Motif ID: RREB1.p2

Z-value: 3.267


Transcription factors associated with RREB1.p2:

Gene SymbolEntrez IDGene Name
RREB1 6239 ras responsive element binding protein 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RREB1chr6_+_71088640.686.6e-31Click!


Activity profile for motif RREB1.p2.

activity profile for motif RREB1.p2


Sorted Z-values histogram for motif RREB1.p2

Sorted Z-values for motif RREB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RREB1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_54982271 66.310 NM_006741
 PPP1R1A
protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr1_-_204380903 63.945 NM_032833
 PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr4_-_5890142 60.184 CRMP1
collapsin response mediator protein 1
chr21_+_47649066 52.879 MCM3AP-AS1
MCM3AP antisense RNA 1 (non-protein coding)
chr10_-_135150474 52.339 NM_015722
 CALY
calcyon neuron-specific vesicular protein
chr4_-_5890266 50.813 NM_001313
 CRMP1
collapsin response mediator protein 1
chr7_+_64498643 48.290 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr17_+_42385780 47.972 NM_001144825
NM_001144826
NM_006695
 RUNDC3A


RUN domain containing 3A


chr11_-_125366048 47.721 NM_005103
NM_022549
 FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr19_+_3366589 47.184 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr19_+_35521591 45.128 NM_001037
NM_199037
 SCN1B

sodium channel, voltage-gated, type I, beta

chr20_+_10199455 43.627 NM_003081
NM_130811
 SNAP25

synaptosomal-associated protein, 25kDa

chrX_+_102632108 42.453 NM_014380
 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr6_-_46459010 41.601 NM_001251974
 RCAN2
regulator of calcineurin 2
chr11_-_134281725 41.469 NM_018644
NM_054025
 B3GAT1

beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)

chr10_-_135150368 41.054 CALY
calcyon neuron-specific vesicular protein
chr16_+_28834407 40.199 NM_007245
NM_145714
NM_148414
NM_148415
NM_148416
 ATXN2L




ataxin 2-like




chr15_+_74422920 39.916 ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr6_-_29595746 39.317 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr16_+_28834372 38.371 ATXN2L
ataxin 2-like

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 229 entries
enrichment   p-value GO term description
3.93 3.57e-02 GO:0021879 forebrain neuron differentiation
3.91 5.60e-03 GO:0042551 neuron maturation
3.43 1.00e-02 GO:0071300 cellular response to retinoic acid
3.30 1.98e-02 GO:0071299 cellular response to vitamin A
3.22 3.66e-03 GO:0030516 regulation of axon extension
3.18 3.73e-02 GO:0050771 negative regulation of axonogenesis
3.15 2.11e-02 GO:0048639 positive regulation of developmental growth
2.99 1.34e-06 GO:0007269 neurotransmitter secretion
2.90 1.25e-06 GO:0050770 regulation of axonogenesis
2.78 9.78e-06 GO:0048638 regulation of developmental growth
2.63 9.49e-08 GO:0006836 neurotransmitter transport
2.60 4.76e-06 GO:0001505 regulation of neurotransmitter levels
2.58 2.75e-04 GO:0048469 cell maturation
2.52 4.94e-02 GO:0001764 neuron migration
2.49 2.39e-02 GO:0040014 regulation of multicellular organism growth
2.48 6.63e-06 GO:0021700 developmental maturation
2.39 1.11e-06 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.38 4.15e-02 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
2.37 1.57e-06 GO:0022604 regulation of cell morphogenesis
2.36 3.42e-02 GO:0032526 response to retinoic acid

Gene overrepresentation in compartment category:

Showing 1 to 20 of 35 entries
enrichment   p-value GO term description
3.02 8.46e-04 GO:0005581 collagen
2.62 1.30e-05 GO:0042383 sarcolemma
2.37 7.79e-05 GO:0008076 voltage-gated potassium channel complex
2.37 7.79e-05 GO:0034705 potassium channel complex
2.24 9.53e-07 GO:0034703 cation channel complex
2.14 1.05e-03 GO:0019717 synaptosome
2.03 1.49e-07 GO:0034702 ion channel complex
2.02 3.34e-02 GO:0030665 clathrin coated vesicle membrane
1.97 2.61e-04 GO:0045211 postsynaptic membrane
1.97 5.29e-03 GO:0044420 extracellular matrix part
1.92 5.89e-12 GO:0045202 synapse
1.89 6.00e-08 GO:0044456 synapse part
1.81 4.28e-03 GO:0030136 clathrin-coated vesicle
1.72 4.79e-07 GO:0043005 neuron projection
1.71 1.94e-06 GO:0031012 extracellular matrix
1.68 8.98e-05 GO:0005578 proteinaceous extracellular matrix
1.62 2.71e-08 GO:0030054 cell junction
1.58 2.71e-03 GO:0044433 cytoplasmic vesicle part
1.50 2.77e-02 GO:0005625 soluble fraction
1.49 2.46e-11 GO:0005887 integral to plasma membrane

Gene overrepresentation in function category:

Showing 1 to 20 of 48 entries
enrichment   p-value GO term description
3.30 4.95e-03 GO:0005245 voltage-gated calcium channel activity
3.06 1.68e-02 GO:0017046 peptide hormone binding
2.80 2.54e-04 GO:0003707 steroid hormone receptor activity
2.65 9.99e-04 GO:0004879 ligand-dependent nuclear receptor activity
2.59 2.68e-03 GO:0016247 channel regulator activity
2.30 1.70e-07 GO:0022843 voltage-gated cation channel activity
2.16 1.58e-03 GO:0005249 voltage-gated potassium channel activity
2.14 1.87e-05 GO:0005516 calmodulin binding
2.09 2.81e-04 GO:0005267 potassium channel activity
2.07 1.72e-07 GO:0000975 regulatory region DNA binding
2.07 1.72e-07 GO:0001067 regulatory region nucleic acid binding
2.07 1.72e-07 GO:0044212 transcription regulatory region DNA binding
2.03 1.19e-06 GO:0010843 promoter binding
1.95 5.17e-08 GO:0005261 cation channel activity
1.93 6.52e-05 GO:0005244 voltage-gated ion channel activity
1.93 6.52e-05 GO:0022832 voltage-gated channel activity
1.89 3.04e-19 GO:0043565 sequence-specific DNA binding
1.88 2.55e-02 GO:0015276 ligand-gated ion channel activity
1.88 2.55e-02 GO:0022834 ligand-gated channel activity
1.85 9.62e-03 GO:0003714 transcription corepressor activity