Motif ID: ZIC1..3.p2

Z-value: 2.303


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZIC1chr3_+_1471271510.485.4e-14Click!
ZIC3chrX_+_1366483130.452.3e-12Click!


Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_6798419 65.491 ZNF384
zinc finger protein 384
chr11_-_111782447 65.049 NM_001885
 CRYAB
crystallin, alpha B
chr12_-_45270071 52.149 NELL2
NEL-like 2 (chicken)
chr2_-_26205327 52.145 KIF3C
kinesin family member 3C
chr12_-_45269953 48.473 NELL2
NEL-like 2 (chicken)
chr6_-_29595934 48.184 NM_021903
 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr14_-_103988829 45.955 CKB
creatine kinase, brain
chr12_-_45270157 42.183 NM_001145108
NM_006159
 NELL2

NEL-like 2 (chicken)

chr11_-_12030539 41.786 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr14_+_29236882 36.194 FOXG1
forkhead box G1
chr12_+_79258588 35.682 SYT1
synaptotagmin I
chr5_+_175792444 35.381 NM_173664
 ARL10
ADP-ribosylation factor-like 10
chrX_-_48858617 35.009 NM_020137
NM_207672
 GRIPAP1

GRIP1 associated protein 1

chr14_-_103989195 34.950 NM_001823
 CKB
creatine kinase, brain
chr14_+_101292483 33.021


chr12_+_79258517 32.851 SYT1
synaptotagmin I
chrX_-_13956445 32.266


chr11_-_12030622 31.941 NM_015881
 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr14_-_103989112 31.736 CKB
creatine kinase, brain
chr9_-_113800243 31.145 NM_001401
NM_057159
 LPAR1

lysophosphatidic acid receptor 1


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 188 entries
enrichment   p-value GO term description
5.19 3.85e-02 GO:0043536 positive regulation of blood vessel endothelial cell migration
4.10 3.13e-02 GO:0043535 regulation of blood vessel endothelial cell migration
4.04 7.03e-03 GO:0030516 regulation of axon extension
3.46 3.06e-02 GO:0051149 positive regulation of muscle cell differentiation
3.34 1.39e-02 GO:0010594 regulation of endothelial cell migration
2.94 6.55e-03 GO:0050770 regulation of axonogenesis
2.89 1.16e-03 GO:0030879 mammary gland development
2.82 1.45e-02 GO:0022612 gland morphogenesis
2.77 3.27e-02 GO:0048638 regulation of developmental growth
2.74 5.56e-04 GO:0035107 appendage morphogenesis
2.74 5.56e-04 GO:0035108 limb morphogenesis
2.73 4.05e-04 GO:0048736 appendage development
2.73 4.05e-04 GO:0060173 limb development
2.73 4.18e-02 GO:0010721 negative regulation of cell development
2.70 5.19e-03 GO:0030326 embryonic limb morphogenesis
2.70 5.19e-03 GO:0035113 embryonic appendage morphogenesis
2.69 8.96e-04 GO:0061138 morphogenesis of a branching epithelium
2.65 7.42e-08 GO:0048732 gland development
2.50 1.55e-03 GO:0001763 morphogenesis of a branching structure
2.44 4.34e-04 GO:0031344 regulation of cell projection organization

Gene overrepresentation in compartment category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
2.74 7.26e-07 GO:0034703 cation channel complex
2.60 4.68e-02 GO:0031256 leading edge membrane
2.44 1.61e-02 GO:0008076 voltage-gated potassium channel complex
2.44 1.61e-02 GO:0034705 potassium channel complex
2.35 7.79e-07 GO:0034702 ion channel complex
1.91 3.55e-02 GO:0031252 cell leading edge
1.71 1.42e-03 GO:0045202 synapse
1.70 3.41e-02 GO:0044456 synapse part
1.69 3.33e-03 GO:0043005 neuron projection
1.63 2.23e-04 GO:0030054 cell junction
1.60 2.13e-09 GO:0005887 integral to plasma membrane
1.58 3.81e-09 GO:0031226 intrinsic to plasma membrane
1.55 4.70e-16 GO:0044459 plasma membrane part
1.51 4.24e-04 GO:0005626 insoluble fraction
1.47 2.76e-03 GO:0005624 membrane fraction
1.45 4.26e-03 GO:0042995 cell projection
1.43 3.69e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.42 3.00e-02 GO:0031410 cytoplasmic vesicle
1.41 1.82e-03 GO:0000267 cell fraction
1.28 2.15e-09 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
5.28 2.56e-02 GO:0005248 voltage-gated sodium channel activity
4.89 1.81e-02 GO:0005212 structural constituent of eye lens
3.26 2.67e-03 GO:0003707 steroid hormone receptor activity
3.25 1.51e-03 GO:0004879 ligand-dependent nuclear receptor activity
2.88 8.78e-04 GO:0005262 calcium channel activity
2.73 5.64e-07 GO:0022843 voltage-gated cation channel activity
2.32 1.90e-05 GO:0005244 voltage-gated ion channel activity
2.32 1.90e-05 GO:0022832 voltage-gated channel activity
2.31 3.69e-08 GO:0005261 cation channel activity
2.31 3.90e-02 GO:0005057 receptor signaling protein activity
2.06 1.48e-03 GO:0000975 regulatory region DNA binding
2.06 1.48e-03 GO:0001067 regulatory region nucleic acid binding
2.06 1.48e-03 GO:0044212 transcription regulatory region DNA binding
2.05 2.87e-03 GO:0010843 promoter binding
2.03 1.22e-05 GO:0022836 gated channel activity
1.91 6.89e-06 GO:0005216 ion channel activity
1.89 1.42e-05 GO:0022838 substrate-specific channel activity
1.87 1.21e-05 GO:0015267 channel activity
1.87 1.36e-05 GO:0022803 passive transmembrane transporter activity
1.86 7.35e-08 GO:0008324 cation transmembrane transporter activity