRIM29
tripartite motif containing 29
chr14_+_92788924 2.867 NM_153648
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr6_+_32121228 2.859 NM_138717
PPT2
palmitoyl-protein thioesterase 2
chr1_-_151798552 2.855 NM_001001523
RORC
RAR-related orphan receptor C
chr4_+_110749149 2.724 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chrX_-_57147850 2.542 NM_001006681
NM_001006682
NM_001006683
SPIN2B


spindlin family, member 2B


chr19_+_58361219 2.524 ZNF587
zinc finger protein 587
chr6_-_34101272 2.504 NM_000841
GRM4
glutamate receptor, metabotropic 4
chr4_+_85504056 2.368 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr3_+_23987514 2.340 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr1_-_202896315 2.216 KLHL12
kelch-like 12 (Drosophila)
chr3_+_48488180 2.212 NM_032166
NM_130384
TREX1
ATRIP

three prime repair exonuclease 1
ATR interacting protein

chr2_+_139259476 2.175


chr19_+_42381189 2.173 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr11_-_72380107 2.170 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr12_+_2921786 2.159 NM_018463
ITFG2
integrin alpha FG-GAP repeat containing 2
chr13_+_109248499 2.148 NM_015011
MYO16
myosin XVI
chr2_+_171034654 2.115 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr11_-_73720281 1.996 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr19_+_8478181 1.991 NM_001005415
NM_001005416
NM_016496
MARCH2


membrane-associated ring finger (C3HC4) 2


chr17_+_26369617 1.924 NM_016231
NLK
nemo-like kinase
chr10_+_51549552 1.921 NM_002443
NM_138634
MSMB

microseminoprotein, beta-

chr17_+_40688264 1.907 NAGLU
N-acetylglucosaminidase, alpha
chr1_-_156786500 1.906 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr17_+_7554711 1.864 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr1_+_67632168 1.857 NM_144701
IL23R
interleukin 23 receptor
chr2_-_228497801 1.828 NM_001162483
NM_020161
C2orf83

chromosome 2 open reading frame 83

chr7_+_129008044 1.816 AHCYL2
adenosylhomocysteinase-like 2
chr6_-_111927082 1.806 TRAF3IP2
TRAF3 interacting protein 2
chr10_-_72362513 1.796 NM_001083116
NM_005041
PRF1

perforin 1 (pore forming protein)

chr10_+_18041217 1.783 NM_001098844
TMEM236
transmembrane protein 236
chr1_+_154966061 1.778 NM_018655
LENEP
lens epithelial protein
chr19_+_16059817 1.757 NM_001004465
OR10H4
olfactory receptor, family 10, subfamily H, member 4
chr7_+_97736118 1.751 NM_014916
LMTK2
lemur tyrosine kinase 2
chr19_+_57791794 1.743 NM_006635
ZNF460
zinc finger protein 460
chr1_-_173176314 1.726 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chrX_-_102774416 1.714 NM_080879
RAB40A
RAB40A, member RAS oncogene family
chr12_-_48119224 1.709 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr17_+_73043319 1.707 KCTD2
potassium channel tetramerisation domain containing 2
chr11_-_2159472 1.674 IGF2
insulin-like growth factor 2 (somatomedin A)
chrX_-_62648209 1.614 LOC92249
uncharacterized LOC92249
chrX_-_32173585 1.607 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr10_-_72362441 1.607 PRF1
perforin 1 (pore forming protein)
chr11_-_102651321 1.606 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr1_-_203155827 1.573 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr18_+_32073343 1.573 DTNA
dystrobrevin, alpha
chr14_-_75389144 1.569 NM_031464
RPS6KL1
ribosomal protein S6 kinase-like 1
chr17_-_2304217 1.555 NM_020310
MNT
MAX binding protein
chr11_-_124806302 1.553 NM_152722
HEPACAM
hepatic and glial cell adhesion molecule
chr4_+_156824846 1.512 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr3_+_151531860 1.475 NM_001086
AADAC
arylacetamide deacetylase (esterase)
chr11_-_129062092 1.474 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr15_+_45422130 1.473 NM_017434
NM_175940
DUOX1

dual oxidase 1

chr13_-_103719195 1.440 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr1_+_111833473 1.439 NM_021797
NM_201653
CHIA

chitinase, acidic

chr11_+_131780537 1.425 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr15_-_77176191 1.415 NM_020843
SCAPER
S-phase cyclin A-associated protein in the ER
chr5_-_137071703 1.400 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr18_-_3874688 1.391 NM_001242762
NM_001242763
DLGAP1

discs, large (Drosophila) homolog-associated protein 1

chr6_-_30181197 1.380 NM_001242783
NM_003449
TRIM26

tripartite motif containing 26

chr16_-_90096308 1.357 NM_001214
C16orf3
chromosome 16 open reading frame 3
chr1_+_157963062 1.334 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr12_+_56623819 1.251 NM_173596
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr1_-_120311466 1.248 NM_001166107
NM_005518
HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr17_+_40688189 1.246 NAGLU
N-acetylglucosaminidase, alpha
chr6_+_43737937 1.244 NM_001025366
NM_001025367
NM_001025368
NM_001025369
NM_001025370
NM_001033756
NM_001171622
NM_001171623
NM_001171624
NM_001171625
NM_001171626
NM_001171627
NM_001171628
NM_001171629
NM_001171630
NM_001204384
NM_001204385
NM_003376
VEGFA

















vascular endothelial growth factor A

















chr11_-_18258383 1.236 NM_006512
SAA4
serum amyloid A4, constitutive
chr6_-_155635611 1.227 NM_016020
TFB1M
transcription factor B1, mitochondrial
chr5_-_54830369 1.200 NM_003711
NM_176895
RNF138P1
PPAP2A

ring finger protein 138 pseudogene 1
phosphatidic acid phosphatase type 2A

chr6_+_42883726 1.179 NM_001243168
NM_001243169
NM_001243170
NM_138296
PTCRA



pre T-cell antigen receptor alpha



chr17_+_71161110 1.135 NM_001050
SSTR2
somatostatin receptor 2
chr11_+_71903172 1.122 NM_016729
FOLR1
folate receptor 1 (adult)
chr6_+_31913708 1.112 NM_001710
CFB
complement factor B
chr9_+_120466453 1.101 NM_138554
TLR4
toll-like receptor 4
chr7_-_126883568 1.094 NM_000845
GRM8
glutamate receptor, metabotropic 8
chr6_-_32634287 1.069 NM_001243961
NM_002123
HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

chrX_-_2882288 1.064 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr14_+_94492747 1.054 OTUB2
OTU domain, ubiquitin aldehyde binding 2
chr14_+_74815194 1.053 VRTN
vertebrae development homolog (pig)
chr12_-_53600999 1.045 NM_000889
ITGB7
integrin, beta 7
chr19_+_40093163 1.024 NM_013268
LGALS13
lectin, galactoside-binding, soluble, 13
chr19_-_10491172 1.001 TYK2
tyrosine kinase 2
chr11_-_119599253 0.968 NM_002855
NM_203285
NM_203286
PVRL1


poliovirus receptor-related 1 (herpesvirus entry mediator C)


chr8_-_82395401 0.963 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr15_+_40509628 0.958 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr13_+_102104941 0.937 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr10_+_102295700 0.923 HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr2_-_191872322 0.909 STAT1
signal transducer and activator of transcription 1, 91kDa
chr17_-_3499124 0.906 NM_080705
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr22_-_33402648 0.863 NM_003490
NM_133633
SYN3

synapsin III

chr10_+_102729249 0.842 SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr6_+_31913920 0.808 CFB
complement factor B
chr6_+_43738177 0.745 VEGFA
vascular endothelial growth factor A
chr15_-_78369825 0.726 NM_015079
NM_144572
TBC1D2B

TBC1 domain family, member 2B

chr3_+_132318980 0.720 NM_178445
CCRL1
chemokine (C-C motif) receptor-like 1
chr11_-_4629371 0.700 NM_018073
TRIM68
tripartite motif containing 68
chr4_+_39408472 0.688 NM_175737
KLB
klotho beta
chr2_-_37193609 0.654 NM_003162
STRN
striatin, calmodulin binding protein
chr17_+_32646058 0.619 NM_005623
CCL8
chemokine (C-C motif) ligand 8
chr6_+_121756744 0.609 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr12_-_10588543 0.605 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3
chr12_-_57351381 0.605 NM_003708
RDH16
retinol dehydrogenase 16 (all-trans)
chr6_-_30128688 0.583 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr6_+_43738394 0.564 VEGFA
vascular endothelial growth factor A
chr2_+_102927961 0.540 NM_016232
IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1
chr6_-_110736748 0.539 NM_003649
NM_004032
DDO

D-aspartate oxidase

chr8_+_28174648 0.511 NM_006228
PNOC
prepronociceptin
chr17_+_26989193 0.506 SUPT6H
suppressor of Ty 6 homolog (S. cerevisiae)
chr3_-_184095927 0.490 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr10_+_101542554 0.487 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chrX_+_12924738 0.452 NM_138636
TLR8
toll-like receptor 8
chrX_+_119495939 0.445 NM_001142447
NM_012069
ATP1B4

ATPase, Na+/K+ transporting, beta 4 polypeptide

chr1_+_46640748 0.439 NM_005727
TSPAN1
tetraspanin 1
chr22_+_21771661 0.433 NM_015094
HIC2
hypermethylated in cancer 2
chr2_+_233243243 0.413 NM_001632
ALPP
alkaline phosphatase, placental
chr12_-_56848398 0.410 NM_012064
MIP
major intrinsic protein of lens fiber
chr15_-_66084438 0.403 DENND4A
DENN/MADD domain containing 4A
chr19_+_55417507 0.374 NM_001145457
NM_001145458
NM_001242356
NM_001242357
NM_004829
NCR1




natural cytotoxicity triggering receptor 1




chr1_-_150602089 0.364 NM_004436
NM_207042
NM_207043
NM_207044
NM_207168
ENSA




endosulfine alpha




chr3_-_17741511 0.321 NM_001134381
TBC1D5
TBC1 domain family, member 5
chr8_+_17396285 0.317 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr11_+_5710816 0.218 NM_001199573
NM_006074
TRIM22

tripartite motif containing 22

chr5_+_64859098 0.207 NM_015342
PPWD1
peptidylprolyl isomerase domain and WD repeat containing 1
chr1_-_19217384 0.189 NM_001161504
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr19_-_51220194 0.176 NM_016148
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr1_+_178310605 0.168 NM_004841
RASAL2
RAS protein activator like 2
chr6_-_35696359 0.156 NM_001145775
FKBP5
FK506 binding protein 5
chrX_-_24690740 0.151 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr7_-_107880492 0.135 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr2_-_216003068 0.133 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.69 2.75e-04 GO:0002376 immune system process
3.12 1.63e-03 GO:0006955 immune response
10.73 1.59e-02 GO:0051591 response to cAMP
1.36 2.39e-02 GO:0065007 biological regulation
1.64 2.92e-02 GO:0023052 signaling
36.19 4.96e-02 GO:0002532 production of molecular mediator involved in inflammatory response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.14 5.17e-05 GO:0044459 plasma membrane part
1.56 9.02e-03 GO:0005886 plasma membrane
1.54 1.40e-02 GO:0071944 cell periphery
2.17 1.77e-02 GO:0005887 integral to plasma membrane
2.13 2.39e-02 GO:0031226 intrinsic to plasma membrane

Nothing significant found in function category.