Motif ID: TBX4,5.p2

Z-value: 2.070


Transcription factors associated with TBX4,5.p2:

Gene SymbolEntrez IDGene Name
TBX4 9496 T-box 4
TBX5 6910 T-box 5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TBX5chr12_-_1148417020.665.5e-29Click!
TBX4chr17_+_595338060.572.3e-20Click!


Activity profile for motif TBX4,5.p2.

activity profile for motif TBX4,5.p2


Sorted Z-values histogram for motif TBX4,5.p2

Sorted Z-values for motif TBX4,5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX4,5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_44581045 35.829 CASC4
cancer susceptibility candidate 4
chr15_+_74421986 32.746 NM_001130137
 ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr3_+_167453431 29.133 NM_001122752
NM_005025
 SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

chr9_+_139872014 28.805 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr15_+_74421698 28.790 NM_001130136
 ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr12_-_45270071 27.480 NELL2
NEL-like 2 (chicken)
chr1_+_156698270 25.018 RRNAD1
ribosomal RNA adenine dimethylase domain containing 1
chr1_-_156399183 24.476 NM_006365
 C1orf61
chromosome 1 open reading frame 61
chr15_+_44580954 24.113 CASC4
cancer susceptibility candidate 4
chr14_+_95078713 23.540 NM_001085
 SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr12_+_66218879 23.422 HMGA2
high mobility group AT-hook 2
chr15_+_44580870 23.203 NM_138423
NM_177974
 CASC4

cancer susceptibility candidate 4

chrX_+_75392763 23.112 NM_016500
 CXorf26
chromosome X open reading frame 26
chr16_+_22825481 22.268 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chrX_+_101906293 21.641 NM_001099410
NM_001099411
NM_014710
NM_001184727
 GPRASP1



G protein-coupled receptor associated sorting protein 1



chr11_+_71791376 21.375 NM_001145307
NM_001145308
NM_001205138
NM_145309
 LRTOMT



leucine rich transmembrane and 0-methyltransferase domain containing



chrY_+_15016698 20.161 NM_004660
 DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr1_+_156698250 20.005 NM_001142560
NM_015997
 RRNAD1

ribosomal RNA adenine dimethylase domain containing 1

chr5_-_131132642 19.992 FNIP1
folliculin interacting protein 1
chr12_-_45270157 19.500 NM_001145108
NM_006159
 NELL2

NEL-like 2 (chicken)


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 53 entries
enrichment   p-value GO term description
2.87 4.38e-02 GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
1.86 8.18e-11 GO:0007267 cell-cell signaling
1.83 1.06e-05 GO:0019226 transmission of nerve impulse
1.83 1.06e-05 GO:0035637 multicellular organismal signaling
1.82 2.25e-02 GO:0006954 inflammatory response
1.75 1.07e-03 GO:0007268 synaptic transmission
1.73 1.93e-03 GO:0032583 regulation of gene-specific transcription
1.72 3.70e-04 GO:0006935 chemotaxis
1.72 3.70e-04 GO:0042330 taxis
1.71 5.87e-10 GO:0007154 cell communication
1.66 2.51e-02 GO:0040008 regulation of growth
1.61 9.52e-06 GO:0040011 locomotion
1.61 1.08e-04 GO:0006955 immune response
1.61 4.21e-03 GO:0048666 neuron development
1.60 1.02e-02 GO:0006928 cellular component movement
1.59 4.78e-02 GO:0030001 metal ion transport
1.58 5.07e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.57 2.63e-03 GO:0010628 positive regulation of gene expression
1.54 1.68e-07 GO:0051239 regulation of multicellular organismal process
1.54 6.95e-03 GO:0030182 neuron differentiation

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
2.00 4.22e-02 GO:0009897 external side of plasma membrane
1.88 3.26e-03 GO:0016323 basolateral plasma membrane
1.68 3.27e-02 GO:0044456 synapse part
1.53 4.65e-08 GO:0005887 integral to plasma membrane
1.53 5.00e-08 GO:0031226 intrinsic to plasma membrane
1.50 7.42e-14 GO:0044459 plasma membrane part
1.49 1.51e-02 GO:0030054 cell junction
1.40 3.04e-02 GO:0005624 membrane fraction
1.38 3.34e-02 GO:0042995 cell projection
1.24 4.43e-07 GO:0005886 plasma membrane
1.24 4.45e-07 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
4.31 2.08e-06 GO:0003823 antigen binding
3.21 1.61e-03 GO:0003707 steroid hormone receptor activity
3.19 9.66e-04 GO:0004879 ligand-dependent nuclear receptor activity
2.28 3.31e-03 GO:0015276 ligand-gated ion channel activity
2.28 3.31e-03 GO:0022834 ligand-gated channel activity
2.01 2.05e-02 GO:0005085 guanyl-nucleotide exchange factor activity
1.80 9.05e-03 GO:0005261 cation channel activity
1.72 1.53e-02 GO:0022836 gated channel activity
1.71 2.45e-04 GO:0030695 GTPase regulator activity
1.69 4.35e-02 GO:0005083 small GTPase regulator activity
1.66 8.05e-04 GO:0060589 nucleoside-triphosphatase regulator activity
1.66 3.79e-03 GO:0015267 channel activity
1.66 4.17e-03 GO:0022803 passive transmembrane transporter activity
1.60 2.74e-02 GO:0022838 substrate-specific channel activity
1.53 1.29e-02 GO:0008324 cation transmembrane transporter activity
1.50 3.11e-05 GO:0005102 receptor binding
1.48 2.67e-02 GO:0004672 protein kinase activity
1.46 2.33e-02 GO:0043565 sequence-specific DNA binding
1.45 1.32e-02 GO:0015075 ion transmembrane transporter activity
1.45 2.02e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor