Motif ID: SRF.p3

Z-value: 2.730


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SRFchr6_+_431391900.171.2e-02Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_35169876 210.156 NM_006097
NM_181526
MYL9

myosin, light chain 9, regulatory

chr20_+_35169897 178.254 MYL9
myosin, light chain 9, regulatory
chr2_+_74120132 132.470 ACTG2
actin, gamma 2, smooth muscle, enteric
chr2_+_74120092 129.384 NM_001199893
NM_001615
ACTG2

actin, gamma 2, smooth muscle, enteric

chr11_+_117070039 111.337 NM_001001522
NM_003186
TAGLN

transgelin

chr5_+_137801178 110.076 NM_001964
EGR1
early growth response 1
chr5_+_137801166 103.253 EGR1
early growth response 1
chr10_-_90712510 82.201 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr3_-_123339423 62.395 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr3_-_123339178 60.160 MYLK
myosin light chain kinase
chr19_-_45826131 56.558 CKM
creatine kinase, muscle
chr1_-_229569839 50.036 NM_001100
ACTA1
actin, alpha 1, skeletal muscle
chr19_-_45826232 48.687 NM_001824
CKM
creatine kinase, muscle
chr15_-_35087748 36.898 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr19_-_36247917 36.320 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr10_-_29923900 34.555 NM_021738
SVIL
supervillin
chr22_+_31480981 34.248 NM_001207018
SMTN
smoothelin
chr7_-_107643330 30.485 NM_002291
LAMB1
laminin, beta 1
chr4_-_88450601 28.613 NM_001128310
NM_004684
SPARCL1

SPARC-like 1 (hevin)

chr6_+_151561094 27.144 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr10_+_75757847 27.010 NM_003373
NM_014000
VCL

vinculin

chr2_-_106015423 26.379 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr12_-_50616425 26.301 NM_001113547
LIMA1
LIM domain and actin binding 1
chr7_-_94285426 25.779 SGCE
sarcoglycan, epsilon
chr7_-_94285477 25.611 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr16_-_11375094 25.509 NM_002761
PRM1
protamine 1
chr7_-_94285372 25.021 SGCE
sarcoglycan, epsilon
chr15_+_96869156 24.509 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr3_-_99594915 24.148 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr14_-_53417808 23.817 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr20_+_4702499 23.343 NM_012409
PRND
prion protein 2 (dublet)
chr12_+_52445185 21.946 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr7_+_143078399 21.380 ZYX
zyxin
chr7_+_143078358 20.940 NM_001010972
NM_003461
ZYX

zyxin

chrX_-_153602928 20.924 FLNA
filamin A, alpha
chr11_+_75273245 20.692 SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr1_+_223889253 19.868 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr7_+_134464161 19.700 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr1_-_16344438 19.644 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr3_-_46904879 19.370 NM_000258
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr17_+_42634598 19.317 NM_001466
FZD2
frizzled family receptor 2
chr6_+_151561508 19.058 AKAP12
A kinase (PRKA) anchor protein 12
chr1_+_11994710 18.619 NM_000302
PLOD1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr1_-_20306093 18.429 NM_001161729
PLA2G2A
phospholipase A2, group IIA (platelets, synovial fluid)
chr7_+_143078444 18.293 ZYX
zyxin
chr16_+_56966025 17.853 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr1_-_89530890 17.845 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible
chr7_+_143078395 17.548 ZYX
zyxin
chr3_+_187930720 17.491 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr7_+_143078447 17.349 ZYX
zyxin
chr15_+_96873845 16.908 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr7_+_143078457 16.000 ZYX
zyxin
chr19_+_45971249 15.778 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chrX_-_153602998 15.505 NM_001110556
NM_001456
FLNA

filamin A, alpha

chr7_-_27183225 15.179 NM_019102
HOXA5
homeobox A5
chr11_-_65667860 14.133 NM_005438
FOSL1
FOS-like antigen 1
chr17_+_41003184 13.961 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr4_+_24797084 13.909 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr15_+_74218962 13.875 LOXL1
lysyl oxidase-like 1
chr4_-_88450243 13.520 SPARCL1
SPARC-like 1 (hevin)
chr3_+_187871473 13.321 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr11_-_65667858 13.222 FOSL1
FOS-like antigen 1
chr14_+_75745480 12.732 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr12_-_91505541 12.705 NM_002345
LUM
lumican
chr10_-_16859389 12.414 RSU1
Ras suppressor protein 1
chr2_-_128432642 12.320 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr11_-_65667809 12.055 FOSL1
FOS-like antigen 1
chr19_+_16178170 11.960 NM_001145160
TPM4
tropomyosin 4
chr9_+_116356199 11.874 NM_144489
RGS3
regulator of G-protein signaling 3
chr12_-_11508509 11.705 NM_005039
NM_199353
NM_199354
PRB1


proline-rich protein BstNI subfamily 1


chr15_-_65360297 11.658 NM_016563
RASL12
RAS-like, family 12
chr2_+_26915390 11.606 NM_002246
KCNK3
potassium channel, subfamily K, member 3
chr17_-_79479780 11.370 ACTG1
actin, gamma 1
chr16_+_31483066 10.437 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr12_-_11548485 9.681 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr7_+_143078608 9.654 ZYX
zyxin
chr17_-_79479831 9.582 NM_001199954
NM_001614
ACTG1

actin, gamma 1

chr18_-_3219846 9.246 MYOM1
myomesin 1, 185kDa
chr19_+_2476122 9.166 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr1_-_154164551 9.092 NM_152263
TPM3
tropomyosin 3
chrX_-_11284094 8.804 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chrX_-_153599719 8.721 FLNA
filamin A, alpha
chr10_+_112257624 8.641 NM_004419
DUSP5
dual specificity phosphatase 5
chr4_-_10118460 8.605 WDR1
WD repeat domain 1
chr4_-_10118444 8.374 WDR1
WD repeat domain 1
chr11_+_66314373 8.158 NM_001104
ACTN3
actinin, alpha 3
chr17_-_46671043 8.049 NM_002147
HOXB5
homeobox B5
chr2_+_139259476 8.037


chr1_+_11994778 8.015 PLOD1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr12_-_11463353 7.885 NM_002723
PRB4
proline-rich protein BstNI subfamily 4
chr2_-_151344145 7.869 NM_005168
RND3
Rho family GTPase 3
chr7_+_93551015 7.470 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr8_-_48650683 7.135 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr1_-_208084432 6.937 NM_001025109
NM_001773
CD34

CD34 molecule

chr5_-_33891967 6.810 NM_030955
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr6_+_43139190 6.808 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr10_-_45474210 6.781 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr21_-_28217272 6.758 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr12_-_9268522 6.662 NM_000014
A2M
alpha-2-macroglobulin
chr9_-_79520878 6.610 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr14_-_106111114 6.587 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr4_-_10118500 6.450 NM_005112
NM_017491
WDR1

WD repeat domain 1

chr12_+_75874512 6.414 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr9_+_116356407 6.335 RGS3
regulator of G-protein signaling 3
chr9_+_97521930 6.265 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr17_-_46671322 6.231 HOXB5
homeobox B5
chrX_+_35816458 5.983 NM_001099921
MAGEB16
melanoma antigen family B, 16
chr19_+_16187306 5.958 TPM4
tropomyosin 4
chr5_-_33892292 5.901 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr19_+_1026627 5.862 CNN2
calponin 2
chr10_+_88428167 5.820 NM_001171610
LDB3
LIM domain binding 3
chr10_-_64576074 5.746 EGR2
early growth response 2
chr12_+_26348488 5.595 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr2_-_242254984 5.579 HDLBP
high density lipoprotein binding protein
chr18_-_3219986 5.378 NM_003803
NM_019856
MYOM1

myomesin 1, 185kDa

chr7_+_115863004 5.361 NM_152829
TES
testis derived transcript (3 LIM domains)
chr8_+_86351055 5.123 NM_005181
CA3
carbonic anhydrase III, muscle specific
chr7_-_44180911 4.923 NM_021223
MYL7
myosin, light chain 7, regulatory
chr6_+_43139201 4.853 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr3_-_9834357 4.779 NM_006354
NM_133480
TADA3

transcriptional adaptor 3

chr17_-_39684585 4.658 NM_002276
KRT19
keratin 19
chr14_-_106209380 4.407 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106092256 4.320 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr10_+_88428263 4.264 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr1_+_244816434 4.260 PPPDE1
PPPDE peptidase domain containing 1
chr1_-_242162364 4.241 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr22_-_36784055 4.214 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr17_+_80193649 4.160 NM_001206952
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr19_+_57901188 4.141 NM_001172773
NM_152909
ZNF548

zinc finger protein 548

chr5_+_140749830 4.116 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr15_-_45406345 4.100 NM_014080
DUOX2
dual oxidase 2
chr1_-_168106535 3.937 GPR161
G protein-coupled receptor 161
chr17_+_32612686 3.731 NM_002986
CCL11
chemokine (C-C motif) ligand 11
chr10_+_123922940 3.690 TACC2
transforming, acidic coiled-coil containing protein 2
chr19_+_16187047 3.392 NM_003290
TPM4
tropomyosin 4
chr19_+_1026608 3.296 CNN2
calponin 2
chr5_-_39425297 3.247 NM_001244871
NM_001343
DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

chrX_-_10851808 3.244 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr15_-_45406322 3.243 DUOX2
dual oxidase 2
chrX_-_32430370 3.197 NM_004011
NM_004012
DMD

dystrophin

chr1_+_19970674 3.164 NM_005380
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr14_-_23877480 3.116 NM_002471
MYH6
myosin, heavy chain 6, cardiac muscle, alpha
chr7_-_5569200 3.097 ACTB
actin, beta
chr7_-_80548666 3.053 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr1_-_11907741 2.975 NM_006172
NPPA
natriuretic peptide A
chr6_-_29527701 2.929 NM_006398
UBD
ubiquitin D
chr1_-_35324645 2.916 NM_001164824
C1orf212
chromosome 1 open reading frame 212
chr1_-_168106810 2.855 GPR161
G protein-coupled receptor 161
chr17_-_73505914 2.841 NM_001142643
CASKIN2
CASK interacting protein 2
chr4_+_87968191 2.830 AFF1
AF4/FMR2 family, member 1
chr11_-_19223516 2.827 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chrX_+_99839789 2.761 NM_022144
TNMD
tenomodulin
chr7_-_80548322 2.724 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr1_-_89591685 2.696 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr19_+_45417576 2.665 APOC1
apolipoprotein C-I
chr10_+_31610063 2.653 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr17_-_1389013 2.597 NM_001080950
MYO1C
myosin IC
chr6_+_144612872 2.557 NM_007124
UTRN
utrophin
chr1_-_168106727 2.545 GPR161
G protein-coupled receptor 161
chr1_-_150552077 2.485 MCL1
myeloid cell leukemia sequence 1 (BCL2-related)
chr20_-_62258330 2.451 NM_012384
GMEB2
glucocorticoid modulatory element binding protein 2
chr10_-_16859336 2.354 RSU1
Ras suppressor protein 1
chr19_+_1026271 2.338 NM_004368
NM_201277
CNN2

calponin 2

chr6_-_73935174 2.281 NM_001126063
KHDC1L
KH homology domain containing 1-like
chr2_-_161056762 2.249 ITGB6
integrin, beta 6
chr6_-_29527477 2.223 UBD
ubiquitin D
chr18_+_3247527 2.198 NM_006471
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr1_-_150552005 2.161 MCL1
myeloid cell leukemia sequence 1 (BCL2-related)
chr11_-_30605748 2.112 MPPED2
metallophosphoesterase domain containing 2
chr5_-_169816637 2.006 NM_004137
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr10_-_16859408 1.987 NM_012425
NM_152724
RSU1

Ras suppressor protein 1

chr12_+_50497790 1.931 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr6_+_25754926 1.847 NM_005495
SLC17A4
solute carrier family 17 (sodium phosphate), member 4
chr1_+_43148048 1.815 NM_004559
YBX1
Y box binding protein 1
chr18_-_44550533 1.803 NM_001242907
NM_145653
LOC100506888
TCEB3C
transcription elongation factor B polypeptide 3C-like
transcription elongation factor B polypeptide 3C (elongin A3)
chr1_-_31845818 1.787 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr4_-_185747051 1.772 ACSL1
acyl-CoA synthetase long-chain family member 1
chr7_-_559479 1.754 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr2_-_161056573 1.724 NM_000888
ITGB6
integrin, beta 6
chr11_-_75921785 1.713 WNT11
wingless-type MMTV integration site family, member 11
chr14_-_21944826 1.663 NM_001163380
RAB2B
RAB2B, member RAS oncogene family
chr11_+_58390145 1.640 NM_000614
CNTF
ciliary neurotrophic factor
chr19_-_46283763 1.637 NM_001081563
DMPK
dystrophia myotonica-protein kinase
chr3_+_25470067 1.636 RARB
retinoic acid receptor, beta
chr10_+_88516340 1.583 NM_004329
BMPR1A
bone morphogenetic protein receptor, type IA
chr17_-_66287256 1.560 NM_001174166
NM_004694
SLC16A6

solute carrier family 16, member 6 (monocarboxylic acid transporter 7)

chr8_-_62602285 1.461 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr20_-_62680880 1.430 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chrX_-_45060081 1.387 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr1_+_167691156 1.384 NM_001146191
NM_003953
NM_024569
MPZL1


myelin protein zero-like 1


chr18_-_47806361 1.359 NM_001204151
MBD1
methyl-CpG binding domain protein 1
chr1_+_153388999 1.342 NM_176823
S100A7A
S100 calcium binding protein A7A
chr1_+_43996478 1.338 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr10_+_6186758 1.314 NM_001145443
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr10_+_106034886 1.290 NM_001191014
NM_001191015
GSTO2

glutathione S-transferase omega 2

chr15_-_59665053 1.190 MYO1E
myosin IE
chr15_-_59665069 1.149 NM_004998
MYO1E
myosin IE
chr7_+_12726413 1.143 NM_001037164
NM_212460
ARL4A

ADP-ribosylation factor-like 4A

chr19_+_45417920 1.142 NM_001645
APOC1
apolipoprotein C-I
chr21_+_35190586 1.128 ITSN1
intersectin 1 (SH3 domain protein)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
13.36 4.84e-19 GO:0006936 muscle contraction
12.28 4.58e-18 GO:0003012 muscle system process
22.29 1.06e-12 GO:0030048 actin filament-based movement
6.92 3.21e-10 GO:0030029 actin filament-based process
24.14 5.00e-10 GO:0030049 muscle filament sliding
24.14 5.00e-10 GO:0033275 actin-myosin filament sliding
23.51 6.96e-10 GO:0070252 actin-mediated cell contraction
6.90 1.15e-09 GO:0061061 muscle structure development
7.95 1.35e-08 GO:0007517 muscle organ development
1.77 4.01e-08 GO:0032501 multicellular organismal process
2.24 3.90e-06 GO:0042221 response to chemical stimulus
2.47 4.67e-06 GO:0003008 system process
1.84 1.20e-05 GO:0032502 developmental process
2.31 2.74e-05 GO:0048513 organ development
1.92 3.30e-05 GO:0048856 anatomical structure development
1.87 3.72e-05 GO:0007275 multicellular organismal development
1.53 1.61e-04 GO:0050896 response to stimulus
8.55 2.67e-04 GO:0003007 heart morphogenesis
14.96 3.59e-04 GO:0048644 muscle organ morphogenesis
6.93 5.78e-04 GO:0060537 muscle tissue development
18.05 7.82e-04 GO:0031032 actomyosin structure organization
13.22 8.69e-04 GO:0003206 cardiac chamber morphogenesis
4.88 1.22e-03 GO:0030036 actin cytoskeleton organization
2.43 1.40e-03 GO:0010033 response to organic substance
1.85 1.43e-03 GO:0048731 system development
11.84 1.89e-03 GO:0003205 cardiac chamber development
6.89 2.02e-03 GO:0014706 striated muscle tissue development
15.23 2.27e-03 GO:0060415 muscle tissue morphogenesis
2.72 3.72e-03 GO:0009888 tissue development
4.39 4.23e-03 GO:0010035 response to inorganic substance
19.34 4.72e-03 GO:0030239 myofibril assembly
7.10 5.13e-03 GO:0032970 regulation of actin filament-based process
3.40 6.92e-03 GO:0072358 cardiovascular system development
3.40 6.92e-03 GO:0072359 circulatory system development
12.18 8.87e-03 GO:0003231 cardiac ventricle development
4.09 9.51e-03 GO:0048729 tissue morphogenesis
27.07 1.03e-02 GO:0043534 blood vessel endothelial cell migration
4.02 1.16e-02 GO:0034097 response to cytokine stimulus
1.22 1.50e-02 GO:0009987 cellular process
1.35 1.95e-02 GO:0065007 biological regulation
8.36 2.02e-02 GO:0006937 regulation of muscle contraction
4.37 2.17e-02 GO:0007507 heart development
2.80 2.19e-02 GO:0010628 positive regulation of gene expression
5.76 2.81e-02 GO:0034329 cell junction assembly
3.94 2.95e-02 GO:0040012 regulation of locomotion
1.60 3.38e-02 GO:0023052 signaling
2.18 3.53e-02 GO:0051239 regulation of multicellular organismal process
13.10 3.56e-02 GO:0055008 cardiac muscle tissue morphogenesis
2.62 3.98e-02 GO:0007155 cell adhesion
2.62 3.98e-02 GO:0022610 biological adhesion
12.69 4.18e-02 GO:0003208 cardiac ventricle morphogenesis
7.48 4.18e-02 GO:0007015 actin filament organization
7.48 4.18e-02 GO:0090257 regulation of muscle system process
2.07 4.22e-02 GO:0009653 anatomical structure morphogenesis
19.11 4.72e-02 GO:0043462 regulation of ATPase activity
4.03 4.84e-02 GO:0030334 regulation of cell migration
7.29 4.95e-02 GO:0051146 striated muscle cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
8.80 2.47e-18 GO:0015629 actin cytoskeleton
14.53 2.10e-17 GO:0043292 contractile fiber
15.09 6.36e-17 GO:0044449 contractile fiber part
14.70 1.13e-16 GO:0030016 myofibril
14.09 5.76e-13 GO:0030017 sarcomere
24.61 7.83e-10 GO:0042641 actomyosin
26.10 5.17e-09 GO:0001725 stress fiber
24.36 1.05e-08 GO:0032432 actin filament bundle
2.71 2.11e-08 GO:0005856 cytoskeleton
10.67 4.23e-08 GO:0005925 focal adhesion
13.96 5.35e-08 GO:0016459 myosin complex
10.15 7.92e-08 GO:0005924 cell-substrate adherens junction
9.78 1.28e-07 GO:0030055 cell-substrate junction
7.63 7.56e-07 GO:0005912 adherens junction
6.89 2.83e-06 GO:0070161 anchoring junction
27.07 8.85e-06 GO:0005859 muscle myosin complex
24.36 1.81e-05 GO:0016460 myosin II complex
31.23 5.32e-05 GO:0031672 A band
11.84 3.10e-04 GO:0031674 I band
2.53 3.10e-04 GO:0044430 cytoskeletal part
1.96 4.62e-04 GO:0044459 plasma membrane part
4.61 9.08e-04 GO:0016323 basolateral plasma membrane
27.07 1.69e-03 GO:0043034 costamere
24.99 2.42e-03 GO:0005865 striated muscle thin filament
2.87 4.14e-03 GO:0030054 cell junction
1.73 4.66e-03 GO:0043228 non-membrane-bounded organelle
1.73 4.66e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.88 4.76e-03 GO:0005576 extracellular region
11.94 9.31e-03 GO:0005884 actin filament
18.05 9.88e-03 GO:0032982 myosin filament
10.69 1.61e-02 GO:0030018 Z disc
1.48 3.69e-02 GO:0005886 plasma membrane
6.77 4.28e-02 GO:0042383 sarcolemma

Gene overrepresentation in function category:

enrichment   p-value GO term description
22.66 2.16e-11 GO:0008307 structural constituent of muscle
5.69 1.13e-08 GO:0003779 actin binding
4.10 2.45e-07 GO:0008092 cytoskeletal protein binding
3.15 1.56e-04 GO:0046983 protein dimerization activity
25.38 2.32e-04 GO:0000146 microfilament motor activity
1.41 2.91e-04 GO:0005515 protein binding
3.11 5.95e-04 GO:0005198 structural molecule activity
1.21 1.75e-03 GO:0005488 binding
16.24 2.57e-03 GO:0017022 myosin binding
3.31 3.85e-03 GO:0042803 protein homodimerization activity
2.59 2.26e-02 GO:0005509 calcium ion binding
2.19 4.45e-02 GO:0001071 nucleic acid binding transcription factor activity
2.19 4.45e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
2.40 4.46e-02 GO:0042802 identical protein binding