Motif ID: TFEB.p2

Z-value: 1.914


Transcription factors associated with TFEB.p2:

Gene SymbolEntrez IDGene Name
TFEB 7942 transcription factor EB

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFEBchr6_-_41702734,
chr6_-_41703938		0.211.9e-03Click!


Activity profile for motif TFEB.p2.

activity profile for motif TFEB.p2


Sorted Z-values histogram for motif TFEB.p2

Sorted Z-values for motif TFEB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFEB.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_113951537 91.759 LAMP1
lysosomal-associated membrane protein 1
chr1_-_154193044 83.179 C1orf43
chromosome 1 open reading frame 43
chr13_+_113951461 80.153 NM_005561
 LAMP1
lysosomal-associated membrane protein 1
chr19_-_10764449 72.680 LOC147727
uncharacterized LOC147727
chr20_+_44520021 69.536 CTSA
cathepsin A
chr19_+_40854529 64.063 PLD3
phospholipase D family, member 3
chr13_+_113951589 61.333 LAMP1
lysosomal-associated membrane protein 1
chr16_-_1525020 61.067 CLCN7
chloride channel 7
chr20_+_44519924 58.729 CTSA
cathepsin A
chr20_+_44519965 55.447 CTSA
cathepsin A
chr1_+_11866240 49.304 CLCN6
chloride channel 6
chr16_-_67514989 48.954 NM_004691
 ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr15_-_72668184 47.654 HEXA
hexosaminidase A (alpha polypeptide)
chr16_-_1525006 45.935 CLCN7
chloride channel 7
chr18_+_9708322 39.285 RAB31
RAB31, member RAS oncogene family
chr19_+_7587436 37.730 NM_020533
 MCOLN1
mucolipin 1
chr4_+_128651518 34.403 NM_031291
 SLC25A31
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
chr19_+_5681139 33.956 HSD11B1L
hydroxysteroid (11-beta) dehydrogenase 1-like
chr1_+_154193294 33.611 NM_014847
 UBAP2L
ubiquitin associated protein 2-like
chr1_-_11865963 33.300 MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 38 entries
enrichment   p-value GO term description
9.23 3.48e-06 GO:0015682 ferric iron transport
9.23 3.48e-06 GO:0015988 energy coupled proton transport, against electrochemical gradient
9.23 3.48e-06 GO:0015991 ATP hydrolysis coupled proton transport
9.23 3.48e-06 GO:0033572 transferrin transport
7.69 2.43e-03 GO:0007040 lysosome organization
6.73 1.85e-05 GO:0007033 vacuole organization
5.57 2.59e-04 GO:0015992 proton transport
5.38 4.09e-04 GO:0006818 hydrogen transport
5.13 3.61e-02 GO:0048167 regulation of synaptic plasticity
4.86 9.66e-03 GO:0006826 iron ion transport
4.75 2.10e-03 GO:0055072 iron ion homeostasis
4.62 7.18e-03 GO:0006879 cellular iron ion homeostasis
3.66 1.39e-02 GO:0000041 transition metal ion transport
2.82 2.35e-02 GO:0034220 ion transmembrane transport
2.79 4.73e-03 GO:0032868 response to insulin stimulus
2.61 2.41e-02 GO:0006897 endocytosis
2.61 2.41e-02 GO:0010324 membrane invagination
2.55 1.21e-03 GO:0071495 cellular response to endogenous stimulus
2.49 5.97e-03 GO:0032870 cellular response to hormone stimulus
2.37 1.24e-02 GO:0043434 response to peptide hormone stimulus

Gene overrepresentation in compartment category:

Showing 1 to 20 of 32 entries
enrichment   p-value GO term description
15.38 1.60e-02 GO:0033179 proton-transporting V-type ATPase, V0 domain
12.82 5.39e-03 GO:0033180 proton-transporting V-type ATPase, V1 domain
11.54 9.11e-07 GO:0033176 proton-transporting V-type ATPase complex
8.97 1.92e-03 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain
6.44 5.95e-05 GO:0016469 proton-transporting two-sector ATPase complex
5.19 3.40e-07 GO:0042470 melanosome
5.19 3.40e-07 GO:0048770 pigment granule
4.65 4.80e-10 GO:0005774 vacuolar membrane
4.44 1.66e-09 GO:0044437 vacuolar part
4.12 6.50e-17 GO:0005773 vacuole
4.05 2.96e-05 GO:0005765 lysosomal membrane
3.94 4.62e-05 GO:0005770 late endosome
3.63 2.44e-10 GO:0000323 lytic vacuole
3.63 2.44e-10 GO:0005764 lysosome
3.55 7.63e-05 GO:0005769 early endosome
2.62 1.14e-03 GO:0010008 endosome membrane
2.60 1.34e-03 GO:0044440 endosomal part
2.58 6.48e-07 GO:0005768 endosome
2.03 1.22e-05 GO:0031982 vesicle
2.00 4.21e-05 GO:0031410 cytoplasmic vesicle

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
11.54 8.10e-06 GO:0046961 proton-transporting ATPase activity, rotational mechanism
7.69 1.39e-04 GO:0019829 cation-transporting ATPase activity
4.35 3.25e-03 GO:0042625 ATPase activity, coupled to transmembrane movement of ions
3.73 2.40e-03 GO:0042626 ATPase activity, coupled to transmembrane movement of substances
3.69 2.75e-03 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
3.69 2.75e-03 GO:0043492 ATPase activity, coupled to movement of substances
3.39 8.47e-03 GO:0015399 primary active transmembrane transporter activity
3.39 8.47e-03 GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity
3.33 3.36e-02 GO:0015078 hydrogen ion transmembrane transporter activity
2.24 6.45e-03 GO:0022804 active transmembrane transporter activity
1.20 2.80e-03 GO:0005515 protein binding