Motif ID: TCF4_dimer.p2

Z-value: 2.275


Transcription factors associated with TCF4_dimer.p2:

Gene SymbolEntrez IDGene Name
TCF4 6925 transcription factor 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF4chr18_-_532553610.488.7e-14Click!


Activity profile for motif TCF4_dimer.p2.

activity profile for motif TCF4_dimer.p2


Sorted Z-values histogram for motif TCF4_dimer.p2

Sorted Z-values for motif TCF4_dimer.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF4_dimer.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_13956530 53.798 GPM6B
glycoprotein M6B
chr12_-_49392909 51.755 NM_015086
 DDN
dendrin
chr3_-_195310985 51.495 NM_001647
 APOD
apolipoprotein D
chr18_-_74691951 51.429 MBP
myelin basic protein
chrX_-_13956644 49.023 NM_001001994
 GPM6B
glycoprotein M6B
chr1_+_1981902 43.194 NM_002744
 PRKCZ
protein kinase C, zeta
chrX_-_13956445 40.238


chr17_+_38119225 39.974 NM_178171
 GSDMA
gasdermin A
chr11_+_73358593 39.937 NM_001130034
NM_001130035
 PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr3_-_195310770 39.812 APOD
apolipoprotein D
chr22_+_41777932 38.633 NM_003216
 TEF
thyrotrophic embryonic factor
chr5_+_173472692 36.860 NM_015980
 HMP19
HMP19 protein
chr1_+_150255228 35.380 NM_144697
 C1orf51
chromosome 1 open reading frame 51
chr7_-_124405029 33.203 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr14_-_23821423 30.012 NM_020372
 SLC22A17
solute carrier family 22, member 17
chr19_+_36359346 29.897 NM_001024807
NM_005166
 APLP1

amyloid beta (A4) precursor-like protein 1

chr22_-_19511777 29.371 CLDN5
claudin 5
chr7_-_22396511 28.705 NM_012294
 RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr6_-_136871542 28.473 MAP7
microtubule-associated protein 7
chr10_+_124220990 28.338 NM_002775
 HTRA1
HtrA serine peptidase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 201 entries
enrichment   p-value GO term description
3.01 4.21e-02 GO:0042551 neuron maturation
2.76 1.82e-04 GO:0006941 striated muscle contraction
2.58 2.31e-03 GO:0070252 actin-mediated cell contraction
2.54 6.03e-03 GO:0030049 muscle filament sliding
2.54 6.03e-03 GO:0033275 actin-myosin filament sliding
2.45 2.01e-03 GO:0007422 peripheral nervous system development
2.38 1.22e-02 GO:0007193 inhibition of adenylate cyclase activity by G-protein signaling pathway
2.26 3.45e-03 GO:0007194 negative regulation of adenylate cyclase activity
2.26 3.45e-03 GO:0031280 negative regulation of cyclase activity
2.26 3.45e-03 GO:0051350 negative regulation of lyase activity
2.24 1.47e-02 GO:0030048 actin filament-based movement
2.17 3.54e-11 GO:0006936 muscle contraction
2.17 6.96e-06 GO:0045761 regulation of adenylate cyclase activity
2.15 3.00e-04 GO:0008016 regulation of heart contraction
2.15 2.11e-02 GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
2.14 1.41e-11 GO:0003012 muscle system process
2.13 1.78e-05 GO:0031279 regulation of cyclase activity
2.09 4.37e-05 GO:0051339 regulation of lyase activity
2.09 5.99e-05 GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger
2.08 2.76e-02 GO:0001508 regulation of action potential

Gene overrepresentation in compartment category:

Showing 1 to 20 of 39 entries
enrichment   p-value GO term description
2.38 9.76e-03 GO:0005581 collagen
2.37 4.35e-02 GO:0043204 perikaryon
1.89 6.52e-05 GO:0043292 contractile fiber
1.87 3.17e-04 GO:0030016 myofibril
1.80 7.22e-06 GO:0044297 cell body
1.80 9.69e-06 GO:0043025 neuronal cell body
1.77 5.21e-03 GO:0044449 contractile fiber part
1.75 3.14e-02 GO:0030017 sarcomere
1.67 6.72e-04 GO:0030424 axon
1.65 5.93e-04 GO:0030425 dendrite
1.64 6.27e-05 GO:0016323 basolateral plasma membrane
1.63 3.64e-04 GO:0034702 ion channel complex
1.58 1.78e-07 GO:0045202 synapse
1.56 9.54e-07 GO:0043005 neuron projection
1.54 1.47e-02 GO:0005911 cell-cell junction
1.53 3.46e-22 GO:0031226 intrinsic to plasma membrane
1.53 8.65e-22 GO:0005887 integral to plasma membrane
1.48 1.03e-10 GO:0005615 extracellular space
1.48 1.22e-07 GO:0030054 cell junction
1.48 1.85e-04 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

Showing 1 to 20 of 39 entries
enrichment   p-value GO term description
3.32 3.70e-03 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
2.73 1.91e-02 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
2.62 4.09e-02 GO:0004112 cyclic-nucleotide phosphodiesterase activity
2.49 4.82e-05 GO:0003707 steroid hormone receptor activity
2.42 6.88e-05 GO:0004879 ligand-dependent nuclear receptor activity
2.33 2.87e-05 GO:0005496 steroid binding
1.67 4.45e-03 GO:0005085 guanyl-nucleotide exchange factor activity
1.67 1.10e-02 GO:0008509 anion transmembrane transporter activity
1.65 3.38e-02 GO:0005516 calmodulin binding
1.53 3.30e-04 GO:0022836 gated channel activity
1.50 2.75e-05 GO:0022803 passive transmembrane transporter activity
1.50 4.21e-05 GO:0015267 channel activity
1.50 6.65e-03 GO:0005261 cation channel activity
1.48 8.02e-03 GO:0005083 small GTPase regulator activity
1.47 3.17e-04 GO:0022838 substrate-specific channel activity
1.46 1.05e-07 GO:0043565 sequence-specific DNA binding
1.46 6.36e-04 GO:0005216 ion channel activity
1.43 9.01e-04 GO:0008289 lipid binding
1.43 9.50e-03 GO:0022804 active transmembrane transporter activity
1.42 2.67e-10 GO:0005102 receptor binding