Motif ID: TFAP4.p2

Z-value: 1.590


Transcription factors associated with TFAP4.p2:

Gene SymbolEntrez IDGene Name
TFAP4 7023 transcription factor AP-4 (activating enhancer binding protein 4)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP4chr16_-_4323000,
chr16_-_4322695		-0.153.0e-02Click!


Activity profile for motif TFAP4.p2.

activity profile for motif TFAP4.p2


Sorted Z-values histogram for motif TFAP4.p2

Sorted Z-values for motif TFAP4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_-_23066828 19.557 NM_012072
 CD93
CD93 molecule
chr6_+_37137882 16.830 NM_001243186
NM_002648
 PIM1

pim-1 oncogene

chr1_+_207495086 13.717 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr8_-_48650683 13.421 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr1_+_207495070 12.955 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr1_+_207495009 12.235 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr1_+_207494816 11.805 NM_000574
NM_001114752
 CD55

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

chr10_-_3827205 11.110 KLF6
Kruppel-like factor 6
chr3_+_122785855 10.099 NM_006810
 PDIA5
protein disulfide isomerase family A, member 5
chr22_+_23229959 9.945 NM_001178126
 IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr11_-_320925 9.888 IFITM3
interferon induced transmembrane protein 3
chrX_-_106960028 9.582 TSC22D3
TSC22 domain family, member 3
chr10_-_126849010 9.273 CTBP2
C-terminal binding protein 2
chr12_-_92539614 9.166 NM_001731
 BTG1
B-cell translocation gene 1, anti-proliferative
chr12_-_54813010 9.113 NM_002205
 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr1_+_209848659 9.021 NM_015714
 G0S2
G0/G1switch 2
chr1_+_182992694 8.930


chr1_+_55464605 8.892 NM_057176
 BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr5_-_140013034 8.814 NM_000591
 CD14
CD14 molecule
chr1_-_22263676 8.522 NM_005529
 HSPG2
heparan sulfate proteoglycan 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 67 entries
enrichment   p-value GO term description
2.88 4.31e-03 GO:0007179 transforming growth factor beta receptor signaling pathway
2.83 4.86e-02 GO:0045667 regulation of osteoblast differentiation
2.83 4.86e-02 GO:0048593 camera-type eye morphogenesis
2.33 1.35e-02 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
1.93 8.04e-04 GO:0001568 blood vessel development
1.89 1.10e-03 GO:0001944 vasculature development
1.89 9.67e-03 GO:0006897 endocytosis
1.89 9.67e-03 GO:0010324 membrane invagination
1.86 7.60e-03 GO:0030334 regulation of cell migration
1.86 4.82e-02 GO:0048514 blood vessel morphogenesis
1.84 1.15e-02 GO:2000145 regulation of cell motility
1.80 1.13e-02 GO:0040012 regulation of locomotion
1.79 1.28e-02 GO:0051270 regulation of cellular component movement
1.78 2.89e-05 GO:0072358 cardiovascular system development
1.78 2.89e-05 GO:0072359 circulatory system development
1.69 2.24e-05 GO:0009887 organ morphogenesis
1.68 7.91e-06 GO:0007167 enzyme linked receptor protein signaling pathway
1.58 1.30e-03 GO:0030030 cell projection organization
1.53 1.06e-02 GO:0032989 cellular component morphogenesis
1.52 1.77e-03 GO:0006955 immune response

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
2.42 1.74e-04 GO:0005765 lysosomal membrane
2.13 3.67e-02 GO:0005924 cell-substrate adherens junction
2.12 2.62e-07 GO:0000323 lytic vacuole
2.12 2.62e-07 GO:0005764 lysosome
2.12 1.26e-03 GO:0005774 vacuolar membrane
2.02 2.09e-03 GO:0016324 apical plasma membrane
2.02 4.26e-03 GO:0044437 vacuolar part
2.01 3.12e-03 GO:0070161 anchoring junction
2.01 8.10e-03 GO:0005912 adherens junction
1.95 2.89e-06 GO:0005773 vacuole
1.80 1.81e-02 GO:0045177 apical part of cell
1.79 9.22e-03 GO:0016323 basolateral plasma membrane
1.68 1.33e-03 GO:0031012 extracellular matrix
1.68 8.97e-03 GO:0005578 proteinaceous extracellular matrix
1.47 5.06e-07 GO:0031226 intrinsic to plasma membrane
1.46 1.90e-06 GO:0005887 integral to plasma membrane
1.40 7.53e-10 GO:0044459 plasma membrane part
1.40 9.86e-04 GO:0044421 extracellular region part
1.39 2.79e-02 GO:0005615 extracellular space
1.35 8.47e-03 GO:0000267 cell fraction

Gene overrepresentation in function category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
5.53 3.94e-02 GO:0004576 oligosaccharyl transferase activity
3.55 4.28e-04 GO:0003823 antigen binding
2.98 1.57e-02 GO:0046332 SMAD binding
2.14 4.14e-02 GO:0019838 growth factor binding
2.02 1.77e-02 GO:0003714 transcription corepressor activity
1.47 2.14e-02 GO:0004672 protein kinase activity
1.45 7.45e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.40 2.57e-02 GO:0016301 kinase activity
1.19 3.33e-11 GO:0005515 protein binding
1.17 9.31e-03 GO:0046872 metal ion binding
1.16 2.14e-02 GO:0043169 cation binding
1.16 2.24e-02 GO:0043167 ion binding
1.10 1.17e-09 GO:0005488 binding