Motif ID: VSX1,2.p2

Z-value: 0.478


Transcription factors associated with VSX1,2.p2:

Gene SymbolEntrez IDGene Name
VSX1 30813 visual system homeobox 1
VSX2 338917 visual system homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
VSX1chr20_-_250627560.144.3e-02Click!


Activity profile for motif VSX1,2.p2.

activity profile for motif VSX1,2.p2


Sorted Z-values histogram for motif VSX1,2.p2

Sorted Z-values for motif VSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of VSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_43515406 11.651 NM_000240
MAOA
monoamine oxidase A
chr4_+_169418167 7.949 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chrX_+_43515441 7.156 MAOA
monoamine oxidase A
chr16_+_55515468 6.823 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr2_-_217560247 6.208 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr12_-_91505215 5.483 LUM
lumican
chr15_-_37393364 4.711 NM_001220482
NM_002399
MEIS2

Meis homeobox 2

chr2_+_189839132 4.156 COL3A1
collagen, type III, alpha 1
chr4_-_89978117 3.790 NM_014883
FAM13A
family with sequence similarity 13, member A
chr4_+_78432905 3.555 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr2_+_189839113 3.443 COL3A1
collagen, type III, alpha 1
chr11_-_118135197 3.443 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chrX_+_43515531 3.127 MAOA
monoamine oxidase A
chr16_-_20338808 2.755 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr8_+_22210311 2.655 PIWIL2
piwi-like 2 (Drosophila)
chr4_+_70796798 2.424 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr2_-_190927321 2.319 NM_005259
MSTN
myostatin
chr8_+_9413390 2.004 TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr11_-_120008801 1.972 TRIM29
tripartite motif containing 29
chr11_+_59824054 1.892 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr8_-_86290333 1.847 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr4_-_72669757 1.707 NM_001204307
GC
group-specific component (vitamin D binding protein)
chr5_-_39394423 1.569 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr6_+_90276556 1.505 NM_001242814
ANKRD6
ankyrin repeat domain 6
chr4_+_88571453 1.428 NM_001079911
NM_004407
DMP1

dentin matrix acidic phosphoprotein 1

chr12_-_53012332 1.346 NM_175068
KRT73
keratin 73
chr4_-_122137781 1.284 NM_001128843
TNIP3
TNFAIP3 interacting protein 3
chr6_+_29426130 1.149 NM_030883
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr12_-_4488707 1.118 NM_020638
FGF23
fibroblast growth factor 23
chr11_+_60048013 1.061 NM_001243266
NM_024021
NM_148975
MS4A4A


membrane-spanning 4-domains, subfamily A, member 4


chr19_+_50016490 1.000 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr1_+_160160284 0.967 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr10_+_5136613 0.934 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr6_+_121756744 0.905 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr7_-_99774821 0.904 NM_152742
GPC2
glypican 2
chr6_-_87804773 0.879 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr9_+_21440452 0.852 NM_024013
IFNA1
interferon, alpha 1
chr10_+_96443250 0.848 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr3_-_114343791 0.835 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr11_+_59824129 0.833 MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr11_+_17741109 0.828 NM_002478
MYOD1
myogenic differentiation 1
chr11_-_118134986 0.802 MPZL2
myelin protein zero-like 2
chr11_-_120008738 0.801 TRIM29
tripartite motif containing 29
chr11_-_114466397 0.790 FAM55D
family with sequence similarity 55, member D
chr7_+_37723378 0.780


chr6_+_64231626 0.771 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr14_-_106573348 0.733 IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr16_-_73092533 0.720 NM_001164766
ZFHX3
zinc finger homeobox 3
chr1_-_205325915 0.700 NM_018203
KLHDC8A
kelch domain containing 8A
chr4_+_140587086 0.694 MGST2
microsomal glutathione S-transferase 2
chr13_-_34250899 0.690 NM_001243476
STARD13
StAR-related lipid transfer (START) domain containing 13
chr6_+_161123224 0.689 NM_000301
NM_001168338
PLG

plasminogen

chr18_+_61554938 0.682 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr1_-_68697997 0.642 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr22_-_18923963 0.638 NM_001195226
NM_016335
PRODH

proline dehydrogenase (oxidase) 1

chr22_+_23154240 0.628


chr18_+_46065367 0.622 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr11_-_114466471 0.616 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr1_+_111770280 0.614 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr3_-_101039403 0.602 NM_016247
IMPG2
interphotoreceptor matrix proteoglycan 2
chr8_-_17743062 0.588 FGL1
fibrinogen-like 1
chr6_+_28317687 0.586 NM_001242894
NM_001242895
NM_024493
ZKSCAN3


zinc finger with KRAB and SCAN domains 3


chr8_+_19796581 0.579 NM_000237
LPL
lipoprotein lipase
chr3_-_167191808 0.576 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr8_-_87755880 0.528 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr1_-_150738232 0.524 CTSS
cathepsin S
chr7_-_81399286 0.507 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr10_-_52645430 0.488 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr4_-_39979159 0.488 PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr7_+_129008044 0.479 AHCYL2
adenosylhomocysteinase-like 2
chr9_+_132897342 0.459 GPR107
G protein-coupled receptor 107
chr10_-_33224485 0.454 NM_033668
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr21_-_35899046 0.442 NM_203418
RCAN1
regulator of calcineurin 1
chr12_-_52828105 0.438 NM_004693
KRT75
keratin 75
chr4_-_39979549 0.438 NM_001100399
NM_001100400
PDS5A

PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)

chr7_-_44580857 0.430 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr3_-_108248168 0.426 NM_014981
MYH15
myosin, heavy chain 15
chr9_-_21202201 0.426 NM_021057
IFNA7
interferon, alpha 7
chr6_+_27925018 0.417 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr7_-_83824216 0.406 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr12_+_18414473 0.381 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chrX_+_7137471 0.380 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr4_-_72649734 0.380 NM_000583
GC
group-specific component (vitamin D binding protein)
chr18_+_3447607 0.349 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr4_+_5526882 0.348 NM_005750
C4orf6
chromosome 4 open reading frame 6
chr11_+_89764273 0.346 NM_001195234
TRIM49L2
tripartite motif containing 49-like 2
chr1_+_28261503 0.343 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr11_-_89541742 0.340 NM_020358
TRIM49
tripartite motif containing 49
chr11_-_118134956 0.327 MPZL2
myelin protein zero-like 2
chr3_+_69985750 0.307 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chr12_-_71031174 0.307 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr12_-_25150372 0.304 NM_001101339
C12orf77
chromosome 12 open reading frame 77
chr6_+_29079586 0.296 NM_001005216
OR2J3
olfactory receptor, family 2, subfamily J, member 3
chr11_-_128894008 0.290 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr7_+_116660291 0.281 ST7
suppression of tumorigenicity 7
chr2_+_202047620 0.267 NM_001206524
NM_001206542
NM_001230
NM_032974
NM_032976
NM_032977
CASP10





caspase 10, apoptosis-related cysteine peptidase





chr1_+_207226594 0.257 NM_001018053
NM_006212
PFKFB2

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

chr1_-_93257950 0.240 NM_005665
EVI5
ecotropic viral integration site 5
chr22_+_41957011 0.234 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr11_-_128737132 0.233 NM_153764
NM_153765
NM_153766
NM_153767
KCNJ1



potassium inwardly-rectifying channel, subfamily J, member 1



chr13_-_36050758 0.231 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr4_+_74301932 0.230 NM_001134
AFP
alpha-fetoprotein
chr11_+_87032428 0.229 TMEM135
transmembrane protein 135
chr6_+_160542862 0.227 NM_003057
NM_153187
SLC22A1

solute carrier family 22 (organic cation transporter), member 1

chr6_-_111888520 0.226 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chr6_+_155538096 0.218 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr10_-_92681025 0.215 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr1_-_108231122 0.213 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr1_-_173174611 0.209 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr15_+_100173182 0.203 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr1_+_81771844 0.201 LPHN2
latrophilin 2
chr1_+_117544371 0.179 NM_004258
CD101
CD101 molecule
chr3_-_164796275 0.177 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr18_-_53089722 0.168 NM_001243233
TCF4
transcription factor 4
chr12_-_56106061 0.161 NM_001144997
ITGA7
integrin, alpha 7
chrX_-_24690740 0.149 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr11_+_65984213 0.146 PACS1
phosphofurin acidic cluster sorting protein 1
chr7_-_25268057 0.143 NM_022150
NPVF
neuropeptide VF precursor
chr8_-_62602285 0.141 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr10_+_32856650 0.137 NM_024688
C10orf68
chromosome 10 open reading frame 68
chrX_-_64196268 0.134 NM_001178033
NM_018684
ZC4H2

zinc finger, C4H2 domain containing

chr2_-_219031646 0.130 NM_000634
CXCR1
chemokine (C-X-C motif) receptor 1
chr1_-_186417855 0.125 NM_022576
PDC
phosducin
chr10_-_98321823 0.109 TM9SF3
transmembrane 9 superfamily member 3
chr11_+_45115563 0.107 NM_020229
PRDM11
PR domain containing 11
chr11_-_118900078 0.102 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chrX_-_138790328 0.099 NM_001099855
NM_001171876
MCF2

MCF.2 cell line derived transforming sequence

chr6_+_49467670 0.096 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr4_-_66536182 0.093 EPHA5
EPH receptor A5
chr3_+_155838336 0.085 NM_172160
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chrX_-_151619669 0.075 NM_000808
GABRA3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr6_-_47253962 0.071 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr12_-_58135853 0.069 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr1_-_152386727 0.052 NM_016190
CRNN
cornulin
chr16_-_67977956 0.046 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr10_+_95372344 0.021 NM_006204
PDE6C
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr18_-_51690988 0.015 MBD2
methyl-CpG binding domain protein 2
chr1_-_151431648 0.012 POGZ
pogo transposable element with ZNF domain
chr7_+_141811508 0.010 LOC93432
maltase-glucoamylase (alpha-glucosidase) pseudogene
chr1_+_151735444 0.007 NM_001134939
OAZ3
ornithine decarboxylase antizyme 3
chrX_+_108779009 0.006 NM_018698
NXT2
nuclear transport factor 2-like export factor 2
chr4_-_169239816 0.004 NM_017631
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.63 7.87e-05 GO:0005615 extracellular space
2.27 8.80e-04 GO:0005576 extracellular region
2.94 1.17e-03 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
16.89 1.59e-03 GO:0003823 antigen binding