Motif ID: TFAP2B.p2

Z-value: 1.884


Transcription factors associated with TFAP2B.p2:

Gene SymbolEntrez IDGene Name
TFAP2B 7021 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Bchr6_+_50786438-0.562.7e-19Click!


Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_105261850 35.939 AKT1
v-akt murine thymoma viral oncogene homolog 1
chr12_-_123756164 29.580 NM_004642
 CDK2AP1
cyclin-dependent kinase 2 associated protein 1
chr1_-_1822501 27.322 GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr13_-_99229037 26.631 STK24
serine/threonine kinase 24
chrX_-_153602998 26.138 NM_001110556
NM_001456
 FLNA

filamin A, alpha

chr4_-_1242882 24.689 NM_001012614
NM_001328
 CTBP1

C-terminal binding protein 1

chr11_-_535532 24.559 NM_001130442
NM_005343
NM_176795
 HRAS


v-Ha-ras Harvey rat sarcoma viral oncogene homolog


chr10_+_99185977 23.961 PGAM1
phosphoglycerate mutase 1 (brain)
chr11_-_64014407 23.687 NM_138689
 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr4_-_1242742 23.682 CTBP1
C-terminal binding protein 1
chr11_-_64014264 23.619 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr8_+_146277789 23.156 NM_023080
 C8orf33
chromosome 8 open reading frame 33
chr9_+_131451519 22.942 SET
SET nuclear oncogene
chr14_-_105262078 22.934 NM_001014431
NM_001014432
 AKT1

v-akt murine thymoma viral oncogene homolog 1

chr8_+_146277830 22.817 C8orf33
chromosome 8 open reading frame 33
chr9_+_131451847 22.778 SET
SET nuclear oncogene
chr20_+_57466248 21.890 NM_000516
NM_001077488
NM_001077489
NM_080426
 GNAS



GNAS complex locus



chr2_+_181845605 21.445 UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr12_-_118498893 21.397 NM_018639
 WSB2
WD repeat and SOCS box containing 2
chr2_+_102314162 21.386 NM_001242560
NM_004834
NM_145686
NM_001242559
NM_145687
 MAP4K4




mitogen-activated protein kinase kinase kinase kinase 4





Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 231 entries
enrichment   p-value GO term description
2.75 1.42e-02 GO:0030010 establishment of cell polarity
2.24 4.04e-03 GO:0007163 establishment or maintenance of cell polarity
2.19 5.16e-03 GO:0001889 liver development
2.16 1.22e-03 GO:0006921 cellular component disassembly involved in apoptosis
2.15 8.55e-03 GO:0061008 hepaticobiliary system development
1.96 3.70e-02 GO:0007173 epidermal growth factor receptor signaling pathway
1.95 1.50e-04 GO:0007265 Ras protein signal transduction
1.77 4.99e-02 GO:0051028 mRNA transport
1.76 4.26e-03 GO:0051099 positive regulation of binding
1.76 1.68e-02 GO:0006403 RNA localization
1.75 2.95e-02 GO:0050657 nucleic acid transport
1.75 2.95e-02 GO:0050658 RNA transport
1.75 2.95e-02 GO:0051236 establishment of RNA localization
1.73 1.48e-03 GO:0006417 regulation of translation
1.72 2.32e-02 GO:0006112 energy reserve metabolic process
1.68 2.27e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.64 1.67e-02 GO:0006913 nucleocytoplasmic transport
1.63 2.13e-02 GO:0016569 covalent chromatin modification
1.62 3.02e-03 GO:0045786 negative regulation of cell cycle
1.62 9.05e-03 GO:0044087 regulation of cellular component biogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 57 entries
enrichment   p-value GO term description
3.97 4.53e-02 GO:0005606 laminin-1 complex
3.97 4.53e-02 GO:0005885 Arp2/3 protein complex
2.47 1.55e-03 GO:0032587 ruffle membrane
2.11 1.14e-03 GO:0031256 leading edge membrane
1.99 3.99e-02 GO:0016605 PML body
1.71 1.16e-03 GO:0005912 adherens junction
1.69 2.27e-04 GO:0031252 cell leading edge
1.61 1.38e-04 GO:0005635 nuclear envelope
1.61 6.88e-03 GO:0070161 anchoring junction
1.52 5.54e-03 GO:0000785 chromatin
1.49 4.68e-04 GO:0005625 soluble fraction
1.49 1.59e-02 GO:0016323 basolateral plasma membrane
1.47 4.99e-02 GO:0016604 nuclear body
1.44 1.19e-02 GO:0015629 actin cytoskeleton
1.43 3.95e-03 GO:0048471 perinuclear region of cytoplasm
1.41 9.95e-24 GO:0005829 cytosol
1.41 2.46e-14 GO:0005654 nucleoplasm
1.39 2.37e-04 GO:0005694 chromosome
1.37 1.72e-05 GO:0044451 nucleoplasm part
1.36 1.24e-19 GO:0044428 nuclear part

Gene overrepresentation in function category:

Showing 1 to 20 of 44 entries
enrichment   p-value GO term description
3.36 1.61e-02 GO:0070412 R-SMAD binding
2.38 1.06e-03 GO:0046332 SMAD binding
1.91 1.24e-02 GO:0031625 ubiquitin protein ligase binding
1.90 3.02e-02 GO:0047485 protein N-terminus binding
1.86 1.66e-05 GO:0003714 transcription corepressor activity
1.66 4.20e-04 GO:0010843 promoter binding
1.63 6.78e-04 GO:0000975 regulatory region DNA binding
1.63 6.78e-04 GO:0001067 regulatory region nucleic acid binding
1.63 6.78e-04 GO:0044212 transcription regulatory region DNA binding
1.60 2.02e-05 GO:0008134 transcription factor binding
1.59 1.64e-08 GO:0019904 protein domain specific binding
1.56 2.39e-06 GO:0003712 transcription cofactor activity
1.56 2.97e-06 GO:0000988 protein binding transcription factor activity
1.56 2.97e-06 GO:0000989 transcription factor binding transcription factor activity
1.50 2.60e-02 GO:0046982 protein heterodimerization activity
1.48 7.10e-10 GO:0019899 enzyme binding
1.48 1.55e-02 GO:0032403 protein complex binding
1.47 3.83e-02 GO:0016791 phosphatase activity
1.45 1.95e-04 GO:0004674 protein serine/threonine kinase activity
1.43 9.01e-08 GO:0042802 identical protein binding