Motif ID: TLX2.p2

Z-value: 1.383


Transcription factors associated with TLX2.p2:

Gene SymbolEntrez IDGene Name
TLX2 3196 T-cell leukemia homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX2chr2_+_747415650.464.7e-13Click!


Activity profile for motif TLX2.p2.

activity profile for motif TLX2.p2


Sorted Z-values histogram for motif TLX2.p2

Sorted Z-values for motif TLX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_111303240 22.063 NM_032194
 RPF2
ribosome production factor 2 homolog (S. cerevisiae)
chr12_-_91572328 18.513 NM_133504
NM_133505
NM_133506
NM_133507
 DCN



decorin



chr1_-_153363544 17.530 NM_002964
 S100A8
S100 calcium binding protein A8
chr19_-_37019169 17.038 NM_001012756
NM_001166036
NM_001166037
NM_001166038
 ZNF260



zinc finger protein 260



chr20_+_47895168 16.058 ZNFX1-AS1
ZNFX1 antisense RNA 1 (non-protein coding)
chr16_+_84853585 15.223 NM_031476
 CRISPLD2
cysteine-rich secretory protein LCCL domain containing 2
chr15_+_74422920 14.654 ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr20_-_39766522 13.431


chr19_+_58095507 12.979 NM_001010879
 ZIK1
zinc finger protein interacting with K protein 1 homolog (mouse)
chr11_+_57365577 12.927 NM_001032295
 SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr19_+_37407230 12.452 NM_001204835
NM_001204836
NM_001204837
NM_001204838
NM_001204839
NM_198539
 ZNF568





zinc finger protein 568





chr15_+_74422742 12.147 NM_020851
 ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr2_+_189839132 11.784 COL3A1
collagen, type III, alpha 1
chr11_+_117070039 11.771 NM_001001522
NM_003186
 TAGLN

transgelin

chr16_+_58283819 11.751 NM_001142302
NM_014157
 CCDC113

coiled-coil domain containing 113

chr1_+_153330329 11.138 NM_002965
 S100A9
S100 calcium binding protein A9
chr19_+_57752051 11.107 NM_001023563
NM_001145078
 ZNF805

zinc finger protein 805

chrX_+_117480416 9.887 WDR44
WD repeat domain 44
chr4_-_88450243 9.708 SPARCL1
SPARC-like 1 (hevin)
chr8_-_27941387 9.665 NM_001010906
 C8orf80
chromosome 8 open reading frame 80

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 66 entries
enrichment   p-value GO term description
5.51 2.98e-03 GO:0003156 regulation of organ formation
3.35 1.85e-02 GO:0019724 B cell mediated immunity
3.11 1.05e-02 GO:2000027 regulation of organ morphogenesis
2.33 2.16e-04 GO:0002253 activation of immune response
2.23 4.07e-02 GO:0001654 eye development
2.22 3.47e-02 GO:0010038 response to metal ion
2.21 2.19e-02 GO:0002764 immune response-regulating signaling pathway
2.19 3.36e-02 GO:0002757 immune response-activating signal transduction
2.18 4.83e-03 GO:0051249 regulation of lymphocyte activation
2.16 2.33e-04 GO:0050778 positive regulation of immune response
2.16 2.74e-02 GO:0007517 muscle organ development
2.09 5.15e-03 GO:0050865 regulation of cell activation
2.08 1.04e-02 GO:0002694 regulation of leukocyte activation
2.00 2.02e-05 GO:0002684 positive regulation of immune system process
1.95 7.04e-05 GO:0050776 regulation of immune response
1.94 2.67e-09 GO:0006955 immune response
1.93 1.96e-03 GO:0045087 innate immune response
1.90 3.32e-02 GO:0022603 regulation of anatomical structure morphogenesis
1.82 4.81e-06 GO:0002682 regulation of immune system process
1.81 8.98e-05 GO:0009887 organ morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
6.30 3.42e-03 GO:0042613 MHC class II protein complex
5.51 3.87e-03 GO:0032982 myosin filament
4.90 3.57e-02 GO:0005859 muscle myosin complex
3.39 3.68e-03 GO:0031983 vesicle lumen
3.31 9.78e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
3.29 3.11e-03 GO:0031091 platelet alpha granule
3.28 1.98e-02 GO:0031093 platelet alpha granule lumen
3.27 9.95e-04 GO:0016459 myosin complex
3.22 2.57e-02 GO:0034774 secretory granule lumen
2.56 8.73e-03 GO:0005925 focal adhesion
2.54 6.58e-03 GO:0005924 cell-substrate adherens junction
2.45 1.28e-02 GO:0030055 cell-substrate junction
2.32 6.32e-03 GO:0009897 external side of plasma membrane
2.26 8.08e-09 GO:0031012 extracellular matrix
2.16 3.79e-06 GO:0005578 proteinaceous extracellular matrix
2.15 1.65e-03 GO:0030141 stored secretory granule
2.14 1.31e-02 GO:0070161 anchoring junction
1.97 9.68e-04 GO:0015629 actin cytoskeleton
1.86 1.33e-12 GO:0044421 extracellular region part
1.86 1.73e-09 GO:0005615 extracellular space

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
5.51 2.20e-02 GO:0000146 microfilament motor activity
5.51 2.20e-02 GO:0019865 immunoglobulin binding
1.83 1.22e-02 GO:0003779 actin binding
1.58 2.81e-05 GO:0005102 receptor binding
1.15 4.29e-04 GO:0005515 protein binding
1.09 1.79e-04 GO:0005488 binding