Motif ID: TP53.p2

Z-value: 1.714


Transcription factors associated with TP53.p2:

Gene SymbolEntrez IDGene Name
TP53 7157 tumor protein p53

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TP53chr17_-_75907310.511.4e-15Click!


Activity profile for motif TP53.p2.

activity profile for motif TP53.p2


Sorted Z-values histogram for motif TP53.p2

Sorted Z-values for motif TP53.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_64455184 39.376 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr15_-_64455206 37.642 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr15_-_64455158 36.840 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr15_-_64455190 36.717 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr15_-_64455299 35.464 NM_000942
 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr6_+_36644236 34.946 NM_001220777
NM_078467
 CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr20_-_32891075 32.064 NM_000687
 AHCY
adenosylhomocysteinase
chr1_+_156052330 30.992 LMNA
lamin A/C
chr17_+_76210329 28.562 BIRC5
baculoviral IAP repeat containing 5
chr2_-_74756824 27.604 AUP1
ancient ubiquitous protein 1
chr17_+_76210276 25.226 NM_001012270
NM_001012271
NM_001168
 BIRC5


baculoviral IAP repeat containing 5


chr6_-_138428477 25.028 NM_022121
 PERP
PERP, TP53 apoptosis effector
chr12_+_56498324 24.855 PA2G4
proliferation-associated 2G4, 38kDa
chr20_+_35234152 24.576 C20orf24
chromosome 20 open reading frame 24
chr6_-_30712294 24.416 NM_003897
 IER3
immediate early response 3
chr4_-_10118358 24.234 WDR1
WD repeat domain 1
chr1_+_224544550 23.621 CNIH4
cornichon homolog 4 (Drosophila)
chr3_+_127771287 23.326 SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr12_+_56498347 23.135 PA2G4
proliferation-associated 2G4, 38kDa
chr4_-_10118378 23.040 WDR1
WD repeat domain 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
4.17 1.17e-02 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
3.81 3.35e-02 GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade
3.63 3.00e-02 GO:0031400 negative regulation of protein modification process
2.77 1.24e-02 GO:0006917 induction of apoptosis
2.76 1.30e-02 GO:0012502 induction of programmed cell death
2.73 1.06e-02 GO:0044271 cellular nitrogen compound biosynthetic process
2.36 3.28e-02 GO:0043065 positive regulation of apoptosis
2.34 3.69e-02 GO:0043068 positive regulation of programmed cell death
2.25 1.72e-05 GO:0042981 regulation of apoptosis
2.24 2.32e-05 GO:0043067 regulation of programmed cell death
2.20 4.02e-05 GO:0010941 regulation of cell death
2.09 4.72e-02 GO:0006915 apoptosis
1.68 1.83e-04 GO:0048522 positive regulation of cellular process
1.66 1.88e-02 GO:0044281 small molecule metabolic process
1.64 1.28e-03 GO:0044249 cellular biosynthetic process
1.62 1.41e-03 GO:0009058 biosynthetic process
1.61 6.04e-04 GO:0048518 positive regulation of biological process
1.56 1.27e-02 GO:0044267 cellular protein metabolic process
1.51 7.20e-03 GO:0019538 protein metabolic process
1.51 2.28e-02 GO:0071841 cellular component organization or biogenesis at cellular level

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
5.06 1.17e-03 GO:0042470 melanosome
5.06 1.17e-03 GO:0048770 pigment granule
2.66 6.23e-03 GO:0019866 organelle inner membrane
2.53 3.12e-06 GO:0031967 organelle envelope
2.49 5.33e-06 GO:0031975 envelope
2.48 2.14e-03 GO:0005740 mitochondrial envelope
2.41 7.17e-03 GO:0031966 mitochondrial membrane
2.19 2.16e-03 GO:0044429 mitochondrial part
2.09 1.11e-06 GO:0005739 mitochondrion
2.01 5.62e-10 GO:0005829 cytosol
1.64 6.34e-04 GO:0031090 organelle membrane
1.61 7.38e-17 GO:0044444 cytoplasmic part
1.60 3.50e-02 GO:0012505 endomembrane system
1.59 1.25e-03 GO:0031974 membrane-enclosed lumen
1.54 1.19e-02 GO:0044428 nuclear part
1.52 1.11e-02 GO:0043233 organelle lumen
1.50 2.68e-02 GO:0070013 intracellular organelle lumen
1.48 3.14e-04 GO:0032991 macromolecular complex
1.45 1.59e-07 GO:0044446 intracellular organelle part
1.44 1.78e-07 GO:0044422 organelle part

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.39 3.07e-09 GO:0005515 protein binding
1.29 1.60e-02 GO:0003824 catalytic activity
1.14 1.65e-03 GO:0005488 binding