• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: TFAP2B.p2

Z-value: 1.884

---

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr14_-_105261850	35.939		AKT1	v-akt murine thymoma viral oncogene homolog 1
chr12_-_123756164	29.580	NM_004642	CDK2AP1	cyclin-dependent kinase 2 associated protein 1
chr1_-_1822501	27.322		GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1
chr13_-_99229037	26.631		STK24	serine/threonine kinase 24
chrX_-_153602998	26.138	NM_001110556 NM_001456	FLNA	filamin A, alpha
chr4_-_1242882	24.689	NM_001012614 NM_001328	CTBP1	C-terminal binding protein 1
chr11_-_535532	24.559	NM_001130442 NM_005343 NM_176795	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog
chr10_+_99185977	23.961		PGAM1	phosphoglycerate mutase 1 (brain)
chr11_-_64014407	23.687	NM_138689	PPP1R14B	protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr4_-_1242742	23.682		CTBP1	C-terminal binding protein 1
chr11_-_64014264	23.619		PPP1R14B	protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr8_+_146277789	23.156	NM_023080	C8orf33	chromosome 8 open reading frame 33
chr9_+_131451519	22.942		SET	SET nuclear oncogene
chr14_-_105262078	22.934	NM_001014431 NM_001014432	AKT1	v-akt murine thymoma viral oncogene homolog 1
chr8_+_146277830	22.817		C8orf33	chromosome 8 open reading frame 33
chr9_+_131451847	22.778		SET	SET nuclear oncogene
chr20_+_57466248	21.890	NM_000516 NM_001077488 NM_001077489 NM_080426	GNAS	GNAS complex locus
chr2_+_181845605	21.445		UBE2E3	ubiquitin-conjugating enzyme E2E 3
chr12_-_118498893	21.397	NM_018639	WSB2	WD repeat and SOCS box containing 2
chr2_+_102314162	21.386	NM_001242560 NM_004834 NM_145686 NM_001242559 NM_145687	MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4
chr9_+_131451823	20.897		SET	SET nuclear oncogene
chr2_-_10588273	20.890		ODC1	ornithine decarboxylase 1
chr1_+_87794576	20.770		LMO4	LIM domain only 4
chr2_+_10262694	20.308	NM_001165931	RRM2	ribonucleotide reductase M2
chr1_-_1822493	20.213		GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1
chr1_-_150947202	19.840		CERS2	ceramide synthase 2
chr1_-_1822432	19.734		GNB1 CDK11B	guanine nucleotide binding protein (G protein), beta polypeptide 1 cyclin-dependent kinase 11B
chr10_+_99186012	19.709		PGAM1	phosphoglycerate mutase 1 (brain)
chr11_-_64014381	19.553		PPP1R14B	protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr14_-_105262015	19.493		AKT1	v-akt murine thymoma viral oncogene homolog 1
chr13_-_99229117	18.811		STK24	serine/threonine kinase 24
chr3_-_52567708	18.597	NM_001134231	NT5DC2	5'-nucleotidase domain containing 2
chrX_-_153285334	18.534	NM_001025242 NM_001025243 NM_001569	IRAK1	interleukin-1 receptor-associated kinase 1
chr2_+_10262853	18.369	NM_001034	RRM2	ribonucleotide reductase M2
chr15_-_101792125	18.276	NM_014918	CHSY1	chondroitin sulfate synthase 1
chr16_+_1359636	18.058		UBE2I	ubiquitin-conjugating enzyme E2I
chr18_-_9614454	17.660		PPP4R1	protein phosphatase 4, regulatory subunit 1
chr19_-_1567875	17.642	NM_001174118 NM_203304	MEX3D	mex-3 homolog D (C. elegans)
chr3_-_185542807	17.512	NM_001007225 NM_006548	IGF2BP2	insulin-like growth factor 2 mRNA binding protein 2
chr10_+_82213892	17.466	NM_001128309 NM_030927	TSPAN14	tetraspanin 14
chr16_+_1359673	17.342		UBE2I	ubiquitin-conjugating enzyme E2I
chr1_-_150947127	17.236		CERS2	ceramide synthase 2
chr2_+_216176818	17.230		ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr11_-_64014140	17.159		PPP1R14B	protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr13_+_33160651	16.797		PDS5B	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr16_+_89989686	16.710	NM_006086	TUBB3	tubulin, beta 3 class III
chrX_+_154611748	16.659	NM_001007523 NM_001007524 NM_012151	F8A2 F8A3 F8A1	coagulation factor VIII-associated 2 coagulation factor VIII-associated 3 coagulation factor VIII-associated 1
chr2_-_10588451	16.580	NM_002539	ODC1	ornithine decarboxylase 1
chr9_+_131452253	16.545	NM_001248001	SET	SET nuclear oncogene
chr1_-_94374986	16.516	NM_002061	GCLM	glutamate-cysteine ligase, modifier subunit
chr1_-_150947456	16.478	NM_022075 NM_181746	CERS2	ceramide synthase 2
chr20_+_62371109	16.260	NM_020062	SLC2A4RG	SLC2A4 regulator
chr1_-_150947292	16.189		CERS2	ceramide synthase 2
chr10_+_99186040	16.174		PGAM1	phosphoglycerate mutase 1 (brain)
chr1_-_156721501	16.106	NM_004494	HDGF	hepatoma-derived growth factor
chr20_+_62371730	16.102		SLC2A4RG	SLC2A4 regulator
chr5_+_6714717	16.080	NM_001171805 NM_006999	PAPD7	PAP associated domain containing 7
chr17_-_62658311	16.053	NM_022739	SMURF2	SMAD specific E3 ubiquitin protein ligase 2
chr20_+_62371218	15.882		SLC2A4RG	SLC2A4 regulator
chrX_-_15872905	15.856
chr10_+_99186042	15.845		PGAM1	phosphoglycerate mutase 1 (brain)
chr11_-_14380591	15.694	NM_012250	RRAS2	related RAS viral (r-ras) oncogene homolog 2
chr16_-_87903028	15.645	NM_003486	SLC7A5	solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr20_+_62371619	15.496		SLC2A4RG	SLC2A4 regulator
chrX_-_153285262	15.381		IRAK1	interleukin-1 receptor-associated kinase 1
chr20_+_388941	15.224		RBCK1	RanBP-type and C3HC4-type zinc finger containing 1
chr1_-_94374949	15.216		GCLM	glutamate-cysteine ligase, modifier subunit
chr20_-_60718358	15.097		PSMA7	proteasome (prosome, macropain) subunit, alpha type, 7
chr20_+_57466509	14.908		GNAS	GNAS complex locus
chr1_-_150947154	14.903		CERS2	ceramide synthase 2
chr3_-_195808934	14.801		TFRC	transferrin receptor (p90, CD71)
chr13_-_99229226	14.760	NM_001032296	STK24	serine/threonine kinase 24
chr1_+_230202928	14.666	NM_004481	GALNT2	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
chr12_-_109125289	14.551	NM_014325	CORO1C	coronin, actin binding protein, 1C
chr2_-_225449721	14.499		CUL3	cullin 3
chr16_+_1359653	14.425		UBE2I	ubiquitin-conjugating enzyme E2I
chr12_-_109125275	14.409		CORO1C	coronin, actin binding protein, 1C
chr1_-_150947305	14.393		CERS2	ceramide synthase 2
chr16_-_85832900	14.380	NM_001142288 NM_006067	COX4NB	COX4 neighbor
chr2_+_216176678	14.346	NM_004044	ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chrX_+_150151757	14.281	NM_005342	HMGB3	high mobility group box 3
chr1_-_1284297	14.268	NM_004421	DVL1	dishevelled, dsh homolog 1 (Drosophila)
chr14_+_56046796	14.212	NM_001079521 NM_001079522 NM_004986 NM_182926	KTN1	kinectin 1 (kinesin receptor)
chr18_-_9614555	14.022	NM_001042388 NM_005134	PPP4R1	protein phosphatase 4, regulatory subunit 1
chr3_-_52567809	14.001		NT5DC2	5'-nucleotidase domain containing 2
chr3_-_33481862	13.978	NM_001128160 NM_014517	UBP1	upstream binding protein 1 (LBP-1a)
chr16_+_1359692	13.949		UBE2I	ubiquitin-conjugating enzyme E2I
chrX_+_154114609	13.655	NM_001007523 NM_001007524 NM_012151	F8A2 F8A3 F8A1	coagulation factor VIII-associated 2 coagulation factor VIII-associated 3 coagulation factor VIII-associated 1
chr22_+_21922020	13.640		UBE2L3	ubiquitin-conjugating enzyme E2L 3
chr2_-_161349874	13.598		RBMS1	RNA binding motif, single stranded interacting protein 1
chr19_-_41859519	13.570		TGFB1	transforming growth factor, beta 1
chr18_-_51750934	13.558		MBD2	methyl-CpG binding domain protein 2
chr20_-_60718407	13.501		PSMA7	proteasome (prosome, macropain) subunit, alpha type, 7
chr12_-_106641675	13.494	NM_006825	CKAP4	cytoskeleton-associated protein 4
chr2_-_174829108	13.468		SP3	Sp3 transcription factor
chr9_+_131451470	13.461	NM_003011	SET	SET nuclear oncogene
chr2_+_216176808	13.368		ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr20_-_60718440	13.326	NM_002792	PSMA7	proteasome (prosome, macropain) subunit, alpha type, 7
chr3_-_182698291	13.260	NM_020640	DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
chr3_-_185542744	13.247		IGF2BP2	insulin-like growth factor 2 mRNA binding protein 2
chr3_-_195808958	13.223	NM_003234	TFRC	transferrin receptor (p90, CD71)
chr3_-_129035069	13.220	NM_006026	H1FX	H1 histone family, member X
chr3_-_149688638	13.140	NM_002628 NM_053024	PFN2	profilin 2
chr10_+_99186017	13.040	NM_002629	PGAM1	phosphoglycerate mutase 1 (brain)
chr10_+_99186004	13.024		PGAM1	phosphoglycerate mutase 1 (brain)
chr5_+_138089073	13.015	NM_001903	CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa
chr5_+_138089118	12.953		CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa
chrX_-_15872882	12.947		AP1S2	adaptor-related protein complex 1, sigma 2 subunit
chr15_+_63796793	12.890	NM_006537	USP3	ubiquitin specific peptidase 3
chr22_+_21922026	12.780		UBE2L3	ubiquitin-conjugating enzyme E2L 3
chr1_-_224622000	12.779	NM_001115113 NM_025160	WDR26	WD repeat domain 26
chr19_-_41859830	12.763	NM_000660	TGFB1	transforming growth factor, beta 1
chr11_-_14380030	12.578	NM_001177315 NM_001102669	RRAS2	related RAS viral (r-ras) oncogene homolog 2
chr5_-_1524022	12.490	NM_024830	LPCAT1	lysophosphatidylcholine acyltransferase 1
chr20_+_388717	12.464		RBCK1	RanBP-type and C3HC4-type zinc finger containing 1
chr17_-_56065596	12.440	NM_007146	VEZF1	vascular endothelial zinc finger 1
chr9_+_114659023	12.414	NM_003358	UGCG	UDP-glucose ceramide glucosyltransferase
chr6_-_7910716	12.395	NM_030810	TXNDC5	thioredoxin domain containing 5 (endoplasmic reticulum)
chr22_+_21922004	12.240		UBE2L3	ubiquitin-conjugating enzyme E2L 3
chr1_-_156721280	12.230		HDGF	hepatoma-derived growth factor
chrX_-_154688260	12.207	NM_001007523 NM_001007524 NM_012151	F8A2 F8A3 F8A1	coagulation factor VIII-associated 2 coagulation factor VIII-associated 3 coagulation factor VIII-associated 1
chr17_-_76921076	12.082		TIMP2	TIMP metallopeptidase inhibitor 2
chr19_-_41859332	11.947		TGFB1	transforming growth factor, beta 1
chr12_-_109125254	11.911		CORO1C	coronin, actin binding protein, 1C
chr3_-_63849456	11.791		THOC7	THO complex 7 homolog (Drosophila)
chr3_+_141595368	11.737	NM_001679	ATP1B3	ATPase, Na+/K+ transporting, beta 3 polypeptide
chr9_+_133710746	11.708	NM_005157	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase
chr11_-_64545864	11.686		SF1	splicing factor 1
chr6_-_13814546	11.682	NM_001031713	CCDC90A	coiled-coil domain containing 90A
chr9_+_114659439	11.618		UGCG	UDP-glucose ceramide glucosyltransferase
chr12_-_111180730	11.533	NM_001244974 NM_002710	PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme
chr7_+_56119377	11.525	NM_001009186 NM_001762	CCT6A	chaperonin containing TCP1, subunit 6A (zeta 1)
chr15_+_80351909	11.499	NM_001242911 NM_001242912 NM_001242917 NM_001242918 NM_019006	ZFAND6	zinc finger, AN1-type domain 6
chr11_+_67033929	11.491		ADRBK1	adrenergic, beta, receptor kinase 1
chr13_+_33160630	11.410		PDS5B	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr6_-_53213586	11.383		ELOVL5	ELOVL fatty acid elongase 5
chr12_-_47473424	11.358	NM_001143668 NM_181847	AMIGO2	adhesion molecule with Ig-like domain 2
chr11_+_67033889	11.356	NM_001619	ADRBK1	adrenergic, beta, receptor kinase 1
chr9_+_110045551	11.241		RAD23B	RAD23 homolog B (S. cerevisiae)
chr1_-_94375028	11.191		GCLM	glutamate-cysteine ligase, modifier subunit
chr16_-_9057250	11.180	NM_003470	USP7	ubiquitin specific peptidase 7 (herpes virus-associated)
chr9_+_110045516	11.115	NM_002874	RAD23B	RAD23 homolog B (S. cerevisiae)
chr6_+_163835668	11.018	NM_006775 NM_206853 NM_206854 NM_206855	QKI	QKI, KH domain containing, RNA binding
chr4_+_174089889	10.986	NM_017423	GALNT7	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr6_-_52441815	10.952	NM_012288	TRAM2	translocation associated membrane protein 2
chr7_-_121036355	10.931	NM_001040020 NM_014888	FAM3C	family with sequence similarity 3, member C
chr17_-_62658175	10.795		SMURF2	SMAD specific E3 ubiquitin protein ligase 2
chr17_-_4851797	10.778	NM_005022	PFN1	profilin 1
chrX_-_15872938	10.772		AP1S2	adaptor-related protein complex 1, sigma 2 subunit
chr2_+_85198176	10.737	NM_020122	KCMF1	potassium channel modulatory factor 1
chr9_+_96338671	10.700	NM_005392	PHF2	PHD finger protein 2
chr16_-_88851371	10.667	NM_001142864	PIEZO1	piezo-type mechanosensitive ion channel component 1
chrX_-_15872921	10.633		AP1S2	adaptor-related protein complex 1, sigma 2 subunit
chr5_+_892950	10.600	NM_001166260 NM_004237	TRIP13	thyroid hormone receptor interactor 13
chr17_+_30771520	10.581		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr9_+_128509616	10.569	NM_006195	PBX3	pre-B-cell leukemia homeobox 3
chr14_+_100705101	10.563	NM_003403	YY1	YY1 transcription factor
chr17_-_4269610	10.499		UBE2G1	ubiquitin-conjugating enzyme E2G 1
chr3_+_141595512	10.489		ATP1B3	ATPase, Na+/K+ transporting, beta 3 polypeptide
chr17_-_4851688	10.386		PFN1	profilin 1
chr12_+_2904289	10.323		FKBP4	FK506 binding protein 4, 59kDa
chr5_-_57755787	10.250	NM_001252226 NM_006622	PLK2	polo-like kinase 2
chr20_+_57556322	10.163		TH1L	TH1-like (Drosophila)
chr1_-_11120001	10.133		SRM	spermidine synthase
chr15_+_63334753	10.111	NM_000366 NM_001018004 NM_001018005 NM_001018006 NM_001018007 NM_001018020	TPM1	tropomyosin 1 (alpha)
chr3_-_195808997	10.062	NM_001128148	TFRC	transferrin receptor (p90, CD71)
chr1_-_1284755	10.029		DVL1	dishevelled, dsh homolog 1 (Drosophila)
chr16_+_730114	10.016	NM_005861	STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
chr9_-_139378192	9.981		SEC16A	SEC16 homolog A (S. cerevisiae)
chrX_+_118602362	9.941	NM_001152	SLC25A5	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chrX_+_133594225	9.895		HPRT1	hypoxanthine phosphoribosyltransferase 1
chr16_+_2564000	9.891		ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr1_-_95392501	9.887	NM_001839	CNN3	calponin 3, acidic
chr1_+_29063443	9.880	NM_001172828	YTHDF2	YTH domain family, member 2
chrX_+_118602391	9.842		SLC25A5	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr1_-_1822516	9.791	NM_002074	GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1
chr5_-_112257877	9.781	NM_005669	REEP5	receptor accessory protein 5
chr14_+_105941061	9.769	NM_001312	CRIP2	cysteine-rich protein 2
chr14_-_89883306	9.763	NM_005197	FOXN3	forkhead box N3
chr9_+_110046333	9.757	NM_001244724	RAD23B	RAD23 homolog B (S. cerevisiae)
chr1_+_214454276	9.747	NM_020197	SMYD2	SET and MYND domain containing 2
chr20_+_31407696	9.679	NM_012325	MAPRE1	microtubule-associated protein, RP/EB family, member 1
chr17_-_56065474	9.643		VEZF1	vascular endothelial zinc finger 1
chr19_+_1941157	9.561	NM_001319	CSNK1G2	casein kinase 1, gamma 2
chr1_+_955468	9.513	NM_198576	AGRN	agrin
chr4_+_1723212	9.478	NM_006342	TACC3	transforming, acidic coiled-coil containing protein 3
chr7_-_121036320	9.465		FAM3C	family with sequence similarity 3, member C
chr2_+_231921595	9.369		PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr16_+_29817810	9.278	NM_001042539 NM_002383	MAZ	MYC-associated zinc finger protein (purine-binding transcription factor)
chr6_-_160114318	9.257	NM_000636 NM_001024465 NM_001024466	SOD2	superoxide dismutase 2, mitochondrial
chr16_-_47177902	9.170	NM_001201477 NM_018092	NETO2	neuropilin (NRP) and tolloid (TLL)-like 2
chr2_-_61764661	9.163		XPO1	exportin 1 (CRM1 homolog, yeast)
chr16_-_47177832	9.151		NETO2	neuropilin (NRP) and tolloid (TLL)-like 2
chr16_+_67562704	9.136	NM_024519 NM_001193522	FAM65A	family with sequence similarity 65, member A
chr14_+_100705279	9.087		YY1	YY1 transcription factor
chr4_+_62066945	9.021		LPHN3	latrophilin 3
chr4_-_1713914	8.918	NM_006527	SLBP	stem-loop binding protein
chr8_+_98656494	8.909		MTDH	metadherin
chr8_-_30669934	8.896		PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme
chr15_+_80352257	8.892	NM_001242913	ZFAND6	zinc finger, AN1-type domain 6

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.17	4.21e-58	GO:0009987	cellular process
1.30	1.09e-50	GO:0044237	cellular metabolic process
1.25	2.31e-44	GO:0008152	metabolic process
1.26	1.49e-39	GO:0044238	primary metabolic process
1.31	8.68e-33	GO:0044260	cellular macromolecule metabolic process
1.27	4.69e-29	GO:0043170	macromolecule metabolic process
1.19	1.16e-26	GO:0050789	regulation of biological process
1.20	2.14e-26	GO:0050794	regulation of cellular process
1.18	4.53e-26	GO:0065007	biological regulation
1.32	3.66e-24	GO:0016043	cellular component organization
1.30	3.80e-22	GO:0071840	cellular component organization or biogenesis
1.37	7.10e-19	GO:0048523	negative regulation of cellular process
1.34	1.13e-18	GO:0044267	cellular protein metabolic process
1.29	1.47e-18	GO:0006807	nitrogen compound metabolic process
1.35	1.80e-18	GO:0048519	negative regulation of biological process
1.29	2.16e-18	GO:0034641	cellular nitrogen compound metabolic process
1.25	5.64e-18	GO:0019222	regulation of metabolic process
1.32	2.66e-17	GO:0071842	cellular component organization at cellular level
1.26	3.93e-17	GO:0031323	regulation of cellular metabolic process
1.39	6.20e-17	GO:0006464	protein modification process
1.33	1.39e-16	GO:0044249	cellular biosynthetic process
1.30	7.22e-16	GO:0071841	cellular component organization or biogenesis at cellular level
1.28	7.87e-16	GO:0019538	protein metabolic process
1.37	8.11e-16	GO:0043412	macromolecule modification
1.25	9.33e-16	GO:0080090	regulation of primary metabolic process
1.32	1.14e-15	GO:0048522	positive regulation of cellular process
1.30	1.55e-15	GO:0048518	positive regulation of biological process
1.31	2.50e-15	GO:0009058	biosynthetic process
1.29	1.64e-14	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.25	3.63e-14	GO:0060255	regulation of macromolecule metabolic process
1.23	1.19e-13	GO:0032502	developmental process
1.37	9.61e-13	GO:0023051	regulation of signaling
1.43	3.92e-12	GO:0010604	positive regulation of macromolecule metabolic process
1.24	2.30e-11	GO:0048856	anatomical structure development
1.22	2.33e-11	GO:0007275	multicellular organismal development
1.40	2.99e-11	GO:0009893	positive regulation of metabolic process
1.20	4.04e-11	GO:0051716	cellular response to stimulus
1.37	6.03e-11	GO:0009966	regulation of signal transduction
1.34	6.07e-11	GO:0006996	organelle organization
1.20	3.08e-10	GO:0023052	signaling
1.38	4.60e-10	GO:0051641	cellular localization
1.24	7.45e-10	GO:0048731	system development
1.24	1.31e-09	GO:0031326	regulation of cellular biosynthetic process
1.24	1.54e-09	GO:0009889	regulation of biosynthetic process
1.40	1.61e-09	GO:0051246	regulation of protein metabolic process
1.26	1.87e-09	GO:2000112	regulation of cellular macromolecule biosynthetic process
1.38	2.13e-09	GO:0031325	positive regulation of cellular metabolic process
1.21	2.87e-09	GO:0007165	signal transduction
1.41	3.95e-09	GO:0032268	regulation of cellular protein metabolic process
1.24	5.03e-09	GO:0010468	regulation of gene expression
1.27	5.24e-09	GO:0048869	cellular developmental process
1.26	6.13e-09	GO:0042221	response to chemical stimulus
1.30	6.17e-09	GO:0044281	small molecule metabolic process
1.26	7.42e-09	GO:0090304	nucleic acid metabolic process
1.25	8.40e-09	GO:0010556	regulation of macromolecule biosynthetic process
1.33	1.01e-08	GO:0007399	nervous system development
1.31	1.10e-08	GO:0034645	cellular macromolecule biosynthetic process
1.43	1.36e-08	GO:0006351	transcription, DNA-dependent
1.41	1.36e-08	GO:0006357	regulation of transcription from RNA polymerase II promoter
1.50	2.38e-08	GO:0007167	enzyme linked receptor protein signaling pathway
1.30	2.67e-08	GO:0009059	macromolecule biosynthetic process
1.34	2.72e-08	GO:0033036	macromolecule localization
1.45	2.95e-08	GO:0046907	intracellular transport
1.26	6.63e-08	GO:0030154	cell differentiation
1.43	7.96e-08	GO:0051128	regulation of cellular component organization
1.36	1.47e-07	GO:0051649	establishment of localization in cell
1.22	1.60e-07	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.25	1.81e-07	GO:0065008	regulation of biological quality
1.40	2.25e-07	GO:0050793	regulation of developmental process
1.50	3.05e-07	GO:0000902	cell morphogenesis
1.21	3.06e-07	GO:0051171	regulation of nitrogen compound metabolic process
1.53	4.33e-07	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
1.37	7.05e-07	GO:0032774	RNA biosynthetic process
1.37	7.07e-07	GO:0006793	phosphorus metabolic process
1.37	7.07e-07	GO:0006796	phosphate metabolic process
1.37	8.86e-07	GO:0032879	regulation of localization
1.27	1.04e-06	GO:0016070	RNA metabolic process
1.29	1.32e-06	GO:0065009	regulation of molecular function
1.29	1.38e-06	GO:0009653	anatomical structure morphogenesis
1.38	1.73e-06	GO:0048468	cell development
1.39	2.19e-06	GO:0033554	cellular response to stress
1.17	2.49e-06	GO:0051179	localization
1.34	3.07e-06	GO:0010646	regulation of cell communication
1.45	3.08e-06	GO:0032989	cellular component morphogenesis
1.36	3.28e-06	GO:0009892	negative regulation of metabolic process
1.41	3.88e-06	GO:0016192	vesicle-mediated transport
1.34	4.60e-06	GO:0008104	protein localization
1.41	5.06e-06	GO:0006468	protein phosphorylation
1.22	5.12e-06	GO:0051252	regulation of RNA metabolic process
1.56	6.24e-06	GO:0051247	positive regulation of protein metabolic process
1.43	7.62e-06	GO:0045595	regulation of cell differentiation
1.50	8.13e-06	GO:0000904	cell morphogenesis involved in differentiation
1.61	8.81e-06	GO:0071495	cellular response to endogenous stimulus
1.24	1.11e-05	GO:0010467	gene expression
1.30	1.27e-05	GO:0010033	response to organic substance
1.49	1.43e-05	GO:0048858	cell projection morphogenesis
1.49	1.65e-05	GO:0032990	cell part morphogenesis
1.24	1.75e-05	GO:0048583	regulation of response to stimulus
1.33	1.75e-05	GO:0043067	regulation of programmed cell death
1.35	1.80e-05	GO:0010605	negative regulation of macromolecule metabolic process
1.36	2.13e-05	GO:0031324	negative regulation of cellular metabolic process
1.22	2.59e-05	GO:0006355	regulation of transcription, DNA-dependent
1.35	2.85e-05	GO:0022008	neurogenesis
1.34	3.01e-05	GO:0042127	regulation of cell proliferation
1.36	3.08e-05	GO:0008219	cell death
1.32	3.11e-05	GO:0010941	regulation of cell death
1.36	3.18e-05	GO:0048699	generation of neurons
1.36	3.34e-05	GO:0016265	death
1.42	3.51e-05	GO:0030030	cell projection organization
1.18	3.58e-05	GO:0051234	establishment of localization
1.54	3.61e-05	GO:0032270	positive regulation of cellular protein metabolic process
1.32	3.63e-05	GO:0042981	regulation of apoptosis
1.35	4.04e-05	GO:0045184	establishment of protein localization
1.36	4.44e-05	GO:0016310	phosphorylation
1.29	5.19e-05	GO:0051239	regulation of multicellular organismal process
1.18	6.55e-05	GO:0006810	transport
1.59	9.06e-05	GO:0032870	cellular response to hormone stimulus
1.32	1.06e-04	GO:0007049	cell cycle
1.39	1.14e-04	GO:0009719	response to endogenous stimulus
1.41	1.17e-04	GO:0051726	regulation of cell cycle
1.36	1.20e-04	GO:0031399	regulation of protein modification process
1.49	1.22e-04	GO:0048812	neuron projection morphogenesis
1.39	1.29e-04	GO:0009890	negative regulation of biosynthetic process
1.54	1.35e-04	GO:0016568	chromatin modification
1.27	1.36e-04	GO:0035556	intracellular signal transduction
1.39	1.38e-04	GO:0031327	negative regulation of cellular biosynthetic process
1.61	1.41e-04	GO:0032446	protein modification by small protein conjugation
1.56	1.44e-04	GO:0070647	protein modification by small protein conjugation or removal
1.95	1.50e-04	GO:0007265	Ras protein signal transduction
1.39	1.54e-04	GO:0010628	positive regulation of gene expression
1.10	1.73e-04	GO:0050896	response to stimulus
1.48	2.01e-04	GO:0048667	cell morphogenesis involved in neuron differentiation
1.68	2.27e-04	GO:0048011	nerve growth factor receptor signaling pathway
1.29	2.30e-04	GO:0044248	cellular catabolic process
1.34	2.36e-04	GO:0015031	protein transport
1.34	2.75e-04	GO:0031328	positive regulation of cellular biosynthetic process
1.38	2.81e-04	GO:0051254	positive regulation of RNA metabolic process
1.36	2.99e-04	GO:2000026	regulation of multicellular organismal development
1.49	3.02e-04	GO:0007409	axonogenesis
1.55	3.12e-04	GO:0051098	regulation of binding
1.25	3.69e-04	GO:0009056	catabolic process
1.33	3.87e-04	GO:0009891	positive regulation of biosynthetic process
1.52	4.01e-04	GO:0044419	interspecies interaction between organisms
1.37	4.77e-04	GO:0019220	regulation of phosphate metabolic process
1.37	4.77e-04	GO:0051174	regulation of phosphorus metabolic process
1.38	4.92e-04	GO:0010558	negative regulation of macromolecule biosynthetic process
1.39	5.65e-04	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
1.44	6.27e-04	GO:0031175	neuron projection development
1.44	7.13e-04	GO:0006325	chromatin organization
1.58	7.62e-04	GO:0010608	posttranscriptional regulation of gene expression
1.35	8.35e-04	GO:0010557	positive regulation of macromolecule biosynthetic process
1.34	1.05e-03	GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.16	1.22e-03	GO:0006921	cellular component disassembly involved in apoptosis
1.38	1.32e-03	GO:0009725	response to hormone stimulus
1.59	1.41e-03	GO:0016567	protein ubiquitination
1.73	1.48e-03	GO:0006417	regulation of translation
1.51	1.66e-03	GO:0007411	axon guidance
1.37	1.67e-03	GO:0051276	chromosome organization
1.36	1.69e-03	GO:0042325	regulation of phosphorylation
1.33	1.70e-03	GO:0051173	positive regulation of nitrogen compound metabolic process
1.38	1.80e-03	GO:0010629	negative regulation of gene expression
1.42	1.84e-03	GO:0070271	protein complex biogenesis
1.40	1.92e-03	GO:0051253	negative regulation of RNA metabolic process
1.34	1.96e-03	GO:0012501	programmed cell death
1.34	2.04e-03	GO:0006915	apoptosis
1.26	2.31e-03	GO:0050790	regulation of catalytic activity
1.46	2.66e-03	GO:0007264	small GTPase mediated signal transduction
1.32	2.74e-03	GO:0044093	positive regulation of molecular function
1.36	2.84e-03	GO:0001932	regulation of protein phosphorylation
1.62	3.02e-03	GO:0045786	negative regulation of cell cycle
1.32	3.24e-03	GO:0022402	cell cycle process
1.41	3.27e-03	GO:0006461	protein complex assembly
1.33	3.40e-03	GO:0051049	regulation of transport
1.36	3.44e-03	GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.24	4.04e-03	GO:0007163	establishment or maintenance of cell polarity
1.76	4.26e-03	GO:0051099	positive regulation of binding
1.43	4.62e-03	GO:0010648	negative regulation of cell communication
1.36	4.65e-03	GO:0045893	positive regulation of transcription, DNA-dependent
2.19	5.16e-03	GO:0001889	liver development
1.38	5.26e-03	GO:0045892	negative regulation of transcription, DNA-dependent
1.35	5.62e-03	GO:0051172	negative regulation of nitrogen compound metabolic process
1.39	5.62e-03	GO:0070727	cellular macromolecule localization
1.52	6.34e-03	GO:0051270	regulation of cellular component movement
1.41	6.74e-03	GO:0060548	negative regulation of cell death
1.39	7.33e-03	GO:0044283	small molecule biosynthetic process
1.19	7.65e-03	GO:0048513	organ development
1.47	8.25e-03	GO:0018193	peptidyl-amino acid modification
1.40	8.27e-03	GO:0072358	cardiovascular system development
1.40	8.27e-03	GO:0072359	circulatory system development
2.15	8.55e-03	GO:0061008	hepaticobiliary system development
1.48	8.63e-03	GO:0032535	regulation of cellular component size
1.36	8.71e-03	GO:0048666	neuron development
1.54	8.81e-03	GO:0030334	regulation of cell migration
1.62	9.05e-03	GO:0044087	regulation of cellular component biogenesis
1.57	9.17e-03	GO:0051129	negative regulation of cellular component organization
1.16	9.65e-03	GO:0006950	response to stress
1.38	9.69e-03	GO:0034613	cellular protein localization
1.41	1.13e-02	GO:0023057	negative regulation of signaling
1.57	1.21e-02	GO:0071375	cellular response to peptide hormone stimulus
1.44	1.25e-02	GO:0044271	cellular nitrogen compound biosynthetic process
2.75	1.42e-02	GO:0030010	establishment of cell polarity
1.44	1.55e-02	GO:0090066	regulation of anatomical structure size
1.52	1.63e-02	GO:2000145	regulation of cell motility
1.64	1.67e-02	GO:0006913	nucleocytoplasmic transport
1.76	1.68e-02	GO:0006403	RNA localization
1.32	1.70e-02	GO:0065003	macromolecular complex assembly
1.33	1.87e-02	GO:0071310	cellular response to organic substance
1.32	1.90e-02	GO:0030182	neuron differentiation
1.29	1.90e-02	GO:0043933	macromolecular complex subunit organization
1.49	2.02e-02	GO:0006366	transcription from RNA polymerase II promoter
1.32	2.06e-02	GO:0046483	heterocycle metabolic process
1.63	2.13e-02	GO:0016569	covalent chromatin modification
1.41	2.21e-02	GO:0009968	negative regulation of signal transduction
1.72	2.32e-02	GO:0006112	energy reserve metabolic process
1.25	2.35e-02	GO:0022607	cellular component assembly
1.47	2.56e-02	GO:0031401	positive regulation of protein modification process
1.61	2.60e-02	GO:0010562	positive regulation of phosphorus metabolic process
1.61	2.60e-02	GO:0045937	positive regulation of phosphate metabolic process
1.39	2.67e-02	GO:0008283	cell proliferation
1.62	2.71e-02	GO:0051169	nuclear transport
1.75	2.95e-02	GO:0050657	nucleic acid transport
1.75	2.95e-02	GO:0050658	RNA transport
1.75	2.95e-02	GO:0051236	establishment of RNA localization
1.46	3.03e-02	GO:0051093	negative regulation of developmental process
1.33	3.30e-02	GO:0009057	macromolecule catabolic process
1.47	3.67e-02	GO:0009199	ribonucleoside triphosphate metabolic process
1.96	3.70e-02	GO:0007173	epidermal growth factor receptor signaling pathway
1.33	3.78e-02	GO:0071822	protein complex subunit organization
1.61	4.56e-02	GO:0016570	histone modification
1.34	4.81e-02	GO:0055086	nucleobase, nucleoside and nucleotide metabolic process
1.77	4.99e-02	GO:0051028	mRNA transport

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.17	4.29e-65	GO:0044424	intracellular part
1.16	1.43e-64	GO:0005622	intracellular
1.23	3.84e-54	GO:0005737	cytoplasm
1.18	6.42e-45	GO:0043226	organelle
1.18	1.13e-44	GO:0043229	intracellular organelle
1.19	1.36e-41	GO:0043227	membrane-bounded organelle
1.19	5.34e-41	GO:0043231	intracellular membrane-bounded organelle
1.24	2.58e-34	GO:0044444	cytoplasmic part
1.23	4.83e-26	GO:0044422	organelle part
1.23	1.12e-25	GO:0044446	intracellular organelle part
1.41	9.95e-24	GO:0005829	cytosol
1.21	2.07e-21	GO:0005634	nucleus
1.36	1.24e-19	GO:0044428	nuclear part
1.33	1.58e-17	GO:0031974	membrane-enclosed lumen
1.33	1.02e-16	GO:0043233	organelle lumen
1.33	2.56e-16	GO:0070013	intracellular organelle lumen
1.36	5.54e-16	GO:0031981	nuclear lumen
1.41	2.46e-14	GO:0005654	nucleoplasm
1.05	4.80e-14	GO:0044464	cell part
1.05	5.32e-14	GO:0005623	cell
1.21	2.45e-09	GO:0043234	protein complex
1.19	6.26e-09	GO:0032991	macromolecular complex
1.29	1.36e-08	GO:0012505	endomembrane system
1.31	2.29e-06	GO:0000267	cell fraction
1.33	3.04e-06	GO:0005794	Golgi apparatus
1.18	5.54e-06	GO:0043228	non-membrane-bounded organelle
1.18	5.54e-06	GO:0043232	intracellular non-membrane-bounded organelle
1.37	1.72e-05	GO:0044451	nucleoplasm part
1.20	7.37e-05	GO:0031090	organelle membrane
1.61	1.38e-04	GO:0005635	nuclear envelope
1.69	2.27e-04	GO:0031252	cell leading edge
1.39	2.37e-04	GO:0005694	chromosome
1.49	4.68e-04	GO:0005625	soluble fraction
1.30	7.05e-04	GO:0005626	insoluble fraction
1.32	8.12e-04	GO:0031975	envelope
2.11	1.14e-03	GO:0031256	leading edge membrane
1.71	1.16e-03	GO:0005912	adherens junction
2.47	1.55e-03	GO:0032587	ruffle membrane
1.31	2.32e-03	GO:0031967	organelle envelope
1.28	3.13e-03	GO:0005624	membrane fraction
1.33	3.54e-03	GO:0044431	Golgi apparatus part
1.43	3.95e-03	GO:0048471	perinuclear region of cytoplasm
1.52	5.54e-03	GO:0000785	chromatin
1.61	6.88e-03	GO:0070161	anchoring junction
1.26	9.33e-03	GO:0042995	cell projection
1.44	1.19e-02	GO:0015629	actin cytoskeleton
1.26	1.37e-02	GO:0031982	vesicle
1.49	1.59e-02	GO:0016323	basolateral plasma membrane
1.18	2.47e-02	GO:0005856	cytoskeleton
1.26	3.61e-02	GO:0031988	membrane-bounded vesicle
1.33	3.88e-02	GO:0044427	chromosomal part
1.99	3.99e-02	GO:0016605	PML body
1.26	4.05e-02	GO:0016023	cytoplasmic membrane-bounded vesicle
1.25	4.22e-02	GO:0031410	cytoplasmic vesicle
3.97	4.53e-02	GO:0005606	laminin-1 complex
3.97	4.53e-02	GO:0005885	Arp2/3 protein complex
1.47	4.99e-02	GO:0016604	nuclear body

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.29	1.10e-65	GO:0005515	protein binding
1.14	1.50e-47	GO:0005488	binding
1.27	4.44e-11	GO:0000166	nucleotide binding
1.15	1.34e-10	GO:0003824	catalytic activity
1.48	7.10e-10	GO:0019899	enzyme binding
1.41	9.48e-09	GO:0016772	transferase activity, transferring phosphorus-containing groups
1.59	1.64e-08	GO:0019904	protein domain specific binding
1.42	7.75e-08	GO:0016301	kinase activity
1.43	9.01e-08	GO:0042802	identical protein binding
1.25	3.70e-07	GO:0017076	purine nucleotide binding
1.24	8.02e-07	GO:0032553	ribonucleotide binding
1.24	8.02e-07	GO:0032555	purine ribonucleotide binding
1.26	8.33e-07	GO:0016740	transferase activity
1.41	9.29e-07	GO:0016773	phosphotransferase activity, alcohol group as acceptor
1.24	1.56e-06	GO:0035639	purine ribonucleoside triphosphate binding
1.56	2.39e-06	GO:0003712	transcription cofactor activity
1.56	2.97e-06	GO:0000988	protein binding transcription factor activity
1.56	2.97e-06	GO:0000989	transcription factor binding transcription factor activity
1.42	3.29e-06	GO:0046983	protein dimerization activity
1.26	3.65e-06	GO:0030554	adenyl nucleotide binding
1.25	9.79e-06	GO:0032559	adenyl ribonucleotide binding
1.86	1.66e-05	GO:0003714	transcription corepressor activity
1.60	2.02e-05	GO:0008134	transcription factor binding
1.41	2.17e-05	GO:0004672	protein kinase activity
1.32	2.23e-05	GO:0001071	nucleic acid binding transcription factor activity
1.32	2.23e-05	GO:0003700	sequence-specific DNA binding transcription factor activity
1.25	2.65e-05	GO:0005524	ATP binding
1.45	1.95e-04	GO:0004674	protein serine/threonine kinase activity
1.66	4.20e-04	GO:0010843	promoter binding
1.63	6.78e-04	GO:0000975	regulatory region DNA binding
1.63	6.78e-04	GO:0001067	regulatory region nucleic acid binding
1.63	6.78e-04	GO:0044212	transcription regulatory region DNA binding
2.38	1.06e-03	GO:0046332	SMAD binding
1.33	1.74e-03	GO:0043565	sequence-specific DNA binding
1.16	3.10e-03	GO:0003677	DNA binding
1.13	4.91e-03	GO:0003676	nucleic acid binding
1.91	1.24e-02	GO:0031625	ubiquitin protein ligase binding
1.33	1.38e-02	GO:0008092	cytoskeletal protein binding
1.48	1.55e-02	GO:0032403	protein complex binding
3.36	1.61e-02	GO:0070412	R-SMAD binding
1.43	1.89e-02	GO:0016563	transcription activator activity
1.50	2.60e-02	GO:0046982	protein heterodimerization activity
1.90	3.02e-02	GO:0047485	protein N-terminus binding
1.47	3.83e-02	GO:0016791	phosphatase activity