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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for AAUCUCU

Z-value: 0.27

Motif logo

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miRNA associated with seed AAUCUCU

NamemiRBASE accession
hsa-miR-216b-5p
MIMAT0004959

Activity profile of AAUCUCU motif

Sorted Z-values of AAUCUCU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_31038370 3.73 ENST00000399489.1
ENST00000339872.4
HMGB1
high mobility group box 1
chr14_+_57735614 3.32 ENST00000261558.3
AP5M1
adaptor-related protein complex 5, mu 1 subunit
chr4_+_99916765 2.93 ENST00000296411.6
METAP1
methionyl aminopeptidase 1
chr3_-_113465065 2.57 ENST00000497255.1
ENST00000478020.1
ENST00000240922.3
ENST00000493900.1
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr2_+_48010221 2.56 ENST00000234420.5
MSH6
mutS homolog 6
chr8_+_48920960 2.46 ENST00000523111.2
ENST00000523432.1
ENST00000521346.1
ENST00000517630.1
UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
chr16_-_46723066 2.03 ENST00000299138.7
VPS35
vacuolar protein sorting 35 homolog (S. cerevisiae)
chr10_+_11206925 1.80 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CELF2
CUGBP, Elav-like family member 2
chr4_-_105416039 1.47 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr7_+_12250886 1.26 ENST00000444443.1
ENST00000396667.3
TMEM106B
transmembrane protein 106B
chr7_+_35840542 1.24 ENST00000435235.1
ENST00000399034.2
ENST00000350320.6
ENST00000469679.2
SEPT7
septin 7
chr17_+_30677136 1.23 ENST00000394670.4
ENST00000321233.6
ENST00000394673.2
ENST00000341711.6
ENST00000579634.1
ENST00000580759.1
ENST00000342555.6
ENST00000577908.1
ENST00000394679.5
ENST00000582165.1
ZNF207
zinc finger protein 207
chr6_+_42749759 1.08 ENST00000314073.5
GLTSCR1L
GLTSCR1-like
chr6_+_114178512 0.86 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr2_-_242212227 0.76 ENST00000427007.1
ENST00000458564.1
ENST00000452065.1
ENST00000427183.2
ENST00000426343.1
ENST00000422080.1
ENST00000449504.1
ENST00000449864.1
ENST00000391975.1
HDLBP
high density lipoprotein binding protein
chr8_+_76452097 0.42 ENST00000396423.2
HNF4G
hepatocyte nuclear factor 4, gamma
chr9_-_20622478 0.35 ENST00000355930.6
ENST00000380338.4
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr1_+_2323260 0.23 ENST00000378518.1
ENST00000605895.1
ENST00000378513.3
ENST00000306256.9
ENST00000378512.1
RER1
retention in endoplasmic reticulum sorting receptor 1
chr12_+_60083118 0.12 ENST00000261187.4
ENST00000543448.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr14_+_71108460 0.11 ENST00000256367.2
TTC9
tetratricopeptide repeat domain 9

Network of associatons between targets according to the STRING database.

First level regulatory network of AAUCUCU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.7 GO:0002840 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
0.7 2.0 GO:1903179 positive regulation of Wnt protein secretion(GO:0061357) regulation of late endosome to lysosome transport(GO:1902822) regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) negative regulation of vacuolar transport(GO:1903336) negative regulation of protein catabolic process in the vacuole(GO:1904351) negative regulation of lysosomal protein catabolic process(GO:1905166)
0.4 2.6 GO:0000710 meiotic mismatch repair(GO:0000710)
0.3 2.6 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.2 1.2 GO:0016476 regulation of embryonic cell shape(GO:0016476)
0.2 1.5 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.2 2.9 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.1 2.5 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 1.8 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.8 GO:0034384 high-density lipoprotein particle clearance(GO:0034384)
0.0 0.9 GO:0051764 actin crosslink formation(GO:0051764)
0.0 1.2 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.0 0.4 GO:0007379 segment specification(GO:0007379) positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 1.3 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.1 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.2 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 3.3 GO:0016197 endosomal transport(GO:0016197)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.7 2.0 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.6 2.6 GO:0032301 MutSalpha complex(GO:0032301)
0.4 2.6 GO:0031415 NatA complex(GO:0031415)
0.1 1.2 GO:0097227 sperm annulus(GO:0097227)
0.1 3.3 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.1 0.9 GO:0043073 germ cell nucleus(GO:0043073)
0.0 3.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 1.2 GO:0000777 condensed chromosome kinetochore(GO:0000777)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.6 GO:0032143 single thymine insertion binding(GO:0032143)
0.6 3.7 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.2 2.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 2.0 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.1 2.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 2.9 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 1.8 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.9 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.2 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 1.5 GO:0030165 PDZ domain binding(GO:0030165)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.5 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells