Motif ID: SP1.p2

Z-value: 1.842


Transcription factors associated with SP1.p2:

Gene SymbolEntrez IDGene Name
SP1 6667 Sp1 transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SP1chr12_+_53774422-0.446.7e-12Click!


Activity profile for motif SP1.p2.

activity profile for motif SP1.p2


Sorted Z-values histogram for motif SP1.p2

Sorted Z-values for motif SP1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SP1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_6875686 31.596 PTMS
parathymosin
chr19_-_291335 31.547 NM_003712
NM_177526
 PPAP2C

phosphatidic acid phosphatase type 2C

chr19_+_54694118 27.514 NM_024075
 TSEN34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chr11_+_65686727 27.022 NM_006442
 DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr19_-_291168 25.397 NM_177543
 PPAP2C
phosphatidic acid phosphatase type 2C
chr20_+_43514340 23.060 NM_003404
NM_139323
 YWHAB

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

chr16_+_2564000 22.692 ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr19_+_50180492 22.665 PRMT1
protein arginine methyltransferase 1
chr17_-_80606095 22.268 NM_019613
 WDR45L
WDR45-like
chr10_+_120863558 22.226 FAM45A
family with sequence similarity 45, member A
chr19_+_50180408 21.790 NM_001207042
NM_001536
NM_198318
 PRMT1


protein arginine methyltransferase 1


chr10_+_134351272 21.720 NM_005539
 INPP5A
inositol polyphosphate-5-phosphatase, 40kDa
chr11_+_65686908 20.911 DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr18_+_12947972 20.627 NM_001013437
NM_031216
 SEH1L

SEH1-like (S. cerevisiae)

chr1_-_20812727 20.073 NM_018584
 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr8_+_146277789 19.792 NM_023080
 C8orf33
chromosome 8 open reading frame 33
chrX_-_152989822 19.724 NM_005745
 BCAP31
B-cell receptor-associated protein 31
chr20_+_44034632 19.555 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
 DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr3_-_149688638 19.101 NM_002628
NM_053024
 PFN2

profilin 2

chr16_-_81129882 18.926 NM_004483
 GCSH
glycine cleavage system protein H (aminomethyl carrier)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 324 entries
enrichment   p-value GO term description
2.49 1.75e-04 GO:0033261 regulation of S phase
2.43 1.65e-02 GO:0051017 actin filament bundle assembly
2.42 4.03e-02 GO:0007090 regulation of S phase of mitotic cell cycle
1.99 1.28e-02 GO:0051084 'de novo' posttranslational protein folding
1.89 3.49e-02 GO:0006458 'de novo' protein folding
1.77 5.14e-06 GO:0007265 Ras protein signal transduction
1.77 4.58e-02 GO:0046364 monosaccharide biosynthetic process
1.76 4.67e-03 GO:0032271 regulation of protein polymerization
1.74 4.63e-02 GO:0008064 regulation of actin polymerization or depolymerization
1.73 4.62e-02 GO:0030832 regulation of actin filament length
1.71 4.53e-02 GO:0031346 positive regulation of cell projection organization
1.70 2.55e-03 GO:0008203 cholesterol metabolic process
1.68 4.28e-02 GO:0007015 actin filament organization
1.67 4.10e-04 GO:0043254 regulation of protein complex assembly
1.67 2.33e-02 GO:0019080 viral genome expression
1.67 2.33e-02 GO:0019083 viral transcription
1.66 1.37e-07 GO:0022411 cellular component disassembly
1.66 1.37e-07 GO:0071845 cellular component disassembly at cellular level
1.66 3.95e-03 GO:0016125 sterol metabolic process
1.63 5.72e-03 GO:0032984 macromolecular complex disassembly

Gene overrepresentation in compartment category:

Showing 1 to 20 of 70 entries
enrichment   p-value GO term description
2.09 2.84e-02 GO:0032154 cleavage furrow
1.99 6.52e-03 GO:0022625 cytosolic large ribosomal subunit
1.68 1.10e-03 GO:0042470 melanosome
1.68 1.10e-03 GO:0048770 pigment granule
1.61 7.83e-03 GO:0016585 chromatin remodeling complex
1.59 6.49e-03 GO:0005925 focal adhesion
1.54 1.86e-02 GO:0030055 cell-substrate junction
1.54 2.11e-02 GO:0005924 cell-substrate adherens junction
1.53 6.58e-04 GO:0005912 adherens junction
1.50 8.69e-04 GO:0070161 anchoring junction
1.49 4.92e-03 GO:0045121 membrane raft
1.46 3.58e-02 GO:0043235 receptor complex
1.45 1.84e-02 GO:0044445 cytosolic part
1.43 9.66e-07 GO:0048471 perinuclear region of cytoplasm
1.42 5.92e-05 GO:0015629 actin cytoskeleton
1.41 1.81e-02 GO:0031252 cell leading edge
1.40 2.25e-14 GO:0005624 membrane fraction
1.40 3.44e-02 GO:0005819 spindle
1.39 2.10e-14 GO:0005626 insoluble fraction
1.39 1.05e-04 GO:0005625 soluble fraction

Gene overrepresentation in function category:

Showing 1 to 20 of 35 entries
enrichment   p-value GO term description
1.72 2.43e-03 GO:0031625 ubiquitin protein ligase binding
1.54 1.51e-03 GO:0008022 protein C-terminus binding
1.45 1.24e-03 GO:0003924 GTPase activity
1.45 5.24e-03 GO:0003682 chromatin binding
1.43 1.68e-08 GO:0019904 protein domain specific binding
1.40 1.17e-12 GO:0019899 enzyme binding
1.40 1.45e-04 GO:0003779 actin binding
1.36 1.65e-02 GO:0032403 protein complex binding
1.35 1.34e-06 GO:0008092 cytoskeletal protein binding
1.32 4.09e-03 GO:0000988 protein binding transcription factor activity
1.32 4.09e-03 GO:0000989 transcription factor binding transcription factor activity
1.32 5.47e-03 GO:0003712 transcription cofactor activity
1.31 4.78e-07 GO:0042802 identical protein binding
1.26 1.50e-05 GO:0003723 RNA binding
1.26 1.03e-03 GO:0046983 protein dimerization activity
1.24 1.09e-79 GO:0005515 protein binding
1.22 4.87e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.22 8.99e-03 GO:0017111 nucleoside-triphosphatase activity
1.21 1.07e-12 GO:0000166 nucleotide binding
1.21 8.75e-03 GO:0016462 pyrophosphatase activity