Motif ID: bHLH_family.p2

Z-value: 3.186


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HEYLchr1_-_40105341,
chr1_-_40098639		-0.686.5e-31Click!
HEY2chr6_+_126070724,
chr6_+_126070813		-0.659.8e-28Click!
OLIG2chr21_+_34398210-0.614.8e-24Click!
MLXIPLchr7_-_73038814-0.605.1e-23Click!
ARNTLchr11_+_13299260-0.547.8e-18Click!
MXD4chr4_-_2263808-0.492.4e-14Click!
ID1chr20_+_301930830.452.7e-12Click!
MXI1chr10_+_111967302-0.384.3e-09Click!
HEY1chr8_-_80679897-0.366.8e-08Click!
ARNTL2chr12_+_274857670.357.3e-08Click!
NPAS2chr2_+_101436491-0.321.7e-06Click!
TFE3chrX_-_48900932-0.244.6e-04Click!
MXD3chr5_-_176738831-0.161.5e-02Click!
CLOCKchr4_-_56412968-0.144.5e-02Click!
MITFchr3_+_698129610.111.1e-01Click!
MNTchr17_-_23042170.063.5e-01Click!


Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_58146108 283.386 CDK4
cyclin-dependent kinase 4
chr12_-_58146110 280.453 CDK4
cyclin-dependent kinase 4
chr12_-_58146025 280.326 CDK4
cyclin-dependent kinase 4
chr12_-_58146118 264.246 NM_000075
 CDK4
cyclin-dependent kinase 4
chr2_+_216176818 89.213 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr2_+_216176808 86.379 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr17_+_76164624 83.300 NM_004710
 SYNGR2
synaptogyrin 2
chr8_+_97274106 80.650 PTDSS1
phosphatidylserine synthase 1
chr2_+_216176678 76.734 NM_004044
 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr2_-_10588451 74.329 NM_002539
 ODC1
ornithine decarboxylase 1
chr4_-_100871482 71.323 NM_002106
 H2AFZ
H2A histone family, member Z
chr20_+_44519924 71.206 CTSA
cathepsin A
chr20_+_44519965 69.443 CTSA
cathepsin A
chr11_-_64014381 67.786 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr14_+_20923705 66.832 APEX1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr8_+_55047780 64.741 NM_014175
 MRPL15
mitochondrial ribosomal protein L15
chr20_+_44519590 63.488 NM_000308
NM_001127695
NM_001167594
 CTSA


cathepsin A


chr11_-_64014264 62.374 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr14_+_20923364 61.603 APEX1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr11_+_61560352 58.401 FEN1
flap structure-specific endonuclease 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 144 entries
enrichment   p-value GO term description
5.64 4.15e-02 GO:0042451 purine nucleoside biosynthetic process
5.64 4.15e-02 GO:0042455 ribonucleoside biosynthetic process
5.64 4.15e-02 GO:0046129 purine ribonucleoside biosynthetic process
4.09 4.78e-03 GO:0043488 regulation of mRNA stability
3.95 7.99e-03 GO:0043487 regulation of RNA stability
3.91 4.91e-02 GO:0009156 ribonucleoside monophosphate biosynthetic process
3.39 1.86e-02 GO:0006413 translational initiation
3.01 3.28e-08 GO:0042254 ribosome biogenesis
2.92 1.94e-02 GO:0009119 ribonucleoside metabolic process
2.89 1.30e-04 GO:0006364 rRNA processing
2.75 4.93e-03 GO:0006839 mitochondrial transport
2.73 5.32e-04 GO:0016072 rRNA metabolic process
2.58 2.25e-08 GO:0022613 ribonucleoprotein complex biogenesis
2.58 1.61e-04 GO:0050657 nucleic acid transport
2.58 1.61e-04 GO:0050658 RNA transport
2.58 1.61e-04 GO:0051236 establishment of RNA localization
2.57 1.25e-04 GO:0006403 RNA localization
2.50 1.20e-04 GO:0007005 mitochondrion organization
2.49 7.10e-08 GO:0071843 cellular component biogenesis at cellular level
2.47 8.07e-07 GO:0034470 ncRNA processing

Gene overrepresentation in compartment category:

Showing 1 to 20 of 51 entries
enrichment   p-value GO term description
6.11 2.27e-06 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
5.39 3.74e-02 GO:0005732 small nucleolar ribonucleoprotein complex
5.21 1.53e-02 GO:0005852 eukaryotic translation initiation factor 3 complex
3.72 3.08e-02 GO:0044452 nucleolar part
3.24 3.91e-02 GO:0042645 mitochondrial nucleoid
2.57 1.33e-03 GO:0042470 melanosome
2.57 1.33e-03 GO:0048770 pigment granule
2.35 3.58e-02 GO:0046930 pore complex
2.23 4.69e-16 GO:0005730 nucleolus
2.13 6.59e-06 GO:0005635 nuclear envelope
2.08 1.13e-12 GO:0030529 ribonucleoprotein complex
1.94 1.04e-13 GO:0031967 organelle envelope
1.92 2.38e-13 GO:0031975 envelope
1.90 2.13e-05 GO:0019866 organelle inner membrane
1.85 7.96e-07 GO:0005740 mitochondrial envelope
1.82 7.59e-04 GO:0005743 mitochondrial inner membrane
1.81 7.35e-06 GO:0031966 mitochondrial membrane
1.73 2.71e-29 GO:0044428 nuclear part
1.72 9.19e-24 GO:0031981 nuclear lumen
1.70 9.22e-26 GO:0005829 cytosol

Gene overrepresentation in function category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
3.29 2.86e-02 GO:0004536 deoxyribonuclease activity
2.51 1.28e-02 GO:0008135 translation factor activity, nucleic acid binding
2.16 3.79e-03 GO:0003714 transcription corepressor activity
1.86 2.08e-13 GO:0003723 RNA binding
1.65 1.31e-02 GO:0003712 transcription cofactor activity
1.65 1.44e-02 GO:0000988 protein binding transcription factor activity
1.65 1.44e-02 GO:0000989 transcription factor binding transcription factor activity
1.51 9.99e-03 GO:0005198 structural molecule activity
1.45 1.40e-02 GO:0042802 identical protein binding
1.44 1.24e-61 GO:0005515 protein binding
1.42 4.01e-02 GO:0019899 enzyme binding
1.35 7.87e-07 GO:0000166 nucleotide binding
1.29 8.25e-03 GO:0016740 transferase activity
1.28 8.95e-03 GO:0032553 ribonucleotide binding
1.28 8.95e-03 GO:0032555 purine ribonucleotide binding
1.28 9.48e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.27 1.37e-02 GO:0017076 purine nucleotide binding
1.20 5.39e-07 GO:0003824 catalytic activity
1.16 9.99e-27 GO:0005488 binding