Motif ID: SRF.p3

Z-value: 2.730


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SRFchr6_+_431391900.171.2e-02Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_35169876 210.156 NM_006097
NM_181526
 MYL9

myosin, light chain 9, regulatory

chr20_+_35169897 178.254 MYL9
myosin, light chain 9, regulatory
chr2_+_74120132 132.470 ACTG2
actin, gamma 2, smooth muscle, enteric
chr2_+_74120092 129.384 NM_001199893
NM_001615
 ACTG2

actin, gamma 2, smooth muscle, enteric

chr11_+_117070039 111.337 NM_001001522
NM_003186
 TAGLN

transgelin

chr5_+_137801178 110.076 NM_001964
 EGR1
early growth response 1
chr5_+_137801166 103.253 EGR1
early growth response 1
chr10_-_90712510 82.201 NM_001613
 ACTA2
actin, alpha 2, smooth muscle, aorta
chr3_-_123339423 62.395 NM_053031
NM_053032
 MYLK

myosin light chain kinase

chr3_-_123339178 60.160 MYLK
myosin light chain kinase
chr19_-_45826131 56.558 CKM
creatine kinase, muscle
chr1_-_229569839 50.036 NM_001100
 ACTA1
actin, alpha 1, skeletal muscle
chr19_-_45826232 48.687 NM_001824
 CKM
creatine kinase, muscle
chr15_-_35087748 36.898 NM_005159
 ACTC1
actin, alpha, cardiac muscle 1
chr19_-_36247917 36.320 NM_144617
 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr10_-_29923900 34.555 NM_021738
 SVIL
supervillin
chr22_+_31480981 34.248 NM_001207018
 SMTN
smoothelin
chr7_-_107643330 30.485 NM_002291
 LAMB1
laminin, beta 1
chr4_-_88450601 28.613 NM_001128310
NM_004684
 SPARCL1

SPARC-like 1 (hevin)

chr6_+_151561094 27.144 NM_005100
 AKAP12
A kinase (PRKA) anchor protein 12

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 57 entries
enrichment   p-value GO term description
27.07 1.03e-02 GO:0043534 blood vessel endothelial cell migration
24.14 5.00e-10 GO:0030049 muscle filament sliding
24.14 5.00e-10 GO:0033275 actin-myosin filament sliding
23.51 6.96e-10 GO:0070252 actin-mediated cell contraction
22.29 1.06e-12 GO:0030048 actin filament-based movement
19.34 4.72e-03 GO:0030239 myofibril assembly
19.11 4.72e-02 GO:0043462 regulation of ATPase activity
18.05 7.82e-04 GO:0031032 actomyosin structure organization
15.23 2.27e-03 GO:0060415 muscle tissue morphogenesis
14.96 3.59e-04 GO:0048644 muscle organ morphogenesis
13.36 4.84e-19 GO:0006936 muscle contraction
13.22 8.69e-04 GO:0003206 cardiac chamber morphogenesis
13.10 3.56e-02 GO:0055008 cardiac muscle tissue morphogenesis
12.69 4.18e-02 GO:0003208 cardiac ventricle morphogenesis
12.28 4.58e-18 GO:0003012 muscle system process
12.18 8.87e-03 GO:0003231 cardiac ventricle development
11.84 1.89e-03 GO:0003205 cardiac chamber development
8.55 2.67e-04 GO:0003007 heart morphogenesis
8.36 2.02e-02 GO:0006937 regulation of muscle contraction
7.95 1.35e-08 GO:0007517 muscle organ development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
31.23 5.32e-05 GO:0031672 A band
27.07 8.85e-06 GO:0005859 muscle myosin complex
27.07 1.69e-03 GO:0043034 costamere
26.10 5.17e-09 GO:0001725 stress fiber
24.99 2.42e-03 GO:0005865 striated muscle thin filament
24.61 7.83e-10 GO:0042641 actomyosin
24.36 1.05e-08 GO:0032432 actin filament bundle
24.36 1.81e-05 GO:0016460 myosin II complex
18.05 9.88e-03 GO:0032982 myosin filament
15.09 6.36e-17 GO:0044449 contractile fiber part
14.70 1.13e-16 GO:0030016 myofibril
14.53 2.10e-17 GO:0043292 contractile fiber
14.09 5.76e-13 GO:0030017 sarcomere
13.96 5.35e-08 GO:0016459 myosin complex
11.94 9.31e-03 GO:0005884 actin filament
11.84 3.10e-04 GO:0031674 I band
10.69 1.61e-02 GO:0030018 Z disc
10.67 4.23e-08 GO:0005925 focal adhesion
10.15 7.92e-08 GO:0005924 cell-substrate adherens junction
9.78 1.28e-07 GO:0030055 cell-substrate junction

Gene overrepresentation in function category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
25.38 2.32e-04 GO:0000146 microfilament motor activity
22.66 2.16e-11 GO:0008307 structural constituent of muscle
16.24 2.57e-03 GO:0017022 myosin binding
5.69 1.13e-08 GO:0003779 actin binding
4.10 2.45e-07 GO:0008092 cytoskeletal protein binding
3.31 3.85e-03 GO:0042803 protein homodimerization activity
3.15 1.56e-04 GO:0046983 protein dimerization activity
3.11 5.95e-04 GO:0005198 structural molecule activity
2.59 2.26e-02 GO:0005509 calcium ion binding
2.40 4.46e-02 GO:0042802 identical protein binding
2.19 4.45e-02 GO:0001071 nucleic acid binding transcription factor activity
2.19 4.45e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.41 2.91e-04 GO:0005515 protein binding
1.21 1.75e-03 GO:0005488 binding