Motif ID: SPI1.p2

Z-value: 3.385


Transcription factors associated with SPI1.p2:

Gene SymbolEntrez IDGene Name
SPI1 6688 spleen focus forming virus (SFFV) proviral integration oncogene spi1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPI1chr11_-_474000960.537.5e-17Click!


Activity profile for motif SPI1.p2.

activity profile for motif SPI1.p2


Sorted Z-values histogram for motif SPI1.p2

Sorted Z-values for motif SPI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_153518265 59.426 NM_002961
NM_019554
 S100A4

S100 calcium binding protein A4

chr1_+_26644458 51.606 CD52
CD52 molecule
chr11_-_46142955 51.341 NM_001101802
NM_016621
 PHF21A

PHD finger protein 21A

chr16_-_88717395 47.078 NM_000101
 CYBA
cytochrome b-245, alpha polypeptide
chr21_-_46340821 44.407 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr22_+_37257004 44.255 NM_000631
NM_013416
 NCF4

neutrophil cytosolic factor 4, 40kDa

chr6_-_31704272 43.958 CLIC1
chloride intracellular channel 1
chr15_+_75074714 42.427 CSK
c-src tyrosine kinase
chrX_+_48542159 40.855 NM_000377
 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr6_-_32160289 40.716 GPSM3
G-protein signaling modulator 3
chr19_+_35645614 40.233 NM_014164
 FXYD5
FXYD domain containing ion transport regulator 5
chr1_-_31230673 39.446 NM_006762
 LAPTM5
lysosomal protein transmembrane 5
chr5_+_118691692 39.015 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chrX_-_47489243 38.903 NM_001145252
 CFP
complement factor properdin
chr19_+_35645640 37.902 NM_144779
NM_001164605
 FXYD5

FXYD domain containing ion transport regulator 5

chr6_-_31704070 37.884 CLIC1
chloride intracellular channel 1
chr10_-_88281486 37.827 WAPAL
wings apart-like homolog (Drosophila)
chrX_-_47489703 36.895 NM_002621
 CFP
complement factor properdin
chr15_+_75074417 35.900 NM_001127190
NM_004383
 CSK

c-src tyrosine kinase

chr19_+_49838700 35.649 CD37
CD37 molecule

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 296 entries
enrichment   p-value GO term description
2.75 3.85e-04 GO:0002274 myeloid leukocyte activation
2.55 2.05e-02 GO:0006283 transcription-coupled nucleotide-excision repair
2.48 9.58e-03 GO:0002263 cell activation involved in immune response
2.48 9.58e-03 GO:0002366 leukocyte activation involved in immune response
2.38 2.97e-03 GO:0006368 transcription elongation from RNA polymerase II promoter
2.30 2.95e-13 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.30 2.95e-13 GO:0000398 nuclear mRNA splicing, via spliceosome
2.30 1.99e-05 GO:0050851 antigen receptor-mediated signaling pathway
2.29 1.95e-13 GO:0000375 RNA splicing, via transesterification reactions
2.25 3.69e-06 GO:0051320 S phase
2.24 5.61e-06 GO:0000084 S phase of mitotic cell cycle
2.23 1.66e-02 GO:0071158 positive regulation of cell cycle arrest
2.22 3.02e-03 GO:0050852 T cell receptor signaling pathway
2.22 2.53e-02 GO:0048524 positive regulation of viral reproduction
2.20 1.55e-04 GO:0030098 lymphocyte differentiation
2.19 2.95e-03 GO:0000216 M/G1 transition of mitotic cell cycle
2.18 1.51e-04 GO:0006414 translational elongation
2.18 1.88e-03 GO:0019080 viral genome expression
2.18 1.88e-03 GO:0019083 viral transcription
2.18 1.03e-02 GO:0042113 B cell activation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 66 entries
enrichment   p-value GO term description
4.75 1.24e-02 GO:0005885 Arp2/3 protein complex
3.43 3.15e-03 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
2.62 3.98e-02 GO:0008305 integrin complex
2.55 6.25e-05 GO:0016605 PML body
2.52 2.90e-02 GO:0042645 mitochondrial nucleoid
2.44 4.79e-02 GO:0009295 nucleoid
2.17 6.55e-04 GO:0071013 catalytic step 2 spliceosome
2.15 4.63e-02 GO:0034708 methyltransferase complex
2.15 4.63e-02 GO:0035097 histone methyltransferase complex
2.09 1.34e-06 GO:0005681 spliceosomal complex
2.06 9.92e-03 GO:0016591 DNA-directed RNA polymerase II, holoenzyme
2.06 9.92e-03 GO:0022626 cytosolic ribosome
2.03 3.35e-02 GO:0034399 nuclear periphery
1.99 4.48e-03 GO:0016585 chromatin remodeling complex
1.98 3.48e-09 GO:0016604 nuclear body
1.98 6.66e-03 GO:0042470 melanosome
1.98 6.66e-03 GO:0048770 pigment granule
1.97 1.60e-02 GO:0000790 nuclear chromatin
1.94 1.92e-03 GO:0030055 cell-substrate junction
1.90 1.30e-03 GO:0016607 nuclear speck

Gene overrepresentation in function category:

Showing 1 to 20 of 49 entries
enrichment   p-value GO term description
4.75 4.73e-03 GO:0019864 IgG binding
2.97 2.05e-05 GO:0003823 antigen binding
2.50 1.45e-02 GO:0003678 DNA helicase activity
2.38 1.05e-02 GO:0003743 translation initiation factor activity
2.34 3.00e-03 GO:0003697 single-stranded DNA binding
2.26 3.03e-03 GO:0008094 DNA-dependent ATPase activity
2.15 4.12e-03 GO:0047485 protein N-terminus binding
2.11 2.47e-03 GO:0008135 translation factor activity, nucleic acid binding
2.11 3.73e-03 GO:0031625 ubiquitin protein ligase binding
2.07 1.35e-06 GO:0003714 transcription corepressor activity
2.06 1.80e-02 GO:0042393 histone binding
1.98 4.72e-02 GO:0003729 mRNA binding
1.78 3.93e-10 GO:0000988 protein binding transcription factor activity
1.78 3.93e-10 GO:0000989 transcription factor binding transcription factor activity
1.78 7.15e-10 GO:0003712 transcription cofactor activity
1.77 3.75e-04 GO:0043566 structure-specific DNA binding
1.77 1.32e-02 GO:0004386 helicase activity
1.75 4.61e-06 GO:0032403 protein complex binding
1.71 1.25e-02 GO:0004721 phosphoprotein phosphatase activity
1.71 2.56e-02 GO:0003735 structural constituent of ribosome