Motif ID: STAT2,4,6.p2

Z-value: 1.988


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
STAT2 6773 signal transducer and activator of transcription 2, 113kDa
STAT4 6775 signal transducer and activator of transcription 4
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
STAT6chr12_-_57505176-0.314.4e-06Click!
STAT2chr12_-_567539160.188.6e-03Click!
STAT4chr2_-_192015733-0.136.1e-02Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_71502700 51.446 MAP1B
microtubule-associated protein 1B
chr14_+_95078713 39.281 NM_001085
 SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr12_-_9268522 32.247 NM_000014
 A2M
alpha-2-macroglobulin
chr1_+_6845381 27.133 NM_001195563
NM_001242701
NM_015215
 CAMTA1


calmodulin binding transcription activator 1


chr12_-_7245006 24.410 NM_001733
 C1R
complement component 1, r subcomponent
chr12_-_7245048 24.165 C1R
complement component 1, r subcomponent
chr12_+_53443834 23.601 NM_170754
 TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr11_+_57365026 23.363 NM_000062
 SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr11_+_57365577 22.334 NM_001032295
 SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr12_+_58138663 19.063 NM_005981
 TSPAN31
tetraspanin 31
chr8_-_120651019 18.991 NM_001040092
NM_001130863
NM_006209
 ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr12_-_9268440 18.576 A2M
alpha-2-macroglobulin
chr1_+_155853546 18.465 SYT11
synaptotagmin XI
chr11_+_61197574 17.939 NM_017841
 SDHAF2
succinate dehydrogenase complex assembly factor 2
chr12_-_9268513 17.467 A2M
alpha-2-macroglobulin
chr11_-_12030128 17.077 NM_001018057
 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr3_+_159557745 16.909 SCHIP1
schwannomin interacting protein 1
chr1_-_230850335 16.583 NM_000029
 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr12_+_133656984 15.707 NM_003440
 ZNF140
zinc finger protein 140
chr1_-_230849863 15.647 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 68 entries
enrichment   p-value GO term description
5.93 2.81e-02 GO:0032835 glomerulus development
3.60 1.58e-02 GO:0006953 acute-phase response
1.90 3.53e-02 GO:0030168 platelet activation
1.89 2.44e-05 GO:0007409 axonogenesis
1.88 1.38e-05 GO:0048812 neuron projection morphogenesis
1.87 2.42e-06 GO:0048858 cell projection morphogenesis
1.86 3.93e-06 GO:0032990 cell part morphogenesis
1.85 3.26e-02 GO:2000145 regulation of cell motility
1.84 4.92e-02 GO:0030334 regulation of cell migration
1.83 1.32e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.82 5.12e-03 GO:0007411 axon guidance
1.82 8.14e-03 GO:0051050 positive regulation of transport
1.81 4.28e-05 GO:0031175 neuron projection development
1.79 7.47e-05 GO:0000904 cell morphogenesis involved in differentiation
1.76 1.72e-05 GO:0048666 neuron development
1.75 1.72e-05 GO:0000902 cell morphogenesis
1.73 3.30e-04 GO:0006935 chemotaxis
1.73 3.30e-04 GO:0042330 taxis
1.71 5.05e-06 GO:0030182 neuron differentiation
1.68 9.15e-05 GO:0030030 cell projection organization

Gene overrepresentation in compartment category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
2.33 1.17e-02 GO:0005925 focal adhesion
2.22 2.13e-02 GO:0030055 cell-substrate junction
2.22 2.91e-02 GO:0005924 cell-substrate adherens junction
2.03 1.87e-02 GO:0005912 adherens junction
2.02 2.34e-04 GO:0016323 basolateral plasma membrane
1.92 2.49e-02 GO:0030424 axon
1.76 6.57e-03 GO:0044456 synapse part
1.63 1.04e-02 GO:0045202 synapse
1.62 1.14e-10 GO:0005887 integral to plasma membrane
1.60 4.20e-10 GO:0031226 intrinsic to plasma membrane
1.60 3.75e-02 GO:0031012 extracellular matrix
1.59 1.46e-05 GO:0005615 extracellular space
1.58 4.04e-02 GO:0043005 neuron projection
1.57 1.33e-03 GO:0030054 cell junction
1.53 2.47e-15 GO:0044459 plasma membrane part
1.51 1.50e-05 GO:0044421 extracellular region part
1.30 3.28e-04 GO:0005576 extracellular region
1.24 1.03e-06 GO:0005886 plasma membrane
1.24 1.34e-06 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
3.81 1.76e-02 GO:0005158 insulin receptor binding
2.96 1.96e-02 GO:0003707 steroid hormone receptor activity
2.80 4.51e-02 GO:0004879 ligand-dependent nuclear receptor activity
1.55 3.25e-06 GO:0005102 receptor binding
1.51 5.53e-03 GO:0005509 calcium ion binding
1.37 4.16e-02 GO:0001071 nucleic acid binding transcription factor activity
1.37 4.16e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.19 1.85e-03 GO:0043167 ion binding
1.19 2.38e-03 GO:0043169 cation binding
1.19 3.18e-03 GO:0046872 metal ion binding
1.14 5.14e-05 GO:0005515 protein binding
1.09 2.63e-06 GO:0005488 binding