Motif ID: TBP.p2

Z-value: 4.086


Transcription factors associated with TBP.p2:

Gene SymbolEntrez IDGene Name
TBP 6908 TATA box binding protein

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TBPchr6_+_170863420-0.499.5e-15Click!


Activity profile for motif TBP.p2.

activity profile for motif TBP.p2


Sorted Z-values histogram for motif TBP.p2

Sorted Z-values for motif TBP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBP.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_5248180 114.995 NM_000518
 HBB
hemoglobin, beta
chr5_-_42811959 91.322 NM_001085486
NM_001093726
NM_005410
 SEPP1


selenoprotein P, plasma, 1


chr11_+_61129831 86.796 TMEM138
transmembrane protein 138
chr12_-_15038724 82.440 NM_000900
NM_001190839
 MGP

matrix Gla protein

chr1_-_59042827 81.505 TACSTD2
tumor-associated calcium signal transducer 2
chr2_-_216300770 76.550 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
 FN1





fibronectin 1





chr7_+_142829169 74.579 NM_002652
 PIP
prolactin-induced protein
chr8_-_27472188 71.693 CLU
clusterin
chr16_+_56659584 70.172 NM_175617
 MT1E
metallothionein 1E
chr19_-_6720585 68.309 NM_000064
 C3
complement component 3
chr16_+_56659679 67.856 MT1E
metallothionein 1E
chr7_+_94024201 60.703 COL1A2
collagen, type I, alpha 2
chr11_+_65190272 59.620


chr16_+_56685810 56.009 NM_005947
 MT1B
metallothionein 1B
chr1_+_153330329 55.618 NM_002965
 S100A9
S100 calcium binding protein A9
chr3_+_193853937 53.482 HES1
hairy and enhancer of split 1, (Drosophila)
chr3_+_193853930 52.832 NM_005524
 HES1
hairy and enhancer of split 1, (Drosophila)
chr1_-_153029987 52.346 NM_005988
 SPRR2A
small proline-rich protein 2A
chr1_-_230849863 51.828 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_-_153363544 50.830 NM_002964
 S100A8
S100 calcium binding protein A8

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 170 entries
enrichment   p-value GO term description
20.18 2.47e-03 GO:0042738 exogenous drug catabolic process
16.15 1.06e-02 GO:0001542 ovulation from ovarian follicle
16.15 1.06e-02 GO:0042737 drug catabolic process
16.15 1.06e-02 GO:0045672 positive regulation of osteoclast differentiation
13.84 3.44e-03 GO:0071347 cellular response to interleukin-1
12.69 4.19e-07 GO:0070301 cellular response to hydrogen peroxide
12.56 9.92e-04 GO:0042744 hydrogen peroxide catabolic process
12.11 3.15e-05 GO:0042743 hydrogen peroxide metabolic process
10.76 1.88e-08 GO:0034614 cellular response to reactive oxygen species
9.69 3.81e-02 GO:0045103 intermediate filament-based process
9.04 1.25e-02 GO:0002763 positive regulation of myeloid leukocyte differentiation
8.61 2.88e-08 GO:0034599 cellular response to oxidative stress
8.37 8.32e-07 GO:0002526 acute inflammatory response
8.37 2.19e-02 GO:0031032 actomyosin structure organization
8.07 4.39e-12 GO:0006334 nucleosome assembly
8.07 3.99e-04 GO:0072593 reactive oxygen species metabolic process
8.07 2.85e-02 GO:0032963 collagen metabolic process
7.95 1.09e-07 GO:0042542 response to hydrogen peroxide
7.86 2.12e-03 GO:0030049 muscle filament sliding
7.86 2.12e-03 GO:0033275 actin-myosin filament sliding

Gene overrepresentation in compartment category:

Showing 1 to 20 of 30 entries
enrichment   p-value GO term description
13.46 3.63e-03 GO:0005833 hemoglobin complex
12.56 1.14e-04 GO:0032982 myosin filament
12.38 1.02e-17 GO:0000786 nucleosome
10.76 2.21e-03 GO:0005859 muscle myosin complex
9.69 4.38e-03 GO:0016460 myosin II complex
9.23 5.98e-03 GO:0001533 cornified envelope
7.82 1.08e-12 GO:0032993 protein-DNA complex
6.83 7.08e-05 GO:0031983 vesicle lumen
6.06 2.45e-03 GO:0034774 secretory granule lumen
5.81 3.47e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
5.54 4.75e-12 GO:0005882 intermediate filament
5.50 1.58e-02 GO:0031093 platelet alpha granule lumen
4.80 2.10e-10 GO:0045111 intermediate filament cytoskeleton
4.73 1.28e-03 GO:0045095 keratin filament
4.64 1.35e-41 GO:0005615 extracellular space
4.54 2.64e-02 GO:0016459 myosin complex
4.20 1.85e-04 GO:0043292 contractile fiber
4.18 4.41e-04 GO:0030016 myofibril
4.00 2.03e-40 GO:0044421 extracellular region part
4.00 1.61e-03 GO:0044449 contractile fiber part

Gene overrepresentation in function category:

Showing 1 to 20 of 39 entries
enrichment   p-value GO term description
25.83 1.35e-03 GO:0046870 cadmium ion binding
24.22 3.65e-02 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor
24.22 3.65e-02 GO:0034875 caffeine oxidase activity
14.90 3.49e-04 GO:0005344 oxygen transporter activity
13.30 1.08e-04 GO:0005212 structural constituent of eye lens
11.53 1.31e-02 GO:0004089 carbonate dehydratase activity
10.09 2.73e-02 GO:0008395 steroid hydroxylase activity
9.83 1.32e-08 GO:0008009 chemokine activity
9.42 1.60e-03 GO:0070330 aromatase activity
9.33 1.39e-07 GO:0019825 oxygen binding
8.87 6.22e-08 GO:0042379 chemokine receptor binding
8.81 2.29e-16 GO:0005179 hormone activity
8.70 2.88e-03 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
7.51 1.44e-04 GO:0008307 structural constituent of muscle
6.65 1.91e-02 GO:0004601 peroxidase activity
6.65 1.91e-02 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor
6.04 5.75e-10 GO:0020037 heme binding
5.92 2.99e-10 GO:0046906 tetrapyrrole binding
5.91 5.43e-05 GO:0005200 structural constituent of cytoskeleton
5.87 1.45e-02 GO:0043498 cell surface binding