Motif ID: SMAD1..7,9.p2

Z-value: 2.997


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
SMAD1 4086 SMAD family member 1
SMAD2 4087 SMAD family member 2
SMAD3 4088 SMAD family member 3
SMAD4 4089 SMAD family member 4
SMAD5 4090 SMAD family member 5
SMAD6 4091 SMAD family member 6
SMAD7 4092 SMAD family member 7
SMAD9 4093 SMAD family member 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SMAD9chr13_-_374943700.793.0e-47Click!
SMAD6chr15_+_669946690.681.7e-31Click!
SMAD2chr18_-_45457145-0.575.0e-20Click!
SMAD4chr18_+_48556600-0.472.1e-13Click!
SMAD1chr4_+_146403955-0.441.2e-11Click!
SMAD5chr5_+_1354685220.389.2e-09Click!
SMAD7chr18_-_464770800.252.3e-04Click!
SMAD3chr15_+_67430358-0.242.7e-04Click!


Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_139871954 70.687 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr1_+_55464605 67.312 NM_057176
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr9_+_139872014 54.535 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chrX_-_70288155 45.006 NM_013346
SNX12
sorting nexin 12
chrX_-_106960028 41.185 TSC22D3
TSC22 domain family, member 3
chr5_-_58334936 37.968 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr9_+_124086842 36.532 GSN
gelsolin
chr3_-_195306274 35.699 APOD
apolipoprotein D
chr11_-_125366048 34.400 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr20_+_58515408 33.704 NM_001190827
NM_022106
C20orf177

chromosome 20 open reading frame 177

chrX_+_110339374 33.680 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr2_+_17721806 33.146 NM_003385
VSNL1
visinin-like 1
chr20_+_10199455 33.125 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr12_+_53443834 32.590 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr9_-_97402530 32.287 NM_001127628
FBP1
fructose-1,6-bisphosphatase 1
chr16_-_4466595 31.224 CORO7
coronin 7
chr21_+_41239346 29.187 NM_006198
PCP4
Purkinje cell protein 4
chr14_-_93651242 28.790 NM_022151
MOAP1
modulator of apoptosis 1
chr11_-_60719116 28.714 NM_016582
SLC15A3
solute carrier family 15, member 3
chr12_+_112451229 28.675



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 153 entries
enrichment   p-value GO term description
5.36 5.63e-03 GO:0048484 enteric nervous system development
4.46 4.02e-04 GO:0048483 autonomic nervous system development
3.73 3.95e-02 GO:0021545 cranial nerve development
3.39 2.30e-03 GO:0007422 peripheral nervous system development
3.35 4.26e-02 GO:0021675 nerve development
3.06 8.13e-04 GO:0007269 neurotransmitter secretion
2.74 4.81e-04 GO:0001505 regulation of neurotransmitter levels
2.59 1.20e-03 GO:0045761 regulation of adenylate cyclase activity
2.57 6.20e-04 GO:0061138 morphogenesis of a branching epithelium
2.54 2.00e-03 GO:0031279 regulation of cyclase activity
2.53 4.13e-04 GO:0030817 regulation of cAMP biosynthetic process
2.51 5.30e-04 GO:0030814 regulation of cAMP metabolic process
2.50 1.32e-03 GO:0007204 elevation of cytosolic calcium ion concentration
2.49 3.27e-03 GO:0051339 regulation of lyase activity
2.48 3.47e-04 GO:0030802 regulation of cyclic nucleotide biosynthetic process
2.48 3.47e-04 GO:0030808 regulation of nucleotide biosynthetic process
2.44 5.56e-04 GO:0001763 morphogenesis of a branching structure
2.42 7.01e-04 GO:0030799 regulation of cyclic nucleotide metabolic process
2.36 2.70e-03 GO:0051480 cytosolic calcium ion homeostasis
2.36 1.64e-02 GO:0006836 neurotransmitter transport

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
2.01 1.10e-02 GO:0045211 postsynaptic membrane
1.82 1.63e-02 GO:0034702 ion channel complex
1.81 5.92e-04 GO:0044456 synapse part
1.78 1.05e-18 GO:0005887 integral to plasma membrane
1.78 2.83e-05 GO:0045202 synapse
1.76 1.67e-18 GO:0031226 intrinsic to plasma membrane
1.71 5.04e-03 GO:0005578 proteinaceous extracellular matrix
1.70 1.32e-06 GO:0030054 cell junction
1.67 2.55e-03 GO:0031012 extracellular matrix
1.66 1.92e-03 GO:0043005 neuron projection
1.64 5.16e-25 GO:0044459 plasma membrane part
1.63 7.21e-03 GO:0009986 cell surface
1.53 3.09e-05 GO:0005626 insoluble fraction
1.47 3.14e-05 GO:0044421 extracellular region part
1.47 7.50e-04 GO:0005624 membrane fraction
1.47 1.22e-03 GO:0005615 extracellular space
1.43 1.50e-04 GO:0000267 cell fraction
1.39 1.70e-02 GO:0042995 cell projection
1.33 8.46e-15 GO:0005886 plasma membrane
1.33 1.17e-14 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
3.21 1.01e-02 GO:0003823 antigen binding
2.23 1.42e-02 GO:0019955 cytokine binding
2.08 7.24e-03 GO:0005539 glycosaminoglycan binding
2.07 1.80e-02 GO:0004713 protein tyrosine kinase activity
1.97 2.07e-02 GO:0001871 pattern binding
1.97 2.07e-02 GO:0030247 polysaccharide binding
1.76 6.92e-09 GO:0043565 sequence-specific DNA binding
1.74 5.54e-03 GO:0022836 gated channel activity
1.71 4.46e-04 GO:0022803 passive transmembrane transporter activity
1.69 7.81e-04 GO:0015267 channel activity
1.66 2.97e-03 GO:0022838 substrate-specific channel activity
1.65 6.53e-10 GO:0001071 nucleic acid binding transcription factor activity
1.65 6.53e-10 GO:0003700 sequence-specific DNA binding transcription factor activity
1.65 5.72e-03 GO:0005216 ion channel activity
1.56 1.84e-02 GO:0030695 GTPase regulator activity
1.46 2.83e-04 GO:0022857 transmembrane transporter activity
1.45 1.06e-02 GO:0015075 ion transmembrane transporter activity
1.42 1.57e-03 GO:0005102 receptor binding
1.41 8.57e-03 GO:0022891 substrate-specific transmembrane transporter activity
1.39 5.12e-03 GO:0030528 transcription regulator activity