Motif ID: SPIB.p2

Z-value: 2.637


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPIBchr19_+_509221940.186.2e-03Click!


Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_15114495 107.151 NM_001175
 ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chrX_+_48542159 60.204 NM_000377
 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr19_+_49838673 42.039 NM_001040031
NM_001774
 CD37

CD37 molecule

chr19_+_49838700 41.913 CD37
CD37 molecule
chr19_-_41859253 41.857 TGFB1
transforming growth factor, beta 1
chr19_+_49838646 40.151 CD37
CD37 molecule
chr6_+_31553955 37.698 NM_205838
NM_205839
 LST1

leukocyte specific transcript 1

chr6_-_32160289 35.723 GPSM3
G-protein signaling modulator 3
chr3_-_121379757 34.369 NM_005335
 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr16_+_30194925 33.401 CORO1A
coronin, actin binding protein, 1A
chr19_+_49838734 32.469 CD37
CD37 molecule
chr1_-_183560010 32.250 NM_001127651
 NCF2
neutrophil cytosolic factor 2
chr3_-_121379701 31.390 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr11_-_58343308 31.120 NM_004811
 LPXN
leupaxin
chr1_-_183559669 29.665 NM_000433
NM_001190789
NM_001190794
 NCF2


neutrophil cytosolic factor 2


chr19_-_41859519 29.264 TGFB1
transforming growth factor, beta 1
chr2_-_175499275 28.722 NM_003387
 WIPF1
WAS/WASL interacting protein family, member 1
chr5_+_169064274 28.235 DOCK2
dedicator of cytokinesis 2
chr12_+_54891539 28.069 NCKAP1L
NCK-associated protein 1-like
chr19_-_41859332 27.978 TGFB1
transforming growth factor, beta 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 266 entries
enrichment   p-value GO term description
4.47 8.80e-03 GO:0042274 ribosomal small subunit biogenesis
4.22 6.39e-09 GO:0006413 translational initiation
3.91 4.42e-17 GO:0019080 viral genome expression
3.91 4.42e-17 GO:0019083 viral transcription
3.78 1.03e-18 GO:0006414 translational elongation
3.78 3.92e-16 GO:0006415 translational termination
3.49 1.92e-14 GO:0043241 protein complex disassembly
3.49 1.92e-14 GO:0043624 cellular protein complex disassembly
3.46 1.95e-08 GO:0031294 lymphocyte costimulation
3.46 1.95e-08 GO:0031295 T cell costimulation
3.40 2.19e-15 GO:0032984 macromolecular complex disassembly
3.40 2.19e-15 GO:0034623 cellular macromolecular complex disassembly
3.35 1.47e-12 GO:0050851 antigen receptor-mediated signaling pathway
3.30 7.12e-18 GO:0019058 viral infectious cycle
3.21 2.06e-08 GO:0050852 T cell receptor signaling pathway
3.15 1.78e-11 GO:0002429 immune response-activating cell surface receptor signaling pathway
3.10 3.16e-06 GO:0002756 MyD88-independent toll-like receptor signaling pathway
3.09 6.42e-03 GO:0045582 positive regulation of T cell differentiation
3.05 6.89e-04 GO:0051403 stress-activated MAPK cascade
3.04 1.03e-16 GO:0022415 viral reproductive process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 67 entries
enrichment   p-value GO term description
5.57 4.59e-02 GO:0005885 Arp2/3 protein complex
5.05 3.13e-02 GO:0016281 eukaryotic translation initiation factor 4F complex
5.00 7.67e-04 GO:0005852 eukaryotic translation initiation factor 3 complex
4.33 7.37e-04 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
4.33 4.92e-02 GO:0042101 T cell receptor complex
3.96 4.76e-04 GO:0005689 U12-type spliceosomal complex
3.86 6.17e-07 GO:0022625 cytosolic large ribosomal subunit
3.60 1.21e-12 GO:0022626 cytosolic ribosome
3.44 2.32e-04 GO:0022627 cytosolic small ribosomal subunit
2.88 4.19e-05 GO:0015934 large ribosomal subunit
2.83 1.40e-02 GO:0005747 mitochondrial respiratory chain complex I
2.83 1.40e-02 GO:0030964 NADH dehydrogenase complex
2.83 1.40e-02 GO:0045271 respiratory chain complex I
2.80 2.15e-06 GO:0071013 catalytic step 2 spliceosome
2.77 1.82e-04 GO:0005746 mitochondrial respiratory chain
2.72 9.56e-11 GO:0005681 spliceosomal complex
2.68 1.94e-14 GO:0005840 ribosome
2.66 2.95e-04 GO:0070469 respiratory chain
2.65 8.55e-09 GO:0044455 mitochondrial membrane part
2.57 9.65e-03 GO:0015935 small ribosomal subunit

Gene overrepresentation in function category:

Showing 1 to 20 of 38 entries
enrichment   p-value GO term description
6.50 1.31e-02 GO:0001085 RNA polymerase II transcription factor binding
5.69 1.40e-02 GO:0019864 IgG binding
4.06 2.39e-02 GO:0019865 immunoglobulin binding
3.66 8.06e-08 GO:0003743 translation initiation factor activity
3.41 5.28e-05 GO:0003823 antigen binding
3.33 1.83e-04 GO:0004715 non-membrane spanning protein tyrosine kinase activity
2.97 9.52e-08 GO:0008135 translation factor activity, nucleic acid binding
2.87 6.32e-14 GO:0003735 structural constituent of ribosome
2.81 4.76e-02 GO:0003954 NADH dehydrogenase activity
2.81 4.76e-02 GO:0008137 NADH dehydrogenase (ubiquinone) activity
2.81 4.76e-02 GO:0050136 NADH dehydrogenase (quinone) activity
2.72 2.77e-02 GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
2.36 5.13e-03 GO:0003729 mRNA binding
2.25 1.55e-02 GO:0016651 oxidoreductase activity, acting on NADH or NADPH
2.22 2.76e-02 GO:0031625 ubiquitin protein ligase binding
2.17 2.43e-02 GO:0035257 nuclear hormone receptor binding
2.10 1.92e-02 GO:0051427 hormone receptor binding
2.05 2.62e-28 GO:0003723 RNA binding
2.01 3.08e-02 GO:0017124 SH3 domain binding
1.80 9.77e-07 GO:0000988 protein binding transcription factor activity