Motif ID: SREBF1,2.p2

Z-value: 1.318


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
SREBF1 6720 sterol regulatory element binding transcription factor 1
SREBF2 6721 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SREBF1chr17_-_17726855-0.082.3e-01Click!
SREBF2chr22_+_422291070.036.1e-01Click!


Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_113951537 58.019 LAMP1
lysosomal-associated membrane protein 1
chr13_+_113951589 55.313 LAMP1
lysosomal-associated membrane protein 1
chr13_+_113951461 52.717 NM_005561
 LAMP1
lysosomal-associated membrane protein 1
chr19_+_40854529 35.401 PLD3
phospholipase D family, member 3
chr19_+_40854331 34.774 NM_001031696
NM_012268
 PLD3

phospholipase D family, member 3

chr17_+_78075299 28.528 NM_000152
NM_001079803
NM_001079804
 GAA


glucosidase, alpha; acid


chr17_+_78075390 27.735 GAA
glucosidase, alpha; acid
chr20_+_44520021 27.387 CTSA
cathepsin A
chr8_-_54755836 25.560 NM_015941
NM_213619
 ATP6V1H

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

chr8_-_54755821 25.532 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr20_+_44519965 24.564 CTSA
cathepsin A
chr8_-_54755546 23.497 NM_213620
 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr19_-_48018163 23.428 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr15_-_72668301 23.213 NM_000520
 HEXA
hexosaminidase A (alpha polypeptide)
chr1_+_44440595 22.851 NM_001039457
NM_004047
 ATP6V0B

ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b

chr16_-_67514989 22.478 NM_004691
 ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr1_+_44440623 22.396 ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr20_+_44519590 22.109 NM_000308
NM_001127695
NM_001167594
 CTSA


cathepsin A


chr11_-_6640644 22.066 TPP1
tripeptidyl peptidase I
chr1_+_44440642 21.583 ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 49 entries
enrichment   p-value GO term description
9.04 2.08e-08 GO:0015682 ferric iron transport
9.04 2.08e-08 GO:0033572 transferrin transport
7.84 4.85e-06 GO:0015988 energy coupled proton transport, against electrochemical gradient
7.84 4.85e-06 GO:0015991 ATP hydrolysis coupled proton transport
6.70 2.10e-03 GO:0007040 lysosome organization
5.27 4.39e-04 GO:0007033 vacuole organization
5.12 3.52e-05 GO:0006818 hydrogen transport
5.08 1.08e-04 GO:0006826 iron ion transport
4.99 1.41e-04 GO:0015992 proton transport
4.79 4.35e-05 GO:0055072 iron ion homeostasis
4.73 1.31e-04 GO:0006879 cellular iron ion homeostasis
3.90 2.30e-02 GO:0002756 MyD88-independent toll-like receptor signaling pathway
3.76 2.85e-04 GO:0000041 transition metal ion transport
3.45 1.12e-04 GO:0008286 insulin receptor signaling pathway
2.98 4.76e-04 GO:0032869 cellular response to insulin stimulus
2.66 1.49e-03 GO:0048011 nerve growth factor receptor signaling pathway
2.56 4.97e-03 GO:0071375 cellular response to peptide hormone stimulus
2.51 4.73e-02 GO:0034220 ion transmembrane transport
2.47 1.42e-04 GO:0071495 cellular response to endogenous stimulus
2.44 1.90e-02 GO:0032868 response to insulin stimulus

Gene overrepresentation in compartment category:

Showing 1 to 20 of 40 entries
enrichment   p-value GO term description
15.07 1.11e-03 GO:0033179 proton-transporting V-type ATPase, V0 domain
10.85 2.49e-08 GO:0033176 proton-transporting V-type ATPase complex
10.05 2.03e-02 GO:0033180 proton-transporting V-type ATPase, V1 domain
9.04 3.88e-02 GO:0016471 vacuolar proton-transporting V-type ATPase complex
7.03 1.10e-02 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain
5.47 1.26e-04 GO:0016469 proton-transporting two-sector ATPase complex
4.73 6.16e-14 GO:0005774 vacuolar membrane
4.52 3.33e-13 GO:0044437 vacuolar part
4.28 3.48e-08 GO:0005765 lysosomal membrane
4.02 1.17e-02 GO:0005798 Golgi-associated vesicle
3.93 5.53e-20 GO:0005773 vacuole
3.86 1.22e-04 GO:0042470 melanosome
3.86 1.22e-04 GO:0048770 pigment granule
3.71 8.05e-06 GO:0005770 late endosome
3.60 1.78e-13 GO:0000323 lytic vacuole
3.60 1.78e-13 GO:0005764 lysosome
3.04 4.08e-04 GO:0005769 early endosome
2.69 1.56e-10 GO:0005768 endosome
2.58 1.06e-02 GO:0030136 clathrin-coated vesicle
2.56 1.17e-04 GO:0010008 endosome membrane

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
9.04 7.87e-05 GO:0046961 proton-transporting ATPase activity, rotational mechanism
6.03 1.52e-03 GO:0019829 cation-transporting ATPase activity
3.67 1.12e-02 GO:0042625 ATPase activity, coupled to transmembrane movement of ions
3.17 1.17e-02 GO:0015078 hydrogen ion transmembrane transporter activity
1.91 8.62e-03 GO:0030695 GTPase regulator activity
1.86 1.70e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.30 2.02e-11 GO:0005515 protein binding
1.10 1.21e-03 GO:0005488 binding