Motif ID: ZEB1.p2

Z-value: 1.407


Transcription factors associated with ZEB1.p2:

Gene SymbolEntrez IDGene Name
ZEB1 6935 zinc finger E-box binding homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZEB1chr10_+_31607419-0.433.8e-11Click!


Activity profile for motif ZEB1.p2.

activity profile for motif ZEB1.p2


Sorted Z-values histogram for motif ZEB1.p2

Sorted Z-values for motif ZEB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZEB1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_38755097 49.281 NM_001166103
NM_021102
 SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr19_+_38755238 48.152 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_38755422 46.062 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_35739778 23.743 LSR
lipolysis stimulated lipoprotein receptor
chr19_+_35739519 23.185 NM_015925
NM_205834
NM_205835
 LSR


lipolysis stimulated lipoprotein receptor


chr2_+_47596447 22.760 EPCAM
epithelial cell adhesion molecule
chr2_+_47596286 22.377 NM_002354
 EPCAM
epithelial cell adhesion molecule
chr9_-_97401588 22.236 FBP1
fructose-1,6-bisphosphatase 1
chr17_-_39942937 18.999 NM_002230
NM_021991
 JUP

junction plakoglobin

chr9_-_97401746 18.653 FBP1
fructose-1,6-bisphosphatase 1
chr17_-_39684499 18.623 KRT19
keratin 19
chr6_+_7541837 18.119 DSP
desmoplakin
chr17_-_7165788 17.957 CLDN7
claudin 7
chr6_+_7541892 16.811 DSP
desmoplakin
chr19_+_35739282 16.771 LSR
lipolysis stimulated lipoprotein receptor
chr19_+_35739838 16.713 LSR
lipolysis stimulated lipoprotein receptor
chr16_+_68771192 16.501 NM_004360
 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr6_+_7541863 15.522 NM_001008844
NM_004415
 DSP

desmoplakin

chr9_-_97401833 14.479 NM_000507
 FBP1
fructose-1,6-bisphosphatase 1
chr17_-_7166263 14.270 NM_001185023
NM_001307
 CLDN7

claudin 7


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 52 entries
enrichment   p-value GO term description
1.53 2.57e-02 GO:0051094 positive regulation of developmental process
1.49 1.33e-05 GO:0006351 transcription, DNA-dependent
1.47 1.04e-02 GO:0009725 response to hormone stimulus
1.44 5.23e-07 GO:0051239 regulation of multicellular organismal process
1.43 2.25e-04 GO:0032774 RNA biosynthetic process
1.43 6.37e-03 GO:0006468 protein phosphorylation
1.43 6.70e-03 GO:2000026 regulation of multicellular organismal development
1.42 3.99e-02 GO:0010628 positive regulation of gene expression
1.41 1.86e-03 GO:0050793 regulation of developmental process
1.39 4.51e-06 GO:0009966 regulation of signal transduction
1.38 3.09e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.37 8.19e-08 GO:0048583 regulation of response to stimulus
1.37 6.16e-03 GO:0006793 phosphorus metabolic process
1.37 6.16e-03 GO:0006796 phosphate metabolic process
1.37 3.60e-02 GO:0016310 phosphorylation
1.36 9.97e-07 GO:0007166 cell surface receptor linked signaling pathway
1.36 5.38e-06 GO:0023051 regulation of signaling
1.33 1.24e-03 GO:0035556 intracellular signal transduction
1.33 3.49e-03 GO:0010033 response to organic substance
1.31 7.55e-05 GO:0048513 organ development

Gene overrepresentation in compartment category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
1.53 1.18e-07 GO:0005626 insoluble fraction
1.53 3.76e-07 GO:0005624 membrane fraction
1.52 1.01e-02 GO:0043005 neuron projection
1.45 3.32e-08 GO:0005887 integral to plasma membrane
1.44 3.06e-04 GO:0031988 membrane-bounded vesicle
1.43 6.02e-08 GO:0031226 intrinsic to plasma membrane
1.43 6.33e-04 GO:0016023 cytoplasmic membrane-bounded vesicle
1.41 9.09e-04 GO:0031982 vesicle
1.41 1.11e-03 GO:0031410 cytoplasmic vesicle
1.40 1.03e-05 GO:0000267 cell fraction
1.37 3.26e-11 GO:0044459 plasma membrane part
1.36 1.14e-02 GO:0005615 extracellular space
1.32 1.26e-02 GO:0005794 Golgi apparatus
1.15 5.01e-12 GO:0005737 cytoplasm
1.13 7.52e-05 GO:0044444 cytoplasmic part
1.08 1.40e-06 GO:0005622 intracellular
1.08 1.43e-06 GO:0044424 intracellular part
1.07 2.62e-02 GO:0043227 membrane-bounded organelle
1.07 2.88e-02 GO:0043231 intracellular membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
1.85 1.42e-02 GO:0005085 guanyl-nucleotide exchange factor activity
1.74 1.76e-02 GO:0015291 secondary active transmembrane transporter activity
1.52 4.30e-02 GO:0022804 active transmembrane transporter activity
1.44 9.40e-06 GO:0001071 nucleic acid binding transcription factor activity
1.44 9.40e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.43 3.32e-03 GO:0043565 sequence-specific DNA binding
1.39 6.19e-03 GO:0019899 enzyme binding
1.36 4.76e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.18 9.63e-13 GO:0005515 protein binding
1.08 6.51e-08 GO:0005488 binding