Motif ID: RUNX1..3.p2

Z-value: 2.773


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RUNX3chr1_-_252914740.551.7e-18Click!
RUNX1chr21_-_362609720.465.1e-13Click!
RUNX2chr6_+_453902840.283.3e-05Click!


Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_29641068 78.814 EVI2B
ecotropic viral integration site 2B
chr17_-_29641094 77.284 NM_006495
 EVI2B
ecotropic viral integration site 2B
chr17_-_29641087 72.716 EVI2B
ecotropic viral integration site 2B
chr11_+_1889902 66.081 NM_001013253
 LSP1
lymphocyte-specific protein 1
chr16_+_23847321 56.737 PRKCB
protein kinase C, beta
chr1_-_25291474 56.307 NM_001031680
 RUNX3
runt-related transcription factor 3
chr6_-_32163299 54.095 NM_022107
 GPSM3
G-protein signaling modulator 3
chr1_+_198608136 52.962 NM_002838
NM_080921
NM_080923
 PTPRC


protein tyrosine phosphatase, receptor type, C


chr1_+_198608216 51.668 PTPRC
protein tyrosine phosphatase, receptor type, C
chr16_+_23847271 51.537 NM_002738
NM_212535
 PRKCB

protein kinase C, beta

chr1_+_198608244 49.515 PTPRC
protein tyrosine phosphatase, receptor type, C
chr16_+_30194925 48.242 CORO1A
coronin, actin binding protein, 1A
chrX_-_106960028 48.165 TSC22D3
TSC22 domain family, member 3
chr10_+_70847857 47.688 SRGN
serglycin
chr2_-_158300517 46.936 NM_004288
 CYTIP
cytohesin 1 interacting protein
chr4_-_84035908 46.789 NM_001130715
NM_016619
 PLAC8

placenta-specific 8

chr4_-_84035888 46.567 PLAC8
placenta-specific 8
chr11_-_58345593 44.450 NM_001143995
 LPXN
leupaxin
chr10_+_70847817 42.851 NM_002727
 SRGN
serglycin
chr1_+_209929378 41.935 NM_025228
 TRAF3IP3
TRAF3 interacting protein 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 68 entries
enrichment   p-value GO term description
3.30 1.43e-02 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
3.21 2.14e-02 GO:0002250 adaptive immune response
3.09 4.88e-04 GO:0042110 T cell activation
2.93 1.40e-06 GO:0046649 lymphocyte activation
2.75 9.08e-04 GO:0050900 leukocyte migration
2.55 9.88e-05 GO:0002253 activation of immune response
2.54 2.45e-03 GO:0002757 immune response-activating signal transduction
2.48 1.04e-04 GO:0045321 leukocyte activation
2.48 4.16e-03 GO:0002764 immune response-regulating signaling pathway
2.41 9.77e-17 GO:0006955 immune response
2.39 5.65e-10 GO:0001775 cell activation
2.35 8.70e-05 GO:0050778 positive regulation of immune response
2.34 1.99e-03 GO:0030168 platelet activation
2.25 1.34e-23 GO:0002376 immune system process
2.23 2.20e-03 GO:0001817 regulation of cytokine production
2.22 7.60e-03 GO:0051241 negative regulation of multicellular organismal process
2.12 3.17e-02 GO:0050865 regulation of cell activation
2.10 4.50e-05 GO:0002684 positive regulation of immune system process
2.07 6.56e-05 GO:0050776 regulation of immune response
2.06 2.69e-05 GO:0007596 blood coagulation

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
6.78 3.80e-02 GO:0005833 hemoglobin complex
2.56 3.02e-03 GO:0009897 external side of plasma membrane
1.89 3.42e-13 GO:0005887 integral to plasma membrane
1.87 4.01e-13 GO:0031226 intrinsic to plasma membrane
1.75 1.71e-05 GO:0005615 extracellular space
1.66 2.38e-14 GO:0044459 plasma membrane part
1.50 5.11e-03 GO:0044421 extracellular region part
1.33 8.23e-08 GO:0005886 plasma membrane
1.32 1.57e-07 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
6.43 1.90e-03 GO:0005164 tumor necrosis factor receptor binding
5.77 5.69e-07 GO:0003823 antigen binding
4.81 4.62e-03 GO:0032813 tumor necrosis factor receptor superfamily binding
3.92 9.08e-03 GO:0019825 oxygen binding
3.72 8.19e-03 GO:0042379 chemokine receptor binding
2.64 6.56e-05 GO:0005126 cytokine receptor binding
2.24 8.97e-03 GO:0005125 cytokine activity
1.58 3.11e-02 GO:0043565 sequence-specific DNA binding
1.49 1.25e-02 GO:0005102 receptor binding
1.46 4.75e-02 GO:0001071 nucleic acid binding transcription factor activity
1.46 4.75e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.40 2.21e-04 GO:0004871 signal transducer activity
1.40 2.21e-04 GO:0060089 molecular transducer activity
1.40 2.66e-03 GO:0004872 receptor activity
1.18 2.86e-05 GO:0005515 protein binding
1.08 1.39e-02 GO:0005488 binding