Motif ID: SRY.p2

Z-value: 1.324


Transcription factors associated with SRY.p2:

Gene SymbolEntrez IDGene Name
SRY 6736 sex determining region Y

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SRYchrY_-_26554780.351.5e-07Click!


Activity profile for motif SRY.p2.

activity profile for motif SRY.p2


Sorted Z-values histogram for motif SRY.p2

Sorted Z-values for motif SRY.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SRY.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_195310985 52.095 NM_001647
APOD
apolipoprotein D
chr3_+_39509069 50.245 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr3_-_195310770 48.548 APOD
apolipoprotein D
chrX_-_13835213 36.508 GPM6B
glycoprotein M6B
chr8_+_80523048 35.553 NM_001199214
NM_007029
STMN2

stathmin-like 2

chr5_+_36606456 35.393 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr4_-_176733413 32.955 GPM6A
glycoprotein M6A
chr5_+_36606667 32.321 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_+_71502700 32.266 MAP1B
microtubule-associated protein 1B
chr8_-_110655418 28.880 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr5_+_140739589 27.131 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr18_+_29171729 25.198 NM_000371
TTR
transthyretin
chrX_-_13835187 24.909 GPM6B
glycoprotein M6B
chr12_-_16758312 23.807 NM_001243611
LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_-_88450243 23.514 SPARCL1
SPARC-like 1 (hevin)
chr4_-_88450601 22.946 NM_001128310
NM_004684
SPARCL1

SPARC-like 1 (hevin)

chr5_+_173472737 22.702 HMP19
HMP19 protein
chr11_+_112831968 22.654 NM_000615
NM_001076682
NM_001242607
NM_001242608
NM_181351
NCAM1




neural cell adhesion molecule 1




chr5_+_173472692 22.099 NM_015980
HMP19
HMP19 protein
chr12_-_45307710 21.945 NM_001145110
NELL2
NEL-like 2 (chicken)
chrX_-_13835012 21.345 GPM6B
glycoprotein M6B
chr12_+_79439432 20.807 NM_001135806
SYT1
synaptotagmin I
chr2_+_149633173 20.196


chr5_-_146435589 19.984 NM_181674
NM_181676
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr19_+_30863318 19.936 NM_014717
ZNF536
zinc finger protein 536
chrX_-_13835313 19.575 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr16_+_24266873 19.184 NM_006539
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr5_+_140247767 19.049 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr12_-_91573264 18.848 NM_133503
DCN
decorin
chrX_+_103031797 18.073 PLP1
proteolipid protein 1
chr11_-_72380107 17.743 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr16_+_58534045 17.666 NM_001242833
NM_001242834
NM_001242835
NM_001242836
NDRG4



NDRG family member 4



chr12_-_9268440 17.437 A2M
alpha-2-macroglobulin
chr14_-_60097223 17.241 RTN1
reticulon 1
chr1_-_57045129 17.167 PPAP2B
phosphatidic acid phosphatase type 2B
chr11_+_73359734 17.043 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr2_-_2334887 16.859 NM_015025
MYT1L
myelin transcription factor 1-like
chr12_-_9268522 16.748 NM_000014
A2M
alpha-2-macroglobulin
chr8_+_85095501 16.446 NM_173848
RALYL
RALY RNA binding protein-like
chr2_-_174767282 16.360


chr14_-_60097314 16.274 RTN1
reticulon 1
chr21_+_41239346 16.248 NM_006198
PCP4
Purkinje cell protein 4
chr12_-_9268513 16.236 A2M
alpha-2-macroglobulin
chr1_+_151032683 16.026 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_155853546 15.915 SYT11
synaptotagmin XI
chr18_-_52988916 15.738 NM_001243234
NM_001243235
TCF4

transcription factor 4

chr1_+_151032866 15.714 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_160085519 15.583 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chrX_+_103031753 15.126 NM_000533
NM_199478
PLP1

proteolipid protein 1

chr12_-_16757944 15.101 LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_+_151032880 14.747 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr6_-_52710892 14.327 NM_153699
GSTA5
glutathione S-transferase alpha 5
chr1_-_57044980 14.194 PPAP2B
phosphatidic acid phosphatase type 2B
chr13_-_45048436 13.991 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr1_-_156217717 13.906 NM_198406
NM_024897
PAQR6

progestin and adipoQ receptor family member VI

chr7_+_149570004 13.899 NM_001100592
NM_145230
ATP6V0E2

ATPase, H+ transporting V0 subunit e2

chr1_-_57045235 13.587 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_182357871 12.846 GLUL
glutamate-ammonia ligase
chr22_-_19512859 12.844 NM_001130861
NM_003277
CLDN5

claudin 5

chr1_-_182357757 12.632 GLUL
glutamate-ammonia ligase
chrX_+_103031433 12.630 NM_001128834
PLP1
proteolipid protein 1
chr14_+_92788924 12.601 NM_153648
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr3_+_115342302 12.452 GAP43
growth associated protein 43
chr2_-_224467095 12.438 SCG2
secretogranin II
chrX_-_13956644 12.287 NM_001001994
GPM6B
glycoprotein M6B
chr1_+_50571963 12.218 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr15_+_80696569 12.152 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr12_-_9268475 12.060 A2M
alpha-2-macroglobulin
chr11_+_71791376 12.005 NM_001145307
NM_001145308
NM_001205138
NM_145309
LRTOMT



leucine rich transmembrane and 0-methyltransferase domain containing



chr1_+_204913353 11.995 NM_001160331
NFASC
neurofascin
chr19_-_37019169 11.984 NM_001012756
NM_001166036
NM_001166037
NM_001166038
ZNF260



zinc finger protein 260



chr8_-_27115935 11.945 STMN4
stathmin-like 4
chr8_+_80523351 11.937 STMN2
stathmin-like 2
chrX_-_100914816 11.909 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr18_-_21852189 11.690 NM_018030
OSBPL1A
oxysterol binding protein-like 1A
chr5_+_140771482 11.672 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr3_+_115342150 11.670 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr14_-_21493122 11.660 NM_201538
NM_201539
NM_201540
NM_201541
NDRG2



NDRG family member 2



chr3_+_133464883 11.657 NM_001063
TF
transferrin
chr2_-_86564632 11.623 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr15_+_43885251 11.384 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr8_+_80523339 11.377 STMN2
stathmin-like 2
chr3_-_114343052 11.284 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr16_-_21314371 11.282 NM_001014444
NM_001888
CRYM

crystallin, mu

chr15_+_66874506 11.247


chr11_+_113931228 11.207 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr11_-_35440514 11.174 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr12_-_16760935 11.172 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr1_+_84609941 11.111 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr4_+_88896838 11.089 SPP1
secreted phosphoprotein 1
chr1_-_163113938 10.858 RGS5
regulator of G-protein signaling 5
chrX_+_91090459 10.770 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr12_-_11548485 10.765 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr8_-_18666295 10.677 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr8_+_80523304 10.639 STMN2
stathmin-like 2
chr8_+_105352050 10.611 NM_030788
TM7SF4
transmembrane 7 superfamily member 4
chr12_-_16759430 10.563 LMO3
LIM domain only 3 (rhombotin-like 2)
chr2_-_224467049 10.544 SCG2
secretogranin II
chr8_+_80523376 10.486 STMN2
stathmin-like 2
chr10_+_111967302 10.454 NM_130439
MXI1
MAX interactor 1
chr2_-_175869910 10.382 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr11_+_57365026 10.235 NM_000062
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr12_-_45270071 10.158 NELL2
NEL-like 2 (chicken)
chr4_-_176734181 10.099 NM_201591
GPM6A
glycoprotein M6A
chr8_+_22210311 10.092 PIWIL2
piwi-like 2 (Drosophila)
chr11_+_112832089 10.082 NCAM1
neural cell adhesion molecule 1
chr12_-_16758839 10.038 NM_001243612
LMO3
LIM domain only 3 (rhombotin-like 2)
chr16_+_15528324 10.003 NM_033201
C16orf45
chromosome 16 open reading frame 45
chr12_-_21487831 10.001 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr4_-_90759446 9.991 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr10_-_62332666 9.940 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr2_-_175712276 9.891 NM_001206602
CHN1
chimerin (chimaerin) 1
chr1_-_57045214 9.799 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_+_36748164 9.701 THRAP3
thyroid hormone receptor associated protein 3
chr6_-_52628272 9.698 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr16_+_58497628 9.696 NDRG4
NDRG family member 4
chr1_+_50574601 9.644 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr4_+_71587674 9.639 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr2_-_166060552 9.635 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr12_-_16759531 9.559 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_+_41614911 9.541 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr16_+_58497548 9.475 NM_020465
NDRG4
NDRG family member 4
chr7_+_86273219 9.413 NM_000840
GRM3
glutamate receptor, metabotropic 3
chr8_-_27115897 9.404 NM_030795
STMN4
stathmin-like 4
chr1_+_66458389 9.372 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr1_+_163038564 9.183 NM_005613
RGS4
regulator of G-protein signaling 4
chr8_-_110620220 9.162 SYBU
syntabulin (syntaxin-interacting)
chr7_+_26400503 8.918 NM_001199837
SNX10
sorting nexin 10
chr4_+_71263598 8.865 NM_021225
PROL1
proline rich, lacrimal 1
chr17_-_29648631 8.849 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr2_+_31456879 8.822 NM_014600
EHD3
EH-domain containing 3
chr9_-_123476578 8.655 NM_001080497
MEGF9
multiple EGF-like-domains 9
chr1_+_66797775 8.584 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr19_-_17375522 8.581 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr7_+_106505876 8.575 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr18_-_53177999 8.549 NM_001243231
TCF4
transcription factor 4
chr4_+_113970784 8.526 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr8_-_40755328 8.504 NM_001135731
NM_024645
ZMAT4

zinc finger, matrin-type 4

chr8_-_134309448 8.500 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr17_+_38119225 8.457 NM_178171
GSDMA
gasdermin A
chr6_+_39760772 8.413 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr19_-_14939275 8.413 NM_017506
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr5_-_146460991 8.403 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr22_-_50523853 8.368 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr7_-_37488554 8.358 NM_014800
ELMO1
engulfment and cell motility 1
chr7_+_106505696 8.353 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr1_-_177133818 8.305 ASTN1
astrotactin 1
chr5_+_140743755 8.248 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr2_-_71454200 8.225 NM_020459
PAIP2B
poly(A) binding protein interacting protein 2B
chr19_-_21950322 8.199 NM_173531
ZNF100
zinc finger protein 100
chr1_-_177133950 8.164 NM_004319
NM_207108
ASTN1

astrotactin 1

chr11_+_112832201 8.102 NCAM1
neural cell adhesion molecule 1
chr5_+_140186658 8.072 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr11_-_123524881 8.065 SCN3B
sodium channel, voltage-gated, type III, beta
chr5_+_140749830 8.063 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr10_-_123356158 7.982 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr19_-_36523770 7.956 NM_015526
CLIP3
CAP-GLY domain containing linker protein 3
chr7_-_83270746 7.953 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr8_+_85095702 7.845 RALYL
RALY RNA binding protein-like
chr4_-_2263808 7.808 MXD4
MAX dimerization protein 4
chr12_-_45269953 7.807 NELL2
NEL-like 2 (chicken)
chr6_+_99872769 7.801


chr4_-_176733901 7.786 GPM6A
glycoprotein M6A
chr1_-_182360181 7.778 GLUL
glutamate-ammonia ligase
chr10_-_99393175 7.721 NM_178832
MORN4
MORN repeat containing 4
chr8_+_1952875 7.695 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr6_+_151561094 7.652 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr5_+_140220811 7.644 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr7_+_30960914 7.609 NM_001185060
NM_001185061
NM_001185062
AQP1


aquaporin 1 (Colton blood group)


chr4_+_154074269 7.602 NM_001130067
TRIM2
tripartite motif containing 2
chr7_-_37488408 7.586 ELMO1
engulfment and cell motility 1
chr8_+_79428335 7.563 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr17_-_37764165 7.552 NM_006160
NEUROD2
neurogenic differentiation 2
chr17_-_2996289 7.547 NM_002548
OR1D2
olfactory receptor, family 1, subfamily D, member 2
chr5_+_31799030 7.531 NM_178140
PDZD2
PDZ domain containing 2
chr10_-_62149487 7.447 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr4_-_186732208 7.363 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr5_-_42811959 7.313 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr18_-_53257033 7.313 NM_001243227
NM_001243228
TCF4

transcription factor 4

chr4_-_2263706 7.306 NM_006454
MXD4
MAX dimerization protein 4
chr6_-_112080284 7.298 NM_153048
FYN
FYN oncogene related to SRC, FGR, YES
chrX_+_110339374 7.287 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr4_+_113739203 7.262 NM_001127493
ANK2
ankyrin 2, neuronal
chr22_+_19711065 7.256 NM_000407
GP1BB
glycoprotein Ib (platelet), beta polypeptide
chr7_-_99145988 7.089 FAM200A
family with sequence similarity 200, member A
chrX_-_48693934 7.075 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr1_+_2005424 7.056 NM_001242874
PRKCZ
protein kinase C, zeta
chr14_+_35514112 6.983 NM_001079519
FAM177A1
family with sequence similarity 177, member A1
chr18_+_56530060 6.933 NM_018181
ZNF532
zinc finger protein 532
chr20_+_34556528 6.924 NM_001207076
NM_080834
C20orf152

chromosome 20 open reading frame 152

chr17_+_36861398 6.916 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr12_+_32654976 6.897 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr12_-_6233684 6.893 NM_000552
VWF
von Willebrand factor
chr1_-_31345361 6.859 SDC3
syndecan 3
chr11_-_76155704 6.838


chr5_+_161275897 6.828 NM_001127646
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr17_-_9939873 6.798 GAS7
growth arrest-specific 7
chr5_-_997408 6.759 NM_001242737
LOC100506688
uncharacterized LOC100506688
chr2_-_86565205 6.672 NM_001164730
REEP1
receptor accessory protein 1
chr4_+_110749149 6.627 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.28 1.50e-11 GO:0032501 multicellular organismal process
1.34 1.92e-10 GO:0023052 signaling
1.87 2.31e-10 GO:0007155 cell adhesion
1.87 2.31e-10 GO:0022610 biological adhesion
1.31 7.00e-09 GO:0032502 developmental process
1.33 1.59e-08 GO:0007275 multicellular organismal development
1.34 5.18e-08 GO:0048856 anatomical structure development
1.52 8.54e-08 GO:0007399 nervous system development
2.26 1.33e-07 GO:0016337 cell-cell adhesion
1.35 1.49e-07 GO:0048731 system development
2.93 1.73e-07 GO:0007156 homophilic cell adhesion
1.31 3.24e-07 GO:0007165 signal transduction
1.10 6.31e-07 GO:0009987 cellular process
1.16 1.54e-06 GO:0065007 biological regulation
1.39 3.04e-06 GO:0048869 cellular developmental process
1.24 2.73e-05 GO:0051716 cellular response to stimulus
1.40 3.31e-05 GO:0007166 cell surface receptor linked signaling pathway
1.36 5.20e-05 GO:0030154 cell differentiation
1.40 5.62e-04 GO:0009653 anatomical structure morphogenesis
1.64 7.94e-04 GO:0032989 cellular component morphogenesis
1.14 9.62e-04 GO:0050794 regulation of cellular process
1.53 1.10e-03 GO:0040011 locomotion
1.13 1.35e-03 GO:0050789 regulation of biological process
1.63 2.63e-03 GO:0000902 cell morphogenesis
1.57 3.15e-03 GO:0030182 neuron differentiation
2.20 6.43e-03 GO:0001654 eye development
1.14 6.87e-03 GO:0050896 response to stimulus
1.47 8.69e-03 GO:0022008 neurogenesis
1.48 1.28e-02 GO:0048699 generation of neurons
1.46 1.36e-02 GO:0048468 cell development
1.63 1.62e-02 GO:0000904 cell morphogenesis involved in differentiation
1.59 1.79e-02 GO:0048666 neuron development
2.29 2.37e-02 GO:0043010 camera-type eye development
1.60 3.82e-02 GO:0048858 cell projection morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 3.03e-06 GO:0044459 plasma membrane part
1.48 5.98e-06 GO:0005887 integral to plasma membrane
1.46 1.52e-05 GO:0031226 intrinsic to plasma membrane
1.18 1.39e-03 GO:0005886 plasma membrane
1.17 4.47e-03 GO:0071944 cell periphery
1.37 1.71e-02 GO:0044421 extracellular region part
1.59 2.72e-02 GO:0044463 cell projection part
1.60 4.86e-02 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.70 2.96e-06 GO:0005509 calcium ion binding
1.07 1.59e-04 GO:0005488 binding
2.88 3.03e-02 GO:0004879 ligand-dependent nuclear receptor activity