Motif ID: SOX2.p2

Z-value: 1.504


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX2chr3_+_1814300750.307.5e-06Click!


Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_84647342 38.977 NM_001242862
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr20_+_11898536 38.923 NM_014962
 BTBD3
BTB (POZ) domain containing 3
chr4_-_176733413 36.198 GPM6A
glycoprotein M6A
chr3_+_39509069 32.924 NM_182935
 MOBP
myelin-associated oligodendrocyte basic protein
chr2_+_102508333 30.470 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr1_-_32801606 29.340 NM_023009
 MARCKSL1
MARCKS-like 1
chr2_-_2334887 26.738 NM_015025
 MYT1L
myelin transcription factor 1-like
chr7_+_26400503 25.897 NM_001199837
 SNX10
sorting nexin 10
chrX_+_123234462 25.820 STAG2
stromal antigen 2
chr1_-_26233367 23.670 NM_203399
 STMN1
stathmin 1
chr15_+_52311408 23.243 NM_002748
 MAPK6
mitogen-activated protein kinase 6
chr2_+_102508377 23.123 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr12_-_45307710 20.796 NM_001145110
 NELL2
NEL-like 2 (chicken)
chr4_+_166131170 20.462 NM_001161521
NM_001161522
 KLHL2

kelch-like 2, Mayven (Drosophila)

chr15_+_52311438 20.187 MAPK6
mitogen-activated protein kinase 6
chr15_+_52311432 20.038 MAPK6
mitogen-activated protein kinase 6
chr4_+_41258941 19.787 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr7_+_94297448 19.575 PEG10
paternally expressed 10
chr4_-_176733901 19.505 GPM6A
glycoprotein M6A
chr1_+_50571963 19.158 NM_001144775
 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 93 entries
enrichment   p-value GO term description
6.03 2.21e-06 GO:0007416 synapse assembly
6.03 4.28e-02 GO:0007026 negative regulation of microtubule depolymerization
5.53 3.12e-03 GO:0016339 calcium-dependent cell-cell adhesion
4.17 2.47e-04 GO:0050808 synapse organization
3.31 2.17e-07 GO:0007156 homophilic cell adhesion
2.91 3.28e-04 GO:0010975 regulation of neuron projection development
2.85 5.16e-05 GO:0031344 regulation of cell projection organization
2.78 2.37e-03 GO:0010638 positive regulation of organelle organization
2.23 1.53e-02 GO:0044087 regulation of cellular component biogenesis
2.22 3.81e-03 GO:0051129 negative regulation of cellular component organization
2.16 4.77e-04 GO:0016337 cell-cell adhesion
2.16 4.42e-02 GO:0045664 regulation of neuron differentiation
2.08 9.31e-03 GO:0007017 microtubule-based process
2.06 3.54e-03 GO:0051329 interphase of mitotic cell cycle
2.05 1.48e-04 GO:0006397 mRNA processing
2.04 7.82e-05 GO:0007409 axonogenesis
2.04 2.38e-03 GO:0033043 regulation of organelle organization
2.04 4.83e-03 GO:0008380 RNA splicing
2.02 5.20e-05 GO:0048812 neuron projection morphogenesis
2.02 5.92e-03 GO:0051325 interphase

Gene overrepresentation in compartment category:

Showing 1 to 20 of 46 entries
enrichment   p-value GO term description
5.36 2.10e-02 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
3.08 2.51e-09 GO:0030424 axon
2.65 2.14e-02 GO:0016585 chromatin remodeling complex
2.43 2.09e-03 GO:0005912 adherens junction
2.41 8.30e-04 GO:0070161 anchoring junction
2.24 4.50e-08 GO:0043005 neuron projection
2.22 5.18e-03 GO:0005819 spindle
2.15 8.15e-04 GO:0005635 nuclear envelope
2.11 1.31e-06 GO:0045202 synapse
1.99 2.62e-03 GO:0005874 microtubule
1.97 2.76e-03 GO:0044456 synapse part
1.91 7.18e-07 GO:0030054 cell junction
1.80 1.47e-02 GO:0048471 perinuclear region of cytoplasm
1.78 6.06e-04 GO:0030529 ribonucleoprotein complex
1.68 3.89e-03 GO:0005694 chromosome
1.67 1.38e-02 GO:0005730 nucleolus
1.66 4.38e-04 GO:0031967 organelle envelope
1.65 1.15e-03 GO:0015630 microtubule cytoskeleton
1.65 4.18e-02 GO:0044427 chromosomal part
1.63 9.46e-04 GO:0031975 envelope

Gene overrepresentation in function category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
7.23 3.51e-02 GO:0045295 gamma-catenin binding
2.52 2.10e-02 GO:0017124 SH3 domain binding
1.83 5.84e-08 GO:0003723 RNA binding
1.79 2.78e-02 GO:0016887 ATPase activity
1.78 4.24e-04 GO:0008092 cytoskeletal protein binding
1.69 1.22e-04 GO:0019899 enzyme binding
1.62 1.27e-03 GO:0017111 nucleoside-triphosphatase activity
1.57 3.57e-03 GO:0016462 pyrophosphatase activity
1.57 4.23e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.56 5.01e-03 GO:0016817 hydrolase activity, acting on acid anhydrides
1.45 1.38e-07 GO:0000166 nucleotide binding
1.36 5.00e-27 GO:0005515 protein binding
1.16 1.08e-17 GO:0005488 binding